Dymeclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dymeclin

Gene product:

Dyggve-Melchior-Clausen syndrome protein, putative

Species:

Leishmania major

UniProt:

E9AC29_LEIMA

TriTrypDb:

LmjF.01.0380 , LMJLV39_010009000 , LMJSD75_010009100

Length:

818

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AC29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC29

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0007030	Golgi organization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	723	727	PF00656	0.553
CLV_NRD_NRD_1	5	7	PF00675	0.420
CLV_NRD_NRD_1	617	619	PF00675	0.319
CLV_NRD_NRD_1	686	688	PF00675	0.277
CLV_NRD_NRD_1	724	726	PF00675	0.257
CLV_NRD_NRD_1	80	82	PF00675	0.358
CLV_PCSK_KEX2_1	617	619	PF00082	0.319
CLV_PCSK_KEX2_1	686	688	PF00082	0.275
CLV_PCSK_KEX2_1	724	726	PF00082	0.257
CLV_PCSK_KEX2_1	80	82	PF00082	0.358
CLV_PCSK_PC7_1	613	619	PF00082	0.318
CLV_PCSK_SKI1_1	105	109	PF00082	0.322
CLV_PCSK_SKI1_1	148	152	PF00082	0.291
CLV_PCSK_SKI1_1	172	176	PF00082	0.339
CLV_PCSK_SKI1_1	314	318	PF00082	0.291
CLV_PCSK_SKI1_1	413	417	PF00082	0.457
CLV_PCSK_SKI1_1	434	438	PF00082	0.476
CLV_PCSK_SKI1_1	476	480	PF00082	0.356
CLV_PCSK_SKI1_1	602	606	PF00082	0.379
CLV_PCSK_SKI1_1	652	656	PF00082	0.306
CLV_PCSK_SKI1_1	69	73	PF00082	0.262
CLV_Separin_Metazoa	169	173	PF03568	0.527
CLV_Separin_Metazoa	77	81	PF03568	0.474
DEG_APCC_DBOX_1	601	609	PF00400	0.440
DEG_SPOP_SBC_1	268	272	PF00917	0.440
DEG_SPOP_SBC_1	563	567	PF00917	0.530
DEG_SPOP_SBC_1	579	583	PF00917	0.388
DOC_CYCLIN_RxL_1	167	179	PF00134	0.539
DOC_CYCLIN_RxL_1	473	483	PF00134	0.422
DOC_CYCLIN_RxL_1	66	76	PF00134	0.484
DOC_MAPK_FxFP_2	442	445	PF00069	0.262
DOC_MAPK_gen_1	67	74	PF00069	0.481
DOC_MAPK_MEF2A_6	440	449	PF00069	0.339
DOC_PP1_RVXF_1	432	438	PF00149	0.291
DOC_PP1_RVXF_1	65	71	PF00149	0.454
DOC_PP2B_LxvP_1	266	269	PF13499	0.491
DOC_PP4_FxxP_1	442	445	PF00568	0.248
DOC_PP4_FxxP_1	785	788	PF00568	0.437
DOC_USP7_MATH_1	133	137	PF00917	0.439
DOC_USP7_MATH_1	158	162	PF00917	0.518
DOC_USP7_MATH_1	16	20	PF00917	0.605
DOC_USP7_MATH_1	25	29	PF00917	0.425
DOC_USP7_MATH_1	484	488	PF00917	0.513
DOC_USP7_MATH_1	57	61	PF00917	0.587
DOC_USP7_MATH_1	670	674	PF00917	0.539
DOC_WW_Pin1_4	129	134	PF00397	0.539
DOC_WW_Pin1_4	200	205	PF00397	0.539
DOC_WW_Pin1_4	226	231	PF00397	0.483
DOC_WW_Pin1_4	343	348	PF00397	0.480
DOC_WW_Pin1_4	468	473	PF00397	0.539
DOC_WW_Pin1_4	674	679	PF00397	0.504
DOC_WW_Pin1_4	90	95	PF00397	0.539
