Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC30_LEIMA

TriTrypDb:

LmjF.01.0390 , LMJLV39_010009100 , LMJSD75_010009200

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.734
CLV_NRD_NRD_1	166	168	PF00675	0.518
CLV_NRD_NRD_1	380	382	PF00675	0.543
CLV_NRD_NRD_1	478	480	PF00675	0.477
CLV_NRD_NRD_1	570	572	PF00675	0.538
CLV_NRD_NRD_1	654	656	PF00675	0.417
CLV_NRD_NRD_1	735	737	PF00675	0.470
CLV_NRD_NRD_1	779	781	PF00675	0.649
CLV_PCSK_KEX2_1	146	148	PF00082	0.644
CLV_PCSK_KEX2_1	166	168	PF00082	0.542
CLV_PCSK_KEX2_1	350	352	PF00082	0.536
CLV_PCSK_KEX2_1	380	382	PF00082	0.543
CLV_PCSK_KEX2_1	478	480	PF00082	0.543
CLV_PCSK_KEX2_1	570	572	PF00082	0.516
CLV_PCSK_KEX2_1	654	656	PF00082	0.426
CLV_PCSK_KEX2_1	779	781	PF00082	0.649
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.536
CLV_PCSK_PC7_1	162	168	PF00082	0.521
CLV_PCSK_SKI1_1	166	170	PF00082	0.623
CLV_PCSK_SKI1_1	313	317	PF00082	0.396
CLV_PCSK_SKI1_1	342	346	PF00082	0.557
CLV_PCSK_SKI1_1	364	368	PF00082	0.453
CLV_PCSK_SKI1_1	370	374	PF00082	0.464
CLV_PCSK_SKI1_1	450	454	PF00082	0.531
CLV_PCSK_SKI1_1	469	473	PF00082	0.453
CLV_PCSK_SKI1_1	528	532	PF00082	0.589
CLV_PCSK_SKI1_1	573	577	PF00082	0.522
CLV_PCSK_SKI1_1	611	615	PF00082	0.635
CLV_PCSK_SKI1_1	619	623	PF00082	0.497
CLV_PCSK_SKI1_1	643	647	PF00082	0.416
CLV_PCSK_SKI1_1	692	696	PF00082	0.463
CLV_PCSK_SKI1_1	706	710	PF00082	0.463
CLV_PCSK_SKI1_1	804	808	PF00082	0.636
DEG_APCC_DBOX_1	166	174	PF00400	0.617
DEG_APCC_DBOX_1	724	732	PF00400	0.507
DEG_Nend_UBRbox_3	1	3	PF02207	0.776
DOC_CKS1_1	121	126	PF01111	0.578
DOC_CKS1_1	756	761	PF01111	0.540
DOC_CYCLIN_RxL_1	640	650	PF00134	0.487
DOC_CYCLIN_RxL_1	801	809	PF00134	0.636
DOC_MAPK_gen_1	222	229	PF00069	0.674
DOC_MAPK_gen_1	350	358	PF00069	0.594
DOC_MAPK_MEF2A_6	222	229	PF00069	0.674
DOC_MAPK_NFAT4_5	222	230	PF00069	0.581
DOC_PP1_RVXF_1	186	192	PF00149	0.622
DOC_PP2B_LxvP_1	771	774	PF13499	0.554
DOC_PP2B_LxvP_1	819	822	PF13499	0.619
DOC_PP4_FxxP_1	358	361	PF00568	0.452
DOC_USP7_MATH_1	289	293	PF00917	0.720
DOC_USP7_MATH_1	344	348	PF00917	0.462
DOC_USP7_MATH_1	37	41	PF00917	0.727
DOC_USP7_MATH_1	372	376	PF00917	0.530
DOC_USP7_MATH_1	410	414	PF00917	0.537
DOC_USP7_MATH_1	437	441	PF00917	0.614
DOC_USP7_MATH_1	45	49	PF00917	0.645
DOC_USP7_MATH_1	50	54	PF00917	0.589
DOC_USP7_MATH_1	510	514	PF00917	0.594
DOC_USP7_MATH_1	621	625	PF00917	0.520
DOC_USP7_MATH_1	72	76	PF00917	0.707
DOC_USP7_MATH_1	814	818	PF00917	0.698
DOC_USP7_UBL2_3	293	297	PF12436	0.666
DOC_WW_Pin1_4	10	15	PF00397	0.646
DOC_WW_Pin1_4	120	125	PF00397	0.538
DOC_WW_Pin1_4	263	268	PF00397	0.714
