RYDR_ITPR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC26_LEIMA

TriTrypDb:

LmjF.01.0350 , LMJLV39_010008700 , LMJSD75_010008800

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	390	392	PF00675	0.418
CLV_NRD_NRD_1	397	399	PF00675	0.529
CLV_NRD_NRD_1	408	410	PF00675	0.493
CLV_NRD_NRD_1	45	47	PF00675	0.453
CLV_NRD_NRD_1	583	585	PF00675	0.497
CLV_NRD_NRD_1	97	99	PF00675	0.493
CLV_PCSK_KEX2_1	172	174	PF00082	0.287
CLV_PCSK_KEX2_1	392	394	PF00082	0.475
CLV_PCSK_KEX2_1	397	399	PF00082	0.547
CLV_PCSK_KEX2_1	408	410	PF00082	0.493
CLV_PCSK_KEX2_1	45	47	PF00082	0.393
CLV_PCSK_KEX2_1	520	522	PF00082	0.507
CLV_PCSK_KEX2_1	583	585	PF00082	0.497
CLV_PCSK_KEX2_1	97	99	PF00082	0.430
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.277
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.475
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.507
CLV_PCSK_PC7_1	393	399	PF00082	0.620
CLV_PCSK_SKI1_1	332	336	PF00082	0.399
CLV_PCSK_SKI1_1	397	401	PF00082	0.580
CLV_PCSK_SKI1_1	624	628	PF00082	0.549
DEG_APCC_DBOX_1	520	528	PF00400	0.566
DEG_SPOP_SBC_1	218	222	PF00917	0.579
DEG_SPOP_SBC_1	429	433	PF00917	0.764
DEG_SPOP_SBC_1	446	450	PF00917	0.578
DOC_CYCLIN_yClb5_NLxxxL_5	28	37	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	48	54	PF00134	0.340
DOC_MAPK_DCC_7	45	54	PF00069	0.466
DOC_MAPK_gen_1	335	344	PF00069	0.370
DOC_MAPK_gen_1	566	575	PF00069	0.499
DOC_MAPK_gen_1	97	104	PF00069	0.411
DOC_MAPK_HePTP_8	94	106	PF00069	0.403
DOC_MAPK_MEF2A_6	131	139	PF00069	0.387
DOC_MAPK_MEF2A_6	338	346	PF00069	0.364
DOC_MAPK_MEF2A_6	97	106	PF00069	0.488
DOC_MAPK_NFAT4_5	341	349	PF00069	0.353
DOC_PP1_RVXF_1	101	107	PF00149	0.459
DOC_PP1_RVXF_1	272	279	PF00149	0.351
DOC_PP2B_LxvP_1	324	327	PF13499	0.471
DOC_USP7_MATH_1	218	222	PF00917	0.591
DOC_USP7_MATH_1	250	254	PF00917	0.435
DOC_USP7_MATH_1	308	312	PF00917	0.507
DOC_USP7_MATH_1	420	424	PF00917	0.687
DOC_USP7_MATH_1	430	434	PF00917	0.774
DOC_USP7_MATH_1	549	553	PF00917	0.538
DOC_USP7_MATH_1	664	668	PF00917	0.602
DOC_USP7_MATH_1	689	693	PF00917	0.598
DOC_USP7_MATH_1	702	706	PF00917	0.592
DOC_USP7_UBL2_3	627	631	PF12436	0.553
DOC_WW_Pin1_4	296	301	PF00397	0.353
DOC_WW_Pin1_4	423	428	PF00397	0.756
DOC_WW_Pin1_4	7	12	PF00397	0.472
LIG_14-3-3_CanoR_1	154	164	PF00244	0.308
LIG_14-3-3_CanoR_1	208	212	PF00244	0.370
LIG_14-3-3_CanoR_1	292	297	PF00244	0.457
LIG_14-3-3_CanoR_1	373	377	PF00244	0.536
LIG_14-3-3_CanoR_1	380	388	PF00244	0.511
LIG_14-3-3_CanoR_1	391	396	PF00244	0.395
LIG_14-3-3_CanoR_1	397	402	PF00244	0.569
LIG_14-3-3_CanoR_1	438	447	PF00244	0.724
LIG_14-3-3_CanoR_1	45	49	PF00244	0.384
LIG_14-3-3_CanoR_1	454	462	PF00244	0.802
LIG_14-3-3_CanoR_1	529	534	PF00244	0.565
LIG_14-3-3_CanoR_1	583	589	PF00244	0.494
LIG_14-3-3_CanoR_1	624	630	PF00244	0.527
LIG_14-3-3_CanoR_1	642	648	PF00244	0.340
LIG_Actin_WH2_2	125	143	PF00022	0.510
