RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative

Species:

Leishmania major

UniProt:

E9AC34_LEIMA

TriTrypDb:

LmjF.01.0430 , LMJLV39_010009600 , LMJSD75_010009600

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AC34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC34

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0007165	signal transduction	2	2
GO:0007264	small GTPase mediated signal transduction	4	2
GO:0007265	Ras protein signal transduction	5	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0035556	intracellular signal transduction	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.826
CLV_C14_Caspase3-7	252	256	PF00656	0.779
CLV_C14_Caspase3-7	549	553	PF00656	0.765
CLV_NRD_NRD_1	150	152	PF00675	0.536
CLV_NRD_NRD_1	193	195	PF00675	0.720
CLV_NRD_NRD_1	307	309	PF00675	0.844
CLV_NRD_NRD_1	452	454	PF00675	0.335
CLV_NRD_NRD_1	600	602	PF00675	0.626
CLV_NRD_NRD_1	615	617	PF00675	0.631
CLV_NRD_NRD_1	647	649	PF00675	0.577
CLV_NRD_NRD_1	651	653	PF00675	0.573
CLV_NRD_NRD_1	715	717	PF00675	0.609
CLV_PCSK_FUR_1	450	454	PF00082	0.346
CLV_PCSK_FUR_1	597	601	PF00082	0.564
CLV_PCSK_FUR_1	648	652	PF00082	0.575
CLV_PCSK_KEX2_1	150	152	PF00082	0.608
CLV_PCSK_KEX2_1	193	195	PF00082	0.687
CLV_PCSK_KEX2_1	452	454	PF00082	0.335
CLV_PCSK_KEX2_1	597	599	PF00082	0.611
CLV_PCSK_KEX2_1	600	602	PF00082	0.621
CLV_PCSK_KEX2_1	615	617	PF00082	0.546
CLV_PCSK_KEX2_1	647	649	PF00082	0.577
CLV_PCSK_KEX2_1	650	652	PF00082	0.576
CLV_PCSK_PC7_1	593	599	PF00082	0.590
CLV_PCSK_PC7_1	647	653	PF00082	0.573
CLV_PCSK_SKI1_1	159	163	PF00082	0.509
CLV_PCSK_SKI1_1	482	486	PF00082	0.346
CLV_PCSK_SKI1_1	651	655	PF00082	0.579
CLV_PCSK_SKI1_1	717	721	PF00082	0.443
CLV_Separin_Metazoa	129	133	PF03568	0.515
DEG_Nend_UBRbox_2	1	3	PF02207	0.655
DEG_SPOP_SBC_1	103	107	PF00917	0.630
DEG_SPOP_SBC_1	521	525	PF00917	0.801
DEG_SPOP_SBC_1	96	100	PF00917	0.703
DOC_CKS1_1	291	296	PF01111	0.823
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.677
DOC_CYCLIN_yCln2_LP_2	21	24	PF00134	0.606
DOC_PP2B_LxvP_1	170	173	PF13499	0.698
DOC_PP2B_LxvP_1	21	24	PF13499	0.606
DOC_SPAK_OSR1_1	416	420	PF12202	0.559
DOC_USP7_MATH_1	103	107	PF00917	0.741
DOC_USP7_MATH_1	213	217	PF00917	0.606
DOC_USP7_MATH_1	30	34	PF00917	0.625
DOC_USP7_MATH_1	301	305	PF00917	0.772
DOC_USP7_MATH_1	326	330	PF00917	0.728
DOC_USP7_MATH_1	335	339	PF00917	0.625
DOC_USP7_MATH_1	345	349	PF00917	0.560
