Putative DNA excision/repair protein SNF2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA excision/repair protein SNF2, putative

Species:

Leishmania major

UniProt:

E9AC13_LEIMA

TriTrypDb:

LmjF.01.0240 , LMJLV39_010007300 , LMJSD75_010007400

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC13

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008094	ATP-dependent activity, acting on DNA	2	10
GO:0015616	DNA translocase activity	3	2
GO:0016491	oxidoreductase activity	2	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0051213	dioxygenase activity	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140097	catalytic activity, acting on DNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:0140658	ATP-dependent chromatin remodeler activity	3	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.474
CLV_C14_Caspase3-7	702	706	PF00656	0.379
CLV_C14_Caspase3-7	762	766	PF00656	0.608
CLV_NRD_NRD_1	207	209	PF00675	0.275
CLV_NRD_NRD_1	215	217	PF00675	0.258
CLV_NRD_NRD_1	349	351	PF00675	0.233
CLV_NRD_NRD_1	496	498	PF00675	0.217
CLV_NRD_NRD_1	506	508	PF00675	0.210
CLV_NRD_NRD_1	534	536	PF00675	0.274
CLV_NRD_NRD_1	595	597	PF00675	0.401
CLV_NRD_NRD_1	640	642	PF00675	0.605
CLV_NRD_NRD_1	695	697	PF00675	0.497
CLV_NRD_NRD_1	777	779	PF00675	0.663
CLV_PCSK_FUR_1	208	212	PF00082	0.275
CLV_PCSK_FUR_1	504	508	PF00082	0.216
CLV_PCSK_FUR_1	775	779	PF00082	0.623
CLV_PCSK_KEX2_1	210	212	PF00082	0.224
CLV_PCSK_KEX2_1	349	351	PF00082	0.223
CLV_PCSK_KEX2_1	506	508	PF00082	0.186
CLV_PCSK_KEX2_1	534	536	PF00082	0.274
CLV_PCSK_KEX2_1	595	597	PF00082	0.401
CLV_PCSK_KEX2_1	620	622	PF00082	0.544
CLV_PCSK_KEX2_1	640	642	PF00082	0.605
CLV_PCSK_KEX2_1	695	697	PF00082	0.497
CLV_PCSK_KEX2_1	775	777	PF00082	0.672
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.224
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.544
CLV_PCSK_PC7_1	591	597	PF00082	0.315
CLV_PCSK_PC7_1	691	697	PF00082	0.401
CLV_PCSK_SKI1_1	265	269	PF00082	0.299
CLV_PCSK_SKI1_1	275	279	PF00082	0.317
CLV_PCSK_SKI1_1	506	510	PF00082	0.223
CLV_PCSK_SKI1_1	602	606	PF00082	0.297
CLV_PCSK_SKI1_1	653	657	PF00082	0.456
CLV_PCSK_SKI1_1	661	665	PF00082	0.387
DEG_APCC_DBOX_1	218	226	PF00400	0.474
DEG_APCC_DBOX_1	505	513	PF00400	0.424
DEG_APCC_DBOX_1	656	664	PF00400	0.415
DEG_APCC_DBOX_1	690	698	PF00400	0.377
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DEG_SPOP_SBC_1	23	27	PF00917	0.616
DEG_SPOP_SBC_1	32	36	PF00917	0.601
DEG_SPOP_SBC_1	359	363	PF00917	0.481
DOC_CYCLIN_RxL_1	495	505	PF00134	0.436
DOC_CYCLIN_RxL_1	506	518	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	710	716	PF00134	0.458
DOC_MAPK_DCC_7	217	227	PF00069	0.506
DOC_MAPK_gen_1	504	514	PF00069	0.425
DOC_MAPK_gen_1	595	601	PF00069	0.353
DOC_MAPK_gen_1	775	781	PF00069	0.592
DOC_MAPK_MEF2A_6	219	227	PF00069	0.465
DOC_MAPK_MEF2A_6	364	373	PF00069	0.422
DOC_MAPK_MEF2A_6	481	490	PF00069	0.282
DOC_PP1_RVXF_1	496	503	PF00149	0.423
DOC_PP1_RVXF_1	508	515	PF00149	0.423
DOC_PP2B_LxvP_1	174	177	PF13499	0.506
DOC_PP2B_LxvP_1	859	862	PF13499	0.597
DOC_PP4_FxxP_1	111	114	PF00568	0.398
DOC_USP7_MATH_1	23	27	PF00917	0.632
DOC_USP7_MATH_1	238	242	PF00917	0.500
DOC_USP7_MATH_1	33	37	PF00917	0.581
DOC_USP7_MATH_1	331	335	PF00917	0.456
DOC_USP7_MATH_1	428	432	PF00917	0.429
DOC_USP7_MATH_1	624	628	PF00917	0.511
DOC_USP7_MATH_1	670	674	PF00917	0.397
DOC_USP7_MATH_1	832	836	PF00917	0.703
DOC_USP7_MATH_1	855	859	PF00917	0.566
DOC_USP7_MATH_1	93	97	PF00917	0.634
DOC_WW_Pin1_4	11	16	PF00397	0.639
DOC_WW_Pin1_4	278	283	PF00397	0.423
DOC_WW_Pin1_4	38	43	PF00397	0.781
DOC_WW_Pin1_4	527	532	PF00397	0.558
DOC_WW_Pin1_4	726	731	PF00397	0.668
DOC_WW_Pin1_4	741	746	PF00397	0.625
DOC_WW_Pin1_4	814	819	PF00397	0.693
DOC_WW_Pin1_4	828	833	PF00397	0.650
DOC_WW_Pin1_4	875	880	PF00397	0.660
DOC_WW_Pin1_4	97	102	PF00397	0.744
LIG_14-3-3_CanoR_1	372	380	PF00244	0.527
LIG_14-3-3_CanoR_1	497	501	PF00244	0.432
LIG_14-3-3_CanoR_1	510	515	PF00244	0.447
LIG_14-3-3_CanoR_1	520	526	PF00244	0.498
LIG_14-3-3_CanoR_1	602	609	PF00244	0.301
LIG_14-3-3_CanoR_1	661	667	PF00244	0.518
LIG_14-3-3_CanoR_1	672	680	PF00244	0.514
LIG_14-3-3_CanoR_1	810	814	PF00244	0.492
LIG_14-3-3_CterR_2	922	925	PF00244	0.503
LIG_Actin_WH2_2	807	825	PF00022	0.469
LIG_BIR_III_4	646	650	PF00653	0.562
LIG_BIR_III_4	717	721	PF00653	0.580
LIG_BRCT_BRCA1_1	876	880	PF00533	0.491
LIG_BRCT_BRCA1_1	914	918	PF00533	0.579
LIG_deltaCOP1_diTrp_1	288	296	PF00928	0.423
LIG_FHA_1	151	157	PF00498	0.423
LIG_FHA_1	169	175	PF00498	0.423
LIG_FHA_1	227	233	PF00498	0.445
LIG_FHA_1	430	436	PF00498	0.506
LIG_FHA_1	552	558	PF00498	0.438
LIG_FHA_1	709	715	PF00498	0.625
LIG_FHA_1	814	820	PF00498	0.571
LIG_FHA_1	823	829	PF00498	0.528
LIG_FHA_1	843	849	PF00498	0.574
LIG_FHA_1	90	96	PF00498	0.636
LIG_FHA_2	241	247	PF00498	0.474
LIG_FHA_2	284	290	PF00498	0.575
LIG_FHA_2	404	410	PF00498	0.474
LIG_FHA_2	522	528	PF00498	0.496
LIG_FHA_2	606	612	PF00498	0.310
LIG_FHA_2	866	872	PF00498	0.701
LIG_IBAR_NPY_1	464	466	PF08397	0.424
LIG_LIR_Gen_1	246	255	PF02991	0.423
LIG_LIR_Gen_1	286	294	PF02991	0.426
LIG_LIR_Gen_1	307	317	PF02991	0.476
LIG_LIR_Gen_1	446	457	PF02991	0.422
LIG_LIR_LC3C_4	171	176	PF02991	0.474
LIG_LIR_Nem_3	228	233	PF02991	0.415
LIG_LIR_Nem_3	246	250	PF02991	0.523
LIG_LIR_Nem_3	288	294	PF02991	0.448
LIG_LIR_Nem_3	307	312	PF02991	0.423
LIG_LIR_Nem_3	446	452	PF02991	0.378
LIG_LIR_Nem_3	650	655	PF02991	0.474
LIG_LIR_Nem_3	877	883	PF02991	0.484
LIG_MYND_1	178	182	PF01753	0.378
LIG_MYND_1	834	838	PF01753	0.507
LIG_NRBOX	485	491	PF00104	0.214
LIG_NRBOX	511	517	PF00104	0.449
LIG_NRBOX	6	12	PF00104	0.667
LIG_PCNA_PIPBox_1	290	299	PF02747	0.506
LIG_PDZ_Class_1	920	925	PF00595	0.499
LIG_Pex14_1	184	188	PF04695	0.474
LIG_Pex14_2	287	291	PF04695	0.453
LIG_PTAP_UEV_1	14	19	PF05743	0.531
LIG_PTB_Apo_2	613	620	PF02174	0.367
LIG_RPA_C_Fungi	591	603	PF08784	0.356
LIG_SH2_CRK	220	224	PF00017	0.299
LIG_SH2_CRK	230	234	PF00017	0.238
LIG_SH2_CRK	466	470	PF00017	0.404
LIG_SH2_PTP2	247	250	PF00017	0.375
LIG_SH2_STAP1	164	168	PF00017	0.331
LIG_SH2_STAP1	381	385	PF00017	0.375
LIG_SH2_STAT3	122	125	PF00017	0.385
LIG_SH2_STAT3	164	167	PF00017	0.375
LIG_SH2_STAT3	614	617	PF00017	0.358
LIG_SH2_STAT5	247	250	PF00017	0.289
LIG_SH2_STAT5	654	657	PF00017	0.455
LIG_SH3_3	12	18	PF00018	0.571
LIG_SH3_3	172	178	PF00018	0.375
LIG_SH3_3	677	683	PF00018	0.455
LIG_SH3_3	740	746	PF00018	0.798
LIG_SH3_3	873	879	PF00018	0.589
LIG_SH3_3	98	104	PF00018	0.651
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.262
LIG_SUMO_SIM_anti_2	241	246	PF11976	0.261
LIG_SUMO_SIM_anti_2	568	574	PF11976	0.260
LIG_SUMO_SIM_anti_2	676	682	PF11976	0.554
LIG_SUMO_SIM_anti_2	816	823	PF11976	0.581
LIG_SUMO_SIM_par_1	431	439	PF11976	0.265
LIG_SUMO_SIM_par_1	568	574	PF11976	0.321
LIG_TRAF2_1	53	56	PF00917	0.638
LIG_TRAF2_1	608	611	PF00917	0.303
LIG_TRFH_1	111	115	PF08558	0.406
LIG_TYR_ITIM	245	250	PF00017	0.375
LIG_UBA3_1	301	306	PF00899	0.284
LIG_WRC_WIRS_1	284	289	PF05994	0.354
LIG_WRC_WIRS_1	511	516	PF05994	0.331
MOD_CDC14_SPxK_1	733	736	PF00782	0.619
MOD_CDK_SPxK_1	730	736	PF00069	0.617
MOD_CDK_SPxxK_3	527	534	PF00069	0.331
MOD_CK1_1	266	272	PF00069	0.406
MOD_CK1_1	27	33	PF00069	0.657
MOD_CK1_1	36	42	PF00069	0.613
MOD_CK1_1	748	754	PF00069	0.631
MOD_CK1_1	840	846	PF00069	0.560
MOD_CK1_1	96	102	PF00069	0.661
MOD_CK2_1	359	365	PF00069	0.331
MOD_CK2_1	389	395	PF00069	0.291
MOD_CK2_1	403	409	PF00069	0.218
MOD_CK2_1	50	56	PF00069	0.650
MOD_CK2_1	527	533	PF00069	0.328
MOD_CK2_1	605	611	PF00069	0.306
MOD_CK2_1	632	638	PF00069	0.605
MOD_CK2_1	670	676	PF00069	0.521
MOD_Cter_Amidation	638	641	PF01082	0.609
MOD_GlcNHglycan	106	109	PF01048	0.598
MOD_GlcNHglycan	15	18	PF01048	0.533
MOD_GlcNHglycan	265	268	PF01048	0.288
MOD_GlcNHglycan	312	315	PF01048	0.331
MOD_GlcNHglycan	323	327	PF01048	0.222
MOD_GlcNHglycan	391	394	PF01048	0.383
MOD_GlcNHglycan	424	427	PF01048	0.329
MOD_GlcNHglycan	477	480	PF01048	0.338
MOD_GlcNHglycan	567	570	PF01048	0.256
MOD_GlcNHglycan	579	582	PF01048	0.252
MOD_GlcNHglycan	634	637	PF01048	0.661
MOD_GlcNHglycan	71	74	PF01048	0.542
MOD_GlcNHglycan	730	733	PF01048	0.669
MOD_GlcNHglycan	797	800	PF01048	0.613
MOD_GlcNHglycan	84	90	PF01048	0.666
MOD_GlcNHglycan	852	856	PF01048	0.756
MOD_GlcNHglycan	894	897	PF01048	0.516
MOD_GlcNHglycan	914	917	PF01048	0.424
MOD_GlcNHglycan	95	98	PF01048	0.605
MOD_GSK3_1	23	30	PF00069	0.525
MOD_GSK3_1	31	38	PF00069	0.673
MOD_GSK3_1	439	446	PF00069	0.263
MOD_GSK3_1	496	503	PF00069	0.321
MOD_GSK3_1	50	57	PF00069	0.476
MOD_GSK3_1	573	580	PF00069	0.274
MOD_GSK3_1	58	65	PF00069	0.573
MOD_GSK3_1	724	731	PF00069	0.654
MOD_GSK3_1	741	748	PF00069	0.596
MOD_GSK3_1	755	762	PF00069	0.594
MOD_GSK3_1	809	816	PF00069	0.753
MOD_GSK3_1	822	829	PF00069	0.605
MOD_GSK3_1	837	844	PF00069	0.460
MOD_GSK3_1	85	92	PF00069	0.536
MOD_GSK3_1	851	858	PF00069	0.494
MOD_GSK3_1	9	16	PF00069	0.564
MOD_GSK3_1	907	914	PF00069	0.625
MOD_GSK3_1	917	924	PF00069	0.549
MOD_GSK3_1	93	100	PF00069	0.543
MOD_N-GLC_1	69	74	PF02516	0.628
MOD_N-GLC_1	78	83	PF02516	0.505
MOD_N-GLC_2	260	262	PF02516	0.284
MOD_N-GLC_2	706	708	PF02516	0.397
MOD_NEK2_1	150	155	PF00069	0.259
MOD_NEK2_1	168	173	PF00069	0.259
MOD_NEK2_1	226	231	PF00069	0.276
MOD_NEK2_1	297	302	PF00069	0.329
MOD_NEK2_1	414	419	PF00069	0.261
MOD_NEK2_1	436	441	PF00069	0.289
MOD_NEK2_1	500	505	PF00069	0.267
MOD_NEK2_1	521	526	PF00069	0.331
MOD_NEK2_1	54	59	PF00069	0.587
MOD_NEK2_1	552	557	PF00069	0.283
MOD_NEK2_1	813	818	PF00069	0.540
MOD_NEK2_1	822	827	PF00069	0.630
MOD_NEK2_1	851	856	PF00069	0.738
MOD_NEK2_2	624	629	PF00069	0.488
MOD_PIKK_1	439	445	PF00454	0.354
MOD_PIKK_1	521	527	PF00454	0.331
MOD_PIKK_1	552	558	PF00454	0.259
MOD_PIKK_1	745	751	PF00454	0.727
MOD_PIKK_1	822	828	PF00454	0.608
MOD_PK_1	739	745	PF00069	0.618
MOD_PKA_2	371	377	PF00069	0.375
MOD_PKA_2	496	502	PF00069	0.301
MOD_PKA_2	519	525	PF00069	0.449
MOD_PKA_2	671	677	PF00069	0.539
MOD_PKA_2	809	815	PF00069	0.512
MOD_PKA_2	822	828	PF00069	0.538
MOD_PKA_2	862	868	PF00069	0.598
MOD_PKA_2	907	913	PF00069	0.697
MOD_PKB_1	759	767	PF00069	0.610
MOD_Plk_1	238	244	PF00069	0.354
MOD_Plk_1	734	740	PF00069	0.630
MOD_Plk_1	781	787	PF00069	0.609
MOD_Plk_4	169	175	PF00069	0.323
MOD_Plk_4	176	182	PF00069	0.249
MOD_Plk_4	240	246	PF00069	0.331
MOD_Plk_4	297	303	PF00069	0.259
MOD_Plk_4	312	318	PF00069	0.259
MOD_Plk_4	436	442	PF00069	0.295
MOD_Plk_4	448	454	PF00069	0.419
MOD_Plk_4	496	502	PF00069	0.278
MOD_Plk_4	510	516	PF00069	0.303
MOD_Plk_4	809	815	PF00069	0.465
MOD_Plk_4	832	838	PF00069	0.584
MOD_ProDKin_1	11	17	PF00069	0.637
MOD_ProDKin_1	278	284	PF00069	0.259
MOD_ProDKin_1	38	44	PF00069	0.785
MOD_ProDKin_1	527	533	PF00069	0.448
MOD_ProDKin_1	726	732	PF00069	0.668
MOD_ProDKin_1	741	747	PF00069	0.625
MOD_ProDKin_1	814	820	PF00069	0.694
MOD_ProDKin_1	828	834	PF00069	0.645
MOD_ProDKin_1	875	881	PF00069	0.653
MOD_ProDKin_1	97	103	PF00069	0.741
MOD_SUMO_rev_2	607	613	PF00179	0.245
TRG_DiLeu_BaEn_1	2	7	PF01217	0.573
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.375
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.219
TRG_DiLeu_BaLyEn_6	878	883	PF01217	0.481
TRG_ENDOCYTIC_2	230	233	PF00928	0.267
TRG_ENDOCYTIC_2	247	250	PF00928	0.395
TRG_ENDOCYTIC_2	381	384	PF00928	0.283
TRG_ENDOCYTIC_2	652	655	PF00928	0.466
TRG_ER_diArg_1	348	350	PF00400	0.259
TRG_ER_diArg_1	504	507	PF00400	0.208
TRG_ER_diArg_1	640	642	PF00400	0.605
TRG_ER_diArg_1	694	696	PF00400	0.494
TRG_ER_diArg_1	760	763	PF00400	0.704
TRG_ER_diArg_1	774	777	PF00400	0.741
TRG_NLS_MonoCore_2	207	212	PF00514	0.354
TRG_NLS_MonoExtN_4	207	213	PF00514	0.369
TRG_NLS_MonoExtN_4	214	220	PF00514	0.384
TRG_PTS1	922	925	PF00515	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE0	Leptomonas seymouri	60%	94%
A0A0P0WGX7	Oryza sativa subsp. japonica	31%	94%
A0A1X0P3S9	Trypanosomatidae	49%	100%
A0A3R7JZW4	Trypanosoma rangeli	27%	83%
A0A3R7MS90	Trypanosoma rangeli	48%	100%
A0A451EJ80	Leishmania donovani	89%	100%
A4H349	Leishmania braziliensis	79%	100%
A4HRE5	Leishmania infantum	90%	100%
A6QQR4	Bos taurus	31%	74%
A6ZL17	Saccharomyces cerevisiae (strain YJM789)	24%	100%
B3LN76	Saccharomyces cerevisiae (strain RM11-1a)	24%	100%
B5VE38	Saccharomyces cerevisiae (strain AWRI1631)	24%	100%
C7GQI8	Saccharomyces cerevisiae (strain JAY291)	24%	100%
D0A743	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	89%
E9AJB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
F4I2H2	Arabidopsis thaliana	27%	100%
P31244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P34739	Drosophila melanogaster	23%	87%
P38086	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	97%
Q2NKX8	Homo sapiens	30%	74%
Q8BHK9	Mus musculus	30%	75%
Q8W103	Arabidopsis thaliana	32%	85%
Q9M297	Arabidopsis thaliana	22%	74%
Q9UNY4	Homo sapiens	25%	80%
Q9ZV43	Arabidopsis thaliana	29%	78%
V5B5G3	Trypanosoma cruzi	49%	100%