Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC27_LEIMA

TriTrypDb:

LmjF.01.0360 , LMJLV39_010008800 , LMJSD75_010008900

Length:

189

Annotations

LeishMANIAdb annotations

This protein appears to have an Ala-rich signal peptide and a single TM segment

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AC27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	75	79	PF00656	0.809
CLV_NRD_NRD_1	156	158	PF00675	0.722
CLV_NRD_NRD_1	176	178	PF00675	0.765
CLV_NRD_NRD_1	186	188	PF00675	0.662
CLV_PCSK_FUR_1	74	78	PF00082	0.605
CLV_PCSK_KEX2_1	175	177	PF00082	0.771
CLV_PCSK_KEX2_1	18	20	PF00082	0.501
CLV_PCSK_KEX2_1	186	188	PF00082	0.652
CLV_PCSK_KEX2_1	76	78	PF00082	0.596
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.501
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.554
CLV_PCSK_SKI1_1	7	11	PF00082	0.572
DEG_COP1_1	16	23	PF00400	0.741
DOC_MAPK_gen_1	118	127	PF00069	0.636
DOC_MAPK_MEF2A_6	121	129	PF00069	0.491
DOC_PP2B_LxvP_1	23	26	PF13499	0.760
DOC_PP4_MxPP_1	1	4	PF00568	0.766
DOC_USP7_MATH_1	140	144	PF00917	0.487
DOC_USP7_MATH_1	30	34	PF00917	0.610
DOC_USP7_UBL2_3	72	76	PF12436	0.736
DOC_WW_Pin1_4	54	59	PF00397	0.672
LIG_14-3-3_CanoR_1	41	49	PF00244	0.791
LIG_14-3-3_CanoR_1	7	14	PF00244	0.728
LIG_Actin_WH2_2	28	43	PF00022	0.791
LIG_BIR_II_1	1	5	PF00653	0.755
LIG_BIR_III_1	1	5	PF00653	0.755
LIG_BIR_III_3	1	5	PF00653	0.755
LIG_BRCT_BRCA1_1	119	123	PF00533	0.552
LIG_BRCT_BRCA1_1	65	69	PF00533	0.711
LIG_EH_1	138	142	PF12763	0.499
LIG_FHA_1	8	14	PF00498	0.699
LIG_FHA_2	109	115	PF00498	0.679
LIG_FHA_2	66	72	PF00498	0.719
LIG_FXI_DFP_1	89	93	PF00024	0.607
LIG_LIR_Apic_2	143	149	PF02991	0.580
LIG_LIR_Gen_1	120	131	PF02991	0.552
LIG_LIR_Gen_1	68	75	PF02991	0.724
LIG_LIR_Gen_1	86	96	PF02991	0.626
LIG_LIR_Nem_3	120	126	PF02991	0.552
LIG_LIR_Nem_3	68	73	PF02991	0.719
LIG_LIR_Nem_3	86	92	PF02991	0.630
LIG_SH2_CRK	70	74	PF00017	0.781
LIG_SH2_STAT5	136	139	PF00017	0.553
LIG_SH3_2	93	98	PF14604	0.802
LIG_SH3_3	134	140	PF00018	0.530
LIG_SH3_3	46	52	PF00018	0.694
LIG_SH3_3	90	96	PF00018	0.804
LIG_TRFH_1	136	140	PF08558	0.559
LIG_TYR_ITSM	66	73	PF00017	0.719
MOD_CK1_1	108	114	PF00069	0.605
MOD_CK1_1	39	45	PF00069	0.796
MOD_CK1_1	57	63	PF00069	0.544
MOD_CK1_1	65	71	PF00069	0.657
MOD_CK2_1	108	114	PF00069	0.707
MOD_CK2_1	77	83	PF00069	0.814
MOD_Cter_Amidation	173	176	PF01082	0.729
MOD_GlcNHglycan	172	175	PF01048	0.718
MOD_GlcNHglycan	59	62	PF01048	0.473
MOD_GSK3_1	36	43	PF00069	0.725
MOD_N-GLC_1	108	113	PF02516	0.427
MOD_N-GLC_1	168	173	PF02516	0.659
MOD_NEK2_1	105	110	PF00069	0.713
MOD_NEK2_1	31	36	PF00069	0.757
MOD_NEK2_1	40	45	PF00069	0.688
MOD_NEK2_1	62	67	PF00069	0.778
MOD_PKA_2	14	20	PF00069	0.802
MOD_PKA_2	40	46	PF00069	0.798
MOD_Plk_1	108	114	PF00069	0.642
MOD_Plk_4	31	37	PF00069	0.735
MOD_ProDKin_1	54	60	PF00069	0.671
MOD_SUMO_rev_2	150	160	PF00179	0.519
TRG_ENDOCYTIC_2	70	73	PF00928	0.778
TRG_ER_diArg_1	175	177	PF00400	0.565
TRG_ER_diArg_1	185	187	PF00400	0.465
TRG_ER_diArg_1	98	101	PF00400	0.805

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4U8	Leishmania donovani	91%	100%
A4H362	Leishmania braziliensis	65%	100%
A4HRF9	Leishmania infantum	92%	100%
E9AJC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%