LIG_14-3-3_CanoR_1	172	178	PF00244	0.575
LIG_14-3-3_CanoR_1	222	232	PF00244	0.478
LIG_14-3-3_CanoR_1	256	265	PF00244	0.493
LIG_14-3-3_CanoR_1	314	323	PF00244	0.522
LIG_14-3-3_CanoR_1	358	367	PF00244	0.587
LIG_14-3-3_CanoR_1	413	419	PF00244	0.319
LIG_14-3-3_CanoR_1	440	445	PF00244	0.309
LIG_14-3-3_CanoR_1	550	556	PF00244	0.508
LIG_Actin_WH2_2	533	548	PF00022	0.477
LIG_Actin_WH2_2	586	604	PF00022	0.539
LIG_Actin_WH2_2	92	107	PF00022	0.504
LIG_APCC_ABBA_1	193	198	PF00400	0.444
LIG_BRCT_BRCA1_1	442	446	PF00533	0.248
LIG_BRCT_BRCA1_1	781	785	PF00533	0.437
LIG_BRCT_BRCA1_1	9	13	PF00533	0.585
LIG_FHA_1	12	18	PF00498	0.590
LIG_FHA_1	140	146	PF00498	0.537
LIG_FHA_1	190	196	PF00498	0.483
LIG_FHA_1	315	321	PF00498	0.558
LIG_FHA_1	405	411	PF00498	0.352
LIG_FHA_1	451	457	PF00498	0.297
LIG_FHA_1	469	475	PF00498	0.539
LIG_FHA_1	540	546	PF00498	0.519
LIG_FHA_1	63	69	PF00498	0.455
LIG_FHA_1	649	655	PF00498	0.537
LIG_FHA_1	91	97	PF00498	0.463
LIG_FHA_2	164	170	PF00498	0.457
LIG_FHA_2	564	570	PF00498	0.547
LIG_FHA_2	580	586	PF00498	0.566
LIG_GBD_Chelix_1	393	401	PF00786	0.457
LIG_LIR_Apic_2	219	223	PF02991	0.405
LIG_LIR_Apic_2	782	788	PF02991	0.437
LIG_LIR_Gen_1	194	204	PF02991	0.448
LIG_LIR_Gen_1	240	248	PF02991	0.541
LIG_LIR_Gen_1	307	316	PF02991	0.539
LIG_LIR_Gen_1	349	357	PF02991	0.509
LIG_LIR_Gen_1	443	454	PF02991	0.331
LIG_LIR_Gen_1	775	783	PF02991	0.464
LIG_LIR_Nem_3	194	199	PF02991	0.452
LIG_LIR_Nem_3	240	244	PF02991	0.481
LIG_LIR_Nem_3	307	312	PF02991	0.539
LIG_LIR_Nem_3	349	353	PF02991	0.509
LIG_LIR_Nem_3	362	367	PF02991	0.387
LIG_LIR_Nem_3	443	449	PF02991	0.289
LIG_LIR_Nem_3	775	779	PF02991	0.453
LIG_LIR_Nem_3	782	786	PF02991	0.429
LIG_LYPXL_yS_3	444	447	PF13949	0.308
LIG_MLH1_MIPbox_1	9	13	PF16413	0.585
LIG_NRBOX	170	176	PF00104	0.539
LIG_NRBOX	209	215	PF00104	0.510
LIG_NRBOX	366	372	PF00104	0.364
LIG_NRBOX	396	402	PF00104	0.257
LIG_PCNA_yPIPBox_3	502	515	PF02747	0.248
LIG_Pex14_2	241	245	PF04695	0.546
LIG_Pex14_2	442	446	PF04695	0.248
LIG_Pex14_2	785	789	PF04695	0.437
LIG_SH2_NCK_1	647	651	PF00017	0.457
LIG_SH2_PTP2	372	375	PF00017	0.334
LIG_SH2_SRC	647	650	PF00017	0.388
LIG_SH2_STAP1	482	486	PF00017	0.539
LIG_SH2_STAP1	624	628	PF00017	0.439
LIG_SH2_STAT3	532	535	PF00017	0.462
LIG_SH2_STAT3	597	600	PF00017	0.491
LIG_SH2_STAT5	12	15	PF00017	0.501
LIG_SH2_STAT5	264	267	PF00017	0.539
LIG_SH2_STAT5	338	341	PF00017	0.456
LIG_SH2_STAT5	372	375	PF00017	0.289
LIG_SH2_STAT5	532	535	PF00017	0.484
