Putative long-chain-fatty-acid-CoA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

long-chain-fatty-acid-CoA ligase, putative

Species:

Leishmania major

UniProt:

E9AC43_LEIMA

TriTrypDb:

LmjF.01.0520 , LMJLV39_010010500 , LMJSD75_010010500

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 49
NetGPI	no	yes: 0, no: 49

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	6
GO:0005737	cytoplasm	2	6
GO:0005783	endoplasmic reticulum	5	6
GO:0016020	membrane	2	6
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0097014	ciliary plasm	5	6
GO:0099568	cytoplasmic region	3	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AC43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC43

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	35
GO:0004467	long-chain fatty acid-CoA ligase activity	3	33
GO:0015645	fatty acid ligase activity	2	33
GO:0016405	CoA-ligase activity	4	33
GO:0016874	ligase activity	2	35
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	33
GO:0016878	acid-thiol ligase activity	4	33
GO:0140657	ATP-dependent activity	1	33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.548
CLV_NRD_NRD_1	697	699	PF00675	0.426
CLV_PCSK_KEX2_1	11	13	PF00082	0.472
CLV_PCSK_KEX2_1	28	30	PF00082	0.510
CLV_PCSK_KEX2_1	405	407	PF00082	0.302
CLV_PCSK_KEX2_1	673	675	PF00082	0.489
CLV_PCSK_KEX2_1	696	698	PF00082	0.444
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.508
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.337
CLV_PCSK_PC1ET2_1	673	675	PF00082	0.546
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.427
CLV_PCSK_SKI1_1	222	226	PF00082	0.353
CLV_PCSK_SKI1_1	349	353	PF00082	0.339
CLV_PCSK_SKI1_1	359	363	PF00082	0.332
CLV_PCSK_SKI1_1	406	410	PF00082	0.333
CLV_PCSK_SKI1_1	438	442	PF00082	0.383
CLV_PCSK_SKI1_1	446	450	PF00082	0.339
CLV_PCSK_SKI1_1	544	548	PF00082	0.386
CLV_PCSK_SKI1_1	96	100	PF00082	0.473
DOC_CKS1_1	355	360	PF01111	0.409
DOC_MAPK_gen_1	119	126	PF00069	0.500
DOC_MAPK_MEF2A_6	225	234	PF00069	0.323
DOC_MAPK_RevD_3	15	30	PF00069	0.347
DOC_PP2B_PxIxI_1	232	238	PF00149	0.456
DOC_PP4_FxxP_1	355	358	PF00568	0.324
DOC_PP4_FxxP_1	434	437	PF00568	0.362
DOC_USP7_MATH_1	105	109	PF00917	0.466
DOC_USP7_MATH_1	412	416	PF00917	0.380
DOC_USP7_MATH_1	661	665	PF00917	0.453
DOC_USP7_UBL2_3	534	538	PF12436	0.339
DOC_USP7_UBL2_3	574	578	PF12436	0.331
DOC_USP7_UBL2_3	99	103	PF12436	0.550
DOC_WW_Pin1_4	354	359	PF00397	0.343
DOC_WW_Pin1_4	423	428	PF00397	0.331
DOC_WW_Pin1_4	515	520	PF00397	0.368
DOC_WW_Pin1_4	680	685	PF00397	0.447
LIG_14-3-3_CanoR_1	359	368	PF00244	0.385
LIG_14-3-3_CanoR_1	626	631	PF00244	0.486
LIG_14-3-3_CanoR_1	666	670	PF00244	0.459
LIG_Actin_WH2_2	376	393	PF00022	0.358
LIG_APCC_ABBA_1	162	167	PF00400	0.334
LIG_APCC_ABBA_1	607	612	PF00400	0.428
LIG_Clathr_ClatBox_1	507	511	PF01394	0.317
LIG_eIF4E_1	594	600	PF01652	0.452
LIG_FHA_1	244	250	PF00498	0.344
LIG_FHA_1	271	277	PF00498	0.316
LIG_FHA_1	475	481	PF00498	0.347
LIG_FHA_1	541	547	PF00498	0.344
LIG_FHA_1	553	559	PF00498	0.321
LIG_FHA_2	125	131	PF00498	0.472
LIG_FHA_2	134	140	PF00498	0.357
LIG_FHA_2	166	172	PF00498	0.318
LIG_FHA_2	288	294	PF00498	0.339
LIG_FHA_2	358	364	PF00498	0.359
LIG_FHA_2	42	48	PF00498	0.489
LIG_FHA_2	705	711	PF00498	0.481
LIG_HCF-1_HBM_1	410	413	PF13415	0.435
LIG_LIR_Apic_2	431	437	PF02991	0.394
LIG_LIR_Gen_1	127	137	PF02991	0.364
LIG_LIR_Gen_1	188	198	PF02991	0.337
LIG_LIR_Gen_1	459	470	PF02991	0.333
LIG_LIR_Gen_1	583	592	PF02991	0.406
LIG_LIR_Gen_1	668	677	PF02991	0.488
LIG_LIR_Gen_1	75	85	PF02991	0.457
LIG_LIR_Nem_3	127	132	PF02991	0.418
LIG_LIR_Nem_3	188	193	PF02991	0.331
LIG_LIR_Nem_3	253	257	PF02991	0.323
LIG_LIR_Nem_3	325	331	PF02991	0.305
LIG_LIR_Nem_3	459	465	PF02991	0.333
LIG_LIR_Nem_3	583	587	PF02991	0.439
LIG_LIR_Nem_3	637	643	PF02991	0.451
LIG_LIR_Nem_3	668	672	PF02991	0.501
LIG_LIR_Nem_3	75	80	PF02991	0.411
LIG_LYPXL_yS_3	640	643	PF13949	0.405
LIG_Pex14_2	348	352	PF04695	0.423
LIG_PTB_Apo_2	461	468	PF02174	0.347
LIG_SH2_CRK	190	194	PF00017	0.341
LIG_SH2_CRK	77	81	PF00017	0.468
LIG_SH2_CRK	95	99	PF00017	0.424
LIG_SH2_GRB2like	190	193	PF00017	0.350
LIG_SH2_PTP2	584	587	PF00017	0.402
LIG_SH2_STAP1	704	708	PF00017	0.402
LIG_SH2_STAP1	77	81	PF00017	0.565
LIG_SH2_STAT3	536	539	PF00017	0.318
LIG_SH2_STAT5	165	168	PF00017	0.457
LIG_SH2_STAT5	286	289	PF00017	0.344
LIG_SH2_STAT5	328	331	PF00017	0.340
LIG_SH2_STAT5	531	534	PF00017	0.386
LIG_SH2_STAT5	584	587	PF00017	0.405
LIG_SH2_STAT5	615	618	PF00017	0.353
LIG_SH2_STAT5	77	80	PF00017	0.542
LIG_SH3_3	227	233	PF00018	0.335
LIG_SH3_3	608	614	PF00018	0.483
LIG_SUMO_SIM_anti_2	278	285	PF11976	0.412
LIG_SUMO_SIM_par_1	506	512	PF11976	0.312
LIG_TRAF2_1	501	504	PF00917	0.460
LIG_TYR_ITIM	93	98	PF00017	0.443
LIG_UBA3_1	386	392	PF00899	0.345
LIG_UBA3_1	507	514	PF00899	0.460
LIG_WRC_WIRS_1	251	256	PF05994	0.229
LIG_WRC_WIRS_1	372	377	PF05994	0.487
LIG_WRC_WIRS_1	558	563	PF05994	0.409
MOD_CDK_SPK_2	354	359	PF00069	0.353
MOD_CDK_SPxxK_3	515	522	PF00069	0.368
MOD_CK1_1	108	114	PF00069	0.709
MOD_CK1_1	243	249	PF00069	0.472
MOD_CK1_1	288	294	PF00069	0.348
MOD_CK1_1	456	462	PF00069	0.356
MOD_CK2_1	110	116	PF00069	0.664
MOD_CK2_1	133	139	PF00069	0.358
MOD_CK2_1	165	171	PF00069	0.329
MOD_CK2_1	41	47	PF00069	0.492
MOD_CK2_1	592	598	PF00069	0.479
MOD_CK2_1	704	710	PF00069	0.452
MOD_GlcNHglycan	110	113	PF01048	0.731
MOD_GlcNHglycan	182	185	PF01048	0.444
MOD_GlcNHglycan	287	290	PF01048	0.327
MOD_GlcNHglycan	449	452	PF01048	0.332
MOD_GlcNHglycan	455	458	PF01048	0.338
MOD_GlcNHglycan	49	52	PF01048	0.422
