Protein unc-93 homolog A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF791), putative

Species:

Leishmania major

UniProt:

E9AC35_LEIMA

TriTrypDb:

LmjF.01.0440 , LMJLV39_010009700 , LMJSD75_010009700

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AC35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC35

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	6
GO:0008509	monoatomic anion transmembrane transporter activity	4	6
GO:0015075	monoatomic ion transmembrane transporter activity	3	6
GO:0015098	molybdate ion transmembrane transporter activity	5	6
GO:0015103	inorganic anion transmembrane transporter activity	4	6
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	6
GO:0022857	transmembrane transporter activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.740
CLV_C14_Caspase3-7	63	67	PF00656	0.530
CLV_NRD_NRD_1	115	117	PF00675	0.424
CLV_NRD_NRD_1	524	526	PF00675	0.477
CLV_PCSK_KEX2_1	115	117	PF00082	0.424
CLV_PCSK_KEX2_1	524	526	PF00082	0.477
CLV_PCSK_SKI1_1	144	148	PF00082	0.413
CLV_PCSK_SKI1_1	54	58	PF00082	0.530
DEG_COP1_1	358	367	PF00400	0.530
DEG_MDM2_SWIB_1	241	249	PF02201	0.335
DEG_MDM2_SWIB_1	494	502	PF02201	0.435
DEG_Nend_UBRbox_2	1	3	PF02207	0.569
DEG_SCF_FBW7_1	219	226	PF00400	0.530
DOC_CDC14_PxL_1	361	369	PF14671	0.530
DOC_MAPK_gen_1	115	123	PF00069	0.552
DOC_MAPK_gen_1	46	55	PF00069	0.746
DOC_MAPK_gen_1	524	531	PF00069	0.646
DOC_MAPK_JIP1_4	204	210	PF00069	0.636
DOC_MAPK_MEF2A_6	115	123	PF00069	0.631
DOC_MAPK_MEF2A_6	345	352	PF00069	0.636
DOC_MAPK_MEF2A_6	422	430	PF00069	0.558
DOC_MAPK_MEF2A_6	46	55	PF00069	0.691
DOC_MAPK_NFAT4_5	116	124	PF00069	0.636
DOC_PP2B_LxvP_1	316	319	PF13499	0.603
DOC_PP2B_LxvP_1	337	340	PF13499	0.778
DOC_PP2B_LxvP_1	362	365	PF13499	0.530
DOC_PP4_FxxP_1	29	32	PF00568	0.420
DOC_PP4_FxxP_1	393	396	PF00568	0.530
DOC_USP7_MATH_1	129	133	PF00917	0.530
DOC_USP7_MATH_1	14	18	PF00917	0.536
DOC_USP7_MATH_1	149	153	PF00917	0.199
DOC_USP7_MATH_1	223	227	PF00917	0.530
DOC_USP7_MATH_1	251	255	PF00917	0.697
DOC_USP7_MATH_1	256	260	PF00917	0.728
DOC_USP7_MATH_1	286	290	PF00917	0.817
DOC_USP7_MATH_1	311	315	PF00917	0.767
DOC_USP7_MATH_1	456	460	PF00917	0.755
DOC_USP7_MATH_1	60	64	PF00917	0.530
DOC_WW_Pin1_4	103	108	PF00397	0.491
DOC_WW_Pin1_4	168	173	PF00397	0.723
DOC_WW_Pin1_4	219	224	PF00397	0.445
LIG_14-3-3_CanoR_1	115	123	PF00244	0.552
LIG_14-3-3_CanoR_1	315	319	PF00244	0.720
LIG_14-3-3_CanoR_1	416	426	PF00244	0.572
LIG_APCC_ABBA_1	367	372	PF00400	0.435
LIG_BRCT_BRCA1_1	263	267	PF00533	0.750
LIG_BRCT_BRCA1_1	372	376	PF00533	0.435
LIG_BRCT_BRCA1_1	70	74	PF00533	0.530
LIG_BRCT_BRCA1_1	87	91	PF00533	0.235
LIG_CORNRBOX	343	351	PF00104	0.469
LIG_CSL_BTD_1	362	365	PF09270	0.530
