Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC31_LEIMA

TriTrypDb:

LmjF.01.0400 , LMJLV39_010009200 , LMJSD75_010009300

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AC31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC31

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0031123	RNA 3'-end processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071076	RNA 3' uridylation	8	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0050265	RNA uridylyltransferase activity	4	1
GO:0070569	uridylyltransferase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.713
CLV_NRD_NRD_1	196	198	PF00675	0.408
CLV_NRD_NRD_1	342	344	PF00675	0.551
CLV_NRD_NRD_1	347	349	PF00675	0.447
CLV_NRD_NRD_1	366	368	PF00675	0.251
CLV_NRD_NRD_1	394	396	PF00675	0.601
CLV_NRD_NRD_1	424	426	PF00675	0.452
CLV_NRD_NRD_1	520	522	PF00675	0.585
CLV_NRD_NRD_1	63	65	PF00675	0.564
CLV_PCSK_FUR_1	278	282	PF00082	0.534
CLV_PCSK_FUR_1	364	368	PF00082	0.424
CLV_PCSK_KEX2_1	160	162	PF00082	0.713
CLV_PCSK_KEX2_1	196	198	PF00082	0.408
CLV_PCSK_KEX2_1	280	282	PF00082	0.581
CLV_PCSK_KEX2_1	341	343	PF00082	0.535
CLV_PCSK_KEX2_1	347	349	PF00082	0.457
CLV_PCSK_KEX2_1	366	368	PF00082	0.354
CLV_PCSK_KEX2_1	424	426	PF00082	0.459
CLV_PCSK_KEX2_1	519	521	PF00082	0.593
CLV_PCSK_KEX2_1	63	65	PF00082	0.564
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.534
CLV_PCSK_PC7_1	156	162	PF00082	0.637
CLV_PCSK_PC7_1	343	349	PF00082	0.499
CLV_PCSK_SKI1_1	179	183	PF00082	0.325
CLV_PCSK_SKI1_1	286	290	PF00082	0.715
CLV_PCSK_SKI1_1	348	352	PF00082	0.553
CLV_PCSK_SKI1_1	366	370	PF00082	0.306
CLV_PCSK_SKI1_1	430	434	PF00082	0.447
CLV_PCSK_SKI1_1	444	448	PF00082	0.343
DEG_APCC_DBOX_1	365	373	PF00400	0.412
DEG_APCC_DBOX_1	424	432	PF00400	0.380
DEG_Nend_UBRbox_1	1	4	PF02207	0.570
DEG_SPOP_SBC_1	94	98	PF00917	0.598
DOC_CYCLIN_RxL_1	439	449	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	181	187	PF00134	0.381
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.380
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.616
DOC_MAPK_gen_1	63	69	PF00069	0.564
DOC_MAPK_MEF2A_6	327	336	PF00069	0.455
DOC_PP1_RVXF_1	133	140	PF00149	0.634
DOC_PP2B_LxvP_1	148	151	PF13499	0.537
DOC_PP2B_LxvP_1	181	184	PF13499	0.459
DOC_PP2B_LxvP_1	291	294	PF13499	0.630
DOC_PP2B_LxvP_1	77	80	PF13499	0.636
DOC_PP4_FxxP_1	139	142	PF00568	0.532
DOC_USP7_MATH_1	23	27	PF00917	0.565
DOC_USP7_MATH_1	249	253	PF00917	0.740
DOC_USP7_MATH_1	272	276	PF00917	0.669
DOC_USP7_MATH_1	297	301	PF00917	0.625
DOC_USP7_MATH_1	304	308	PF00917	0.629
DOC_USP7_MATH_1	350	354	PF00917	0.574
DOC_USP7_MATH_1	359	363	PF00917	0.497
DOC_USP7_MATH_1	368	372	PF00917	0.296
DOC_USP7_MATH_1	387	391	PF00917	0.430
DOC_USP7_MATH_1	84	88	PF00917	0.636
DOC_USP7_MATH_1	93	97	PF00917	0.776
DOC_USP7_UBL2_3	276	280	PF12436	0.538
DOC_WW_Pin1_4	112	117	PF00397	0.722
DOC_WW_Pin1_4	355	360	PF00397	0.416
DOC_WW_Pin1_4	490	495	PF00397	0.610
LIG_14-3-3_CanoR_1	348	357	PF00244	0.499
LIG_14-3-3_CanoR_1	415	420	PF00244	0.550
LIG_14-3-3_CanoR_1	68	76	PF00244	0.553
LIG_BIR_III_4	226	230	PF00653	0.524
LIG_BIR_III_4	248	252	PF00653	0.608
LIG_eIF4E_1	149	155	PF01652	0.505
LIG_FHA_1	214	220	PF00498	0.485
