Putative cyclophilin 12

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 12, putative

Species:

Leishmania major

UniProt:

E9AC11_LEIMA

TriTrypDb:

LmjF.01.0220 , LMJLV39_010007100 , LMJSD75_010007200

Length:

335

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	2

Expansion

Sequence features

E9AC11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC11

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	22
GO:0006457	protein folding	2	11
GO:0006807	nitrogen compound metabolic process	2	22
GO:0008152	metabolic process	1	22
GO:0009987	cellular process	1	11
GO:0018193	peptidyl-amino acid modification	5	22
GO:0018208	peptidyl-proline modification	6	22
GO:0019538	protein metabolic process	3	22
GO:0036211	protein modification process	4	22
GO:0043170	macromolecule metabolic process	3	22
GO:0043412	macromolecule modification	4	22
GO:0044238	primary metabolic process	2	22
GO:0071704	organic substance metabolic process	2	22
GO:1901564	organonitrogen compound metabolic process	3	22

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	22
GO:0003824	catalytic activity	1	22
GO:0016853	isomerase activity	2	22
GO:0016859	cis-trans isomerase activity	3	22
GO:0140096	catalytic activity, acting on a protein	2	22
GO:0005488	binding	1	2
GO:0016018	cyclosporin A binding	4	2
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.236
CLV_NRD_NRD_1	51	53	PF00675	0.397
CLV_PCSK_FUR_1	135	139	PF00082	0.264
CLV_PCSK_KEX2_1	137	139	PF00082	0.320
CLV_PCSK_KEX2_1	51	53	PF00082	0.395
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.294
CLV_PCSK_SKI1_1	141	145	PF00082	0.399
CLV_PCSK_SKI1_1	2	6	PF00082	0.336
CLV_PCSK_SKI1_1	220	224	PF00082	0.387
CLV_Separin_Metazoa	43	47	PF03568	0.305
DEG_Nend_UBRbox_1	1	4	PF02207	0.374
DEG_SPOP_SBC_1	271	275	PF00917	0.193
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.228
DOC_MAPK_gen_1	147	156	PF00069	0.302
DOC_MAPK_MEF2A_6	149	158	PF00069	0.289
DOC_PP1_RVXF_1	163	169	PF00149	0.276
DOC_PP1_RVXF_1	289	296	PF00149	0.333
DOC_PP2B_LxvP_1	42	45	PF13499	0.305
DOC_PP4_FxxP_1	203	206	PF00568	0.204
DOC_USP7_MATH_1	198	202	PF00917	0.364
DOC_USP7_MATH_1	271	275	PF00917	0.193
DOC_USP7_MATH_1	319	323	PF00917	0.214
DOC_USP7_MATH_1	54	58	PF00917	0.435
LIG_14-3-3_CanoR_1	187	192	PF00244	0.385
LIG_14-3-3_CanoR_1	283	288	PF00244	0.288
LIG_BIR_III_4	259	263	PF00653	0.231
LIG_BRCT_BRCA1_1	199	203	PF00533	0.204
LIG_BRCT_BRCA1_1	274	278	PF00533	0.392
LIG_FHA_1	251	257	PF00498	0.355
LIG_FHA_2	117	123	PF00498	0.492
LIG_FHA_2	219	225	PF00498	0.277
LIG_FHA_2	324	330	PF00498	0.312
LIG_LIR_Apic_2	200	206	PF02991	0.214
LIG_LIR_Apic_2	251	257	PF02991	0.259
LIG_LIR_Gen_1	169	177	PF02991	0.315
LIG_LIR_Gen_1	276	285	PF02991	0.254
LIG_LIR_Gen_1	34	44	PF02991	0.359
LIG_LIR_Nem_3	169	174	PF02991	0.358
LIG_LIR_Nem_3	216	222	PF02991	0.221
LIG_LIR_Nem_3	276	282	PF02991	0.365
LIG_LIR_Nem_3	34	39	PF02991	0.366
LIG_LIR_Nem_3	5	10	PF02991	0.393
LIG_PDZ_Class_1	330	335	PF00595	0.386
LIG_Pex14_1	167	171	PF04695	0.343
LIG_PTB_Apo_2	26	33	PF02174	0.303
LIG_PTB_Phospho_1	26	32	PF10480	0.301
LIG_REV1ctd_RIR_1	216	224	PF16727	0.217
LIG_SH2_CRK	10	14	PF00017	0.400
LIG_SH2_CRK	171	175	PF00017	0.251
LIG_SH2_CRK	254	258	PF00017	0.251
LIG_SH2_CRK	36	40	PF00017	0.289
LIG_SH2_GRB2like	27	30	PF00017	0.324
LIG_SH2_NCK_1	171	175	PF00017	0.236
LIG_SH2_PTP2	279	282	PF00017	0.319
LIG_SH2_STAP1	171	175	PF00017	0.231
LIG_SH2_STAP1	36	40	PF00017	0.426
LIG_SH2_STAT5	132	135	PF00017	0.565
LIG_SH2_STAT5	151	154	PF00017	0.266
LIG_SH2_STAT5	27	30	PF00017	0.271
LIG_SH2_STAT5	279	282	PF00017	0.231
LIG_SH2_STAT5	292	295	PF00017	0.231
LIG_SH3_3	199	205	PF00018	0.357
LIG_TRFH_1	10	14	PF08558	0.229
LIG_TYR_ITSM	6	13	PF00017	0.388
LIG_WRC_WIRS_1	4	9	PF05994	0.295
MOD_CK1_1	76	82	PF00069	0.488
MOD_CK2_1	69	75	PF00069	0.523
MOD_CK2_1	97	103	PF00069	0.623
MOD_Cter_Amidation	135	138	PF01082	0.279
MOD_GlcNHglycan	236	239	PF01048	0.291
MOD_GlcNHglycan	275	278	PF01048	0.352
MOD_GlcNHglycan	56	59	PF01048	0.380
MOD_GlcNHglycan	75	78	PF01048	0.485
MOD_GSK3_1	193	200	PF00069	0.375
MOD_GSK3_1	214	221	PF00069	0.259
MOD_GSK3_1	230	237	PF00069	0.385
MOD_GSK3_1	319	326	PF00069	0.406
MOD_GSK3_1	69	76	PF00069	0.745
MOD_GSK3_1	78	85	PF00069	0.480
MOD_N-GLC_2	181	183	PF02516	0.292
MOD_NEK2_1	143	148	PF00069	0.498
MOD_NEK2_1	170	175	PF00069	0.290
MOD_NEK2_1	193	198	PF00069	0.193
MOD_NEK2_1	218	223	PF00069	0.310
MOD_NEK2_1	278	283	PF00069	0.297
MOD_NEK2_1	73	78	PF00069	0.773
MOD_NEK2_2	198	203	PF00069	0.214
MOD_NEK2_2	240	245	PF00069	0.312
MOD_PIKK_1	60	66	PF00454	0.513
MOD_PKA_2	186	192	PF00069	0.399
MOD_Plk_1	154	160	PF00069	0.297
MOD_Plk_1	250	256	PF00069	0.292
MOD_Plk_1	69	75	PF00069	0.702
MOD_Plk_4	109	115	PF00069	0.374
MOD_Plk_4	198	204	PF00069	0.348
MOD_Plk_4	214	220	PF00069	0.178
MOD_Plk_4	283	289	PF00069	0.252
MOD_Plk_4	319	325	PF00069	0.305
MOD_SUMO_for_1	40	43	PF00179	0.485
TRG_DiLeu_BaEn_1	103	108	PF01217	0.392
TRG_ENDOCYTIC_2	10	13	PF00928	0.390
TRG_ENDOCYTIC_2	151	154	PF00928	0.239
TRG_ENDOCYTIC_2	171	174	PF00928	0.231
TRG_ENDOCYTIC_2	279	282	PF00928	0.232
TRG_ENDOCYTIC_2	292	295	PF00928	0.305
TRG_ENDOCYTIC_2	36	39	PF00928	0.353
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL84	Leptomonas seymouri	55%	100%
A0A0S4IKA5	Bodo saltans	38%	100%
A0A3Q8ICB3	Leishmania donovani	29%	100%
A0A3R7M7E5	Trypanosoma rangeli	42%	100%
A0A3S5H7U6	Leishmania donovani	37%	100%
A0A3S7X325	Leishmania donovani	26%	100%
A0A3S7X410	Leishmania donovani	31%	97%
A0A3S7XB52	Leishmania donovani	34%	100%
A0A451EJ79	Leishmania donovani	94%	100%
A4H346	Leishmania braziliensis	83%	99%
A4HCI8	Leishmania braziliensis	27%	100%
A4HHU7	Leishmania braziliensis	24%	100%
A4HIW9	Leishmania braziliensis	33%	100%
A4HRE3	Leishmania infantum	94%	100%
A4I004	Leishmania infantum	29%	100%
A4I4Z7	Leishmania infantum	25%	100%
A4I698	Leishmania infantum	31%	97%
A4I935	Leishmania infantum	37%	100%
A4IDA1	Leishmania infantum	34%	100%
C9ZXF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AJA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	98%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
P0C1I2	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	30%	100%
Q4Q1A6	Leishmania major	33%	100%
Q4Q6Q9	Leishmania major	31%	97%
Q4Q7V7	Leishmania major	25%	100%
Q4QBK2	Leishmania major	29%	100%
V5B9Y6	Trypanosoma cruzi	42%	100%