MOD_GSK3_1	107	114	PF00069	0.627
MOD_GSK3_1	284	291	PF00069	0.340
MOD_GSK3_1	357	364	PF00069	0.361
MOD_GSK3_1	371	378	PF00069	0.356
MOD_GSK3_1	43	50	PF00069	0.442
MOD_GSK3_1	653	660	PF00069	0.374
MOD_GSK3_1	661	668	PF00069	0.432
MOD_GSK3_1	72	79	PF00069	0.496
MOD_N-GLC_1	160	165	PF02516	0.477
MOD_N-GLC_1	493	498	PF02516	0.414
MOD_NEK2_1	124	129	PF00069	0.424
MOD_NEK2_1	154	159	PF00069	0.394
MOD_NEK2_1	211	216	PF00069	0.338
MOD_NEK2_1	285	290	PF00069	0.342
MOD_NEK2_1	338	343	PF00069	0.409
MOD_NEK2_1	361	366	PF00069	0.377
MOD_NEK2_1	476	481	PF00069	0.337
MOD_NEK2_1	657	662	PF00069	0.386
MOD_NEK2_1	76	81	PF00069	0.450
MOD_NEK2_2	160	165	PF00069	0.347
MOD_NEK2_2	400	405	PF00069	0.399
MOD_PIKK_1	204	210	PF00454	0.403
MOD_PK_1	122	128	PF00069	0.587
MOD_PKA_2	625	631	PF00069	0.491
MOD_PKA_2	661	667	PF00069	0.474
MOD_PKA_2	72	78	PF00069	0.534
MOD_Plk_1	160	166	PF00069	0.343
MOD_Plk_1	338	344	PF00069	0.402
MOD_Plk_4	160	166	PF00069	0.378
MOD_Plk_4	185	191	PF00069	0.333
MOD_Plk_4	327	333	PF00069	0.375
MOD_Plk_4	375	381	PF00069	0.401
MOD_Plk_4	4	10	PF00069	0.436
MOD_Plk_4	72	78	PF00069	0.498
MOD_ProDKin_1	354	360	PF00069	0.343
MOD_ProDKin_1	423	429	PF00069	0.331
MOD_ProDKin_1	515	521	PF00069	0.368
MOD_ProDKin_1	680	686	PF00069	0.451
MOD_SUMO_for_1	118	121	PF00179	0.758
MOD_SUMO_rev_2	288	297	PF00179	0.296
MOD_SUMO_rev_2	500	508	PF00179	0.343
MOD_SUMO_rev_2	509	516	PF00179	0.326
MOD_SUMO_rev_2	560	567	PF00179	0.409
TRG_ENDOCYTIC_2	137	140	PF00928	0.334
TRG_ENDOCYTIC_2	190	193	PF00928	0.345
TRG_ENDOCYTIC_2	331	334	PF00928	0.273
TRG_ENDOCYTIC_2	584	587	PF00928	0.405
TRG_ENDOCYTIC_2	640	643	PF00928	0.398
TRG_ENDOCYTIC_2	77	80	PF00928	0.426
TRG_ENDOCYTIC_2	95	98	PF00928	0.415
TRG_ER_diArg_1	28	30	PF00400	0.578
TRG_ER_diArg_1	444	447	PF00400	0.393
TRG_ER_diArg_1	674	677	PF00400	0.466
TRG_ER_diArg_1	697	699	PF00400	0.446
TRG_NLS_MonoExtC_3	695	701	PF00514	0.368
TRG_NLS_MonoExtN_4	694	700	PF00514	0.414
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	676	680	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2ZF83	Pseudomonas aeruginosa (strain UCBPP-PA14)	24%	100%
A0A0N0P580	Leptomonas seymouri	69%	100%
A0A0N1IG93	Leptomonas seymouri	48%	100%
A0A0N1PBD0	Leptomonas seymouri	44%	100%
A0A0S4IKS1	Bodo saltans	47%	100%
A0A0S4ILZ2	Bodo saltans	42%	100%
A0A1X0P2Q8	Trypanosomatidae	46%	100%
A0A1X0P2W9	Trypanosomatidae	45%	100%
A0A1X0P3Q5	Trypanosomatidae	55%	100%
A0A1X0P428	Trypanosomatidae	51%	100%
A0A1X0P8N7	Trypanosomatidae	50%	100%
A0A3Q8I9I3	Leishmania donovani	23%	100%
A0A3R7KCI7	Trypanosoma rangeli	45%	100%
A0A3R7M7X9	Trypanosoma rangeli	46%	100%
A0A3R7N023	Trypanosoma rangeli	51%	100%
A0A3S5H4V6	Leishmania donovani	97%	100%
A0A3S7WVG2	Leishmania donovani	22%	100%
A0A3S7WVL1	Leishmania donovani	22%	100%
