Putative beta eliminating lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta eliminating lyase,putative

Species:

Leishmania major

UniProt:

E9AC39_LEIMA

TriTrypDb:

LmjF.01.0480 , LMJLV39_010010100 , LMJSD75_010010100

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC39

PDB structure(s): 1svv_A , 1svv_B

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	6
GO:0006520	amino acid metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0019752	carboxylic acid metabolic process	5	6
GO:0043436	oxoacid metabolic process	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044281	small molecule metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016829	lyase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.312
CLV_PCSK_KEX2_1	352	354	PF00082	0.486
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.486
CLV_PCSK_SKI1_1	115	119	PF00082	0.469
CLV_PCSK_SKI1_1	243	247	PF00082	0.400
DEG_SCF_FBW7_1	1	7	PF00400	0.750
DOC_CKS1_1	1	6	PF01111	0.753
DOC_CYCLIN_RxL_1	26	37	PF00134	0.512
DOC_CYCLIN_yClb5_NLxxxL_5	260	269	PF00134	0.401
DOC_MAPK_MEF2A_6	174	182	PF00069	0.512
DOC_MAPK_MEF2A_6	249	257	PF00069	0.503
DOC_PP1_RVXF_1	288	294	PF00149	0.512
DOC_USP7_MATH_1	292	296	PF00917	0.415
DOC_WW_Pin1_4	190	195	PF00397	0.415
LIG_14-3-3_CanoR_1	186	195	PF00244	0.488
LIG_14-3-3_CanoR_1	205	212	PF00244	0.415
LIG_14-3-3_CanoR_1	332	338	PF00244	0.447
LIG_14-3-3_CanoR_1	5	15	PF00244	0.687
LIG_APCC_ABBA_1	178	183	PF00400	0.415
LIG_APCC_ABBAyCdc20_2	262	268	PF00400	0.512
LIG_BIR_II_1	1	5	PF00653	0.755
LIG_FHA_1	104	110	PF00498	0.415
LIG_FHA_1	152	158	PF00498	0.415
LIG_FHA_1	76	82	PF00498	0.512
LIG_FHA_2	160	166	PF00498	0.373
LIG_FHA_2	197	203	PF00498	0.401
LIG_LIR_Nem_3	263	269	PF02991	0.512
LIG_LIR_Nem_3	315	319	PF02991	0.502
LIG_PDZ_Class_1	354	359	PF00595	0.570
LIG_SH2_CRK	16	20	PF00017	0.585
LIG_SH2_STAT3	161	164	PF00017	0.512
LIG_SH2_STAT5	150	153	PF00017	0.415
LIG_SH2_STAT5	161	164	PF00017	0.415
LIG_SH2_STAT5	179	182	PF00017	0.446
LIG_SH2_STAT5	211	214	PF00017	0.415
LIG_SH2_STAT5	319	322	PF00017	0.460
LIG_SH3_3	114	120	PF00018	0.462
LIG_SUMO_SIM_anti_2	223	230	PF11976	0.512
LIG_SUMO_SIM_par_1	223	230	PF11976	0.512
LIG_TRAF2_1	162	165	PF00917	0.512
LIG_TRAF2_1	338	341	PF00917	0.413
LIG_UBA3_1	209	216	PF00899	0.415
LIG_UBA3_1	225	233	PF00899	0.415
MOD_CK1_1	152	158	PF00069	0.415
MOD_CK1_1	189	195	PF00069	0.415
MOD_CK1_1	336	342	PF00069	0.465
MOD_CK1_1	73	79	PF00069	0.415
MOD_CK2_1	159	165	PF00069	0.415
MOD_CK2_1	169	175	PF00069	0.415
MOD_CK2_1	99	105	PF00069	0.415
MOD_GlcNHglycan	132	135	PF01048	0.512
MOD_GlcNHglycan	167	172	PF01048	0.462
MOD_GlcNHglycan	188	191	PF01048	0.415
MOD_GlcNHglycan	294	297	PF01048	0.516
MOD_GlcNHglycan	72	75	PF01048	0.372
MOD_GSK3_1	152	159	PF00069	0.365
MOD_GSK3_1	186	193	PF00069	0.415
MOD_GSK3_1	332	339	PF00069	0.445
MOD_GSK3_1	99	106	PF00069	0.415
MOD_N-GLC_1	137	142	PF02516	0.512
MOD_N-GLC_1	152	157	PF02516	0.415
MOD_N-GLC_1	37	42	PF02516	0.512
MOD_NEK2_1	304	309	PF00069	0.568
MOD_NEK2_1	333	338	PF00069	0.445
MOD_NEK2_1	354	359	PF00069	0.570
MOD_PIKK_1	156	162	PF00454	0.415
MOD_PIKK_1	37	43	PF00454	0.512
MOD_PIKK_1	73	79	PF00454	0.415
MOD_PIKK_1	93	99	PF00454	0.187
MOD_PKA_2	204	210	PF00069	0.415
MOD_PKA_2	4	10	PF00069	0.730
MOD_Plk_1	196	202	PF00069	0.415
MOD_Plk_1	20	26	PF00069	0.534
MOD_Plk_1	304	310	PF00069	0.571
MOD_Plk_2-3	317	323	PF00069	0.588
MOD_Plk_4	14	20	PF00069	0.451
MOD_Plk_4	304	310	PF00069	0.571
MOD_ProDKin_1	190	196	PF00069	0.415
TRG_DiLeu_BaEn_2	342	348	PF01217	0.555
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.312
TRG_ENDOCYTIC_2	16	19	PF00928	0.490
TRG_ENDOCYTIC_2	179	182	PF00928	0.512
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9M0	Leptomonas seymouri	66%	94%
A0A3S5H4V5	Leishmania donovani	94%	100%
A4HRH1	Leishmania infantum	94%	100%
E9AJD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	97%
O50584	Pseudomonas sp. (strain NCIMB 10558)	32%	100%
O74267	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	94%
P37303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	93%
Q9HTF1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	31%	100%