LIG_Actin_WH2_2	229	246	PF00022	0.428
LIG_Actin_WH2_2	364	382	PF00022	0.585
LIG_Actin_WH2_2	575	592	PF00022	0.574
LIG_APCC_ABBA_1	143	148	PF00400	0.394
LIG_BIR_II_1	1	5	PF00653	0.436
LIG_BRCT_BRCA1_1	187	191	PF00533	0.448
LIG_eIF4E_1	297	303	PF01652	0.439
LIG_FHA_1	10	16	PF00498	0.369
LIG_FHA_1	231	237	PF00498	0.673
LIG_FHA_1	252	258	PF00498	0.407
LIG_FHA_1	379	385	PF00498	0.489
LIG_FHA_1	592	598	PF00498	0.607
LIG_FHA_1	711	717	PF00498	0.483
LIG_FHA_2	373	379	PF00498	0.530
LIG_FHA_2	448	454	PF00498	0.705
LIG_FHA_2	80	86	PF00498	0.420
LIG_GBD_Chelix_1	29	37	PF00786	0.341
LIG_IBAR_NPY_1	239	241	PF08397	0.366
LIG_LIR_Apic_2	294	300	PF02991	0.330
LIG_LIR_Gen_1	277	285	PF02991	0.416
LIG_LIR_Gen_1	325	336	PF02991	0.360
LIG_LIR_Gen_1	85	95	PF02991	0.435
LIG_LIR_Nem_3	109	114	PF02991	0.305
LIG_LIR_Nem_3	199	205	PF02991	0.308
LIG_LIR_Nem_3	277	281	PF02991	0.423
LIG_LIR_Nem_3	295	301	PF02991	0.285
LIG_LIR_Nem_3	325	331	PF02991	0.344
LIG_LIR_Nem_3	85	90	PF02991	0.433
LIG_NRBOX	159	165	PF00104	0.435
LIG_NRBOX	3	9	PF00104	0.489
LIG_NRBOX	609	615	PF00104	0.403
LIG_REV1ctd_RIR_1	109	117	PF16727	0.336
LIG_RPA_C_Fungi	93	105	PF08784	0.403
LIG_SH2_NCK_1	508	512	PF00017	0.658
LIG_SH2_PTP2	347	350	PF00017	0.504
LIG_SH2_SRC	328	331	PF00017	0.329
LIG_SH2_SRC	347	350	PF00017	0.510
LIG_SH2_STAP1	571	575	PF00017	0.581
LIG_SH2_STAT3	682	685	PF00017	0.559
LIG_SH2_STAT5	241	244	PF00017	0.466
LIG_SH2_STAT5	297	300	PF00017	0.310
LIG_SH2_STAT5	323	326	PF00017	0.447
LIG_SH2_STAT5	347	350	PF00017	0.504
LIG_SH2_STAT5	42	45	PF00017	0.449
LIG_SH2_STAT5	682	685	PF00017	0.465
LIG_SH3_3	17	23	PF00018	0.509
LIG_SH3_3	302	308	PF00018	0.432
LIG_SH3_3	396	402	PF00018	0.702
LIG_SH3_3	424	430	PF00018	0.733
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.356
LIG_SUMO_SIM_par_1	303	312	PF11976	0.428
LIG_SUMO_SIM_par_1	657	663	PF11976	0.655
LIG_TRAF2_1	492	495	PF00917	0.752
LIG_TRAF2_1	511	514	PF00917	0.618
LIG_TRAF2_1	553	556	PF00917	0.593
LIG_TRAF2_1	77	80	PF00917	0.399
LIG_TYR_ITIM	326	331	PF00017	0.323
LIG_UBA3_1	136	141	PF00899	0.274
LIG_UBA3_1	639	644	PF00899	0.561
LIG_WRC_WIRS_1	275	280	PF05994	0.457
MOD_CK1_1	210	216	PF00069	0.418
MOD_CK1_1	223	229	PF00069	0.616
MOD_CK1_1	311	317	PF00069	0.611
MOD_CK1_1	407	413	PF00069	0.682
MOD_CK1_1	423	429	PF00069	0.728
MOD_CK1_1	433	439	PF00069	0.663
MOD_CK1_1	660	666	PF00069	0.651
MOD_CK1_1	677	683	PF00069	0.453
MOD_CK1_1	9	15	PF00069	0.494
MOD_CK2_1	372	378	PF00069	0.617
MOD_CK2_1	447	453	PF00069	0.815
MOD_CK2_1	549	555	PF00069	0.637
MOD_CK2_1	561	567	PF00069	0.422
MOD_GlcNHglycan	157	160	PF01048	0.405
MOD_GlcNHglycan	227	230	PF01048	0.579
MOD_GlcNHglycan	381	384	PF01048	0.392
MOD_GlcNHglycan	423	426	PF01048	0.621
MOD_GlcNHglycan	504	507	PF01048	0.676
MOD_GlcNHglycan	551	554	PF01048	0.598
MOD_GlcNHglycan	563	566	PF01048	0.604
MOD_GlcNHglycan	591	594	PF01048	0.558
MOD_GlcNHglycan	662	665	PF01048	0.603
MOD_GlcNHglycan	691	694	PF01048	0.552
MOD_GlcNHglycan	717	720	PF01048	0.757
MOD_GlcNHglycan	723	726	PF01048	0.577
MOD_GSK3_1	155	162	PF00069	0.289
MOD_GSK3_1	206	213	PF00069	0.326
MOD_GSK3_1	218	225	PF00069	0.560
MOD_GSK3_1	292	299	PF00069	0.420
MOD_GSK3_1	307	314	PF00069	0.593
MOD_GSK3_1	330	337	PF00069	0.369
MOD_GSK3_1	351	358	PF00069	0.403
MOD_GSK3_1	429	436	PF00069	0.649
MOD_GSK3_1	445	452	PF00069	0.780
MOD_GSK3_1	625	632	PF00069	0.496
MOD_GSK3_1	650	657	PF00069	0.480
MOD_GSK3_1	660	667	PF00069	0.475
MOD_GSK3_1	710	717	PF00069	0.624
MOD_N-GLC_1	250	255	PF02516	0.442
MOD_N-GLC_1	502	507	PF02516	0.630
MOD_N-GLC_2	38	40	PF02516	0.441
MOD_N-GLC_2	69	71	PF02516	0.256
MOD_NEK2_1	112	117	PF00069	0.351
MOD_NEK2_1	224	229	PF00069	0.593
MOD_NEK2_1	262	267	PF00069	0.347
MOD_NEK2_1	367	372	PF00069	0.376
MOD_NEK2_1	379	384	PF00069	0.403
MOD_NEK2_1	447	452	PF00069	0.696
MOD_NEK2_1	589	594	PF00069	0.546
MOD_NEK2_1	625	630	PF00069	0.509
MOD_NEK2_2	120	125	PF00069	0.340
MOD_PIKK_1	112	118	PF00454	0.293
MOD_PIKK_1	164	170	PF00454	0.465
MOD_PIKK_1	463	469	PF00454	0.623
MOD_PKA_1	391	397	PF00069	0.533
MOD_PKA_2	164	170	PF00069	0.358
MOD_PKA_2	207	213	PF00069	0.399
MOD_PKA_2	291	297	PF00069	0.472
MOD_PKA_2	372	378	PF00069	0.435
MOD_PKA_2	379	385	PF00069	0.371
MOD_PKA_2	397	403	PF00069	0.571
MOD_PKA_2	407	413	PF00069	0.654
MOD_PKA_2	44	50	PF00069	0.345
MOD_PKA_2	561	567	PF00069	0.520
MOD_PKA_2	582	588	PF00069	0.493
MOD_PKA_2	702	708	PF00069	0.685
MOD_PKA_2	719	725	PF00069	0.753
MOD_Plk_1	250	256	PF00069	0.490
MOD_Plk_1	654	660	PF00069	0.551
MOD_Plk_4	207	213	PF00069	0.493
MOD_Plk_4	251	257	PF00069	0.393
MOD_Plk_4	292	298	PF00069	0.374
MOD_Plk_4	54	60	PF00069	0.431
MOD_Plk_4	654	660	PF00069	0.533
MOD_ProDKin_1	296	302	PF00069	0.351
MOD_ProDKin_1	423	429	PF00069	0.750
MOD_ProDKin_1	7	13	PF00069	0.478
MOD_SUMO_for_1	553	556	PF00179	0.577
MOD_SUMO_for_1	614	617	PF00179	0.411
MOD_SUMO_rev_2	333	342	PF00179	0.399
MOD_SUMO_rev_2	386	394	PF00179	0.453
TRG_DiLeu_BaEn_4	555	561	PF01217	0.490
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.328
TRG_ENDOCYTIC_2	323	326	PF00928	0.378
TRG_ENDOCYTIC_2	328	331	PF00928	0.331
TRG_ER_diArg_1	396	398	PF00400	0.539
TRG_ER_diArg_1	44	46	PF00400	0.374
TRG_ER_diArg_1	582	584	PF00400	0.494
TRG_NES_CRM1_1	134	149	PF08389	0.368
TRG_Pf-PMV_PEXEL_1	598	603	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N7	Leptomonas seymouri	60%	100%
A0A1X0P2P6	Trypanosomatidae	36%	100%
A0A422NY96	Trypanosoma rangeli	37%	100%
A0A451EJ92	Leishmania donovani	94%	98%
A4H361	Leishmania braziliensis	77%	99%
A4HRF8	Leishmania infantum	93%	98%
C9ZXI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AJC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
V5D5U6	Trypanosoma cruzi	37%	100%