Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CUE domain/Domain of unknown function (DUF1771)/Smr domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AC10_LEIMA

TriTrypDb:

LmjF.01.0210 , LMJLV39_010007000 , LMJSD75_010007100

Length:

897

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC10

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004519	endonuclease activity	5	2
GO:0005488	binding	1	11
GO:0005515	protein binding	2	10
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0032182	ubiquitin-like protein binding	3	10
GO:0043130	ubiquitin binding	4	10
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.641
CLV_C14_Caspase3-7	398	402	PF00656	0.713
CLV_C14_Caspase3-7	436	440	PF00656	0.693
CLV_C14_Caspase3-7	699	703	PF00656	0.528
CLV_C14_Caspase3-7	767	771	PF00656	0.292
CLV_NRD_NRD_1	101	103	PF00675	0.533
CLV_NRD_NRD_1	223	225	PF00675	0.598
CLV_NRD_NRD_1	329	331	PF00675	0.720
CLV_NRD_NRD_1	366	368	PF00675	0.443
CLV_NRD_NRD_1	405	407	PF00675	0.751
CLV_NRD_NRD_1	742	744	PF00675	0.277
CLV_NRD_NRD_1	782	784	PF00675	0.469
CLV_NRD_NRD_1	828	830	PF00675	0.271
CLV_PCSK_KEX2_1	101	103	PF00082	0.574
CLV_PCSK_KEX2_1	2	4	PF00082	0.774
CLV_PCSK_KEX2_1	223	225	PF00082	0.598
CLV_PCSK_KEX2_1	329	331	PF00082	0.712
CLV_PCSK_KEX2_1	366	368	PF00082	0.443
CLV_PCSK_KEX2_1	742	744	PF00082	0.271
CLV_PCSK_KEX2_1	782	784	PF00082	0.444
CLV_PCSK_KEX2_1	828	830	PF00082	0.274
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.774
CLV_PCSK_SKI1_1	425	429	PF00082	0.572
CLV_PCSK_SKI1_1	842	846	PF00082	0.318
CLV_PCSK_SKI1_1	879	883	PF00082	0.379
DEG_Nend_UBRbox_1	1	4	PF02207	0.763
DEG_SCF_SKP2-CKS1_1	674	681	PF00560	0.458
DEG_SPOP_SBC_1	314	318	PF00917	0.718
DEG_SPOP_SBC_1	64	68	PF00917	0.615
DEG_SPOP_SBC_1	84	88	PF00917	0.724
DOC_MAPK_gen_1	628	636	PF00069	0.555
DOC_MAPK_gen_1	790	799	PF00069	0.304
DOC_MAPK_gen_1	835	843	PF00069	0.311
DOC_MAPK_gen_1	879	888	PF00069	0.413
DOC_MAPK_MEF2A_6	355	363	PF00069	0.361
DOC_MAPK_MEF2A_6	628	636	PF00069	0.418
DOC_MAPK_MEF2A_6	882	890	PF00069	0.388
DOC_PP2B_LxvP_1	225	228	PF13499	0.580
DOC_PP2B_LxvP_1	445	448	PF13499	0.633
DOC_USP7_MATH_1	277	281	PF00917	0.547
DOC_USP7_MATH_1	446	450	PF00917	0.759
DOC_USP7_MATH_1	64	68	PF00917	0.723
DOC_USP7_MATH_1	74	78	PF00917	0.716
DOC_USP7_MATH_1	765	769	PF00917	0.292
DOC_WW_Pin1_4	249	254	PF00397	0.581
DOC_WW_Pin1_4	288	293	PF00397	0.647
DOC_WW_Pin1_4	315	320	PF00397	0.665
DOC_WW_Pin1_4	619	624	PF00397	0.543
