Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CUE domain/Domain of unknown function (DUF1771)/Smr domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AC10_LEIMA

TriTrypDb:

LmjF.01.0210 , LMJLV39_010007000 , LMJSD75_010007100

Length:

897

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC10

Function

Could not find GO biological_process term for this entry.

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004519	endonuclease activity	5	2
GO:0005488	binding	1	11
GO:0005515	protein binding	2	10
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0032182	ubiquitin-like protein binding	3	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.641
CLV_C14_Caspase3-7	398	402	PF00656	0.713
CLV_C14_Caspase3-7	436	440	PF00656	0.693
CLV_C14_Caspase3-7	699	703	PF00656	0.528
CLV_C14_Caspase3-7	767	771	PF00656	0.292
CLV_NRD_NRD_1	101	103	PF00675	0.533
CLV_NRD_NRD_1	223	225	PF00675	0.598
CLV_NRD_NRD_1	329	331	PF00675	0.720
CLV_NRD_NRD_1	366	368	PF00675	0.443
CLV_NRD_NRD_1	405	407	PF00675	0.751

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE15	Leptomonas seymouri	46%	99%
A0A1X0P3G2	Trypanosomatidae	33%	100%
A0A3R7KV90	Trypanosoma rangeli	35%	100%
A0A3S5H4T8	Leishmania donovani	92%	100%
A4H345	Leishmania braziliensis	74%	100%
A4HRE2	Leishmania infantum	92%	100%
C9ZXF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AJA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5D5T7	Trypanosoma cruzi	34%	100%

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