Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC45_LEIMA

TriTrypDb:

LmjF.01.0540 , LMJLV39_010010700 , LMJSD75_010010700

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	543	547	PF00656	0.827
CLV_C14_Caspase3-7	571	575	PF00656	0.669
CLV_NRD_NRD_1	108	110	PF00675	0.640
CLV_NRD_NRD_1	124	126	PF00675	0.678
CLV_NRD_NRD_1	151	153	PF00675	0.632
CLV_NRD_NRD_1	16	18	PF00675	0.596
CLV_NRD_NRD_1	336	338	PF00675	0.809
CLV_NRD_NRD_1	341	343	PF00675	0.730
CLV_NRD_NRD_1	437	439	PF00675	0.676
CLV_NRD_NRD_1	50	52	PF00675	0.579
CLV_NRD_NRD_1	54	56	PF00675	0.560
CLV_NRD_NRD_1	569	571	PF00675	0.694
CLV_NRD_NRD_1	644	646	PF00675	0.816
CLV_NRD_NRD_1	69	71	PF00675	0.687
CLV_PCSK_FUR_1	334	338	PF00082	0.815
CLV_PCSK_FUR_1	567	571	PF00082	0.682
CLV_PCSK_KEX2_1	108	110	PF00082	0.640
CLV_PCSK_KEX2_1	151	153	PF00082	0.632
CLV_PCSK_KEX2_1	16	18	PF00082	0.596
CLV_PCSK_KEX2_1	201	203	PF00082	0.547
CLV_PCSK_KEX2_1	232	234	PF00082	0.624
CLV_PCSK_KEX2_1	336	338	PF00082	0.820
CLV_PCSK_KEX2_1	341	343	PF00082	0.762
CLV_PCSK_KEX2_1	437	439	PF00082	0.676
CLV_PCSK_KEX2_1	50	52	PF00082	0.579
CLV_PCSK_KEX2_1	54	56	PF00082	0.560
CLV_PCSK_KEX2_1	569	571	PF00082	0.686
CLV_PCSK_KEX2_1	638	640	PF00082	0.744
CLV_PCSK_KEX2_1	644	646	PF00082	0.767
CLV_PCSK_KEX2_1	69	71	PF00082	0.687
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.547
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.624
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.685
CLV_PCSK_PC7_1	337	343	PF00082	0.639
CLV_PCSK_PC7_1	50	56	PF00082	0.621
CLV_PCSK_SKI1_1	233	237	PF00082	0.480
CLV_PCSK_SKI1_1	252	256	PF00082	0.517
CLV_PCSK_SKI1_1	405	409	PF00082	0.773
CLV_PCSK_SKI1_1	54	58	PF00082	0.662
CLV_PCSK_SKI1_1	605	609	PF00082	0.668
CLV_PCSK_SKI1_1	91	95	PF00082	0.637
CLV_Separin_Metazoa	641	645	PF03568	0.656
DEG_APCC_DBOX_1	49	57	PF00400	0.646
DEG_SPOP_SBC_1	504	508	PF00917	0.591
DOC_MAPK_gen_1	125	132	PF00069	0.615
DOC_MAPK_gen_1	148	157	PF00069	0.588
DOC_MAPK_gen_1	617	626	PF00069	0.663
DOC_MAPK_gen_1	644	651	PF00069	0.687
DOC_MAPK_MEF2A_6	644	651	PF00069	0.687
DOC_PP4_FxxP_1	166	169	PF00568	0.637
DOC_PP4_FxxP_1	9	12	PF00568	0.631
DOC_PP4_MxPP_1	650	653	PF00568	0.625
DOC_USP7_MATH_1	100	104	PF00917	0.610
DOC_USP7_MATH_1	137	141	PF00917	0.699
DOC_USP7_MATH_1	217	221	PF00917	0.645
DOC_USP7_MATH_1	383	387	PF00917	0.677
DOC_USP7_MATH_1	443	447	PF00917	0.656
DOC_USP7_MATH_1	504	508	PF00917	0.730
DOC_USP7_MATH_1	547	551	PF00917	0.716
DOC_USP7_MATH_1	553	557	PF00917	0.737
DOC_USP7_MATH_1	613	617	PF00917	0.807
DOC_USP7_MATH_1	632	636	PF00917	0.660
DOC_WW_Pin1_4	376	381	PF00397	0.781
DOC_WW_Pin1_4	407	412	PF00397	0.728
DOC_WW_Pin1_4	454	459	PF00397	0.740
DOC_WW_Pin1_4	470	475	PF00397	0.692
DOC_WW_Pin1_4	483	488	PF00397	0.618
DOC_WW_Pin1_4	534	539	PF00397	0.708
DOC_WW_Pin1_4	575	580	PF00397	0.730
LIG_14-3-3_CanoR_1	118	124	PF00244	0.580
LIG_14-3-3_CanoR_1	125	132	PF00244	0.651
LIG_14-3-3_CanoR_1	136	146	PF00244	0.596
