LMWPc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Low molecular weight phosphotyrosine protein phosphatase, putative

Species:

Leishmania major

UniProt:

E9AC09_LEIMA

TriTrypDb:

LmjF.01.0200 , LMJLV39_010006900 , LMJSD75_010007000

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC09

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004725	protein tyrosine phosphatase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.438
CLV_NRD_NRD_1	107	109	PF00675	0.290
CLV_NRD_NRD_1	133	135	PF00675	0.561
CLV_NRD_NRD_1	204	206	PF00675	0.454
CLV_NRD_NRD_1	226	228	PF00675	0.493
CLV_NRD_NRD_1	234	236	PF00675	0.445
CLV_NRD_NRD_1	32	34	PF00675	0.485
CLV_PCSK_KEX2_1	107	109	PF00082	0.289
CLV_PCSK_KEX2_1	133	135	PF00082	0.544
CLV_PCSK_KEX2_1	234	236	PF00082	0.480
CLV_PCSK_KEX2_1	31	33	PF00082	0.502
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.445
CLV_PCSK_SKI1_1	244	248	PF00082	0.549
CLV_PCSK_SKI1_1	261	265	PF00082	0.282
CLV_PCSK_SKI1_1	60	64	PF00082	0.297
DEG_APCC_DBOX_1	260	268	PF00400	0.443
DEG_APCC_DBOX_1	5	13	PF00400	0.464
DEG_SCF_FBW7_1	11	18	PF00400	0.509
DEG_SPOP_SBC_1	156	160	PF00917	0.602
DOC_CKS1_1	12	17	PF01111	0.508
DOC_MAPK_gen_1	107	117	PF00069	0.389
DOC_MAPK_MEF2A_6	110	119	PF00069	0.389
DOC_PP2B_LxvP_1	151	154	PF13499	0.644
DOC_PP4_FxxP_1	162	165	PF00568	0.567
DOC_USP7_MATH_1	141	145	PF00917	0.666
DOC_USP7_MATH_1	154	158	PF00917	0.572
DOC_WW_Pin1_4	11	16	PF00397	0.483
DOC_WW_Pin1_4	168	173	PF00397	0.508
DOC_WW_Pin1_4	189	194	PF00397	0.411
DOC_WW_Pin1_4	4	9	PF00397	0.477
LIG_14-3-3_CanoR_1	185	191	PF00244	0.550
LIG_14-3-3_CanoR_1	32	42	PF00244	0.549
LIG_14-3-3_CanoR_1	6	12	PF00244	0.463
LIG_14-3-3_CanoR_1	97	106	PF00244	0.424
LIG_Actin_WH2_2	214	229	PF00022	0.531
LIG_CSL_BTD_1	190	193	PF09270	0.403
LIG_eIF4E_1	212	218	PF01652	0.392
LIG_FHA_1	110	116	PF00498	0.333
LIG_FHA_1	202	208	PF00498	0.602
LIG_FHA_2	247	253	PF00498	0.544
LIG_FHA_2	280	286	PF00498	0.555
LIG_FHA_2	85	91	PF00498	0.320
LIG_GBD_Chelix_1	267	275	PF00786	0.465
LIG_HCF-1_HBM_1	209	212	PF13415	0.434
LIG_LIR_Apic_2	159	165	PF02991	0.560
LIG_LIR_Gen_1	114	123	PF02991	0.333
LIG_LIR_Gen_1	215	226	PF02991	0.414
LIG_LIR_Nem_3	111	116	PF02991	0.314
LIG_LIR_Nem_3	215	221	PF02991	0.400
LIG_PDZ_Class_1	295	300	PF00595	0.468
LIG_Pex14_2	58	62	PF04695	0.433
LIG_RPA_C_Fungi	92	104	PF08784	0.351
LIG_SH2_NCK_1	292	296	PF00017	0.533
LIG_SH2_PTP2	116	119	PF00017	0.313
LIG_SH2_STAP1	113	117	PF00017	0.338
LIG_SH2_STAP1	292	296	PF00017	0.571