LIG_FHA_1	257	263	PF00498	0.561
LIG_FHA_1	453	459	PF00498	0.383
LIG_FHA_1	491	497	PF00498	0.589
LIG_FHA_2	31	37	PF00498	0.514
LIG_FHA_2	498	504	PF00498	0.538
LIG_LIR_Nem_3	70	76	PF02991	0.549
LIG_NRBOX	177	183	PF00104	0.380
LIG_SH2_CRK	149	153	PF00017	0.556
LIG_SH2_NCK_1	42	46	PF00017	0.572
LIG_SH2_SRC	149	152	PF00017	0.603
LIG_SH2_SRC	404	407	PF00017	0.441
LIG_SH2_STAP1	168	172	PF00017	0.400
LIG_SH2_STAT3	553	556	PF00017	0.378
LIG_SH2_STAT5	207	210	PF00017	0.334
LIG_SH2_STAT5	344	347	PF00017	0.404
LIG_SH2_STAT5	377	380	PF00017	0.369
LIG_SH2_STAT5	399	402	PF00017	0.433
LIG_SH2_STAT5	553	556	PF00017	0.499
LIG_SH3_1	403	409	PF00018	0.495
LIG_SH3_3	110	116	PF00018	0.584
LIG_SH3_3	261	267	PF00018	0.624
LIG_SH3_3	291	297	PF00018	0.625
LIG_SH3_3	353	359	PF00018	0.354
LIG_SH3_3	381	387	PF00018	0.451
LIG_SH3_3	403	409	PF00018	0.497
LIG_SH3_3	96	102	PF00018	0.580
LIG_TRAF2_1	309	312	PF00917	0.619
LIG_WW_3	412	416	PF00397	0.495
MOD_CK1_1	25	31	PF00069	0.605
MOD_CK1_1	252	258	PF00069	0.751
MOD_CK1_1	295	301	PF00069	0.608
MOD_CK1_1	349	355	PF00069	0.418
MOD_CK2_1	118	124	PF00069	0.654
MOD_CK2_1	306	312	PF00069	0.600
MOD_CK2_1	387	393	PF00069	0.446
MOD_CK2_1	497	503	PF00069	0.618
MOD_Cter_Amidation	61	64	PF01082	0.565
MOD_GlcNHglycan	247	252	PF01048	0.618
MOD_GlcNHglycan	254	257	PF01048	0.641
MOD_GlcNHglycan	29	32	PF01048	0.523
MOD_GlcNHglycan	297	300	PF01048	0.674
MOD_GlcNHglycan	316	319	PF01048	0.662
MOD_GlcNHglycan	348	351	PF01048	0.406
MOD_GlcNHglycan	352	355	PF01048	0.372
MOD_GlcNHglycan	379	382	PF01048	0.476
MOD_GlcNHglycan	483	486	PF01048	0.556
MOD_GlcNHglycan	91	94	PF01048	0.662
MOD_GSK3_1	118	125	PF00069	0.665
MOD_GSK3_1	209	216	PF00069	0.409
MOD_GSK3_1	23	30	PF00069	0.468
MOD_GSK3_1	252	259	PF00069	0.721
MOD_GSK3_1	262	269	PF00069	0.525
MOD_GSK3_1	346	353	PF00069	0.485
MOD_GSK3_1	355	362	PF00069	0.390
MOD_GSK3_1	84	91	PF00069	0.628
MOD_LATS_1	513	519	PF00433	0.591
MOD_N-GLC_1	490	495	PF02516	0.607
MOD_NEK2_1	336	341	PF00069	0.568
MOD_NEK2_1	398	403	PF00069	0.388
MOD_NEK2_1	446	451	PF00069	0.363
MOD_PIKK_1	385	391	PF00454	0.494
MOD_PKA_2	252	258	PF00069	0.537
MOD_PKA_2	272	278	PF00069	0.636
MOD_PKA_2	346	352	PF00069	0.444
MOD_PKA_2	67	73	PF00069	0.605
MOD_Plk_2-3	164	170	PF00069	0.413
MOD_Plk_2-3	213	219	PF00069	0.429
MOD_Plk_4	118	124	PF00069	0.647
MOD_Plk_4	173	179	PF00069	0.459
MOD_Plk_4	368	374	PF00069	0.480
MOD_ProDKin_1	112	118	PF00069	0.719
MOD_ProDKin_1	355	361	PF00069	0.411
MOD_ProDKin_1	490	496	PF00069	0.612
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.566
TRG_ER_diArg_1	160	162	PF00400	0.659
TRG_ER_diArg_1	267	270	PF00400	0.523
TRG_ER_diArg_1	331	334	PF00400	0.553
TRG_ER_diArg_1	340	343	PF00400	0.502
TRG_ER_diArg_1	363	366	PF00400	0.443
TRG_ER_diArg_1	423	425	PF00400	0.475
TRG_ER_diArg_1	51	54	PF00400	0.677
TRG_ER_diArg_1	519	521	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	550	555	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL81	Leptomonas seymouri	35%	95%
A0A451EJ97	Leishmania donovani	88%	98%
A4H366	Leishmania braziliensis	67%	97%
A4HRG3	Leishmania infantum	88%	88%
E9AJC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%