DOC_USP7_MATH_1	406	410	PF00917	0.411
DOC_USP7_MATH_1	521	525	PF00917	0.817
DOC_USP7_MATH_1	739	743	PF00917	0.650
DOC_USP7_MATH_1	80	84	PF00917	0.724
DOC_USP7_MATH_1	94	98	PF00917	0.619
DOC_USP7_MATH_2	173	179	PF00917	0.503
DOC_WW_Pin1_4	280	285	PF00397	0.780
DOC_WW_Pin1_4	290	295	PF00397	0.618
DOC_WW_Pin1_4	297	302	PF00397	0.767
DOC_WW_Pin1_4	327	332	PF00397	0.715
DOC_WW_Pin1_4	343	348	PF00397	0.744
DOC_WW_Pin1_4	503	508	PF00397	0.755
DOC_WW_Pin1_4	535	540	PF00397	0.740
DOC_WW_Pin1_4	619	624	PF00397	0.580
DOC_WW_Pin1_4	62	67	PF00397	0.547
DOC_WW_Pin1_4	87	92	PF00397	0.644
LIG_14-3-3_CanoR_1	416	420	PF00244	0.509
LIG_14-3-3_CanoR_1	477	485	PF00244	0.614
LIG_14-3-3_CanoR_1	546	551	PF00244	0.666
LIG_APCC_ABBA_1	483	488	PF00400	0.546
LIG_APCC_ABBAyCdc20_2	482	488	PF00400	0.546
LIG_APCC_ABBAyCdc20_2	650	656	PF00400	0.448
LIG_BIR_III_2	179	183	PF00653	0.622
LIG_BRCT_BRCA1_1	371	375	PF00533	0.574
LIG_BRCT_BRCA1_1	480	484	PF00533	0.546
LIG_Clathr_ClatBox_1	54	58	PF01394	0.525
LIG_FHA_1	123	129	PF00498	0.567
LIG_FHA_1	14	20	PF00498	0.607
LIG_FHA_1	169	175	PF00498	0.569
LIG_FHA_1	375	381	PF00498	0.450
LIG_FHA_1	38	44	PF00498	0.554
LIG_FHA_1	4	10	PF00498	0.647
LIG_FHA_1	511	517	PF00498	0.596
LIG_FHA_1	521	527	PF00498	0.544
LIG_FHA_1	574	580	PF00498	0.531
LIG_FHA_1	659	665	PF00498	0.650
LIG_FHA_1	709	715	PF00498	0.658
LIG_FHA_2	431	437	PF00498	0.546
LIG_FHA_2	63	69	PF00498	0.568
LIG_LIR_Gen_1	125	135	PF02991	0.596
LIG_LIR_Gen_1	227	237	PF02991	0.777
LIG_LIR_Gen_1	372	383	PF02991	0.394
LIG_LIR_Gen_1	400	410	PF02991	0.515
LIG_LIR_Gen_1	418	426	PF02991	0.384
LIG_LIR_Gen_1	433	442	PF02991	0.546
LIG_LIR_Nem_3	125	130	PF02991	0.656
LIG_LIR_Nem_3	227	232	PF02991	0.764
LIG_LIR_Nem_3	372	378	PF02991	0.534
LIG_LIR_Nem_3	400	405	PF02991	0.515
LIG_LIR_Nem_3	418	423	PF02991	0.390
LIG_LIR_Nem_3	433	437	PF02991	0.546
LIG_PCNA_PIPBox_1	689	698	PF02747	0.537
LIG_PDZ_Class_1	738	743	PF00595	0.545
LIG_SH2_CRK	143	147	PF00017	0.492
LIG_SH2_CRK	402	406	PF00017	0.411
LIG_SH2_CRK	420	424	PF00017	0.582
LIG_SH2_STAP1	434	438	PF00017	0.546
LIG_SH2_STAP1	575	579	PF00017	0.533
LIG_SH2_STAP1	590	594	PF00017	0.563
LIG_SH2_STAT3	574	577	PF00017	0.637
LIG_SH2_STAT5	135	138	PF00017	0.554
LIG_SH2_STAT5	143	146	PF00017	0.495
LIG_SH2_STAT5	176	179	PF00017	0.671
LIG_SH2_STAT5	384	387	PF00017	0.512
LIG_SH2_STAT5	575	578	PF00017	0.531
LIG_SH2_STAT5	657	660	PF00017	0.645
LIG_SH3_1	344	350	PF00018	0.795