LIG_deltaCOP1_diTrp_1	20	29	PF00928	0.580
LIG_deltaCOP1_diTrp_1	495	504	PF00928	0.435
LIG_EH_1	264	268	PF12763	0.750
LIG_FHA_1	135	141	PF00498	0.366
LIG_FHA_1	149	155	PF00498	0.462
LIG_FHA_1	220	226	PF00498	0.436
LIG_FHA_1	356	362	PF00498	0.530
LIG_FHA_1	364	370	PF00498	0.299
LIG_FHA_1	39	45	PF00498	0.343
LIG_FHA_1	390	396	PF00498	0.530
LIG_FHA_1	427	433	PF00498	0.530
LIG_FHA_1	470	476	PF00498	0.487
LIG_FHA_1	509	515	PF00498	0.369
LIG_FHA_1	564	570	PF00498	0.770
LIG_FHA_1	95	101	PF00498	0.530
LIG_FHA_2	154	160	PF00498	0.633
LIG_FHA_2	418	424	PF00498	0.575
LIG_LIR_Apic_2	391	396	PF02991	0.636
LIG_LIR_Apic_2	421	427	PF02991	0.565
LIG_LIR_Gen_1	198	208	PF02991	0.691
LIG_LIR_Gen_1	495	505	PF02991	0.435
LIG_LIR_LC3C_4	404	409	PF02991	0.452
LIG_LIR_Nem_3	198	203	PF02991	0.698
LIG_LIR_Nem_3	37	42	PF02991	0.530
LIG_LIR_Nem_3	373	379	PF02991	0.435
LIG_LIR_Nem_3	440	444	PF02991	0.375
LIG_LIR_Nem_3	495	501	PF02991	0.435
LIG_MLH1_MIPbox_1	87	91	PF16413	0.380
LIG_MYND_1	28	32	PF01753	0.530
LIG_MYND_3	364	368	PF01753	0.530
LIG_NRBOX	406	412	PF00104	0.452
LIG_NRBOX	463	469	PF00104	0.452
LIG_PCNA_yPIPBox_3	315	327	PF02747	0.614
LIG_Pex14_1	451	455	PF04695	0.776
LIG_Pex14_2	241	245	PF04695	0.452
LIG_Pex14_2	352	356	PF04695	0.530
LIG_Pex14_2	376	380	PF04695	0.530
LIG_Pex14_2	494	498	PF04695	0.321
LIG_SH2_CRK	424	428	PF00017	0.549
LIG_SH2_CRK	441	445	PF00017	0.249
LIG_SH2_SRC	326	329	PF00017	0.781
LIG_SH2_SRC	370	373	PF00017	0.380
LIG_SH2_SRC	424	427	PF00017	0.556
LIG_SH2_SRC	455	458	PF00017	0.619
LIG_SH2_STAP1	330	334	PF00017	0.750
LIG_SH2_STAP1	370	374	PF00017	0.380
LIG_SH2_STAT5	217	220	PF00017	0.491
LIG_SH2_STAT5	237	240	PF00017	0.238
LIG_SH2_STAT5	326	329	PF00017	0.700
LIG_SH2_STAT5	342	345	PF00017	0.586
LIG_SH3_3	537	543	PF00018	0.689
LIG_SH3_3	8	14	PF00018	0.503
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.277
LIG_SUMO_SIM_par_1	365	373	PF11976	0.530
LIG_SUMO_SIM_par_1	406	412	PF11976	0.530
LIG_SUMO_SIM_par_1	60	66	PF11976	0.532
LIG_TYR_ITIM	235	240	PF00017	0.530
LIG_TYR_ITIM	439	444	PF00017	0.375
LIG_UBA3_1	464	469	PF00899	0.530
LIG_WRC_WIRS_1	385	390	PF05994	0.530
MOD_CK1_1	132	138	PF00069	0.530
MOD_CK1_1	152	158	PF00069	0.291
MOD_CK1_1	259	265	PF00069	0.726
MOD_CK1_1	288	294	PF00069	0.799
MOD_CK1_1	307	313	PF00069	0.755
MOD_CK1_1	314	320	PF00069	0.697
MOD_CK1_1	333	339	PF00069	0.617
MOD_CK1_1	391	397	PF00069	0.636
MOD_CK1_1	414	420	PF00069	0.435
MOD_CK1_1	85	91	PF00069	0.435
MOD_CK2_1	153	159	PF00069	0.628
MOD_CK2_1	279	285	PF00069	0.745
MOD_CK2_1	286	292	PF00069	0.742
MOD_Cter_Amidation	522	525	PF01082	0.471
MOD_GlcNHglycan	100	103	PF01048	0.265
MOD_GlcNHglycan	131	134	PF01048	0.601
MOD_GlcNHglycan	151	154	PF01048	0.199
MOD_GlcNHglycan	193	196	PF01048	0.486
MOD_GlcNHglycan	253	256	PF01048	0.606
MOD_GlcNHglycan	279	282	PF01048	0.528
MOD_GlcNHglycan	309	312	PF01048	0.579
MOD_GlcNHglycan	316	319	PF01048	0.465
MOD_GlcNHglycan	330	333	PF01048	0.351
MOD_GlcNHglycan	36	39	PF01048	0.452
MOD_GlcNHglycan	458	461	PF01048	0.510
MOD_GlcNHglycan	534	538	PF01048	0.490
MOD_GlcNHglycan	544	547	PF01048	0.533
MOD_GlcNHglycan	84	87	PF01048	0.735
MOD_GSK3_1	144	151	PF00069	0.471
MOD_GSK3_1	191	198	PF00069	0.802
MOD_GSK3_1	208	215	PF00069	0.407
MOD_GSK3_1	219	226	PF00069	0.483
MOD_GSK3_1	251	258	PF00069	0.699
MOD_GSK3_1	284	291	PF00069	0.824
MOD_GSK3_1	292	299	PF00069	0.710
MOD_GSK3_1	307	314	PF00069	0.740
MOD_GSK3_1	34	41	PF00069	0.316
MOD_GSK3_1	384	391	PF00069	0.465
MOD_GSK3_1	414	421	PF00069	0.435
MOD_GSK3_1	456	463	PF00069	0.769
MOD_GSK3_1	568	575	PF00069	0.778
MOD_GSK3_1	68	75	PF00069	0.368
MOD_GSK3_1	94	101	PF00069	0.411
MOD_LATS_1	277	283	PF00433	0.843
MOD_N-GLC_1	3	8	PF02516	0.754
MOD_NEK2_1	191	196	PF00069	0.768
MOD_NEK2_1	208	213	PF00069	0.530
MOD_NEK2_1	293	298	PF00069	0.774
MOD_NEK2_1	357	362	PF00069	0.487
MOD_NEK2_1	384	389	PF00069	0.475
MOD_NEK2_1	411	416	PF00069	0.296
MOD_NEK2_1	437	442	PF00069	0.530
MOD_NEK2_1	68	73	PF00069	0.389
MOD_NEK2_1	82	87	PF00069	0.482
MOD_NEK2_2	14	19	PF00069	0.533
MOD_NEK2_2	195	200	PF00069	0.701
MOD_NEK2_2	330	335	PF00069	0.770
MOD_PIKK_1	212	218	PF00454	0.532
MOD_PIKK_1	411	417	PF00454	0.275
MOD_PIKK_1	508	514	PF00454	0.530
MOD_PKA_2	114	120	PF00069	0.552
MOD_PKA_2	314	320	PF00069	0.696
MOD_Plk_1	293	299	PF00069	0.674
MOD_Plk_1	3	9	PF00069	0.553
MOD_Plk_1	370	376	PF00069	0.435
MOD_Plk_4	14	20	PF00069	0.533
MOD_Plk_4	153	159	PF00069	0.550
MOD_Plk_4	195	201	PF00069	0.727
MOD_Plk_4	22	28	PF00069	0.279
MOD_Plk_4	245	251	PF00069	0.573
MOD_Plk_4	256	262	PF00069	0.728
MOD_Plk_4	296	302	PF00069	0.629
MOD_Plk_4	31	37	PF00069	0.381
MOD_Plk_4	357	363	PF00069	0.487
MOD_Plk_4	38	44	PF00069	0.265
MOD_Plk_4	384	390	PF00069	0.530
MOD_Plk_4	426	432	PF00069	0.435
MOD_Plk_4	446	452	PF00069	0.377
MOD_Plk_4	460	466	PF00069	0.216
MOD_Plk_4	94	100	PF00069	0.530
MOD_ProDKin_1	103	109	PF00069	0.491
MOD_ProDKin_1	168	174	PF00069	0.728
MOD_ProDKin_1	219	225	PF00069	0.445
MOD_SUMO_rev_2	173	182	PF00179	0.818
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.616
TRG_ENDOCYTIC_2	237	240	PF00928	0.452
TRG_ENDOCYTIC_2	441	444	PF00928	0.375
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.380
TRG_PTS1	584	587	PF00515	0.776

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4V2	Leishmania donovani	89%	100%
A4H370	Leishmania braziliensis	72%	100%
A4HRG7	Leishmania infantum	90%	100%
E9AJD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%