DOC_WW_Pin1_4	675	680	PF00397	0.504
DOC_WW_Pin1_4	91	96	PF00397	0.655
LIG_14-3-3_CanoR_1	14	20	PF00244	0.425
LIG_14-3-3_CanoR_1	367	377	PF00244	0.479
LIG_14-3-3_CanoR_1	425	430	PF00244	0.594
LIG_14-3-3_CanoR_1	514	522	PF00244	0.353
LIG_14-3-3_CanoR_1	657	661	PF00244	0.475
LIG_14-3-3_CanoR_1	775	784	PF00244	0.468
LIG_14-3-3_CanoR_1	803	812	PF00244	0.445
LIG_BIR_III_2	170	174	PF00653	0.519
LIG_BIR_III_4	271	275	PF00653	0.744
LIG_BIR_III_4	401	405	PF00653	0.625
LIG_BRCT_BRCA1_1	342	346	PF00533	0.505
LIG_Clathr_ClatBox_1	669	673	PF01394	0.503
LIG_EVH1_2	253	257	PF00568	0.591
LIG_FHA_1	204	210	PF00498	0.773
LIG_FHA_1	24	30	PF00498	0.403
LIG_FHA_1	526	532	PF00498	0.583
LIG_FHA_1	657	663	PF00498	0.456
LIG_FHA_1	664	670	PF00498	0.490
LIG_FHA_1	751	757	PF00498	0.412
LIG_FHA_1	771	777	PF00498	0.214
LIG_FHA_1	807	813	PF00498	0.386
LIG_FHA_1	84	90	PF00498	0.723
LIG_FHA_1	887	893	PF00498	0.491
LIG_FHA_2	276	282	PF00498	0.646
LIG_FHA_2	379	385	PF00498	0.519
LIG_FHA_2	434	440	PF00498	0.670
LIG_FHA_2	467	473	PF00498	0.587
LIG_FHA_2	525	531	PF00498	0.530
LIG_FHA_2	620	626	PF00498	0.424
LIG_FHA_2	697	703	PF00498	0.573
LIG_FHA_2	714	720	PF00498	0.593
LIG_FHA_2	859	865	PF00498	0.425
LIG_LIR_Apic_2	244	248	PF02991	0.627
LIG_LIR_Apic_2	687	693	PF02991	0.634
LIG_LIR_Gen_1	233	243	PF02991	0.714
LIG_LIR_Gen_1	491	501	PF02991	0.546
LIG_LIR_Gen_1	596	604	PF02991	0.348
LIG_LIR_Gen_1	787	796	PF02991	0.331
LIG_LIR_Nem_3	116	122	PF02991	0.456
LIG_LIR_Nem_3	233	238	PF02991	0.716
LIG_LIR_Nem_3	291	296	PF02991	0.762
LIG_LIR_Nem_3	491	496	PF02991	0.519
LIG_LIR_Nem_3	573	578	PF02991	0.337
LIG_LIR_Nem_3	596	601	PF02991	0.288
LIG_LIR_Nem_3	723	728	PF02991	0.546
LIG_LIR_Nem_3	740	744	PF02991	0.150
LIG_LIR_Nem_3	787	791	PF02991	0.299
LIG_LIR_Nem_3	857	862	PF02991	0.318
LIG_LYPXL_S_1	858	862	PF13949	0.314
LIG_LYPXL_yS_3	859	862	PF13949	0.314
LIG_SH2_CRK	122	126	PF00017	0.416
LIG_SH2_CRK	598	602	PF00017	0.290
LIG_SH2_CRK	788	792	PF00017	0.314
LIG_SH2_PTP2	885	888	PF00017	0.392
LIG_SH2_SRC	885	888	PF00017	0.392
LIG_SH2_STAT3	255	258	PF00017	0.581
LIG_SH2_STAT5	122	125	PF00017	0.479
LIG_SH2_STAT5	161	164	PF00017	0.514
LIG_SH2_STAT5	245	248	PF00017	0.619
LIG_SH2_STAT5	411	414	PF00017	0.557
LIG_SH2_STAT5	648	651	PF00017	0.479
LIG_SH2_STAT5	749	752	PF00017	0.319
LIG_SH2_STAT5	885	888	PF00017	0.380
LIG_SH3_2	306	311	PF14604	0.685
LIG_SH3_3	284	290	PF00018	0.592
LIG_SH3_3	303	309	PF00018	0.524
LIG_SH3_3	316	322	PF00018	0.718
LIG_SH3_3	631	637	PF00018	0.388
LIG_SH3_3	689	695	PF00018	0.696
LIG_SH3_3	887	893	PF00018	0.492
LIG_SUMO_SIM_par_1	488	494	PF11976	0.351
LIG_SUMO_SIM_par_1	567	573	PF11976	0.411
LIG_SUMO_SIM_par_1	579	584	PF11976	0.422
LIG_SUMO_SIM_par_1	668	674	PF11976	0.573
LIG_SUMO_SIM_par_1	734	740	PF11976	0.317
LIG_SUMO_SIM_par_1	795	800	PF11976	0.271
LIG_TRAF2_1	542	545	PF00917	0.490
LIG_TRAF2_1	716	719	PF00917	0.550
LIG_TYR_ITIM	786	791	PF00017	0.349
LIG_WRC_WIRS_1	90	95	PF05994	0.460
MOD_CDK_SPxK_1	288	294	PF00069	0.629
MOD_CDK_SPxK_1	675	681	PF00069	0.464
MOD_CK1_1	241	247	PF00069	0.576
MOD_CK1_1	317	323	PF00069	0.663
MOD_CK1_1	478	484	PF00069	0.579
MOD_CK1_1	615	621	PF00069	0.550
MOD_CK1_1	656	662	PF00069	0.424
MOD_CK1_1	67	73	PF00069	0.622
MOD_CK1_1	671	677	PF00069	0.680
MOD_CK2_1	241	247	PF00069	0.715
MOD_CK2_1	368	374	PF00069	0.494
MOD_CK2_1	378	384	PF00069	0.376
MOD_CK2_1	491	497	PF00069	0.481
MOD_CK2_1	524	530	PF00069	0.515
MOD_CK2_1	713	719	PF00069	0.644
MOD_CK2_1	858	864	PF00069	0.292
MOD_Cter_Amidation	780	783	PF01082	0.335
MOD_GlcNHglycan	144	147	PF01048	0.479
MOD_GlcNHglycan	299	302	PF01048	0.705
MOD_GlcNHglycan	370	373	PF01048	0.531
MOD_GlcNHglycan	431	434	PF01048	0.584
MOD_GlcNHglycan	477	480	PF01048	0.619
MOD_GlcNHglycan	5	8	PF01048	0.601
MOD_GlcNHglycan	507	510	PF01048	0.502
MOD_GlcNHglycan	610	613	PF01048	0.580
MOD_GlcNHglycan	614	617	PF01048	0.647
MOD_GlcNHglycan	645	648	PF01048	0.400
MOD_GlcNHglycan	673	676	PF01048	0.597
MOD_GlcNHglycan	705	710	PF01048	0.692
MOD_GlcNHglycan	71	74	PF01048	0.751
MOD_GlcNHglycan	718	723	PF01048	0.456
MOD_GlcNHglycan	725	728	PF01048	0.481
MOD_GlcNHglycan	767	770	PF01048	0.373
MOD_GlcNHglycan	872	875	PF01048	0.459
MOD_GSK3_1	313	320	PF00069	0.705
MOD_GSK3_1	421	428	PF00069	0.822
MOD_GSK3_1	429	436	PF00069	0.681
MOD_GSK3_1	608	615	PF00069	0.506
MOD_GSK3_1	63	70	PF00069	0.701
MOD_GSK3_1	671	678	PF00069	0.691
MOD_GSK3_1	713	720	PF00069	0.707
MOD_GSK3_1	74	81	PF00069	0.718
MOD_GSK3_1	760	767	PF00069	0.292
MOD_GSK3_1	803	810	PF00069	0.444
MOD_GSK3_1	85	92	PF00069	0.696
MOD_GSK3_1	854	861	PF00069	0.348
MOD_LATS_1	840	846	PF00433	0.292
MOD_N-GLC_1	425	430	PF02516	0.532
MOD_N-GLC_1	78	83	PF02516	0.603
MOD_NEK2_1	137	142	PF00069	0.409
MOD_NEK2_1	390	395	PF00069	0.677
MOD_NEK2_1	505	510	PF00069	0.522
MOD_NEK2_1	750	755	PF00069	0.434
MOD_NEK2_1	78	83	PF00069	0.715
MOD_NEK2_1	89	94	PF00069	0.672
MOD_NEK2_2	854	859	PF00069	0.349
MOD_OFUCOSY	110	117	PF10250	0.488
MOD_OFUCOSY	337	344	PF10250	0.363
MOD_PIKK_1	23	29	PF00454	0.453
MOD_PIKK_1	585	591	PF00454	0.404
MOD_PIKK_1	663	669	PF00454	0.321
MOD_PIKK_1	750	756	PF00454	0.335
MOD_PK_1	877	883	PF00069	0.399
MOD_PKA_2	13	19	PF00069	0.435
MOD_PKA_2	149	155	PF00069	0.436
MOD_PKA_2	238	244	PF00069	0.681
MOD_PKA_2	368	374	PF00069	0.438
MOD_PKA_2	433	439	PF00069	0.707
MOD_PKA_2	505	511	PF00069	0.503
MOD_PKA_2	513	519	PF00069	0.457
MOD_PKA_2	656	662	PF00069	0.472
MOD_PKB_1	376	384	PF00069	0.456
MOD_PKB_1	715	723	PF00069	0.466
MOD_Plk_1	451	457	PF00069	0.510
MOD_Plk_1	886	892	PF00069	0.557
MOD_Plk_2-3	668	674	PF00069	0.575
MOD_Plk_4	567	573	PF00069	0.284
MOD_Plk_4	85	91	PF00069	0.628
MOD_Plk_4	854	860	PF00069	0.368
MOD_Plk_4	867	873	PF00069	0.302
MOD_ProDKin_1	249	255	PF00069	0.583
MOD_ProDKin_1	288	294	PF00069	0.647
MOD_ProDKin_1	315	321	PF00069	0.665
MOD_ProDKin_1	619	625	PF00069	0.530
MOD_ProDKin_1	675	681	PF00069	0.507
MOD_ProDKin_1	91	97	PF00069	0.648
MOD_SUMO_rev_2	401	409	PF00179	0.601
TRG_DiLeu_BaEn_1	746	751	PF01217	0.464
TRG_DiLeu_BaEn_2	481	487	PF01217	0.518
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.578
TRG_ENDOCYTIC_2	122	125	PF00928	0.378
TRG_ENDOCYTIC_2	598	601	PF00928	0.271
TRG_ENDOCYTIC_2	788	791	PF00928	0.271
TRG_ENDOCYTIC_2	859	862	PF00928	0.293
TRG_ENDOCYTIC_2	885	888	PF00928	0.357
TRG_ER_diArg_1	100	102	PF00400	0.606
TRG_ER_diArg_1	182	185	PF00400	0.456
TRG_ER_diArg_1	223	225	PF00400	0.598
TRG_ER_diArg_1	329	332	PF00400	0.703
TRG_ER_diArg_1	366	369	PF00400	0.451
TRG_ER_diArg_1	392	395	PF00400	0.464
TRG_ER_diArg_1	415	418	PF00400	0.799
TRG_ER_diArg_1	56	59	PF00400	0.436
TRG_ER_diArg_1	741	743	PF00400	0.271
TRG_ER_diArg_1	755	758	PF00400	0.271
TRG_ER_diArg_1	782	784	PF00400	0.475
TRG_ER_diArg_1	827	829	PF00400	0.283
TRG_ER_diArg_1	835	838	PF00400	0.297
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	757	761	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	775	780	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	782	787	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE15	Leptomonas seymouri	46%	99%
A0A1X0P3G2	Trypanosomatidae	33%	100%
A0A3R7KV90	Trypanosoma rangeli	35%	100%
A0A3S5H4T8	Leishmania donovani	92%	100%
A4H345	Leishmania braziliensis	74%	100%
A4HRE2	Leishmania infantum	92%	100%
C9ZXF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AJA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5D5T7	Trypanosoma cruzi	34%	100%