A0A422NFF5	Trypanosoma rangeli	56%	100%
A0A422NQH3	Trypanosoma rangeli	49%	100%
A0A451EJA3	Leishmania donovani	49%	100%
A0A451EJA5	Leishmania donovani	55%	100%
A0A451EJA6	Leishmania donovani	46%	100%
A0A451EJM7	Leishmania donovani	47%	100%
A0R4Q2	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	25%	100%
A1L1K7	Rattus norvegicus	23%	100%
A4H373	Leishmania braziliensis	48%	100%
A4H374	Leishmania braziliensis	53%	100%
A4H375	Leishmania braziliensis	85%	100%
A4H376	Leishmania braziliensis	33%	96%
A4H3J5	Leishmania braziliensis	46%	100%
A4H731	Leishmania braziliensis	24%	100%
A4HRH0	Leishmania infantum	49%	100%
A4HRH2	Leishmania infantum	55%	100%
A4HRH3	Leishmania infantum	46%	100%
A4HRH5	Leishmania infantum	97%	100%
A4HRT4	Leishmania infantum	47%	100%
A4HVG5	Leishmania infantum	23%	100%
A4HYA8	Leishmania infantum	22%	100%
A9MYJ6	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	25%	100%
B2HGV4	Mycobacterium marinum (strain ATCC BAA-535 / M)	26%	100%
B4EY25	Proteus mirabilis (strain HI4320)	25%	100%
B4T6J6	Salmonella newport (strain SL254)	26%	100%
B4TIH0	Salmonella heidelberg (strain SL476)	26%	100%
B4TWR4	Salmonella schwarzengrund (strain CVM19633)	26%	100%
B5BL55	Salmonella paratyphi A (strain AKU_12601)	26%	100%
B5F750	Salmonella agona (strain SL483)	26%	100%
B5FHG5	Salmonella dublin (strain CT_02021853)	26%	100%
B5R1R0	Salmonella enteritidis PT4 (strain P125109)	25%	100%
C0Q4L3	Salmonella paratyphi C (strain RKS4594)	26%	100%
C9ZXK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
C9ZXK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZXK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
C9ZXK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D0A233	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AC38	Leishmania major	49%	97%
E9AC40	Leishmania major	54%	97%
E9AC41	Leishmania major	46%	100%
E9ACH0	Leishmania major	47%	100%
E9AGS6	Leishmania infantum	23%	100%
E9AJD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AJD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E9AJD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AJD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AJQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AP66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
M4IQQ7	Humulus lupulus	24%	100%
M4IQS1	Humulus lupulus	24%	100%
M4IS90	Humulus lupulus	25%	100%
M4ISH1	Humulus lupulus	27%	100%
O22898	Arabidopsis thaliana	30%	100%
O35547	Rattus norvegicus	32%	100%
O53521	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
O60135	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O60488	Homo sapiens	33%	100%
O74976	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O80658	Arabidopsis thaliana	24%	100%
