Putative acidocalcisomal exopolyphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acidocalcisomal exopolyphosphatase, putative

Species:

Leishmania major

UniProt:

E9AC20_LEIMA

TriTrypDb:

LmjF.01.0310 , LMJLV39_010008000 , LMJSD75_010008100

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AC20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC20

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006797	polyphosphate metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004309	exopolyphosphatase activity	6	8
GO:0005488	binding	1	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.418
CLV_C14_Caspase3-7	334	338	PF00656	0.488
CLV_NRD_NRD_1	10	12	PF00675	0.399
CLV_NRD_NRD_1	244	246	PF00675	0.246
CLV_NRD_NRD_1	367	369	PF00675	0.227
CLV_PCSK_KEX2_1	10	12	PF00082	0.365
CLV_PCSK_KEX2_1	244	246	PF00082	0.238
CLV_PCSK_SKI1_1	11	15	PF00082	0.459
CLV_PCSK_SKI1_1	196	200	PF00082	0.399
DEG_APCC_DBOX_1	9	17	PF00400	0.418
DEG_SPOP_SBC_1	263	267	PF00917	0.366
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.285
DOC_MAPK_DCC_7	15	25	PF00069	0.437
DOC_MAPK_gen_1	229	237	PF00069	0.483
DOC_MAPK_MEF2A_6	231	239	PF00069	0.458
DOC_PP1_RVXF_1	312	319	PF00149	0.458
DOC_PP2B_LxvP_1	180	183	PF13499	0.307
DOC_PP2B_LxvP_1	237	240	PF13499	0.483
DOC_PP4_FxxP_1	327	330	PF00568	0.456
DOC_PP4_FxxP_1	55	58	PF00568	0.496
DOC_USP7_MATH_1	263	267	PF00917	0.507
DOC_USP7_UBL2_3	145	149	PF12436	0.376
DOC_USP7_UBL2_3	15	19	PF12436	0.472
DOC_USP7_UBL2_3	307	311	PF12436	0.506
DOC_WW_Pin1_4	196	201	PF00397	0.442
LIG_14-3-3_CanoR_1	151	157	PF00244	0.497
LIG_BIR_II_1	1	5	PF00653	0.385
LIG_EH1_1	278	286	PF00400	0.506
LIG_FHA_1	179	185	PF00498	0.428
LIG_FHA_1	263	269	PF00498	0.519
LIG_FHA_1	311	317	PF00498	0.519
LIG_FHA_1	381	387	PF00498	0.561
LIG_FHA_2	197	203	PF00498	0.346
LIG_GBD_Chelix_1	37	45	PF00786	0.256
LIG_LIR_Apic_2	326	330	PF02991	0.456
LIG_LIR_Nem_3	246	250	PF02991	0.427
LIG_LIR_Nem_3	326	331	PF02991	0.512
LIG_LIR_Nem_3	340	344	PF02991	0.401
LIG_LIR_Nem_3	353	359	PF02991	0.415
LIG_LIR_Nem_3	76	82	PF02991	0.487
LIG_Pex14_2	327	331	PF04695	0.456
LIG_Rb_pABgroove_1	41	49	PF01858	0.496
LIG_SH2_SRC	354	357	PF00017	0.456
LIG_SH2_STAT3	291	294	PF00017	0.549
LIG_SH2_STAT5	143	146	PF00017	0.458
LIG_SH2_STAT5	291	294	PF00017	0.542
LIG_SH2_STAT5	42	45	PF00017	0.429
LIG_SH3_3	171	177	PF00018	0.500
LIG_SUMO_SIM_anti_2	280	285	PF11976	0.558
LIG_SUMO_SIM_anti_2	298	303	PF11976	0.382
LIG_SUMO_SIM_par_1	181	188	PF11976	0.297
LIG_SUMO_SIM_par_1	232	238	PF11976	0.501
LIG_UBA3_1	223	231	PF00899	0.312
LIG_WRC_WIRS_1	324	329	PF05994	0.488
MOD_CK1_1	158	164	PF00069	0.435
MOD_CK1_1	262	268	PF00069	0.472
MOD_CK1_1	362	368	PF00069	0.462
MOD_CK2_1	382	388	PF00069	0.389
MOD_GlcNHglycan	1	4	PF01048	0.454
MOD_GlcNHglycan	157	160	PF01048	0.227
MOD_GlcNHglycan	216	219	PF01048	0.350
MOD_GlcNHglycan	261	264	PF01048	0.263
MOD_GSK3_1	121	128	PF00069	0.456
MOD_GSK3_1	259	266	PF00069	0.528
MOD_GSK3_1	342	349	PF00069	0.465
MOD_GSK3_1	355	362	PF00069	0.453
MOD_GSK3_1	84	91	PF00069	0.438
MOD_N-GLC_1	107	112	PF02516	0.296
MOD_N-GLC_1	121	126	PF02516	0.176
MOD_NEK2_1	107	112	PF00069	0.440
MOD_NEK2_1	235	240	PF00069	0.470
MOD_NEK2_1	88	93	PF00069	0.458
MOD_PIKK_1	253	259	PF00454	0.456
MOD_Plk_1	107	113	PF00069	0.522
MOD_Plk_1	84	90	PF00069	0.519
MOD_Plk_4	107	113	PF00069	0.549
MOD_Plk_4	158	164	PF00069	0.435
MOD_Plk_4	175	181	PF00069	0.296
MOD_Plk_4	21	27	PF00069	0.370
MOD_Plk_4	33	39	PF00069	0.392
MOD_Plk_4	84	90	PF00069	0.464
MOD_ProDKin_1	196	202	PF00069	0.433
TRG_ENDOCYTIC_2	206	209	PF00928	0.423
TRG_ENDOCYTIC_2	247	250	PF00928	0.427
TRG_ENDOCYTIC_2	42	45	PF00928	0.453
TRG_ER_diArg_1	243	245	PF00400	0.427
TRG_ER_diArg_1	9	11	PF00400	0.399
TRG_NES_CRM1_1	103	115	PF08389	0.483
TRG_NES_CRM1_1	274	287	PF08389	0.496
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I007	Leptomonas seymouri	57%	100%
A0A0S4IZ18	Bodo saltans	38%	100%
A0A1X0P2Z3	Trypanosomatidae	46%	100%
A0A3S5H4U4	Leishmania donovani	95%	100%
A0A422NY62	Trypanosoma rangeli	45%	100%
A4H355	Leishmania braziliensis	84%	100%
A4HRF2	Leishmania infantum	95%	100%
C9ZXE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AJB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O14094	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P38698	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	98%
Q5E9Y6	Bos taurus	26%	86%
Q6AYG3	Rattus norvegicus	27%	85%
Q86TP1	Homo sapiens	27%	86%
Q8BIW1	Mus musculus	26%	85%