cwf21 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC08_LEIMA

TriTrypDb:

LmjF.01.0190 , LMJLV39_010006800 , LMJSD75_010006900

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AC08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.598
CLV_NRD_NRD_1	113	115	PF00675	0.535
CLV_NRD_NRD_1	172	174	PF00675	0.519
CLV_NRD_NRD_1	187	189	PF00675	0.546
CLV_NRD_NRD_1	53	55	PF00675	0.653
CLV_PCSK_FUR_1	185	189	PF00082	0.571
CLV_PCSK_KEX2_1	112	114	PF00082	0.594
CLV_PCSK_KEX2_1	171	173	PF00082	0.525
CLV_PCSK_KEX2_1	184	186	PF00082	0.493
CLV_PCSK_KEX2_1	187	189	PF00082	0.484
CLV_PCSK_KEX2_1	53	55	PF00082	0.653
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.518
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.518
CLV_PCSK_SKI1_1	113	117	PF00082	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.520
DEG_SPOP_SBC_1	141	145	PF00917	0.697
DOC_MAPK_DCC_7	86	96	PF00069	0.461
DOC_MAPK_gen_1	70	79	PF00069	0.431
DOC_MAPK_MEF2A_6	70	79	PF00069	0.413
DOC_USP7_UBL2_3	112	116	PF12436	0.573
DOC_USP7_UBL2_3	125	129	PF12436	0.577
LIG_Actin_WH2_2	59	75	PF00022	0.477
LIG_APCC_ABBA_1	79	84	PF00400	0.429
LIG_FHA_1	137	143	PF00498	0.612
LIG_FHA_1	27	33	PF00498	0.644
LIG_FHA_2	165	171	PF00498	0.600
LIG_LIR_Gen_1	102	111	PF02991	0.482
LIG_LIR_Nem_3	102	107	PF02991	0.488
LIG_Pex14_2	130	134	PF04695	0.456
LIG_SH2_CRK	104	108	PF00017	0.508
LIG_SH2_STAP1	104	108	PF00017	0.456
LIG_SH2_STAT5	18	21	PF00017	0.461
LIG_SUMO_SIM_par_1	92	97	PF11976	0.352
LIG_TRAF2_1	158	161	PF00917	0.619
LIG_TRAF2_1	167	170	PF00917	0.530
LIG_TRAF2_1	33	36	PF00917	0.699
MOD_CK2_1	155	161	PF00069	0.592
MOD_CK2_1	164	170	PF00069	0.511
MOD_GlcNHglycan	144	147	PF01048	0.684
MOD_GlcNHglycan	15	18	PF01048	0.463
MOD_GlcNHglycan	150	153	PF01048	0.690
MOD_GSK3_1	136	143	PF00069	0.658
MOD_NEK2_1	103	108	PF00069	0.399
MOD_NEK2_1	155	160	PF00069	0.644
MOD_Plk_1	155	161	PF00069	0.587
MOD_Plk_2-3	92	98	PF00069	0.550
MOD_Plk_4	103	109	PF00069	0.404
TRG_ENDOCYTIC_2	104	107	PF00928	0.486
TRG_ENDOCYTIC_2	2	5	PF00928	0.485
TRG_ER_diArg_1	113	115	PF00400	0.533
TRG_ER_diArg_1	171	173	PF00400	0.572
TRG_ER_diArg_1	185	188	PF00400	0.519
TRG_ER_diArg_1	21	24	PF00400	0.567
TRG_NLS_Bipartite_1	171	188	PF00514	0.540
TRG_NLS_MonoExtC_3	111	116	PF00514	0.506
TRG_NLS_MonoExtC_3	183	188	PF00514	0.516
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8C9	Leptomonas seymouri	64%	100%
A0A0S4IKH1	Bodo saltans	37%	95%
A0A1X0P2X2	Trypanosomatidae	44%	100%
A0A3R7MZG4	Trypanosoma rangeli	44%	100%
A0A3S5H4T7	Leishmania donovani	96%	95%
A4H343	Leishmania braziliensis	77%	100%
A4HRE0	Leishmania infantum	96%	95%
C9ZXF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AJA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q38FI2	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	43%	100%