LIG_SH3_3	288	294	PF00018	0.831
LIG_SH3_3	344	350	PF00018	0.800
LIG_SH3_3	352	358	PF00018	0.643
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.533
LIG_SUMO_SIM_anti_2	488	495	PF11976	0.545
LIG_SUMO_SIM_anti_2	661	666	PF11976	0.640
LIG_SUMO_SIM_par_1	181	186	PF11976	0.609
LIG_SUMO_SIM_par_1	223	230	PF11976	0.705
LIG_SUMO_SIM_par_1	52	58	PF11976	0.534
LIG_TRAF2_1	161	164	PF00917	0.569
LIG_TRAF2_1	566	569	PF00917	0.572
LIG_TRAF2_1	726	729	PF00917	0.592
LIG_WW_3	211	215	PF00397	0.647
MOD_CDC14_SPxK_1	295	298	PF00782	0.731
MOD_CDC14_SPxK_1	346	349	PF00782	0.733
MOD_CDK_SPK_2	327	332	PF00069	0.714
MOD_CDK_SPxK_1	292	298	PF00069	0.731
MOD_CDK_SPxK_1	343	349	PF00069	0.745
MOD_CK1_1	107	113	PF00069	0.574
MOD_CK1_1	283	289	PF00069	0.773
MOD_CK1_1	337	343	PF00069	0.809
MOD_CK1_1	369	375	PF00069	0.466
MOD_CK1_1	463	469	PF00069	0.411
MOD_CK1_1	506	512	PF00069	0.755
MOD_CK1_1	634	640	PF00069	0.686
MOD_CK1_1	92	98	PF00069	0.760
MOD_CK1_1	99	105	PF00069	0.793
MOD_CK2_1	115	121	PF00069	0.753
MOD_CK2_1	123	129	PF00069	0.595
MOD_CK2_1	224	230	PF00069	0.768
MOD_CK2_1	521	527	PF00069	0.795
MOD_CK2_1	563	569	PF00069	0.675
MOD_CMANNOS	35	38	PF00535	0.528
MOD_Cter_Amidation	613	616	PF01082	0.670
MOD_GlcNHglycan	101	104	PF01048	0.749
MOD_GlcNHglycan	106	109	PF01048	0.643
MOD_GlcNHglycan	215	218	PF01048	0.689
MOD_GlcNHglycan	24	27	PF01048	0.628
MOD_GlcNHglycan	243	246	PF01048	0.838
MOD_GlcNHglycan	251	254	PF01048	0.779
MOD_GlcNHglycan	288	291	PF01048	0.765
MOD_GlcNHglycan	337	340	PF01048	0.614
MOD_GlcNHglycan	371	374	PF01048	0.569
MOD_GlcNHglycan	385	388	PF01048	0.394
MOD_GlcNHglycan	406	409	PF01048	0.411
MOD_GlcNHglycan	462	465	PF01048	0.411
MOD_GlcNHglycan	517	520	PF01048	0.748
MOD_GlcNHglycan	539	542	PF01048	0.625
MOD_GlcNHglycan	58	62	PF01048	0.617
MOD_GlcNHglycan	633	636	PF01048	0.583
MOD_GlcNHglycan	697	700	PF01048	0.527
MOD_GlcNHglycan	91	94	PF01048	0.743
MOD_GSK3_1	103	110	PF00069	0.600
MOD_GSK3_1	279	286	PF00069	0.799
MOD_GSK3_1	297	304	PF00069	0.787
MOD_GSK3_1	37	44	PF00069	0.597
MOD_GSK3_1	383	390	PF00069	0.512
MOD_GSK3_1	393	400	PF00069	0.347
MOD_GSK3_1	45	52	PF00069	0.523
MOD_GSK3_1	465	472	PF00069	0.431
MOD_GSK3_1	506	513	PF00069	0.760
MOD_GSK3_1	53	60	PF00069	0.539
MOD_GSK3_1	533	540	PF00069	0.748
MOD_GSK3_1	546	553	PF00069	0.604
MOD_GSK3_1	691	698	PF00069	0.639
MOD_GSK3_1	92	99	PF00069	0.693
MOD_N-GLC_1	477	482	PF02516	0.411
