LeishMANIAdb
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COX assembly mitochondrial protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
COX assembly mitochondrial protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AC18_LEIMA
TriTrypDb:
LmjF.01.0290 , LMJLV39_010007800 , LMJSD75_010007900 *
Length:
172

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

E9AC18
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC18

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 55 57 PF00675 0.341
CLV_PCSK_KEX2_1 118 120 PF00082 0.586
CLV_PCSK_PC1ET2_1 118 120 PF00082 0.586
CLV_PCSK_SKI1_1 57 61 PF00082 0.402
DOC_PP1_RVXF_1 55 62 PF00149 0.420
DOC_USP7_MATH_1 165 169 PF00917 0.545
DOC_USP7_UBL2_3 114 118 PF12436 0.568
DOC_WW_Pin1_4 27 32 PF00397 0.525
LIG_14-3-3_CanoR_1 56 62 PF00244 0.456
LIG_BIR_II_1 1 5 PF00653 0.627
LIG_eIF4E_1 107 113 PF01652 0.491
LIG_FHA_2 162 168 PF00498 0.750
LIG_FHA_2 28 34 PF00498 0.633
LIG_LIR_Nem_3 97 103 PF02991 0.355
LIG_PCNA_yPIPBox_3 20 29 PF02747 0.545
LIG_Pex14_1 138 142 PF04695 0.566
LIG_SH2_STAP1 65 69 PF00017 0.355
LIG_SH2_STAT5 107 110 PF00017 0.464
LIG_SH3_3 126 132 PF00018 0.548
LIG_TRAF2_1 164 167 PF00917 0.782
LIG_UBA3_1 46 51 PF00899 0.335
MOD_CK2_1 161 167 PF00069 0.739
MOD_CK2_1 27 33 PF00069 0.632
MOD_GSK3_1 157 164 PF00069 0.697
MOD_N-GLC_2 88 90 PF02516 0.335
MOD_PIKK_1 68 74 PF00454 0.447
MOD_Plk_1 15 21 PF00069 0.671
MOD_ProDKin_1 27 33 PF00069 0.529
MOD_SUMO_for_1 50 53 PF00179 0.355
TRG_ENDOCYTIC_2 103 106 PF00928 0.478
TRG_ENDOCYTIC_2 146 149 PF00928 0.516

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCP6 Leptomonas seymouri 88% 100%
A0A0S4J3U9 Bodo saltans 65% 100%
A0A1X0P3F2 Trypanosomatidae 71% 100%
A0A3R7LAI1 Trypanosoma rangeli 69% 100%
A0A3S5H4U2 Leishmania donovani 94% 100%
A4H353 Leishmania braziliensis 91% 100%
A4HRF0 Leishmania infantum 94% 100%
C9ZXE7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 100%
E9AJB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS