Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Calmodulin-binding, putative

Species:

Leishmania major

UniProt:

E9AC15_LEIMA

TriTrypDb:

LmjF.01.0260 , LMJLV39_010007500 , LMJSD75_010007600

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005874	microtubule	6	2
GO:0005881	cytoplasmic microtubule	7	2
GO:0005930	axoneme	2	2
GO:0036064	ciliary basal body	3	2
GO:0097542	ciliary tip	2	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	4
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9AC15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.729
CLV_NRD_NRD_1	182	184	PF00675	0.291
CLV_NRD_NRD_1	212	214	PF00675	0.320
CLV_NRD_NRD_1	23	25	PF00675	0.586
CLV_NRD_NRD_1	253	255	PF00675	0.313
CLV_NRD_NRD_1	32	34	PF00675	0.536
CLV_NRD_NRD_1	39	41	PF00675	0.485
CLV_PCSK_FUR_1	21	25	PF00082	0.607
CLV_PCSK_KEX2_1	122	124	PF00082	0.729
CLV_PCSK_KEX2_1	212	214	PF00082	0.386
CLV_PCSK_KEX2_1	23	25	PF00082	0.586
CLV_PCSK_KEX2_1	252	254	PF00082	0.291
CLV_PCSK_KEX2_1	32	34	PF00082	0.536
CLV_PCSK_KEX2_1	39	41	PF00082	0.485
CLV_PCSK_SKI1_1	93	97	PF00082	0.619
DEG_SPOP_SBC_1	98	102	PF00917	0.643
DOC_MAPK_RevD_3	238	253	PF00069	0.418
DOC_PP2B_LxvP_1	276	279	PF13499	0.405
DOC_USP7_MATH_1	110	114	PF00917	0.716
DOC_USP7_MATH_1	144	148	PF00917	0.731
DOC_USP7_MATH_1	61	65	PF00917	0.717
DOC_USP7_MATH_1	98	102	PF00917	0.679
DOC_USP7_UBL2_3	269	273	PF12436	0.369
DOC_WW_Pin1_4	131	136	PF00397	0.647
DOC_WW_Pin1_4	137	142	PF00397	0.682
LIG_14-3-3_CanoR_1	202	207	PF00244	0.418
LIG_14-3-3_CanoR_1	267	277	PF00244	0.304
LIG_14-3-3_CanoR_1	67	75	PF00244	0.737
LIG_BIR_III_4	158	162	PF00653	0.527
LIG_BRCT_BRCA1_1	86	90	PF00533	0.635
LIG_FHA_1	244	250	PF00498	0.291
LIG_FHA_2	67	73	PF00498	0.609
LIG_LIR_Nem_3	275	280	PF02991	0.543
LIG_SH2_NCK_1	45	49	PF00017	0.519
LIG_SH2_SRC	45	48	PF00017	0.623
LIG_SH2_STAT3	179	182	PF00017	0.310
LIG_SH2_STAT5	179	182	PF00017	0.294
LIG_SH2_STAT5	78	81	PF00017	0.610
LIG_SH3_3	138	144	PF00018	0.673
LIG_SH3_3	165	171	PF00018	0.677
LIG_SxIP_EBH_1	200	213	PF03271	0.418
LIG_TRAF2_1	215	218	PF00917	0.299
LIG_TRAF2_1	255	258	PF00917	0.474
MOD_CDC14_SPxK_1	134	137	PF00782	0.513
MOD_CDK_SPxK_1	131	137	PF00069	0.512
MOD_CK1_1	101	107	PF00069	0.665
MOD_CK1_1	108	114	PF00069	0.747
MOD_CK1_1	115	121	PF00069	0.563
MOD_CK1_1	147	153	PF00069	0.724
MOD_CK1_1	157	163	PF00069	0.757
MOD_CK1_1	66	72	PF00069	0.545
MOD_CK2_1	212	218	PF00069	0.313
MOD_CK2_1	88	94	PF00069	0.566
MOD_GlcNHglycan	107	110	PF01048	0.694
MOD_GlcNHglycan	114	117	PF01048	0.679
MOD_GlcNHglycan	146	149	PF01048	0.621
MOD_GlcNHglycan	158	162	PF01048	0.572
MOD_GlcNHglycan	3	6	PF01048	0.463
MOD_GlcNHglycan	57	60	PF01048	0.670
MOD_GlcNHglycan	63	66	PF01048	0.619
MOD_GSK3_1	101	108	PF00069	0.541
MOD_GSK3_1	111	118	PF00069	0.713
MOD_GSK3_1	153	160	PF00069	0.695
MOD_GSK3_1	268	275	PF00069	0.342
MOD_GSK3_1	63	70	PF00069	0.692
MOD_GSK3_1	84	91	PF00069	0.565
MOD_GSK3_1	93	100	PF00069	0.533
MOD_N-GLC_1	98	103	PF02516	0.698
MOD_NEK2_1	38	43	PF00069	0.568
MOD_PIKK_1	243	249	PF00454	0.337
MOD_PIKK_1	84	90	PF00454	0.608
MOD_PKA_1	212	218	PF00069	0.341
MOD_PKA_2	212	218	PF00069	0.418
MOD_PKA_2	38	44	PF00069	0.557
MOD_PKA_2	66	72	PF00069	0.551
MOD_PKB_1	200	208	PF00069	0.375
MOD_Plk_4	202	208	PF00069	0.471
MOD_Plk_4	272	278	PF00069	0.533
MOD_ProDKin_1	131	137	PF00069	0.650
MOD_SUMO_rev_2	215	220	PF00179	0.312
TRG_ENDOCYTIC_2	45	48	PF00928	0.526
TRG_ER_diArg_1	173	176	PF00400	0.610
TRG_ER_diArg_1	21	24	PF00400	0.607
TRG_ER_diArg_1	212	214	PF00400	0.418
TRG_ER_diArg_1	252	254	PF00400	0.375
TRG_ER_diArg_1	38	40	PF00400	0.603
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N2	Leptomonas seymouri	56%	96%
A0A0S4J2X9	Bodo saltans	38%	100%
A0A1X0P2S2	Trypanosomatidae	42%	100%
A0A422NYA8	Trypanosoma rangeli	39%	100%
A0A451EJ82	Leishmania donovani	93%	100%
A4HRE7	Leishmania infantum	93%	100%
C9ZXF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AJB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%