MOD_N-GLC_1	563	568	PF02516	0.581
MOD_N-GLC_1	618	623	PF02516	0.536
MOD_NEK2_1	168	173	PF00069	0.589
MOD_NEK2_1	3	8	PF00069	0.641
MOD_NEK2_1	37	42	PF00069	0.488
MOD_NEK2_1	383	388	PF00069	0.512
MOD_NEK2_1	397	402	PF00069	0.282
MOD_NEK2_1	47	52	PF00069	0.525
MOD_NEK2_1	533	538	PF00069	0.774
MOD_NEK2_1	691	696	PF00069	0.608
MOD_NEK2_2	231	236	PF00069	0.740
MOD_NEK2_2	366	371	PF00069	0.527
MOD_NEK2_2	393	398	PF00069	0.394
MOD_NEK2_2	415	420	PF00069	0.557
MOD_PIKK_1	511	517	PF00454	0.596
MOD_PIKK_1	573	579	PF00454	0.632
MOD_PK_1	53	59	PF00069	0.534
MOD_PKA_2	113	119	PF00069	0.735
MOD_PKA_2	213	219	PF00069	0.627
MOD_PKA_2	263	269	PF00069	0.743
MOD_PKA_2	415	421	PF00069	0.508
MOD_PKB_1	475	483	PF00069	0.512
MOD_PKB_1	544	552	PF00069	0.719
MOD_PKB_1	650	658	PF00069	0.674
MOD_PKB_1	706	714	PF00069	0.549
MOD_Plk_1	122	128	PF00069	0.616
MOD_Plk_1	57	63	PF00069	0.562
MOD_Plk_2-3	123	129	PF00069	0.685
MOD_Plk_2-3	251	257	PF00069	0.851
MOD_Plk_4	123	129	PF00069	0.685
MOD_Plk_4	224	230	PF00069	0.693
MOD_Plk_4	231	237	PF00069	0.652
MOD_Plk_4	30	36	PF00069	0.592
MOD_Plk_4	302	308	PF00069	0.616
MOD_Plk_4	550	556	PF00069	0.752
MOD_ProDKin_1	280	286	PF00069	0.781
MOD_ProDKin_1	290	296	PF00069	0.613
MOD_ProDKin_1	297	303	PF00069	0.768
MOD_ProDKin_1	327	333	PF00069	0.714
MOD_ProDKin_1	343	349	PF00069	0.744
MOD_ProDKin_1	503	509	PF00069	0.755
MOD_ProDKin_1	535	541	PF00069	0.737
MOD_ProDKin_1	619	625	PF00069	0.583
MOD_ProDKin_1	62	68	PF00069	0.554
MOD_ProDKin_1	87	93	PF00069	0.645
MOD_SUMO_rev_2	83	88	PF00179	0.697
TRG_DiLeu_BaEn_1	488	493	PF01217	0.524
TRG_DiLeu_BaEn_1	731	736	PF01217	0.568
TRG_DiLeu_BaEn_4	163	169	PF01217	0.614
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.607
TRG_ENDOCYTIC_2	143	146	PF00928	0.495
TRG_ENDOCYTIC_2	402	405	PF00928	0.411
TRG_ENDOCYTIC_2	420	423	PF00928	0.581
TRG_ENDOCYTIC_2	434	437	PF00928	0.411
TRG_ENDOCYTIC_2	575	578	PF00928	0.632
TRG_ENDOCYTIC_2	672	675	PF00928	0.538
TRG_ER_diArg_1	450	453	PF00400	0.390
TRG_ER_diArg_1	544	547	PF00400	0.727
TRG_ER_diArg_1	597	600	PF00400	0.609
TRG_ER_diArg_1	647	650	PF00400	0.573
TRG_ER_diArg_1	651	653	PF00400	0.573
TRG_ER_diArg_1	707	710	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L0	Leptomonas seymouri	44%	87%
A0A3S5H4V1	Leishmania donovani	89%	99%
A4H369	Leishmania braziliensis	70%	100%
A4HRG6	Leishmania infantum	90%	100%
E9AJD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%