Putative CLC-type chloride channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CLC-type chloride channel, putative

Species:

Leishmania major

UniProt:

E9AC07_LEIMA

TriTrypDb:

LmjF.01.0180 , LMJLV39_010006700 , LMJSD75_010006800

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0005769	early endosome	8	2
GO:0005794	Golgi apparatus	5	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	12
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AC07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC07

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005244	voltage-gated monoatomic ion channel activity	4	12
GO:0005247	voltage-gated chloride channel activity	6	12
GO:0005253	monoatomic anion channel activity	5	12
GO:0005254	chloride channel activity	6	12
GO:0005451	obsolete monoatomic cation:proton antiporter activity	5	2
GO:0008308	voltage-gated monoatomic anion channel activity	5	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015078	proton transmembrane transporter activity	5	2
GO:0015103	inorganic anion transmembrane transporter activity	4	12
GO:0015108	chloride transmembrane transporter activity	5	12
GO:0015267	channel activity	4	12
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015297	antiporter activity	5	2
GO:0015298	obsolete solute:monoatomic cation antiporter activity	5	2
GO:0015299	obsolete solute:proton antiporter activity	6	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022804	active transmembrane transporter activity	3	2
GO:0022832	voltage-gated channel activity	6	12
GO:0022836	gated channel activity	5	12
GO:0022853	active monoatomic ion transmembrane transporter activity	4	2
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	366	368	PF00675	0.207
CLV_NRD_NRD_1	62	64	PF00675	0.351
CLV_NRD_NRD_1	745	747	PF00675	0.436
CLV_PCSK_FUR_1	743	747	PF00082	0.463
CLV_PCSK_KEX2_1	204	206	PF00082	0.207
CLV_PCSK_KEX2_1	62	64	PF00082	0.361
CLV_PCSK_KEX2_1	745	747	PF00082	0.433
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.249
CLV_PCSK_SKI1_1	426	430	PF00082	0.431
CLV_PCSK_SKI1_1	588	592	PF00082	0.298
CLV_PCSK_SKI1_1	665	669	PF00082	0.346
CLV_PCSK_SKI1_1	692	696	PF00082	0.329
DEG_SCF_FBW7_1	392	397	PF00400	0.274
DEG_SPOP_SBC_1	69	73	PF00917	0.571
DOC_CKS1_1	391	396	PF01111	0.241
DOC_CYCLIN_RxL_1	690	700	PF00134	0.469
DOC_MAPK_gen_1	367	379	PF00069	0.437
DOC_MAPK_gen_1	572	579	PF00069	0.572
DOC_MAPK_gen_1	633	641	PF00069	0.501
DOC_MAPK_gen_1	720	726	PF00069	0.459
DOC_MAPK_MEF2A_6	231	238	PF00069	0.207
DOC_MAPK_MEF2A_6	372	381	PF00069	0.406
DOC_MAPK_MEF2A_6	665	674	PF00069	0.594
DOC_PP1_RVXF_1	320	327	PF00149	0.202
DOC_PP4_FxxP_1	275	278	PF00568	0.241
DOC_PP4_FxxP_1	337	340	PF00568	0.207
DOC_PP4_FxxP_1	391	394	PF00568	0.256
DOC_USP7_MATH_1	114	118	PF00917	0.378
DOC_USP7_MATH_1	184	188	PF00917	0.463
DOC_USP7_MATH_1	249	253	PF00917	0.310
DOC_USP7_MATH_1	26	30	PF00917	0.611
DOC_USP7_MATH_1	394	398	PF00917	0.249
DOC_USP7_MATH_1	644	648	PF00917	0.522
DOC_USP7_MATH_1	661	665	PF00917	0.623
DOC_USP7_MATH_1	68	72	PF00917	0.707
DOC_USP7_MATH_1	687	691	PF00917	0.547
DOC_WW_Pin1_4	390	395	PF00397	0.241
DOC_WW_Pin1_4	409	414	PF00397	0.207
DOC_WW_Pin1_4	79	84	PF00397	0.573
LIG_14-3-3_CanoR_1	426	432	PF00244	0.310
LIG_14-3-3_CanoR_1	645	651	PF00244	0.603
LIG_APCC_ABBA_1	101	106	PF00400	0.252
LIG_BRCT_BRCA1_1	291	295	PF00533	0.510
LIG_BRCT_BRCA1_1	482	486	PF00533	0.232
LIG_Clathr_ClatBox_1	682	686	PF01394	0.574
LIG_eIF4E_1	293	299	PF01652	0.449
LIG_FHA_1	212	218	PF00498	0.300
LIG_FHA_1	29	35	PF00498	0.568
LIG_FHA_1	305	311	PF00498	0.251
LIG_FHA_1	318	324	PF00498	0.192
LIG_FHA_1	353	359	PF00498	0.389
LIG_FHA_1	384	390	PF00498	0.335
LIG_FHA_1	515	521	PF00498	0.249
LIG_FHA_1	526	532	PF00498	0.397
LIG_FHA_1	554	560	PF00498	0.523
LIG_FHA_1	673	679	PF00498	0.488
LIG_FHA_1	701	707	PF00498	0.569
LIG_FHA_1	757	763	PF00498	0.654
LIG_FHA_2	666	672	PF00498	0.630
LIG_KLC1_Yacidic_2	574	578	PF13176	0.600
LIG_LIR_Apic_2	530	536	PF02991	0.408
LIG_LIR_Gen_1	166	175	PF02991	0.271
LIG_LIR_Gen_1	232	242	PF02991	0.207
LIG_LIR_Gen_1	354	363	PF02991	0.256
LIG_LIR_Gen_1	39	48	PF02991	0.525
LIG_LIR_Gen_1	436	446	PF02991	0.350
LIG_LIR_Gen_1	574	584	PF02991	0.553
LIG_LIR_Gen_1	653	661	PF02991	0.534
LIG_LIR_Gen_1	666	677	PF02991	0.547
LIG_LIR_Gen_1	722	729	PF02991	0.493
LIG_LIR_Gen_1	86	97	PF02991	0.262
LIG_LIR_LC3C_4	31	35	PF02991	0.591
LIG_LIR_Nem_3	143	147	PF02991	0.248
LIG_LIR_Nem_3	160	164	PF02991	0.241
LIG_LIR_Nem_3	181	185	PF02991	0.471
LIG_LIR_Nem_3	232	238	PF02991	0.207
LIG_LIR_Nem_3	292	298	PF02991	0.411
LIG_LIR_Nem_3	354	359	PF02991	0.253
LIG_LIR_Nem_3	39	45	PF02991	0.553
LIG_LIR_Nem_3	436	442	PF02991	0.350
LIG_LIR_Nem_3	574	579	PF02991	0.559
LIG_LIR_Nem_3	613	618	PF02991	0.466
LIG_LIR_Nem_3	653	657	PF02991	0.513
LIG_LIR_Nem_3	666	672	PF02991	0.569
LIG_LIR_Nem_3	712	717	PF02991	0.450
LIG_LIR_Nem_3	722	726	PF02991	0.464
LIG_LIR_Nem_3	76	81	PF02991	0.656
LIG_MYND_1	567	571	PF01753	0.462
LIG_Pex14_1	111	115	PF04695	0.291
LIG_Pex14_1	144	148	PF04695	0.267
LIG_Pex14_2	469	473	PF04695	0.390
LIG_Pex14_2	575	579	PF04695	0.588
LIG_PTB_Apo_2	584	591	PF02174	0.578
LIG_REV1ctd_RIR_1	145	155	PF16727	0.289
LIG_RPA_C_Fungi	58	70	PF08784	0.441
LIG_SH2_CRK	501	505	PF00017	0.241
LIG_SH2_CRK	533	537	PF00017	0.386
LIG_SH2_CRK	629	633	PF00017	0.223
LIG_SH2_NCK_1	501	505	PF00017	0.241
LIG_SH2_SRC	501	504	PF00017	0.241
LIG_SH2_SRC	557	560	PF00017	0.323
LIG_SH2_SRC	568	571	PF00017	0.336
LIG_SH2_SRC	629	632	PF00017	0.295
LIG_SH2_STAP1	480	484	PF00017	0.252
LIG_SH2_STAP1	490	494	PF00017	0.252
LIG_SH2_STAT3	596	599	PF00017	0.458
LIG_SH2_STAT5	164	167	PF00017	0.245
LIG_SH2_STAT5	177	180	PF00017	0.254
LIG_SH2_STAT5	206	209	PF00017	0.241
LIG_SH2_STAT5	444	447	PF00017	0.353
LIG_SH2_STAT5	484	487	PF00017	0.286
LIG_SH2_STAT5	568	571	PF00017	0.433
LIG_SH2_STAT5	576	579	PF00017	0.426
LIG_SH2_STAT5	654	657	PF00017	0.394
LIG_SH2_STAT5	696	699	PF00017	0.353
LIG_SH3_3	77	83	PF00018	0.467
LIG_SUMO_SIM_anti_2	378	383	PF11976	0.339
LIG_SUMO_SIM_anti_2	399	406	PF11976	0.277
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.241
LIG_TRAF2_1	475	478	PF00917	0.275
LIG_TYR_ITIM	627	632	PF00017	0.214
LIG_UBA3_1	694	699	PF00899	0.340
LIG_Vh1_VBS_1	503	521	PF01044	0.256
LIG_WRC_WIRS_1	164	169	PF05994	0.258
LIG_WRC_WIRS_1	446	451	PF05994	0.275
MOD_CK1_1	166	172	PF00069	0.262
MOD_CK1_1	222	228	PF00069	0.245
MOD_CK1_1	354	360	PF00069	0.386
MOD_CK1_1	622	628	PF00069	0.402
MOD_CK1_1	700	706	PF00069	0.358
MOD_CK1_1	79	85	PF00069	0.502
MOD_CK2_1	140	146	PF00069	0.318
MOD_CK2_1	396	402	PF00069	0.250
MOD_CK2_1	47	53	PF00069	0.385
MOD_CK2_1	665	671	PF00069	0.504
MOD_CK2_1	709	715	PF00069	0.360
MOD_GlcNHglycan	112	115	PF01048	0.312
MOD_GlcNHglycan	116	119	PF01048	0.304
MOD_GlcNHglycan	186	189	PF01048	0.275
MOD_GlcNHglycan	198	201	PF01048	0.204
MOD_GlcNHglycan	224	227	PF01048	0.241
MOD_GlcNHglycan	246	249	PF01048	0.380
MOD_GlcNHglycan	396	399	PF01048	0.259
MOD_GlcNHglycan	413	416	PF01048	0.283
MOD_GlcNHglycan	64	67	PF01048	0.460
MOD_GSK3_1	110	117	PF00069	0.321
MOD_GSK3_1	390	397	PF00069	0.299
MOD_GSK3_1	409	416	PF00069	0.162
MOD_GSK3_1	427	434	PF00069	0.256
MOD_GSK3_1	476	483	PF00069	0.276
MOD_GSK3_1	64	71	PF00069	0.504
MOD_GSK3_1	661	668	PF00069	0.479
MOD_LATS_1	663	669	PF00433	0.438
MOD_N-GLC_1	35	40	PF02516	0.482
MOD_N-GLC_1	610	615	PF02516	0.448
MOD_N-GLC_2	129	131	PF02516	0.430
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	163	168	PF00069	0.251
MOD_NEK2_1	178	183	PF00069	0.268
MOD_NEK2_1	219	224	PF00069	0.256
MOD_NEK2_1	310	315	PF00069	0.262
MOD_NEK2_1	317	322	PF00069	0.248
MOD_NEK2_1	351	356	PF00069	0.241
MOD_NEK2_1	431	436	PF00069	0.300
MOD_NEK2_1	442	447	PF00069	0.300
MOD_NEK2_1	476	481	PF00069	0.281
MOD_NEK2_1	525	530	PF00069	0.241
MOD_NEK2_1	610	615	PF00069	0.368
MOD_NEK2_1	697	702	PF00069	0.355
MOD_NEK2_2	687	692	PF00069	0.445
MOD_PKA_1	62	68	PF00069	0.582
MOD_PKA_2	62	68	PF00069	0.480
MOD_PKA_2	644	650	PF00069	0.412
MOD_PKA_2	709	715	PF00069	0.329
MOD_Plk_1	26	32	PF00069	0.544
MOD_Plk_1	622	628	PF00069	0.342
MOD_Plk_1	665	671	PF00069	0.529
MOD_Plk_1	687	693	PF00069	0.437
MOD_Plk_2-3	140	146	PF00069	0.368
MOD_Plk_2-3	41	47	PF00069	0.401
MOD_Plk_4	193	199	PF00069	0.386
MOD_Plk_4	396	402	PF00069	0.254
MOD_Plk_4	445	451	PF00069	0.275
MOD_Plk_4	480	486	PF00069	0.258
MOD_Plk_4	622	628	PF00069	0.342
MOD_Plk_4	650	656	PF00069	0.383
MOD_Plk_4	665	671	PF00069	0.450
MOD_ProDKin_1	390	396	PF00069	0.241
MOD_ProDKin_1	409	415	PF00069	0.241
MOD_ProDKin_1	79	85	PF00069	0.460
MOD_SUMO_for_1	571	574	PF00179	0.373
MOD_SUMO_rev_2	187	197	PF00179	0.300
MOD_SUMO_rev_2	558	567	PF00179	0.384
TRG_ENDOCYTIC_2	164	167	PF00928	0.245
TRG_ENDOCYTIC_2	501	504	PF00928	0.262
TRG_ENDOCYTIC_2	576	579	PF00928	0.485
TRG_ENDOCYTIC_2	629	632	PF00928	0.208
TRG_ENDOCYTIC_2	654	657	PF00928	0.394
TRG_ENDOCYTIC_2	711	714	PF00928	0.491
TRG_ER_diArg_1	61	63	PF00400	0.497
