Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC25_LEIMA

TriTrypDb:

LmjF.01.0340 , LMJLV39_010008600 , LMJSD75_010008700

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AC25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.381
CLV_NRD_NRD_1	213	215	PF00675	0.457
CLV_NRD_NRD_1	39	41	PF00675	0.446
CLV_PCSK_FUR_1	10	14	PF00082	0.393
CLV_PCSK_KEX2_1	12	14	PF00082	0.395
CLV_PCSK_KEX2_1	212	214	PF00082	0.427
CLV_PCSK_SKI1_1	154	158	PF00082	0.349
DEG_SPOP_SBC_1	182	186	PF00917	0.286
DOC_CDC14_PxL_1	226	234	PF14671	0.444
DOC_CKS1_1	189	194	PF01111	0.414
DOC_CYCLIN_yClb5_NLxxxL_5	236	245	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.660
DOC_MAPK_DCC_7	212	222	PF00069	0.503
DOC_MAPK_gen_1	212	221	PF00069	0.571
DOC_MAPK_MEF2A_6	135	144	PF00069	0.657
DOC_MAPK_MEF2A_6	212	219	PF00069	0.589
DOC_PP2B_LxvP_1	215	218	PF13499	0.666
DOC_USP7_MATH_1	123	127	PF00917	0.702
DOC_USP7_MATH_1	228	232	PF00917	0.444
DOC_USP7_MATH_1	78	82	PF00917	0.753
DOC_USP7_MATH_1	88	92	PF00917	0.780
DOC_USP7_MATH_1	96	100	PF00917	0.773
DOC_USP7_UBL2_3	41	45	PF12436	0.646
DOC_WW_Pin1_4	188	193	PF00397	0.352
DOC_WW_Pin1_4	50	55	PF00397	0.779
DOC_WW_Pin1_4	86	91	PF00397	0.755
LIG_14-3-3_CanoR_1	61	67	PF00244	0.700
LIG_APCC_ABBA_1	145	150	PF00400	0.651
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BIR_III_2	227	231	PF00653	0.444
LIG_FHA_1	184	190	PF00498	0.310
LIG_FHA_1	3	9	PF00498	0.684
LIG_FHA_2	176	182	PF00498	0.420
LIG_FHA_2	71	77	PF00498	0.741
LIG_GBD_Chelix_1	237	245	PF00786	0.554
LIG_LIR_Gen_1	43	54	PF02991	0.682
LIG_LIR_LC3C_4	235	238	PF02991	0.447
LIG_LIR_Nem_3	43	49	PF02991	0.614
LIG_PDZ_Class_2	253	258	PF00595	0.460
LIG_Pex14_2	144	148	PF04695	0.674
LIG_REV1ctd_RIR_1	141	150	PF16727	0.678
LIG_SH2_CRK	15	19	PF00017	0.598
LIG_SH2_PTP2	223	226	PF00017	0.408
LIG_SH2_STAT5	208	211	PF00017	0.605
LIG_SH2_STAT5	223	226	PF00017	0.270
LIG_SH3_3	176	182	PF00018	0.393
LIG_SH3_3	48	54	PF00018	0.674
LIG_SH3_3	64	70	PF00018	0.738
LIG_SH3_3	74	80	PF00018	0.793
LIG_SH3_3	95	101	PF00018	0.764
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.436
LIG_TRAF2_1	73	76	PF00917	0.772
LIG_TYR_ITIM	221	226	PF00017	0.369
LIG_WW_2	55	58	PF00397	0.687
MOD_CK1_1	183	189	PF00069	0.426
MOD_CK1_1	2	8	PF00069	0.676
MOD_CK1_1	206	212	PF00069	0.596
MOD_CK1_1	24	30	PF00069	0.703
MOD_CK1_1	71	77	PF00069	0.751
MOD_CK1_1	89	95	PF00069	0.801
MOD_CK2_1	1	7	PF00069	0.750
MOD_CK2_1	70	76	PF00069	0.770
MOD_GlcNHglycan	27	30	PF01048	0.501
MOD_GlcNHglycan	64	67	PF01048	0.548
MOD_GlcNHglycan	70	73	PF01048	0.593
MOD_GlcNHglycan	86	89	PF01048	0.372
MOD_GSK3_1	181	188	PF00069	0.461
MOD_GSK3_1	21	28	PF00069	0.698
MOD_GSK3_1	84	91	PF00069	0.703
MOD_N-GLC_1	239	244	PF02516	0.608
MOD_NEK2_1	1	6	PF00069	0.704
MOD_NEK2_1	175	180	PF00069	0.450
MOD_NEK2_1	241	246	PF00069	0.380
MOD_NEK2_1	25	30	PF00069	0.723
MOD_PIKK_1	206	212	PF00454	0.601
MOD_PKA_2	21	27	PF00069	0.687
MOD_Plk_1	239	245	PF00069	0.411
MOD_Plk_4	152	158	PF00069	0.528
MOD_Plk_4	175	181	PF00069	0.386
MOD_Plk_4	185	191	PF00069	0.301
MOD_Plk_4	203	209	PF00069	0.243
MOD_Plk_4	241	247	PF00069	0.407
MOD_Plk_4	252	258	PF00069	0.483
MOD_ProDKin_1	188	194	PF00069	0.352
MOD_ProDKin_1	50	56	PF00069	0.782
MOD_ProDKin_1	86	92	PF00069	0.757
MOD_SUMO_rev_2	37	47	PF00179	0.643
TRG_DiLeu_BaEn_4	37	43	PF01217	0.630
TRG_ENDOCYTIC_2	15	18	PF00928	0.580
TRG_ENDOCYTIC_2	223	226	PF00928	0.344
TRG_ENDOCYTIC_2	46	49	PF00928	0.616
TRG_ER_diArg_1	10	13	PF00400	0.594
TRG_ER_diArg_1	212	214	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8C0	Leptomonas seymouri	41%	97%
A0A1X0P2R1	Trypanosomatidae	28%	100%
A0A3R7NR92	Trypanosoma rangeli	28%	95%
A0A3S5H4U7	Leishmania donovani	90%	100%
A4H360	Leishmania braziliensis	66%	100%
A4HRF7	Leishmania infantum	91%	100%
E9AJC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5AQ19	Trypanosoma cruzi	26%	88%