DOC_WW_Pin1_4	64	69	PF00397	0.713
DOC_WW_Pin1_4	755	760	PF00397	0.607
LIG_14-3-3_CanoR_1	166	171	PF00244	0.550
LIG_14-3-3_CanoR_1	224	228	PF00244	0.671
LIG_14-3-3_CanoR_1	450	458	PF00244	0.522
LIG_14-3-3_CanoR_1	528	536	PF00244	0.603
LIG_14-3-3_CanoR_1	692	697	PF00244	0.466
LIG_14-3-3_CanoR_1	763	769	PF00244	0.545
LIG_Actin_WH2_2	596	613	PF00022	0.550
LIG_BIR_III_2	772	776	PF00653	0.577
LIG_BRCT_BRCA1_1	12	16	PF00533	0.658
LIG_BRCT_BRCA1_1	354	358	PF00533	0.540
LIG_Clathr_ClatBox_1	728	732	PF01394	0.430
LIG_deltaCOP1_diTrp_1	702	708	PF00928	0.560
LIG_FHA_1	112	118	PF00498	0.603
LIG_FHA_1	140	146	PF00498	0.597
LIG_FHA_1	169	175	PF00498	0.434
LIG_FHA_1	328	334	PF00498	0.414
LIG_FHA_1	422	428	PF00498	0.681
LIG_FHA_1	457	463	PF00498	0.476
LIG_FHA_1	579	585	PF00498	0.580
LIG_FHA_1	670	676	PF00498	0.417
LIG_FHA_2	167	173	PF00498	0.620
LIG_FHA_2	529	535	PF00498	0.581
LIG_FHA_2	550	556	PF00498	0.562
LIG_FHA_2	599	605	PF00498	0.585
LIG_FHA_2	634	640	PF00498	0.298
LIG_LIR_Apic_2	355	361	PF02991	0.506
LIG_LIR_Gen_1	455	465	PF02991	0.406
LIG_LIR_Gen_1	690	698	PF02991	0.427
LIG_LIR_Gen_1	758	768	PF02991	0.544
LIG_LIR_Nem_3	150	156	PF02991	0.500
LIG_LIR_Nem_3	455	461	PF02991	0.393
LIG_LIR_Nem_3	690	696	PF02991	0.419
LIG_LIR_Nem_3	732	738	PF02991	0.400
LIG_LIR_Nem_3	758	764	PF02991	0.551
LIG_MLH1_MIPbox_1	12	16	PF16413	0.658
LIG_MYND_3	345	349	PF01753	0.526
LIG_NRBOX	456	462	PF00104	0.480
LIG_NRBOX	630	636	PF00104	0.527
LIG_PCNA_PIPBox_1	591	600	PF02747	0.569
LIG_PCNA_yPIPBox_3	793	807	PF02747	0.649
LIG_Pex14_1	704	708	PF04695	0.527
LIG_Pex14_2	127	131	PF04695	0.602
LIG_Rb_pABgroove_1	640	648	PF01858	0.482
LIG_RPA_C_Fungi	620	632	PF08784	0.556
LIG_SH2_NCK_1	586	590	PF00017	0.579
LIG_SH2_SRC	586	589	PF00017	0.581
LIG_SH2_STAP1	586	590	PF00017	0.405
LIG_SH2_STAP1	689	693	PF00017	0.458
LIG_SH2_STAT3	15	18	PF00017	0.661
LIG_SH2_STAT5	121	124	PF00017	0.630
LIG_SH2_STAT5	15	18	PF00017	0.645
LIG_SH3_3	1	7	PF00018	0.750
LIG_SH3_3	427	433	PF00018	0.494
LIG_SH3_3	753	759	PF00018	0.508
LIG_SH3_4	293	300	PF00018	0.614
LIG_SUMO_SIM_par_1	330	336	PF11976	0.574
LIG_SUMO_SIM_par_1	458	464	PF11976	0.458
LIG_SUMO_SIM_par_1	84	89	PF11976	0.606
LIG_TRAF2_1	532	535	PF00917	0.535
LIG_UBA3_1	461	469	PF00899	0.389
LIG_WW_3	3	7	PF00397	0.742
MOD_CK1_1	139	145	PF00069	0.633
MOD_CK1_1	243	249	PF00069	0.757
MOD_CK1_1	700	706	PF00069	0.609
MOD_CK2_1	437	443	PF00069	0.656
MOD_CK2_1	510	516	PF00069	0.516
MOD_CK2_1	528	534	PF00069	0.363
MOD_CK2_1	549	555	PF00069	0.551
MOD_CK2_1	598	604	PF00069	0.589
MOD_GlcNHglycan	138	141	PF01048	0.615
MOD_GlcNHglycan	246	249	PF01048	0.706