LIG_SH2_STAT5	597	600	PF00017	0.491
LIG_SH2_STAT5	628	631	PF00017	0.534
LIG_SH3_3	152	158	PF00018	0.462
LIG_SH3_3	249	255	PF00018	0.457
LIG_SH3_3	292	298	PF00018	0.491
LIG_SH3_3	511	517	PF00018	0.289
LIG_SH3_3	80	86	PF00018	0.491
LIG_SH3_3	811	817	PF00018	0.689
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.472
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.457
LIG_SUMO_SIM_anti_2	451	459	PF11976	0.290
LIG_SUMO_SIM_anti_2	680	686	PF11976	0.463
LIG_SUMO_SIM_anti_2	769	775	PF11976	0.539
LIG_SUMO_SIM_par_1	264	272	PF11976	0.527
LIG_SUMO_SIM_par_1	399	404	PF11976	0.318
LIG_SUMO_SIM_par_1	451	459	PF11976	0.310
LIG_SUMO_SIM_par_1	492	497	PF11976	0.370
LIG_TRAF2_1	677	680	PF00917	0.507
LIG_TRAF2_1	775	778	PF00917	0.539
LIG_TYR_ITIM	370	375	PF00017	0.289
LIG_TYR_ITIM	622	627	PF00017	0.448
LIG_UBA3_1	103	112	PF00899	0.578
LIG_UBA3_1	319	328	PF00899	0.448
LIG_UBA3_1	400	406	PF00899	0.240
LIG_UBA3_1	654	663	PF00899	0.527
MOD_CK1_1	346	352	PF00069	0.469
MOD_CK1_1	746	752	PF00069	0.537
MOD_CK2_1	163	169	PF00069	0.537
MOD_CK2_1	304	310	PF00069	0.462
MOD_CK2_1	563	569	PF00069	0.467
MOD_CK2_1	579	585	PF00069	0.553
MOD_CK2_1	674	680	PF00069	0.510
MOD_CK2_1	748	754	PF00069	0.556
MOD_CK2_1	772	778	PF00069	0.506
MOD_GlcNHglycan	114	117	PF01048	0.322
MOD_GlcNHglycan	135	138	PF01048	0.282
MOD_GlcNHglycan	160	163	PF01048	0.320
MOD_GlcNHglycan	179	182	PF01048	0.155
MOD_GlcNHglycan	276	279	PF01048	0.329
MOD_GlcNHglycan	286	289	PF01048	0.317
MOD_GlcNHglycan	329	332	PF01048	0.278
MOD_GlcNHglycan	354	357	PF01048	0.334
MOD_GlcNHglycan	483	487	PF01048	0.291
MOD_GlcNHglycan	551	554	PF01048	0.272
MOD_GlcNHglycan	701	704	PF01048	0.347
MOD_GlcNHglycan	708	712	PF01048	0.383
MOD_GlcNHglycan	748	751	PF01048	0.313
MOD_GlcNHglycan	795	798	PF01048	0.409
MOD_GSK3_1	108	115	PF00069	0.499
MOD_GSK3_1	129	136	PF00069	0.436
MOD_GSK3_1	173	180	PF00069	0.482
MOD_GSK3_1	246	253	PF00069	0.519
MOD_GSK3_1	339	346	PF00069	0.517
MOD_GSK3_1	404	411	PF00069	0.263
MOD_GSK3_1	574	581	PF00069	0.568
MOD_GSK3_1	670	677	PF00069	0.434
MOD_GSK3_1	693	700	PF00069	0.507
MOD_GSK3_1	7	14	PF00069	0.567
MOD_GSK3_1	739	746	PF00069	0.548
MOD_GSK3_1	748	755	PF00069	0.556
MOD_N-GLC_1	404	409	PF02516	0.535
MOD_N-GLC_2	304	306	PF02516	0.257
MOD_NEK2_1	108	113	PF00069	0.520
MOD_NEK2_1	153	158	PF00069	0.472
MOD_NEK2_1	173	178	PF00069	0.426
MOD_NEK2_1	199	204	PF00069	0.481
MOD_NEK2_1	213	218	PF00069	0.430
MOD_NEK2_1	248	253	PF00069	0.490
MOD_NEK2_1	302	307	PF00069	0.539
