LeishMANIAdb
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Putative fatty acyl CoA synthetase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:
Putative fatty acyl CoA synthetase 2
Gene product:
fatty acyl CoA synthetase 2, putative
Species:
Leishmania major
UniProt:
E9AC42_LEIMA
TriTrypDb:
LmjF.01.0510 , LMJLV39_010010400 , LMJSD75_010010400 *
Length:
194

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 2
GO:0016020 membrane 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AC42
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC42

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0004467 long-chain fatty acid-CoA ligase activity 3 2
GO:0015645 fatty acid ligase activity 2 2
GO:0016405 CoA-ligase activity 4 2
GO:0016874 ligase activity 2 2
GO:0016877 ligase activity, forming carbon-sulfur bonds 3 2
GO:0016878 acid-thiol ligase activity 4 2
GO:0140657 ATP-dependent activity 1 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 130 132 PF00675 0.830
CLV_NRD_NRD_1 64 66 PF00675 0.821
CLV_NRD_NRD_1 84 86 PF00675 0.468
CLV_PCSK_KEX2_1 130 132 PF00082 0.830
CLV_PCSK_KEX2_1 64 66 PF00082 0.821
CLV_PCSK_KEX2_1 83 85 PF00082 0.484
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.817
CLV_PCSK_PC7_1 80 86 PF00082 0.820
DEG_Nend_UBRbox_2 1 3 PF02207 0.754
DOC_PP2B_LxvP_1 13 16 PF13499 0.667
DOC_USP7_MATH_1 9 13 PF00917 0.701
DOC_USP7_MATH_1 99 103 PF00917 0.782
DOC_WW_Pin1_4 136 141 PF00397 0.822
DOC_WW_Pin1_4 87 92 PF00397 0.804
LIG_14-3-3_CanoR_1 64 72 PF00244 0.825
LIG_BRCT_BRCA1_1 153 157 PF00533 0.795
LIG_FHA_1 48 54 PF00498 0.773
LIG_FHA_2 156 162 PF00498 0.823
LIG_FHA_2 69 75 PF00498 0.827
LIG_LIR_Apic_2 86 91 PF02991 0.806
LIG_LIR_Gen_1 143 153 PF02991 0.810
LIG_LIR_Gen_1 5 16 PF02991 0.695
LIG_LIR_Nem_3 124 129 PF02991 0.823
LIG_LIR_Nem_3 143 149 PF02991 0.491
LIG_LIR_Nem_3 5 11 PF02991 0.709
LIG_MLH1_MIPbox_1 153 157 PF16413 0.795
LIG_PCNA_PIPBox_1 1 10 PF02747 0.725
LIG_Pex14_2 146 150 PF04695 0.812
LIG_SH2_CRK 177 181 PF00017 0.839
LIG_SH2_CRK 8 12 PF00017 0.708
LIG_SH2_CRK 88 92 PF00017 0.803
LIG_SH2_NCK_1 8 12 PF00017 0.708
LIG_SH2_STAT5 29 32 PF00017 0.671
LIG_SH2_STAT5 88 91 PF00017 0.804
LIG_TRAF2_1 71 74 PF00917 0.826
LIG_TRFH_1 123 127 PF08558 0.821
LIG_TYR_ITIM 175 180 PF00017 0.841
LIG_WRC_WIRS_1 146 151 PF05994 0.810
MOD_CDK_SPxxK_3 87 94 PF00069 0.798
MOD_CK1_1 136 142 PF00069 0.822
MOD_CK1_1 184 190 PF00069 0.807
MOD_CK1_1 3 9 PF00069 0.712
MOD_CK1_1 90 96 PF00069 0.782
MOD_CK2_1 155 161 PF00069 0.819
MOD_CK2_1 180 186 PF00069 0.820
MOD_CK2_1 68 74 PF00069 0.828
MOD_CK2_1 99 105 PF00069 0.791
MOD_GlcNHglycan 24 27 PF01048 0.684
MOD_GSK3_1 145 152 PF00069 0.807
MOD_GSK3_1 178 185 PF00069 0.826
MOD_GSK3_1 64 71 PF00069 0.822
MOD_N-GLC_1 136 141 PF02516 0.822
MOD_NEK2_1 180 185 PF00069 0.821
MOD_PIKK_1 151 157 PF00454 0.791
MOD_PKA_1 64 70 PF00069 0.825
MOD_PKA_2 64 70 PF00069 0.825
MOD_Plk_2-3 68 74 PF00069 0.828
MOD_Plk_4 145 151 PF00069 0.813
MOD_Plk_4 3 9 PF00069 0.712
MOD_ProDKin_1 136 142 PF00069 0.822
MOD_ProDKin_1 87 93 PF00069 0.799
TRG_DiLeu_BaEn_4 73 79 PF01217 0.828
TRG_ENDOCYTIC_2 177 180 PF00928 0.842
TRG_ENDOCYTIC_2 8 11 PF00928 0.707
TRG_ER_diArg_1 129 131 PF00400 0.830
TRG_ER_diArg_1 167 170 PF00400 0.837
TRG_ER_diArg_1 172 175 PF00400 0.754
TRG_ER_diArg_1 63 65 PF00400 0.826
TRG_ER_FFAT_2 152 161 PF00635 0.808

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS