LeishMANIAdb
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Thioredoxin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin
Gene product:
thioredoxin, putative
Species:
Leishmania major
UniProt:
E9AC16_LEIMA
TriTrypDb:
LmjF.01.0270 , LMJLV39_010007600 , LMJSD75_010007700
Length:
107

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AC16
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC16

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0015035 protein-disulfide reductase activity 3 8
GO:0015036 disulfide oxidoreductase activity 4 8
GO:0016491 oxidoreductase activity 2 8
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 8
GO:0140096 catalytic activity, acting on a protein 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 52 56 PF00082 0.310
DOC_USP7_UBL2_3 35 39 PF12436 0.378
LIG_14-3-3_CanoR_1 43 47 PF00244 0.455
LIG_BRCT_BRCA1_1 49 53 PF00533 0.349
LIG_BRCT_BRCA1_2 49 55 PF00533 0.221
LIG_FHA_1 18 24 PF00498 0.426
LIG_FHA_1 60 66 PF00498 0.369
LIG_FHA_1 73 79 PF00498 0.291
LIG_LIR_Apic_2 27 33 PF02991 0.291
LIG_LIR_Gen_1 45 56 PF02991 0.332
LIG_LIR_Gen_1 75 84 PF02991 0.310
LIG_LIR_Nem_3 10 15 PF02991 0.291
LIG_LIR_Nem_3 45 51 PF02991 0.296
LIG_LIR_Nem_3 75 79 PF02991 0.310
LIG_Pex14_2 26 30 PF04695 0.291
LIG_SH2_SRC 87 90 PF00017 0.422
LIG_SH2_STAT5 87 90 PF00017 0.369
LIG_SUMO_SIM_anti_2 20 25 PF11976 0.371
LIG_WRC_WIRS_1 73 78 PF05994 0.291
MOD_GlcNHglycan 26 29 PF01048 0.369
MOD_GSK3_1 59 66 PF00069 0.341
MOD_N-GLC_1 59 64 PF02516 0.323
MOD_PKA_2 42 48 PF00069 0.391
MOD_Plk_2-3 42 48 PF00069 0.316
MOD_Plk_4 19 25 PF00069 0.371
MOD_Plk_4 72 78 PF00069 0.294