MOD_NEK2_1	381	386	PF00069	0.250
MOD_NEK2_1	392	397	PF00069	0.226
MOD_NEK2_1	401	406	PF00069	0.145
MOD_NEK2_1	414	419	PF00069	0.234
MOD_NEK2_1	449	454	PF00069	0.276
MOD_NEK2_1	540	545	PF00069	0.491
MOD_NEK2_1	555	560	PF00069	0.466
MOD_NEK2_1	748	753	PF00069	0.388
MOD_PIKK_1	456	462	PF00454	0.284
MOD_PIKK_1	693	699	PF00454	0.559
MOD_PKA_2	108	114	PF00069	0.529
MOD_PKA_2	408	414	PF00069	0.356
MOD_PKA_2	549	555	PF00069	0.500
MOD_PKA_2	807	813	PF00069	0.619
MOD_Plk_1	189	195	PF00069	0.524
MOD_Plk_1	737	743	PF00069	0.457
MOD_Plk_1	753	759	PF00069	0.367
MOD_Plk_2-3	718	724	PF00069	0.403
MOD_Plk_2-3	766	772	PF00069	0.539
MOD_Plk_4	213	219	PF00069	0.509
MOD_Plk_4	237	243	PF00069	0.534
MOD_Plk_4	269	275	PF00069	0.388
MOD_Plk_4	365	371	PF00069	0.253
MOD_Plk_4	381	387	PF00069	0.214
MOD_Plk_4	450	456	PF00069	0.300
MOD_Plk_4	743	749	PF00069	0.491
MOD_Plk_4	790	796	PF00069	0.492
MOD_ProDKin_1	129	135	PF00069	0.539
MOD_ProDKin_1	200	206	PF00069	0.539
MOD_ProDKin_1	226	232	PF00069	0.483
MOD_ProDKin_1	343	349	PF00069	0.480
MOD_ProDKin_1	468	474	PF00069	0.539
MOD_ProDKin_1	674	680	PF00069	0.504
MOD_ProDKin_1	90	96	PF00069	0.539
TRG_DiLeu_BaEn_1	169	174	PF01217	0.432
TRG_DiLeu_BaEn_1	388	393	PF01217	0.348
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.553
TRG_DiLeu_BaLyEn_6	463	468	PF01217	0.491
TRG_DiLeu_LyEn_5	169	174	PF01217	0.527
TRG_ENDOCYTIC_2	372	375	PF00928	0.274
TRG_ENDOCYTIC_2	444	447	PF00928	0.308
TRG_ENDOCYTIC_2	624	627	PF00928	0.439
TRG_ENDOCYTIC_2	776	779	PF00928	0.469
TRG_ENDOCYTIC_2	783	786	PF00928	0.430
TRG_ER_diArg_1	629	632	PF00400	0.446
TRG_ER_diArg_1	67	70	PF00400	0.449
TRG_ER_diArg_1	685	687	PF00400	0.478
TRG_ER_diArg_1	79	81	PF00400	0.492
TRG_ER_FFAT_2	8	18	PF00635	0.544
TRG_NES_CRM1_1	366	377	PF08389	0.388
TRG_NES_CRM1_1	592	606	PF08389	0.491
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.222
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	602	606	PF00026	0.288
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.240

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M9	Leptomonas seymouri	55%	97%
A0A0S4JPV7	Bodo saltans	25%	100%
A0A1X0P2R5	Trypanosomatidae	32%	100%
A0A3S5H4V0	Leishmania donovani	91%	100%
A0A422NY99	Trypanosoma rangeli	33%	100%
A4H364	Leishmania braziliensis	73%	99%
A4HRG1	Leishmania infantum	91%	100%
C9ZXI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AJC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
V5AX12	Trypanosoma cruzi	32%	100%