Putative poly(A) export protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A) export protein, putative

Species:

Leishmania major

UniProt:

E9AC22_LEIMA

TriTrypDb:

LmjF.01.0320 , LMJLV39_010008300 , LMJSD75_010008400

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	2
GO:0032991	protein-containing complex	1	6
GO:0140513	nuclear protein-containing complex	2	2
GO:0005840	ribosome	5	4
GO:0043226	organelle	2	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4
GO:1990904	ribonucleoprotein complex	2	4

Expansion

Sequence features

E9AC22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC22

Function

Biological processes
Term	Name	Level	Count
GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	6	2
GO:0006405	RNA export from nucleus	5	11
GO:0006406	mRNA export from nucleus	6	11
GO:0006810	transport	3	11
GO:0006913	nucleocytoplasmic transport	5	11
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	11
GO:0015931	nucleobase-containing compound transport	5	11
GO:0016043	cellular component organization	3	2
GO:0046907	intracellular transport	3	11
GO:0050657	nucleic acid transport	6	11
GO:0050658	RNA transport	4	11
GO:0051028	mRNA transport	5	11
GO:0051168	nuclear export	6	11
GO:0051169	nuclear transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051236	establishment of RNA localization	3	11
GO:0051276	chromosome organization	5	2
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.476
CLV_NRD_NRD_1	247	249	PF00675	0.545
CLV_PCSK_SKI1_1	170	174	PF00082	0.484
CLV_PCSK_SKI1_1	249	253	PF00082	0.571
CLV_PCSK_SKI1_1	50	54	PF00082	0.350
DEG_Nend_Nbox_1	1	3	PF02207	0.417
DEG_SPOP_SBC_1	31	35	PF00917	0.304
DOC_CYCLIN_yCln2_LP_2	121	127	PF00134	0.439
DOC_PP1_RVXF_1	102	108	PF00149	0.482
DOC_PP1_RVXF_1	187	193	PF00149	0.403
DOC_PP1_RVXF_1	48	54	PF00149	0.334
DOC_PP2B_LxvP_1	159	162	PF13499	0.426
DOC_PP2B_LxvP_1	86	89	PF13499	0.552
DOC_USP7_MATH_1	274	278	PF00917	0.382
DOC_WW_Pin1_4	35	40	PF00397	0.437
LIG_14-3-3_CanoR_1	111	116	PF00244	0.480
LIG_14-3-3_CanoR_1	170	178	PF00244	0.540
LIG_14-3-3_CanoR_1	189	193	PF00244	0.259
LIG_14-3-3_CterR_2	304	307	PF00244	0.480
LIG_BIR_III_4	197	201	PF00653	0.479
LIG_FHA_1	139	145	PF00498	0.508
LIG_FHA_1	225	231	PF00498	0.535
LIG_FHA_1	260	266	PF00498	0.581
LIG_FHA_2	32	38	PF00498	0.447
LIG_LIR_Gen_1	191	199	PF02991	0.581
LIG_LIR_Gen_1	84	92	PF02991	0.552
LIG_LIR_Nem_3	84	88	PF02991	0.552
LIG_SH2_CRK	178	182	PF00017	0.531
LIG_SH2_SRC	281	284	PF00017	0.471
LIG_SH2_STAP1	281	285	PF00017	0.371
LIG_SH2_STAT3	148	151	PF00017	0.502
LIG_SH2_STAT3	294	297	PF00017	0.590
LIG_SH2_STAT5	115	118	PF00017	0.450
LIG_SH2_STAT5	214	217	PF00017	0.519
LIG_SH3_3	220	226	PF00018	0.408
LIG_SUMO_SIM_par_1	227	233	PF11976	0.507
MOD_CK1_1	191	197	PF00069	0.573