TRG_NLS_MonoExtN_4	365	371	PF00514	0.300
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P9	Leptomonas seymouri	78%	100%
A0A0N1IHR6	Leptomonas seymouri	29%	66%
A0A0N1IJL2	Leptomonas seymouri	25%	87%
A0A0S4IKD3	Bodo saltans	59%	100%
A0A0S4IL39	Bodo saltans	54%	100%
A0A0S4JG93	Bodo saltans	24%	91%
A0A0S4JSW7	Bodo saltans	26%	89%
A0A1X0NSH7	Trypanosomatidae	26%	83%
A0A1X0P2R6	Trypanosomatidae	64%	100%
A0A3Q8IH43	Leishmania donovani	24%	87%
A0A3R7KRB4	Trypanosoma rangeli	24%	85%
A0A422NY59	Trypanosoma rangeli	66%	100%
A0A451EJ75	Leishmania donovani	96%	100%
A4H342	Leishmania braziliensis	86%	100%
A4HKY2	Leishmania braziliensis	23%	87%
A4HRD9	Leishmania infantum	96%	100%
C9ZY92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	82%
D0AAR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	84%
E9AHM3	Leishmania infantum	24%	87%
E9AJA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B3C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	87%
O18894	Oryctolagus cuniculus	32%	94%
O35454	Mus musculus	28%	89%
O60159	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O70496	Mus musculus	27%	96%
O94287	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P0C197	Ustilago maydis (strain 521 / FGSC 9021)	33%	68%
P35523	Homo sapiens	28%	78%
P35524	Rattus norvegicus	28%	78%
P35525	Rattus norvegicus	28%	85%
P37020	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	99%
P51788	Homo sapiens	29%	86%
P51789	Oryctolagus cuniculus	28%	86%
P51790	Homo sapiens	32%	94%
P51791	Mus musculus	32%	94%
P51792	Rattus norvegicus	32%	94%
P51793	Homo sapiens	31%	100%
P51794	Rattus norvegicus	32%	100%
P51795	Homo sapiens	31%	95%
P51796	Rattus norvegicus	31%	95%
P51797	Homo sapiens	27%	89%
P51798	Homo sapiens	28%	96%
P51799	Rattus norvegicus	27%	96%
P51800	Homo sapiens	27%	100%
P51801	Homo sapiens	26%	100%
P51802	Rattus norvegicus	27%	100%
P51803	Oryctolagus cuniculus	25%	100%
P51804	Oryctolagus cuniculus	26%	100%
P60300	Arabidopsis thaliana	25%	100%
P92941	Arabidopsis thaliana	25%	100%
P92942	Arabidopsis thaliana	25%	99%
P92943	Arabidopsis thaliana	26%	97%
Q06393	Rattus norvegicus	27%	100%
Q4PKH3	Bos taurus	29%	95%
Q4Q4T5	Leishmania major	25%	88%
Q54AX6	Dictyostelium discoideum	28%	89%
Q5RBK4	Pongo abelii	31%	95%
Q5RDJ7	Pongo abelii	32%	96%
Q61418	Mus musculus	32%	100%
Q64347	Mus musculus	28%	78%
Q75JF3	Dictyostelium discoideum	29%	100%
Q86AZ6	Dictyostelium discoideum	29%	95%
Q96282	Arabidopsis thaliana	25%	99%
Q99P66	Cavia porcellus	32%	100%
Q9BMK9	Caenorhabditis elegans	30%	77%
Q9GKE7	Sus scrofa	31%	95%
Q9MZT1	Canis lupus familiaris	27%	79%
Q9R0A1	Mus musculus	28%	85%
Q9R279	Cavia porcellus	32%	94%
Q9TT16	Oryctolagus cuniculus	27%	89%
Q9TTU3	Oryctolagus cuniculus	31%	95%
Q9W701	Xenopus laevis	25%	100%
Q9WU45	Cavia porcellus	28%	86%
Q9WUB6	Mus musculus	28%	100%
Q9WUB7	Mus musculus	27%	100%
Q9WVD4	Mus musculus	31%	95%
V5AY77	Trypanosoma cruzi	26%	79%
V5BEI7	Trypanosoma cruzi	66%	100%