Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Right handed beta helix region, putative

Species:

Leishmania major

UniProt:

E9AC14_LEIMA

TriTrypDb:

LmjF.01.0250 , LMJLV39_010007400 , LMJSD75_010007500

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.733
CLV_C14_Caspase3-7	351	355	PF00656	0.695
CLV_C14_Caspase3-7	622	626	PF00656	0.449
CLV_NRD_NRD_1	271	273	PF00675	0.727
CLV_NRD_NRD_1	362	364	PF00675	0.723
CLV_NRD_NRD_1	429	431	PF00675	0.779
CLV_NRD_NRD_1	506	508	PF00675	0.554
CLV_PCSK_KEX2_1	271	273	PF00082	0.762
CLV_PCSK_KEX2_1	362	364	PF00082	0.721
CLV_PCSK_KEX2_1	429	431	PF00082	0.766
CLV_PCSK_KEX2_1	505	507	PF00082	0.574
CLV_PCSK_SKI1_1	208	212	PF00082	0.553
CLV_PCSK_SKI1_1	98	102	PF00082	0.542
CLV_Separin_Metazoa	190	194	PF03568	0.558
DEG_APCC_DBOX_1	582	590	PF00400	0.387
DEG_SCF_FBW7_1	90	96	PF00400	0.601
DEG_SPOP_SBC_1	381	385	PF00917	0.607
DOC_CDC14_PxL_1	612	620	PF14671	0.549
DOC_CKS1_1	224	229	PF01111	0.503
DOC_CKS1_1	324	329	PF01111	0.589
DOC_CKS1_1	435	440	PF01111	0.725
DOC_CKS1_1	90	95	PF01111	0.602
DOC_CYCLIN_RxL_1	205	216	PF00134	0.546
DOC_MAPK_gen_1	116	126	PF00069	0.522
DOC_MAPK_gen_1	162	172	PF00069	0.663
DOC_MAPK_gen_1	682	692	PF00069	0.349
DOC_MAPK_gen_1	762	770	PF00069	0.375
DOC_MAPK_MEF2A_6	193	201	PF00069	0.567
DOC_PP2B_LxvP_1	373	376	PF13499	0.579
DOC_USP7_MATH_1	21	25	PF00917	0.672
DOC_USP7_MATH_1	230	234	PF00917	0.643
DOC_USP7_MATH_1	278	282	PF00917	0.754
DOC_USP7_MATH_1	310	314	PF00917	0.783
DOC_USP7_MATH_1	335	339	PF00917	0.688
DOC_USP7_MATH_1	344	348	PF00917	0.644
DOC_USP7_MATH_1	355	359	PF00917	0.524
DOC_USP7_MATH_1	374	378	PF00917	0.527
DOC_USP7_MATH_1	381	385	PF00917	0.679
DOC_USP7_MATH_1	450	454	PF00917	0.657
DOC_USP7_MATH_1	471	475	PF00917	0.614
DOC_USP7_MATH_1	526	530	PF00917	0.497
DOC_USP7_MATH_1	602	606	PF00917	0.627
DOC_USP7_MATH_1	608	612	PF00917	0.576
DOC_WW_Pin1_4	148	153	PF00397	0.640
DOC_WW_Pin1_4	223	228	PF00397	0.513
DOC_WW_Pin1_4	323	328	PF00397	0.667
DOC_WW_Pin1_4	331	336	PF00397	0.643
DOC_WW_Pin1_4	384	389	PF00397	0.728
DOC_WW_Pin1_4	409	414	PF00397	0.722
DOC_WW_Pin1_4	418	423	PF00397	0.620
DOC_WW_Pin1_4	431	436	PF00397	0.590
DOC_WW_Pin1_4	467	472	PF00397	0.704
DOC_WW_Pin1_4	476	481	PF00397	0.660
DOC_WW_Pin1_4	483	488	PF00397	0.644
DOC_WW_Pin1_4	495	500	PF00397	0.573
DOC_WW_Pin1_4	509	514	PF00397	0.380
DOC_WW_Pin1_4	55	60	PF00397	0.602
DOC_WW_Pin1_4	89	94	PF00397	0.675
LIG_14-3-3_CanoR_1	11	20	PF00244	0.672
LIG_14-3-3_CanoR_1	193	201	PF00244	0.542
LIG_14-3-3_CanoR_1	34	38	PF00244	0.785
LIG_14-3-3_CanoR_1	362	370	PF00244	0.716
LIG_14-3-3_CanoR_1	382	390	PF00244	0.725
LIG_14-3-3_CanoR_1	399	404	PF00244	0.566
LIG_14-3-3_CanoR_1	416	421	PF00244	0.729
LIG_14-3-3_CanoR_1	451	459	PF00244	0.646
LIG_14-3-3_CanoR_1	466	471	PF00244	0.601
LIG_14-3-3_CanoR_1	506	512	PF00244	0.534
LIG_14-3-3_CanoR_1	566	575	PF00244	0.421
LIG_14-3-3_CanoR_1	609	619	PF00244	0.534
LIG_14-3-3_CanoR_1	691	699	PF00244	0.349
LIG_14-3-3_CanoR_1	746	754	PF00244	0.359
LIG_14-3-3_CanoR_1	764	769	PF00244	0.259
LIG_14-3-3_CanoR_1	771	775	PF00244	0.324
LIG_BIR_III_2	80	84	PF00653	0.592
LIG_CSL_BTD_1	510	513	PF09270	0.520
LIG_FHA_1	154	160	PF00498	0.680
LIG_FHA_1	415	421	PF00498	0.773
LIG_FHA_1	652	658	PF00498	0.399
LIG_FHA_1	707	713	PF00498	0.375
LIG_FHA_1	749	755	PF00498	0.399
LIG_FHA_1	765	771	PF00498	0.239
LIG_FHA_2	223	229	PF00498	0.635
LIG_FHA_2	313	319	PF00498	0.676
LIG_FHA_2	391	397	PF00498	0.629
LIG_FHA_2	701	707	PF00498	0.399
LIG_LIR_Gen_1	195	206	PF02991	0.511
LIG_LIR_Gen_1	207	213	PF02991	0.425
LIG_LIR_Gen_1	27	33	PF02991	0.604
LIG_LIR_Nem_3	195	201	PF02991	0.513
LIG_LIR_Nem_3	207	212	PF02991	0.428
LIG_LIR_Nem_3	27	31	PF02991	0.610
LIG_LYPXL_SIV_4	557	565	PF13949	0.494
LIG_NRBOX	187	193	PF00104	0.579
LIG_PCNA_yPIPBox_3	180	192	PF02747	0.509
LIG_Pex14_2	198	202	PF04695	0.533
LIG_SH2_NCK_1	581	585	PF00017	0.378
LIG_SH2_SRC	669	672	PF00017	0.349
LIG_SH2_STAP1	541	545	PF00017	0.456
LIG_SH2_STAT5	669	672	PF00017	0.399
LIG_SH2_STAT5	698	701	PF00017	0.399
LIG_SH2_STAT5	774	777	PF00017	0.399
LIG_SH3_3	243	249	PF00018	0.714
LIG_SH3_3	321	327	PF00018	0.748
LIG_SH3_3	432	438	PF00018	0.725
LIG_SH3_3	456	462	PF00018	0.617
LIG_SH3_3	477	483	PF00018	0.677
LIG_SH3_3	493	499	PF00018	0.545
LIG_SH3_3	531	537	PF00018	0.443
LIG_SH3_3	561	567	PF00018	0.550
LIG_SH3_3	613	619	PF00018	0.552
LIG_SUMO_SIM_par_1	619	625	PF11976	0.447
LIG_TRAF2_1	213	216	PF00917	0.549
LIG_TRAF2_1	703	706	PF00917	0.399
LIG_TRAF2_1	741	744	PF00917	0.399
LIG_TYR_ITIM	539	544	PF00017	0.451
LIG_UBA3_1	1	8	PF00899	0.567
LIG_WW_2	616	619	PF00397	0.435
LIG_WW_3	379	383	PF00397	0.690
LIG_WW_3	388	392	PF00397	0.631
LIG_WW_3	479	483	PF00397	0.721
MOD_CDC14_SPxK_1	231	234	PF00782	0.571
MOD_CDK_SPK_2	422	427	PF00069	0.692
MOD_CDK_SPxK_1	228	234	PF00069	0.559
MOD_CDK_SPxK_1	476	482	PF00069	0.722
MOD_CDK_SPxxK_3	148	155	PF00069	0.643
MOD_CDK_SPxxK_3	384	391	PF00069	0.674
MOD_CDK_SPxxK_3	409	416	PF00069	0.727
MOD_CDK_SPxxK_3	422	429	PF00069	0.569
MOD_CDK_SPxxK_3	498	505	PF00069	0.640
MOD_CK1_1	148	154	PF00069	0.622
MOD_CK1_1	15	21	PF00069	0.680
MOD_CK1_1	24	30	PF00069	0.593
MOD_CK1_1	309	315	PF00069	0.681
MOD_CK1_1	333	339	PF00069	0.649
MOD_CK1_1	384	390	PF00069	0.763
MOD_CK1_1	421	427	PF00069	0.693
MOD_CK1_1	431	437	PF00069	0.639
MOD_CK1_1	467	473	PF00069	0.656
MOD_CK1_1	498	504	PF00069	0.677
MOD_CK1_1	610	616	PF00069	0.612
MOD_CK2_1	165	171	PF00069	0.715
MOD_CK2_1	222	228	PF00069	0.576
MOD_CK2_1	24	30	PF00069	0.714
MOD_CK2_1	312	318	PF00069	0.808
MOD_CK2_1	467	473	PF00069	0.586
MOD_CK2_1	579	585	PF00069	0.457
MOD_CK2_1	699	705	PF00069	0.399
MOD_CK2_1	747	753	PF00069	0.377
MOD_CMANNOS	158	161	PF00535	0.537
MOD_GlcNHglycan	145	148	PF01048	0.636
MOD_GlcNHglycan	166	170	PF01048	0.637
MOD_GlcNHglycan	23	26	PF01048	0.661
MOD_GlcNHglycan	280	283	PF01048	0.739
MOD_GlcNHglycan	307	311	PF01048	0.685
MOD_GlcNHglycan	337	340	PF01048	0.695
MOD_GlcNHglycan	384	387	PF01048	0.766
MOD_GlcNHglycan	430	433	PF01048	0.836
MOD_GlcNHglycan	452	455	PF01048	0.705
MOD_GlcNHglycan	528	531	PF01048	0.477
MOD_GlcNHglycan	555	558	PF01048	0.562
MOD_GlcNHglycan	75	78	PF01048	0.689
MOD_GSK3_1	12	19	PF00069	0.672
MOD_GSK3_1	20	27	PF00069	0.564
MOD_GSK3_1	200	207	PF00069	0.483
MOD_GSK3_1	305	312	PF00069	0.695
MOD_GSK3_1	319	326	PF00069	0.596
MOD_GSK3_1	33	40	PF00069	0.574
MOD_GSK3_1	331	338	PF00069	0.602
MOD_GSK3_1	380	387	PF00069	0.767
MOD_GSK3_1	407	414	PF00069	0.746
MOD_GSK3_1	418	425	PF00069	0.602
MOD_GSK3_1	450	457	PF00069	0.700
MOD_GSK3_1	467	474	PF00069	0.611
MOD_GSK3_1	507	514	PF00069	0.580
MOD_GSK3_1	51	58	PF00069	0.637
MOD_GSK3_1	607	614	PF00069	0.629
MOD_GSK3_1	61	68	PF00069	0.583
MOD_GSK3_1	89	96	PF00069	0.652
MOD_GSK3_1	98	105	PF00069	0.625
MOD_LATS_1	360	366	PF00433	0.669
MOD_N-GLC_1	706	711	PF02516	0.375
MOD_NEK2_1	145	150	PF00069	0.575
MOD_NEK2_1	192	197	PF00069	0.618
MOD_NEK2_1	20	25	PF00069	0.574
MOD_NEK2_1	629	634	PF00069	0.442
MOD_NEK2_1	693	698	PF00069	0.399
MOD_NEK2_1	722	727	PF00069	0.399
MOD_NEK2_1	763	768	PF00069	0.349
MOD_NEK2_2	455	460	PF00069	0.694
MOD_NEK2_2	61	66	PF00069	0.508
MOD_PIKK_1	200	206	PF00454	0.655
MOD_PIKK_1	35	41	PF00454	0.547
MOD_PIKK_1	436	442	PF00454	0.658
MOD_PIKK_1	512	518	PF00454	0.537
MOD_PK_1	399	405	PF00069	0.618
MOD_PKA_1	362	368	PF00069	0.715
MOD_PKA_2	192	198	PF00069	0.505
MOD_PKA_2	303	309	PF00069	0.650
MOD_PKA_2	33	39	PF00069	0.780
MOD_PKA_2	361	367	PF00069	0.716
MOD_PKA_2	381	387	PF00069	0.736
MOD_PKA_2	390	396	PF00069	0.643
MOD_PKA_2	398	404	PF00069	0.565
MOD_PKA_2	415	421	PF00069	0.732
MOD_PKA_2	428	434	PF00069	0.598
MOD_PKA_2	441	447	PF00069	0.600
MOD_PKA_2	450	456	PF00069	0.569
MOD_PKA_2	465	471	PF00069	0.584
MOD_PKA_2	565	571	PF00069	0.523
MOD_PKA_2	608	614	PF00069	0.589
MOD_PKA_2	678	684	PF00069	0.399
MOD_PKA_2	763	769	PF00069	0.399
MOD_PKA_2	770	776	PF00069	0.329
MOD_PKB_1	505	513	PF00069	0.518
MOD_PKB_1	762	770	PF00069	0.375
MOD_Plk_1	16	22	PF00069	0.679
MOD_Plk_1	165	171	PF00069	0.688
MOD_Plk_1	353	359	PF00069	0.678
MOD_Plk_1	700	706	PF00069	0.382
MOD_Plk_4	319	325	PF00069	0.664
MOD_Plk_4	61	67	PF00069	0.546
MOD_Plk_4	693	699	PF00069	0.399
MOD_Plk_4	723	729	PF00069	0.399
MOD_Plk_4	770	776	PF00069	0.399
MOD_ProDKin_1	148	154	PF00069	0.641
MOD_ProDKin_1	223	229	PF00069	0.516
MOD_ProDKin_1	323	329	PF00069	0.667
MOD_ProDKin_1	331	337	PF00069	0.640
MOD_ProDKin_1	384	390	PF00069	0.723
MOD_ProDKin_1	409	415	PF00069	0.726
MOD_ProDKin_1	418	424	PF00069	0.621
MOD_ProDKin_1	431	437	PF00069	0.591
MOD_ProDKin_1	467	473	PF00069	0.707
MOD_ProDKin_1	476	482	PF00069	0.661
MOD_ProDKin_1	483	489	PF00069	0.647
MOD_ProDKin_1	495	501	PF00069	0.565
MOD_ProDKin_1	509	515	PF00069	0.386
MOD_ProDKin_1	55	61	PF00069	0.601
MOD_ProDKin_1	89	95	PF00069	0.676
MOD_SUMO_rev_2	582	589	PF00179	0.437
MOD_SUMO_rev_2	701	709	PF00179	0.372
TRG_DiLeu_BaEn_1	122	127	PF01217	0.566
TRG_DiLeu_BaEn_1	187	192	PF01217	0.580
TRG_DiLeu_BaEn_4	214	220	PF01217	0.530
TRG_DiLeu_BaLyEn_6	616	621	PF01217	0.485
TRG_ENDOCYTIC_2	541	544	PF00928	0.452
TRG_ENDOCYTIC_2	581	584	PF00928	0.381
TRG_ER_diArg_1	270	272	PF00400	0.689
TRG_ER_diArg_1	505	507	PF00400	0.574
TRG_ER_diArg_1	575	578	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJ81	Leishmania donovani	89%	99%
A4H350	Leishmania braziliensis	65%	95%
A4HRE6	Leishmania infantum	89%	85%
E9AJB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%