MOD_GlcNHglycan	232	235	PF01048	0.447
MOD_GlcNHglycan	267	270	PF01048	0.388
MOD_GlcNHglycan	271	275	PF01048	0.400
MOD_GlcNHglycan	291	294	PF01048	0.642
MOD_GlcNHglycan	45	48	PF01048	0.421
MOD_GSK3_1	1	8	PF00069	0.384
MOD_GSK3_1	205	212	PF00069	0.583
MOD_GSK3_1	270	277	PF00069	0.389
MOD_GSK3_1	31	38	PF00069	0.430
MOD_GSK3_1	39	46	PF00069	0.419
MOD_GSK3_1	84	91	PF00069	0.527
MOD_N-GLC_1	238	243	PF02516	0.499
MOD_N-GLC_2	220	222	PF02516	0.365
MOD_NEK2_1	1	6	PF00069	0.411
MOD_NEK2_1	216	221	PF00069	0.395
MOD_NEK2_1	230	235	PF00069	0.370
MOD_NEK2_1	289	294	PF00069	0.493
MOD_NEK2_1	41	46	PF00069	0.340
MOD_NEK2_1	95	100	PF00069	0.483
MOD_NEK2_2	199	204	PF00069	0.454
MOD_PIKK_1	214	220	PF00454	0.435
MOD_PIKK_1	25	31	PF00454	0.462
MOD_PIKK_1	259	265	PF00454	0.574
MOD_PIKK_1	90	96	PF00454	0.552
MOD_PKA_2	188	194	PF00069	0.412
MOD_Plk_1	209	215	PF00069	0.559
MOD_Plk_1	238	244	PF00069	0.479
MOD_Plk_4	11	17	PF00069	0.395
MOD_Plk_4	111	117	PF00069	0.475
MOD_Plk_4	188	194	PF00069	0.405
MOD_Plk_4	238	244	PF00069	0.479
MOD_Plk_4	274	280	PF00069	0.375
MOD_ProDKin_1	35	41	PF00069	0.436
MOD_SUMO_rev_2	100	105	PF00179	0.524
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.500
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.430
TRG_ENDOCYTIC_2	178	181	PF00928	0.537
TRG_NES_CRM1_1	151	163	PF08389	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JMM7	Bodo saltans	43%	71%
A0A1W5T363	Penicillium oxalicum	29%	89%
A0A1X0P3S0	Trypanosomatidae	58%	87%
A0A3S5H4U5	Leishmania donovani	99%	100%
A0A3S5ISA2	Trypanosoma rangeli	54%	88%
A4H357	Leishmania braziliensis	91%	100%
A4HRF4	Leishmania infantum	99%	100%
A5GFN6	Sus scrofa	30%	83%
C9ZXH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	88%
E9AJB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
G0SEA3	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	28%	86%
O42860	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	96%
O43684	Homo sapiens	26%	94%
P40066	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	84%
P41838	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	87%
P78406	Homo sapiens	30%	83%
Q1JQB2	Bos taurus	26%	94%
Q38942	Arabidopsis thaliana	32%	88%
Q3SWS8	Rattus norvegicus	30%	83%
Q4R6D2	Macaca fascicularis	31%	83%
Q54DM1	Dictyostelium discoideum	24%	93%
Q5E9A4	Bos taurus	30%	83%
Q5FVA9	Xenopus tropicalis	31%	83%
Q5RB58	Pongo abelii	26%	94%
Q5RF99	Pongo abelii	30%	83%
Q7ZWF0	Danio rerio	30%	83%
Q8C570	Mus musculus	30%	83%
Q93454	Caenorhabditis elegans	29%	82%
Q9C701	Arabidopsis thaliana	26%	91%
Q9LJN8	Arabidopsis thaliana	24%	90%
Q9W2E7	Drosophila melanogaster	30%	89%
Q9WVA3	Mus musculus	26%	94%
Q9XWH0	Caenorhabditis elegans	26%	90%
Q9YGY3	Xenopus laevis	26%	93%
S8ASK6	Penicillium oxalicum (strain 114-2 / CGMCC 5302)	29%	89%
V5B5G8	Trypanosoma cruzi	54%	88%