BPH_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC23_LEIMA

TriTrypDb:

LmjF.01.0330 , LMJLV39_010008400 , LMJSD75_010008500

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005787	signal peptidase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1

Expansion

Sequence features

E9AC23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC23

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	1
GO:0006508	proteolysis	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008233	peptidase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.417
CLV_PCSK_KEX2_1	124	126	PF00082	0.367
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.302
CLV_PCSK_SKI1_1	128	132	PF00082	0.402
CLV_PCSK_SKI1_1	30	34	PF00082	0.367
CLV_PCSK_SKI1_1	54	58	PF00082	0.322
CLV_PCSK_SKI1_1	59	63	PF00082	0.384
DOC_CYCLIN_RxL_1	54	67	PF00134	0.525
DOC_MAPK_FxFP_2	186	189	PF00069	0.573
DOC_MAPK_gen_1	128	137	PF00069	0.563
DOC_MAPK_gen_1	74	82	PF00069	0.365
DOC_MAPK_MEF2A_6	131	139	PF00069	0.552
DOC_PP4_FxxP_1	162	165	PF00568	0.654
DOC_PP4_FxxP_1	186	189	PF00568	0.556
DOC_USP7_MATH_1	202	206	PF00917	0.653
DOC_WW_Pin1_4	160	165	PF00397	0.675
LIG_14-3-3_CanoR_1	138	144	PF00244	0.657
LIG_14-3-3_CanoR_1	18	28	PF00244	0.596
LIG_14-3-3_CanoR_1	30	39	PF00244	0.497
LIG_BIR_II_1	1	5	PF00653	0.723
LIG_BRCT_BRCA1_1	158	162	PF00533	0.691
LIG_BRCT_BRCA1_1	182	186	PF00533	0.643
LIG_BRCT_BRCA1_1	83	87	PF00533	0.417
LIG_Clathr_ClatBox_1	148	152	PF01394	0.568
LIG_EH1_1	74	82	PF00400	0.392
LIG_FHA_1	111	117	PF00498	0.650
LIG_FHA_1	20	26	PF00498	0.652
LIG_FHA_1	31	37	PF00498	0.450
LIG_FHA_1	60	66	PF00498	0.323
LIG_FHA_2	2	8	PF00498	0.687
LIG_LIR_Apic_2	159	165	PF02991	0.658
LIG_LIR_Apic_2	183	189	PF02991	0.569
LIG_LIR_Gen_1	152	161	PF02991	0.639
LIG_LIR_Nem_3	152	156	PF02991	0.591
LIG_LIR_Nem_3	174	180	PF02991	0.585
LIG_LIR_Nem_3	38	42	PF02991	0.612
LIG_LIR_Nem_3	84	89	PF02991	0.383
LIG_MLH1_MIPbox_1	83	87	PF16413	0.369
LIG_PCNA_yPIPBox_3	193	207	PF02747	0.625
LIG_SH2_NCK_1	168	172	PF00017	0.643
LIG_SH2_STAT5	39	42	PF00017	0.548
LIG_SH2_STAT5	70	73	PF00017	0.488
LIG_TYR_ITIM	40	45	PF00017	0.562
LIG_WW_1	165	168	PF00397	0.505
MOD_CK2_1	1	7	PF00069	0.660
MOD_CK2_1	166	172	PF00069	0.507
MOD_GlcNHglycan	77	80	PF01048	0.600
MOD_GSK3_1	156	163	PF00069	0.561
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	110	115	PF00069	0.295
MOD_NEK2_1	180	185	PF00069	0.483
MOD_NEK2_1	75	80	PF00069	0.515
MOD_NEK2_1	81	86	PF00069	0.361
MOD_NEK2_1	95	100	PF00069	0.237
MOD_PIKK_1	137	143	PF00454	0.555
MOD_PIKK_1	166	172	PF00454	0.568
MOD_PKA_2	137	143	PF00069	0.560
MOD_PKA_2	75	81	PF00069	0.493
MOD_Plk_1	171	177	PF00069	0.510
MOD_Plk_4	1	7	PF00069	0.693
MOD_Plk_4	82	88	PF00069	0.408
MOD_Plk_4	97	103	PF00069	0.281
MOD_ProDKin_1	160	166	PF00069	0.595
MOD_SUMO_for_1	149	152	PF00179	0.523
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.387
TRG_ENDOCYTIC_2	168	171	PF00928	0.469
TRG_ENDOCYTIC_2	177	180	PF00928	0.518
TRG_ENDOCYTIC_2	42	45	PF00928	0.517
TRG_ER_diLys_1	206	209	PF00400	0.594
TRG_NLS_MonoExtN_4	125	132	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	128	133	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JMH0	Bodo saltans	29%	76%
A0A1X0P325	Trypanosomatidae	32%	93%
A0A3S5H4U6	Leishmania donovani	94%	100%
A0A3S5ISA1	Trypanosoma rangeli	28%	91%
A4H358	Leishmania braziliensis	74%	99%
A4HRF5	Leishmania infantum	94%	100%
C9ZXH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	95%
E9AJC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%