LIG_SH2_STAT5	116	119	PF00017	0.313
LIG_SH2_STAT5	123	126	PF00017	0.313
LIG_SH2_STAT5	135	138	PF00017	0.532
LIG_SH3_3	116	122	PF00018	0.415
LIG_SH3_3	190	196	PF00018	0.417
LIG_SUMO_SIM_anti_2	266	271	PF11976	0.386
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.466
LIG_SUMO_SIM_par_1	268	274	PF11976	0.260
LIG_SUMO_SIM_par_1	81	87	PF11976	0.383
MOD_CDK_SPK_2	189	194	PF00069	0.411
MOD_CK1_1	157	163	PF00069	0.559
MOD_CK1_1	178	184	PF00069	0.444
MOD_CK1_1	7	13	PF00069	0.466
MOD_CK1_1	96	102	PF00069	0.312
MOD_CK2_1	246	252	PF00069	0.487
MOD_CK2_1	84	90	PF00069	0.320
MOD_CMANNOS	188	191	PF00535	0.415
MOD_GlcNHglycan	151	154	PF01048	0.693
MOD_GlcNHglycan	168	171	PF01048	0.486
MOD_GlcNHglycan	70	73	PF01048	0.301
MOD_GSK3_1	121	128	PF00069	0.338
MOD_GSK3_1	15	22	PF00069	0.652
MOD_GSK3_1	175	182	PF00069	0.573
MOD_GSK3_1	7	14	PF00069	0.617
MOD_GSK3_1	93	100	PF00069	0.357
MOD_N-GLC_1	27	32	PF02516	0.509
MOD_NEK2_1	166	171	PF00069	0.554
MOD_NEK2_1	263	268	PF00069	0.522
MOD_NEK2_1	34	39	PF00069	0.392
MOD_NEK2_1	68	73	PF00069	0.333
MOD_PIKK_1	135	141	PF00454	0.582
MOD_PIKK_1	175	181	PF00454	0.486
MOD_PIKK_1	239	245	PF00454	0.498
MOD_PIKK_1	49	55	PF00454	0.297
MOD_PKA_1	133	139	PF00069	0.565
MOD_PKA_2	109	115	PF00069	0.242
MOD_PKA_2	125	131	PF00069	0.266
MOD_PKA_2	133	139	PF00069	0.521
MOD_PKA_2	184	190	PF00069	0.559
MOD_PKA_2	201	207	PF00069	0.572
MOD_PKA_2	96	102	PF00069	0.446
MOD_Plk_4	279	285	PF00069	0.500
MOD_Plk_4	7	13	PF00069	0.599
MOD_ProDKin_1	11	17	PF00069	0.485
MOD_ProDKin_1	168	174	PF00069	0.511
MOD_ProDKin_1	189	195	PF00069	0.410
MOD_ProDKin_1	4	10	PF00069	0.479
MOD_SUMO_rev_2	248	255	PF00179	0.516
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.483
TRG_ENDOCYTIC_2	116	119	PF00928	0.332
TRG_ENDOCYTIC_2	292	295	PF00928	0.538
TRG_ER_diArg_1	106	108	PF00400	0.315
TRG_ER_diArg_1	133	135	PF00400	0.597
TRG_ER_diArg_1	219	222	PF00400	0.456
TRG_ER_diArg_1	234	236	PF00400	0.356
TRG_ER_diArg_1	32	34	PF00400	0.495
TRG_NES_CRM1_1	262	276	PF08389	0.259
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ3	Leptomonas seymouri	61%	100%
A0A0S4ING3	Bodo saltans	45%	100%
A0A1X0P2S0	Trypanosomatidae	45%	90%
A0A422NY87	Trypanosoma rangeli	50%	100%
A0A451EJ77	Leishmania donovani	90%	99%
A4H344	Leishmania braziliensis	84%	100%
A4HRE1	Leishmania infantum	90%	99%
C9ZXF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AJA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AQ10	Trypanosoma cruzi	48%	100%