LIG_14-3-3_CanoR_1	202	211	PF00244	0.646
LIG_14-3-3_CanoR_1	341	349	PF00244	0.707
LIG_14-3-3_CanoR_1	358	364	PF00244	0.502
LIG_14-3-3_CanoR_1	478	487	PF00244	0.698
LIG_14-3-3_CanoR_1	517	525	PF00244	0.649
LIG_14-3-3_CanoR_1	530	540	PF00244	0.658
LIG_14-3-3_CanoR_1	605	613	PF00244	0.775
LIG_14-3-3_CanoR_1	64	69	PF00244	0.620
LIG_14-3-3_CanoR_1	91	96	PF00244	0.634
LIG_Actin_WH2_2	622	640	PF00022	0.630
LIG_BIR_III_4	546	550	PF00653	0.662
LIG_CtBP_PxDLS_1	458	462	PF00389	0.654
LIG_deltaCOP1_diTrp_1	33	38	PF00928	0.601
LIG_FHA_1	204	210	PF00498	0.592
LIG_FHA_1	292	298	PF00498	0.591
LIG_FHA_1	317	323	PF00498	0.690
LIG_FHA_1	349	355	PF00498	0.639
LIG_FHA_1	372	378	PF00498	0.546
LIG_FHA_1	417	423	PF00498	0.688
LIG_FHA_1	92	98	PF00498	0.747
LIG_FHA_2	253	259	PF00498	0.670
LIG_FHA_2	268	274	PF00498	0.658
LIG_FHA_2	541	547	PF00498	0.832
LIG_LIR_Apic_2	163	169	PF02991	0.629
LIG_LIR_Apic_2	608	613	PF02991	0.661
LIG_LIR_Apic_2	8	13	PF02991	0.661
LIG_LIR_Gen_1	290	298	PF02991	0.615
LIG_LIR_Nem_3	290	296	PF02991	0.614
LIG_MYND_1	454	458	PF01753	0.698
LIG_PCNA_yPIPBox_3	517	529	PF02747	0.581
LIG_Pex14_1	34	38	PF04695	0.602
LIG_SH2_CRK	603	607	PF00017	0.631
LIG_SH2_CRK	610	614	PF00017	0.636
LIG_SH2_STAP1	293	297	PF00017	0.615
LIG_SH2_STAP1	359	363	PF00017	0.683
LIG_SH2_STAP1	622	626	PF00017	0.666
LIG_SH2_STAT3	622	625	PF00017	0.522
LIG_SH2_STAT5	123	126	PF00017	0.676
LIG_SH2_STAT5	156	159	PF00017	0.637
LIG_SH2_STAT5	293	296	PF00017	0.592
LIG_SH2_STAT5	330	333	PF00017	0.674
LIG_SH2_STAT5	540	543	PF00017	0.777
LIG_SH3_3	152	158	PF00018	0.685
LIG_SH3_3	197	203	PF00018	0.662
LIG_SH3_3	271	277	PF00018	0.667
LIG_SH3_3	374	380	PF00018	0.546
LIG_SH3_3	382	388	PF00018	0.584
LIG_SH3_3	395	401	PF00018	0.689
LIG_SH3_3	580	586	PF00018	0.659
LIG_SH3_3	646	652	PF00018	0.674
LIG_SH3_3	8	14	PF00018	0.575
LIG_SUMO_SIM_par_1	208	214	PF11976	0.533
LIG_TRAF2_1	596	599	PF00917	0.552
LIG_TRFH_1	324	328	PF08558	0.689
LIG_WRC_WIRS_1	251	256	PF05994	0.518
MOD_CDC14_SPxK_1	582	585	PF00782	0.682
MOD_CDK_SPxK_1	579	585	PF00069	0.682
MOD_CK1_1	205	211	PF00069	0.487
MOD_CK1_1	343	349	PF00069	0.706
MOD_CK1_1	368	374	PF00069	0.741
MOD_CK1_1	439	445	PF00069	0.813
MOD_CK1_1	446	452	PF00069	0.718
MOD_CK1_1	483	489	PF00069	0.715
MOD_CK1_1	508	514	PF00069	0.752
MOD_CK1_1	532	538	PF00069	0.682
MOD_CK1_1	616	622	PF00069	0.662
MOD_CK2_1	359	365	PF00069	0.697
MOD_CK2_1	454	460	PF00069	0.724
MOD_Cter_Amidation	339	342	PF01082	0.643
MOD_GlcNHglycan	102	105	PF01048	0.524
MOD_GlcNHglycan	109	112	PF01048	0.564
MOD_GlcNHglycan	114	117	PF01048	0.612
MOD_GlcNHglycan	126	129	PF01048	0.662
MOD_GlcNHglycan	139	142	PF01048	0.611
MOD_GlcNHglycan	143	146	PF01048	0.548
MOD_GlcNHglycan	148	151	PF01048	0.572
MOD_GlcNHglycan	304	307	PF01048	0.635
MOD_GlcNHglycan	359	362	PF01048	0.629
MOD_GlcNHglycan	367	370	PF01048	0.660
MOD_GlcNHglycan	385	388	PF01048	0.630
MOD_GlcNHglycan	398	401	PF01048	0.614