O88813	Rattus norvegicus	29%	100%
O95573	Homo sapiens	33%	99%
P16405	Plasmodium falciparum (isolate NF7 / Ghana)	25%	100%
P18163	Rattus norvegicus	29%	100%
P30624	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P33121	Homo sapiens	29%	100%
P33124	Rattus norvegicus	28%	100%
P39002	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P39518	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	96%
P41216	Mus musculus	29%	100%
P47912	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P80436	Streptomyces triostinicus	22%	100%
P94547	Bacillus subtilis (strain 168)	23%	100%
P9WEY3	Penicillium brevicompactum	28%	100%
Q00594	Pseudomonas oleovorans	22%	100%
Q1ZXQ4	Dictyostelium discoideum	28%	100%
Q2XU92	Mus musculus	23%	100%
Q42524	Arabidopsis thaliana	25%	100%
Q4QDB6	Leishmania major	24%	100%
Q4QDB7	Leishmania major	24%	100%
Q4QGB2	Leishmania major	23%	100%
Q4R4Z9	Macaca fascicularis	21%	100%
Q55DR6	Dictyostelium discoideum	31%	100%
Q57TJ0	Salmonella choleraesuis (strain SC-B67)	26%	100%
Q58DN7	Bos taurus	25%	100%
Q5PIL0	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	26%	100%
Q5R668	Pongo abelii	33%	99%
Q5R9G9	Pongo abelii	20%	100%
Q5SKN9	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	25%	100%
Q63151	Rattus norvegicus	32%	99%
Q7TYX8	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	100%
Q7XXL2	Oryza sativa subsp. japonica	26%	100%
Q84HC5	Streptomyces carzinostaticus	26%	100%
Q84P24	Arabidopsis thaliana	27%	100%
Q8GB18	Proteus sp. (strain LE138)	25%	100%
Q8H151	Arabidopsis thaliana	26%	100%
Q8JZR0	Mus musculus	30%	100%
Q8LKS5	Arabidopsis thaliana	33%	100%
Q8LPS1	Arabidopsis thaliana	34%	100%
Q8W471	Arabidopsis thaliana	27%	98%
Q8ZRX4	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	100%
Q91WC3	Mus musculus	29%	100%
Q96CM8	Homo sapiens	21%	100%
Q9C7W4	Arabidopsis thaliana	28%	100%
Q9CAP8	Arabidopsis thaliana	33%	100%
Q9CZW4	Mus musculus	32%	99%
Q9HWG3	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	24%	100%
Q9JID6	Cavia porcellus	29%	100%
Q9LK39	Arabidopsis thaliana	27%	99%
Q9LPK6	Arabidopsis thaliana	24%	100%
Q9P7D7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q9QUJ7	Mus musculus	32%	100%
Q9SJD4	Arabidopsis thaliana	31%	99%
Q9T009	Arabidopsis thaliana	29%	100%
Q9T0A0	Arabidopsis thaliana	30%	100%
Q9UKU0	Homo sapiens	30%	100%
Q9ULC5	Homo sapiens	28%	100%
Q9V3S9	Drosophila melanogaster	23%	100%
Q9V3U0	Drosophila melanogaster	27%	100%
Q9XIA9	Arabidopsis thaliana	26%	100%
V5AX22	Trypanosoma cruzi	54%	100%
V5AZ02	Trypanosoma cruzi	48%	100%
V5BCF5	Trypanosoma cruzi	51%	100%
V5BH13	Trypanosoma cruzi	46%	100%
V5BLJ2	Trypanosoma cruzi	48%	100%
W6R1D9	Penicillium roqueforti (strain FM164)	28%	100%
W7L9F0	Gibberella moniliformis (strain M3125 / FGSC 7600)	32%	100%