Putative fatty acyl CoA synthetase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

fatty acyl CoA synthetase 2, putative

Species:

Leishmania major

UniProt:

E9AC42_LEIMA

TriTrypDb:

LmjF.01.0510 , LMJLV39_010010400 , LMJSD75_010010400

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AC42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC42

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004467	long-chain fatty acid-CoA ligase activity	3	2
GO:0015645	fatty acid ligase activity	2	2
GO:0016405	CoA-ligase activity	4	2
GO:0016874	ligase activity	2	2
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	2
GO:0016878	acid-thiol ligase activity	4	2
GO:0140657	ATP-dependent activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.830
CLV_NRD_NRD_1	64	66	PF00675	0.821
CLV_NRD_NRD_1	84	86	PF00675	0.468
CLV_PCSK_KEX2_1	130	132	PF00082	0.830
CLV_PCSK_KEX2_1	64	66	PF00082	0.821
CLV_PCSK_KEX2_1	83	85	PF00082	0.484
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.817
CLV_PCSK_PC7_1	80	86	PF00082	0.820
DEG_Nend_UBRbox_2	1	3	PF02207	0.754
DOC_PP2B_LxvP_1	13	16	PF13499	0.667
DOC_USP7_MATH_1	9	13	PF00917	0.701
DOC_USP7_MATH_1	99	103	PF00917	0.782
DOC_WW_Pin1_4	136	141	PF00397	0.822
DOC_WW_Pin1_4	87	92	PF00397	0.804
LIG_14-3-3_CanoR_1	64	72	PF00244	0.825
LIG_BRCT_BRCA1_1	153	157	PF00533	0.795
LIG_FHA_1	48	54	PF00498	0.773
LIG_FHA_2	156	162	PF00498	0.823
LIG_FHA_2	69	75	PF00498	0.827
LIG_LIR_Apic_2	86	91	PF02991	0.806
LIG_LIR_Gen_1	143	153	PF02991	0.810
LIG_LIR_Gen_1	5	16	PF02991	0.695
LIG_LIR_Nem_3	124	129	PF02991	0.823
LIG_LIR_Nem_3	143	149	PF02991	0.491
LIG_LIR_Nem_3	5	11	PF02991	0.709
LIG_MLH1_MIPbox_1	153	157	PF16413	0.795
LIG_PCNA_PIPBox_1	1	10	PF02747	0.725
LIG_Pex14_2	146	150	PF04695	0.812
LIG_SH2_CRK	177	181	PF00017	0.839
LIG_SH2_CRK	8	12	PF00017	0.708
LIG_SH2_CRK	88	92	PF00017	0.803
LIG_SH2_NCK_1	8	12	PF00017	0.708
LIG_SH2_STAT5	29	32	PF00017	0.671
LIG_SH2_STAT5	88	91	PF00017	0.804
LIG_TRAF2_1	71	74	PF00917	0.826
LIG_TRFH_1	123	127	PF08558	0.821
LIG_TYR_ITIM	175	180	PF00017	0.841
LIG_WRC_WIRS_1	146	151	PF05994	0.810
MOD_CDK_SPxxK_3	87	94	PF00069	0.798
MOD_CK1_1	136	142	PF00069	0.822
MOD_CK1_1	184	190	PF00069	0.807
MOD_CK1_1	3	9	PF00069	0.712
MOD_CK1_1	90	96	PF00069	0.782
MOD_CK2_1	155	161	PF00069	0.819
MOD_CK2_1	180	186	PF00069	0.820
MOD_CK2_1	68	74	PF00069	0.828
MOD_CK2_1	99	105	PF00069	0.791
MOD_GlcNHglycan	24	27	PF01048	0.684
MOD_GSK3_1	145	152	PF00069	0.807
MOD_GSK3_1	178	185	PF00069	0.826
MOD_GSK3_1	64	71	PF00069	0.822
MOD_N-GLC_1	136	141	PF02516	0.822
MOD_NEK2_1	180	185	PF00069	0.821
MOD_PIKK_1	151	157	PF00454	0.791
MOD_PKA_1	64	70	PF00069	0.825
MOD_PKA_2	64	70	PF00069	0.825
MOD_Plk_2-3	68	74	PF00069	0.828
MOD_Plk_4	145	151	PF00069	0.813
MOD_Plk_4	3	9	PF00069	0.712
MOD_ProDKin_1	136	142	PF00069	0.822
MOD_ProDKin_1	87	93	PF00069	0.799
TRG_DiLeu_BaEn_4	73	79	PF01217	0.828
TRG_ENDOCYTIC_2	177	180	PF00928	0.842
TRG_ENDOCYTIC_2	8	11	PF00928	0.707
TRG_ER_diArg_1	129	131	PF00400	0.830
TRG_ER_diArg_1	167	170	PF00400	0.837
TRG_ER_diArg_1	172	175	PF00400	0.754
TRG_ER_diArg_1	63	65	PF00400	0.826
TRG_ER_FFAT_2	152	161	PF00635	0.808