MOD_GlcNHglycan	260	263	PF01048	0.786
MOD_GlcNHglycan	412	415	PF01048	0.621
MOD_GlcNHglycan	699	702	PF01048	0.547
MOD_GlcNHglycan	710	713	PF01048	0.497
MOD_GlcNHglycan	76	79	PF01048	0.732
MOD_GSK3_1	107	114	PF00069	0.681
MOD_GSK3_1	223	230	PF00069	0.642
MOD_GSK3_1	240	247	PF00069	0.617
MOD_GSK3_1	258	265	PF00069	0.672
MOD_GSK3_1	433	440	PF00069	0.610
MOD_GSK3_1	489	496	PF00069	0.523
MOD_GSK3_1	60	67	PF00069	0.706
MOD_GSK3_1	633	640	PF00069	0.329
MOD_GSK3_1	68	75	PF00069	0.712
MOD_N-GLC_1	719	724	PF02516	0.495
MOD_NEK2_1	227	232	PF00069	0.628
MOD_NEK2_1	322	327	PF00069	0.568
MOD_NEK2_1	493	498	PF00069	0.521
MOD_NEK2_1	536	541	PF00069	0.565
MOD_NEK2_1	547	552	PF00069	0.419
MOD_NEK2_1	598	603	PF00069	0.472
MOD_NEK2_1	764	769	PF00069	0.503
MOD_PIKK_1	279	285	PF00454	0.754
MOD_PIKK_1	549	555	PF00454	0.373
MOD_PKA_1	166	172	PF00069	0.550
MOD_PKA_2	106	112	PF00069	0.695
MOD_PKA_2	166	172	PF00069	0.550
MOD_PKA_2	223	229	PF00069	0.725
MOD_PKA_2	322	328	PF00069	0.578
MOD_PKB_1	526	534	PF00069	0.639
MOD_Plk_1	227	233	PF00069	0.650
MOD_Plk_1	504	510	PF00069	0.540
MOD_Plk_1	536	542	PF00069	0.567
MOD_Plk_2-3	223	229	PF00069	0.610
MOD_Plk_2-3	484	490	PF00069	0.479
MOD_Plk_4	328	334	PF00069	0.413
MOD_Plk_4	352	358	PF00069	0.610
MOD_Plk_4	536	542	PF00069	0.584
MOD_Plk_4	814	820	PF00069	0.640
MOD_ProDKin_1	10	16	PF00069	0.643
MOD_ProDKin_1	120	126	PF00069	0.538
MOD_ProDKin_1	263	269	PF00069	0.713
MOD_ProDKin_1	64	70	PF00069	0.713
MOD_ProDKin_1	755	761	PF00069	0.600
MOD_SUMO_rev_2	203	212	PF00179	0.619
TRG_DiLeu_BaEn_1	423	428	PF01217	0.421
TRG_DiLeu_BaEn_1	760	765	PF01217	0.524
TRG_DiLeu_LyEn_5	423	428	PF01217	0.421
TRG_DiLeu_LyEn_5	760	765	PF01217	0.553
TRG_ENDOCYTIC_2	394	397	PF00928	0.531
TRG_ENDOCYTIC_2	693	696	PF00928	0.452
TRG_ER_diArg_1	145	147	PF00400	0.640
TRG_ER_diArg_1	165	167	PF00400	0.407
TRG_ER_diArg_1	380	382	PF00400	0.480
TRG_ER_diArg_1	526	529	PF00400	0.486
TRG_ER_diArg_1	569	571	PF00400	0.505
TRG_ER_diArg_1	654	656	PF00400	0.436
TRG_ER_diArg_1	779	781	PF00400	0.655
TRG_ER_FFAT_2	115	126	PF00635	0.582
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	643	647	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	804	809	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX8	Leptomonas seymouri	46%	100%
A0A0S4JLD6	Bodo saltans	26%	100%
A0A1X0P2X9	Trypanosomatidae	24%	100%
A0A451EJ96	Leishmania donovani	92%	100%
A4H365	Leishmania braziliensis	67%	100%
A4HRG2	Leishmania infantum	92%	100%
C9ZXI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AJC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DD57	Trypanosoma cruzi	24%	100%