Transmembrane protein 208

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF788), putative

Species:

Leishmania major

UniProt:

E9AC28_LEIMA

TriTrypDb:

LmjF.01.0370 , LMJLV39_010008900 , LMJSD75_010009000

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	2
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AC28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC28

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006624	vacuolar protein processing	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016485	protein processing	5	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.273
CLV_NRD_NRD_1	169	171	PF00675	0.263
CLV_NRD_NRD_1	176	178	PF00675	0.262
CLV_NRD_NRD_1	181	183	PF00675	0.437
CLV_NRD_NRD_1	9	11	PF00675	0.305
CLV_PCSK_KEX2_1	169	171	PF00082	0.261
CLV_PCSK_KEX2_1	181	183	PF00082	0.437
CLV_PCSK_KEX2_1	7	9	PF00082	0.337
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.306
CLV_PCSK_PC7_1	177	183	PF00082	0.466
CLV_PCSK_SKI1_1	177	181	PF00082	0.435
CLV_PCSK_SKI1_1	184	188	PF00082	0.484
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.327
DOC_MAPK_gen_1	10	19	PF00069	0.553
DOC_PP2B_LxvP_1	122	125	PF13499	0.317
DOC_PP4_FxxP_1	120	123	PF00568	0.384
DOC_USP7_UBL2_3	171	175	PF12436	0.502
DOC_USP7_UBL2_3	3	7	PF12436	0.472
DOC_WW_Pin1_4	71	76	PF00397	0.338
LIG_14-3-3_CanoR_1	10	16	PF00244	0.520
LIG_14-3-3_CanoR_1	18	23	PF00244	0.511
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_deltaCOP1_diTrp_1	99	105	PF00928	0.258
LIG_FHA_1	22	28	PF00498	0.316
LIG_LIR_Gen_1	44	53	PF02991	0.303
LIG_LIR_Nem_3	44	48	PF02991	0.282
LIG_LIR_Nem_3	58	62	PF02991	0.240
LIG_LIR_Nem_3	90	96	PF02991	0.310
LIG_SH2_CRK	62	66	PF00017	0.314
LIG_SH2_NCK_1	94	98	PF00017	0.310
LIG_SH2_SRC	121	124	PF00017	0.311
LIG_SH2_STAT5	121	124	PF00017	0.321
LIG_SH2_STAT5	144	147	PF00017	0.538
LIG_SH2_STAT5	31	34	PF00017	0.373
LIG_SH2_STAT5	59	62	PF00017	0.289
LIG_SH2_STAT5	94	97	PF00017	0.330
LIG_SH3_3	133	139	PF00018	0.507
LIG_SH3_3	65	71	PF00018	0.362
LIG_TRAF2_1	55	58	PF00917	0.272
LIG_TYR_ITIM	119	124	PF00017	0.311
LIG_TYR_ITIM	60	65	PF00017	0.338
LIG_TYR_ITIM	91	96	PF00017	0.310
LIG_WRC_WIRS_1	42	47	PF05994	0.299
LIG_WW_3	161	165	PF00397	0.562
MOD_CK1_1	21	27	PF00069	0.400
MOD_CK1_1	41	47	PF00069	0.343
MOD_CK1_1	63	69	PF00069	0.372
MOD_CMANNOS	102	105	PF00535	0.311
MOD_GlcNHglycan	147	150	PF01048	0.345
MOD_GlcNHglycan	184	187	PF01048	0.487
MOD_N-GLC_1	38	43	PF02516	0.562
MOD_NEK2_1	145	150	PF00069	0.570
MOD_NEK2_1	60	65	PF00069	0.324
MOD_PK_1	11	17	PF00069	0.395
MOD_PKA_1	11	17	PF00069	0.395
MOD_PKA_1	177	183	PF00069	0.581
MOD_PKB_1	16	24	PF00069	0.538
MOD_Plk_4	124	130	PF00069	0.538
MOD_Plk_4	132	138	PF00069	0.538
MOD_Plk_4	60	66	PF00069	0.323
MOD_ProDKin_1	71	77	PF00069	0.338
TRG_ENDOCYTIC_2	121	124	PF00928	0.298
TRG_ENDOCYTIC_2	62	65	PF00928	0.267
TRG_ENDOCYTIC_2	93	96	PF00928	0.290
TRG_ER_diArg_1	15	18	PF00400	0.546
TRG_ER_diArg_1	163	166	PF00400	0.477
TRG_NLS_MonoExtC_3	6	11	PF00514	0.395
TRG_NLS_MonoExtN_4	7	14	PF00514	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P720	Leptomonas seymouri	67%	100%
A0A0S4ILZ6	Bodo saltans	42%	100%
A0A1X0P3E2	Trypanosomatidae	55%	100%
A0A3S5H4U9	Leishmania donovani	96%	100%
A0A422NY40	Trypanosoma rangeli	54%	100%
A4H363	Leishmania braziliensis	82%	100%
A4HRG0	Leishmania infantum	96%	100%
C9ZXI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AJC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q54UB0	Dictyostelium discoideum	25%	100%
Q6NYP0	Danio rerio	24%	100%