MOD_GlcNHglycan	40	43	PF01048	0.509
MOD_GlcNHglycan	438	441	PF01048	0.755
MOD_GlcNHglycan	559	562	PF01048	0.767
MOD_GlcNHglycan	88	91	PF01048	0.706
MOD_GSK3_1	137	144	PF00069	0.674
MOD_GSK3_1	201	208	PF00069	0.575
MOD_GSK3_1	258	265	PF00069	0.602
MOD_GSK3_1	302	309	PF00069	0.620
MOD_GSK3_1	312	319	PF00069	0.609
MOD_GSK3_1	322	329	PF00069	0.504
MOD_GSK3_1	353	360	PF00069	0.690
MOD_GSK3_1	367	374	PF00069	0.660
MOD_GSK3_1	396	403	PF00069	0.785
MOD_GSK3_1	412	419	PF00069	0.622
MOD_GSK3_1	439	446	PF00069	0.713
MOD_GSK3_1	479	486	PF00069	0.784
MOD_GSK3_1	504	511	PF00069	0.701
MOD_GSK3_1	512	519	PF00069	0.659
MOD_GSK3_1	528	535	PF00069	0.713
MOD_GSK3_1	536	543	PF00069	0.638
MOD_GSK3_1	553	560	PF00069	0.783
MOD_GSK3_1	575	582	PF00069	0.738
MOD_GSK3_1	82	89	PF00069	0.745
MOD_N-GLC_1	412	417	PF02516	0.694
MOD_N-GLC_1	532	537	PF02516	0.685
MOD_NEK2_1	124	129	PF00069	0.798
MOD_NEK2_1	146	151	PF00069	0.662
MOD_NEK2_1	160	165	PF00069	0.508
MOD_NEK2_1	211	216	PF00069	0.601
MOD_NEK2_1	237	242	PF00069	0.632
MOD_NEK2_1	322	327	PF00069	0.690
MOD_NEK2_1	335	340	PF00069	0.576
MOD_NEK2_1	367	372	PF00069	0.706
MOD_NEK2_1	38	43	PF00069	0.550
MOD_NEK2_1	429	434	PF00069	0.635
MOD_NEK2_1	480	485	PF00069	0.669
MOD_NEK2_1	528	533	PF00069	0.718
MOD_PIKK_1	130	136	PF00454	0.680
MOD_PIKK_1	343	349	PF00454	0.703
MOD_PIKK_1	368	374	PF00454	0.633
MOD_PIKK_1	512	518	PF00454	0.634
MOD_PK_1	64	70	PF00069	0.552
MOD_PKA_1	201	207	PF00069	0.524
MOD_PKA_1	341	347	PF00069	0.637
MOD_PKA_2	107	113	PF00069	0.504
MOD_PKA_2	117	123	PF00069	0.547
MOD_PKA_2	124	130	PF00069	0.644
MOD_PKA_2	201	207	PF00069	0.573
MOD_PKA_2	326	332	PF00069	0.683
MOD_PKA_2	335	341	PF00069	0.618
MOD_PKA_2	357	363	PF00069	0.646
MOD_PKA_2	436	442	PF00069	0.667
MOD_PKA_2	516	522	PF00069	0.640
MOD_PKA_2	529	535	PF00069	0.611
MOD_Plk_1	412	418	PF00069	0.696
MOD_Plk_4	160	166	PF00069	0.617
MOD_Plk_4	205	211	PF00069	0.487
MOD_Plk_4	326	332	PF00069	0.683
MOD_Plk_4	536	542	PF00069	0.666
MOD_Plk_4	632	638	PF00069	0.693
MOD_ProDKin_1	376	382	PF00069	0.782
MOD_ProDKin_1	407	413	PF00069	0.726
MOD_ProDKin_1	454	460	PF00069	0.740
MOD_ProDKin_1	470	476	PF00069	0.693
MOD_ProDKin_1	483	489	PF00069	0.619
MOD_ProDKin_1	534	540	PF00069	0.712
MOD_ProDKin_1	575	581	PF00069	0.732
MOD_SUMO_for_1	313	316	PF00179	0.611
MOD_SUMO_rev_2	224	234	PF00179	0.624
TRG_DiLeu_BaLyEn_6	520	525	PF01217	0.675
TRG_ENDOCYTIC_2	293	296	PF00928	0.616
TRG_ER_diArg_1	334	337	PF00400	0.802
TRG_ER_diArg_1	436	438	PF00400	0.650
TRG_ER_diArg_1	50	52	PF00400	0.576
TRG_ER_diArg_1	53	55	PF00400	0.552
TRG_ER_diArg_1	567	570	PF00400	0.696
TRG_ER_diArg_1	584	587	PF00400	0.557
TRG_ER_diArg_1	643	645	PF00400	0.659
TRG_ER_diArg_1	68	70	PF00400	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4V8	Leishmania donovani	85%	97%
A4H377	Leishmania braziliensis	58%	93%
A4HRH7	Leishmania infantum	85%	97%
E9AJE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	94%