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL85 Leptomonas seymouri 34% 69%
A0A0N1PD08 Leptomonas seymouri 82% 100%
A0A0S4IQ93 Bodo saltans 26% 77%
A0A0S4ISI9 Bodo saltans 37% 70%
A0A0S4IZF8 Bodo saltans 69% 100%
A0A1X0P2Q9 Trypanosomatidae 67% 100%
A0A3Q8IGH5 Leishmania donovani 37% 69%
A0A3R7NZW1 Trypanosoma rangeli 64% 100%
A0A3S5H4U0 Leishmania donovani 98% 100%
A4H351 Leishmania braziliensis 93% 100%
A4HRE8 Leishmania infantum 98% 100%
C9K7C5 Alternaria alternata 35% 91%
C9ZXF0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9AJB3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O14463 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 100%
O17486 Echinococcus granulosus 38% 100%
O22022 Cyanidioschyzon merolae (strain NIES-3377 / 10D) 33% 100%
O64394 Triticum aestivum 34% 84%
O64432 Brassica campestris 32% 87%
O65049 Picea mariana 35% 86%
O94504 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 42% 80%
O96952 Geodia cydonium 39% 100%
O97508 Equus caballus 40% 100%
O97680 Bos taurus 41% 100%
P00275 Corynebacterium nephridii 35% 100%
P07887 Corynebacterium nephridii 32% 99%
P08628 Oryctolagus cuniculus 44% 100%
P08629 Gallus gallus 37% 100%
P0A617 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 36% 92%
P10599 Homo sapiens 43% 100%
P10639 Mus musculus 42% 100%
P11232 Rattus norvegicus 42% 100%
P22217 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 100%
P22803 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 100%
P25372 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 84%
P29429 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 32% 97%
P29445 Dictyostelium discoideum 42% 100%
P29447 Dictyostelium discoideum 40% 100%
P29448 Arabidopsis thaliana 35% 94%
P29449 Nicotiana tabacum 33% 85%
P29451 Macaca mulatta 43% 100%
P34723 Penicillium chrysogenum 32% 100%
P37395 Cyanidium caldarium 35% 100%
P42115 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 29% 84%
P47370 Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) 32% 100%
P47938 Drosophila melanogaster 34% 100%
P50254 Neopyropia yezoensis 29% 100%
P50338 Griffithsia pacifica 27% 98%
P50413 Ovis aries 40% 100%
P51225 Porphyra purpurea 28% 100%
P52230 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 29% 97%
P52231 Synechocystis sp. (strain PCC 6803 / Kazusa) 29% 100%
P52233 Acidithiobacillus ferridurans 34% 99%
P60226 Drosophila yakuba 33% 100%
P66928 Helicobacter pylori (strain ATCC 700392 / 26695) 29% 100%
P66929 Helicobacter pylori (strain J99 / ATCC 700824) 29% 100%
P68176 Brassica oleracea 32% 87%
P68177 Brassica napus 32% 87%
P75512 Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) 32% 100%
P80028 Chlamydomonas reinhardtii 35% 95%
P82460 Sus scrofa 43% 100%
P85801 Populus jackii 31% 77%
P9WG66 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 36% 92%
P9WG67 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 36% 92%
Q05739 Streptomyces clavuligerus 29% 100%
Q07090 Nicotiana tabacum 33% 91%
Q09433 Caenorhabditis elegans 32% 93%
Q0DKF1 Oryza sativa subsp. japonica 28% 81%
Q1RQI9 Malassezia sympodialis 33% 100%
Q1RQJ0 Neosartorya fumigata 38% 97%
Q1RQJ1 Neosartorya fumigata 33% 99%
Q38879 Arabidopsis thaliana 38% 80%
Q39239 Arabidopsis thaliana 36% 90%
Q39241 Arabidopsis thaliana 29% 91%
Q39362 Brassica napus 35% 90%
Q42403 Arabidopsis thaliana 28% 91%
Q43636 Ricinus communis 35% 91%
Q4UNK3 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 34% 100%
Q5R9M3 Pongo abelii 42% 100%
Q5UR29 Acanthamoeba polyphaga mimivirus 36% 78%
Q69AB1 Rattus norvegicus 32% 84%
Q69AB2 Mus musculus 35% 84%
Q6XHI1 Drosophila yakuba 35% 100%
Q6Z4I3 Oryza sativa subsp. japonica 40% 78%
Q75GM1 Oryza sativa subsp. japonica 24% 79%
Q7KQL8 Plasmodium falciparum (isolate 3D7) 31% 100%
Q7M1B9 Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) 34% 97%
Q851R5 Oryza sativa subsp. japonica 35% 80%
Q8IFW4 Drosophila melanogaster 39% 68%
Q8KE49 Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) 25% 98%
Q93VQ9 Arabidopsis thaliana 30% 67%
Q96419 Fagopyrum esculentum 34% 92%
Q98TX1 Ophiophagus hannah 34% 100%
Q9AS75 Oryza sativa subsp. japonica 28% 82%
Q9BDJ3 Callithrix jacchus 43% 100%
Q9C9Y6 Arabidopsis thaliana 35% 76%
Q9CAS1 Arabidopsis thaliana 32% 72%
Q9CM49 Pasteurella multocida (strain Pm70) 32% 100%
Q9DGI3 Ictalurus punctatus 38% 100%
Q9LXZ8 Arabidopsis thaliana 30% 69%
Q9UW02 Coprinus comatus 26% 100%
Q9V429 Drosophila melanogaster 37% 100%
Q9XIF4 Arabidopsis thaliana 34% 83%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS