Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC06_LEIMA

TriTrypDb:

LmjF.01.0170 , LMJLV39_010006600 , LMJSD75_010006700

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	299	305	PF00089	0.693
CLV_NRD_NRD_1	205	207	PF00675	0.798
CLV_NRD_NRD_1	209	211	PF00675	0.726
CLV_NRD_NRD_1	301	303	PF00675	0.698
CLV_NRD_NRD_1	31	33	PF00675	0.834
CLV_NRD_NRD_1	92	94	PF00675	0.594
CLV_PCSK_KEX2_1	205	207	PF00082	0.798
CLV_PCSK_KEX2_1	209	211	PF00082	0.726
CLV_PCSK_KEX2_1	301	303	PF00082	0.596
CLV_PCSK_KEX2_1	31	33	PF00082	0.832
CLV_PCSK_KEX2_1	333	335	PF00082	0.611
CLV_PCSK_KEX2_1	50	52	PF00082	0.503
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.611
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.751
CLV_PCSK_PC7_1	205	211	PF00082	0.599
CLV_PCSK_SKI1_1	285	289	PF00082	0.583
CLV_PCSK_SKI1_1	296	300	PF00082	0.501
CLV_PCSK_SKI1_1	330	334	PF00082	0.548
DEG_APCC_DBOX_1	216	224	PF00400	0.594
DEG_APCC_DBOX_1	230	238	PF00400	0.482
DEG_SCF_FBW7_2	350	355	PF00400	0.566
DEG_SPOP_SBC_1	137	141	PF00917	0.713
DOC_ANK_TNKS_1	159	166	PF00023	0.738
DOC_CKS1_1	306	311	PF01111	0.675
DOC_MAPK_gen_1	217	225	PF00069	0.550
DOC_MAPK_gen_1	444	453	PF00069	0.783
DOC_MAPK_MEF2A_6	226	234	PF00069	0.394
DOC_MAPK_MEF2A_6	251	259	PF00069	0.635
DOC_PP2B_LxvP_1	127	130	PF13499	0.681
DOC_PP2B_LxvP_1	25	28	PF13499	0.612
DOC_PP4_FxxP_1	378	381	PF00568	0.707
DOC_PP4_FxxP_1	425	428	PF00568	0.573
DOC_USP7_MATH_1	120	124	PF00917	0.706
DOC_USP7_MATH_1	137	141	PF00917	0.531
DOC_USP7_MATH_1	175	179	PF00917	0.805
DOC_USP7_MATH_1	279	283	PF00917	0.574
DOC_USP7_MATH_1	314	318	PF00917	0.657
DOC_USP7_MATH_1	339	343	PF00917	0.707
DOC_USP7_MATH_1	371	375	PF00917	0.734
DOC_USP7_MATH_1	397	401	PF00917	0.776
DOC_USP7_MATH_1	412	416	PF00917	0.597
DOC_USP7_MATH_1	440	444	PF00917	0.552
DOC_USP7_MATH_1	86	90	PF00917	0.782
DOC_WW_Pin1_4	121	126	PF00397	0.710
DOC_WW_Pin1_4	20	25	PF00397	0.835
DOC_WW_Pin1_4	305	310	PF00397	0.743
DOC_WW_Pin1_4	348	353	PF00397	0.590
DOC_WW_Pin1_4	376	381	PF00397	0.771
DOC_WW_Pin1_4	417	422	PF00397	0.758
DOC_WW_Pin1_4	424	429	PF00397	0.726
DOC_WW_Pin1_4	88	93	PF00397	0.625
LIG_14-3-3_CanoR_1	231	235	PF00244	0.634
LIG_14-3-3_CanoR_1	244	248	PF00244	0.409
LIG_14-3-3_CanoR_1	323	332	PF00244	0.708
LIG_14-3-3_CanoR_1	370	378	PF00244	0.772
LIG_14-3-3_CanoR_1	401	407	PF00244	0.775
LIG_14-3-3_CanoR_1	447	452	PF00244	0.709
LIG_deltaCOP1_diTrp_1	194	200	PF00928	0.785
LIG_deltaCOP1_diTrp_1	266	276	PF00928	0.616
LIG_FHA_1	429	435	PF00498	0.767
LIG_FHA_1	452	458	PF00498	0.703
LIG_FHA_2	183	189	PF00498	0.708
LIG_FHA_2	344	350	PF00498	0.683
LIG_FHA_2	40	46	PF00498	0.707
LIG_Integrin_RGD_1	71	73	PF01839	0.747
LIG_LIR_Apic_2	192	198	PF02991	0.704
LIG_LIR_Apic_2	423	428	PF02991	0.573
LIG_LIR_Gen_1	185	191	PF02991	0.758
LIG_LIR_Gen_1	252	261	PF02991	0.572
LIG_LIR_Nem_3	185	189	PF02991	0.758
LIG_LIR_Nem_3	199	203	PF02991	0.592
LIG_LIR_Nem_3	252	257	PF02991	0.569
LIG_PROFILIN_1	309	315	PF00235	0.590
LIG_SH2_NCK_1	345	349	PF00017	0.805
LIG_SH2_STAP1	265	269	PF00017	0.514
LIG_SH2_STAT3	238	241	PF00017	0.549
LIG_SH2_STAT5	134	137	PF00017	0.713
LIG_SH2_STAT5	238	241	PF00017	0.511
LIG_SH2_STAT5	340	343	PF00017	0.761
LIG_SH2_STAT5	345	348	PF00017	0.751
LIG_SH3_1	307	313	PF00018	0.698
LIG_SH3_3	169	175	PF00018	0.809
LIG_SH3_3	21	27	PF00018	0.825
LIG_SH3_3	306	312	PF00018	0.696
LIG_SH3_3	406	412	PF00018	0.736
LIG_SH3_3	415	421	PF00018	0.609
LIG_SUMO_SIM_par_1	167	173	PF11976	0.812
LIG_SUMO_SIM_par_1	276	282	PF11976	0.538
LIG_TRAF2_1	352	355	PF00917	0.681
MOD_CDK_SPK_2	88	93	PF00069	0.594
MOD_CDK_SPxK_1	88	94	PF00069	0.595
MOD_CK1_1	136	142	PF00069	0.791
MOD_CK1_1	16	22	PF00069	0.649
MOD_CK1_1	173	179	PF00069	0.728
MOD_CK1_1	26	32	PF00069	0.657
MOD_CK1_1	267	273	PF00069	0.624
MOD_CK1_1	305	311	PF00069	0.705
MOD_CK1_1	37	43	PF00069	0.726
MOD_CK1_1	416	422	PF00069	0.748
MOD_CK1_1	57	63	PF00069	0.477
MOD_CK1_1	88	94	PF00069	0.642
MOD_CK2_1	165	171	PF00069	0.814
MOD_CK2_1	182	188	PF00069	0.508
MOD_CK2_1	190	196	PF00069	0.684
MOD_CK2_1	348	354	PF00069	0.636
MOD_CK2_1	39	45	PF00069	0.826
MOD_CK2_1	50	56	PF00069	0.624
MOD_Cter_Amidation	203	206	PF01082	0.800
MOD_GlcNHglycan	135	138	PF01048	0.729
MOD_GlcNHglycan	212	215	PF01048	0.643
MOD_GlcNHglycan	393	396	PF01048	0.783
MOD_GlcNHglycan	56	59	PF01048	0.683
MOD_GlcNHglycan	75	78	PF01048	0.550
MOD_GlcNHglycan	88	91	PF01048	0.588
MOD_GlcNHglycan	97	100	PF01048	0.634
MOD_GSK3_1	133	140	PF00069	0.783
MOD_GSK3_1	16	23	PF00069	0.697
MOD_GSK3_1	339	346	PF00069	0.697
MOD_GSK3_1	34	41	PF00069	0.576
MOD_GSK3_1	389	396	PF00069	0.793
MOD_GSK3_1	412	419	PF00069	0.767
MOD_GSK3_1	420	427	PF00069	0.672
MOD_GSK3_1	447	454	PF00069	0.708
MOD_GSK3_1	50	57	PF00069	0.538
MOD_GSK3_1	6	13	PF00069	0.755
MOD_N-GLC_1	120	125	PF02516	0.698
MOD_N-GLC_1	16	21	PF02516	0.775
MOD_N-GLC_2	363	365	PF02516	0.688
MOD_NEK2_1	112	117	PF00069	0.534
MOD_NEK2_1	133	138	PF00069	0.789
MOD_NEK2_1	324	329	PF00069	0.754
MOD_NEK2_1	369	374	PF00069	0.709
MOD_NEK2_1	389	394	PF00069	0.773
MOD_NEK2_1	49	54	PF00069	0.745
MOD_NEK2_1	79	84	PF00069	0.651
MOD_NEK2_1	95	100	PF00069	0.542
MOD_NEK2_2	314	319	PF00069	0.575
MOD_NMyristoyl	1	7	PF02799	0.788
MOD_PIKK_1	170	176	PF00454	0.807
MOD_PIKK_1	428	434	PF00454	0.553
MOD_PKA_1	50	56	PF00069	0.581
MOD_PKA_2	204	210	PF00069	0.798
MOD_PKA_2	230	236	PF00069	0.632
MOD_PKA_2	243	249	PF00069	0.412
MOD_PKA_2	34	40	PF00069	0.777
MOD_PKA_2	369	375	PF00069	0.710
MOD_PKA_2	50	56	PF00069	0.526
MOD_PKA_2	79	85	PF00069	0.763
MOD_PKA_2	95	101	PF00069	0.568
MOD_PKB_1	210	218	PF00069	0.550
MOD_Plk_1	215	221	PF00069	0.692
MOD_Plk_1	267	273	PF00069	0.624
MOD_Plk_2-3	182	188	PF00069	0.758
MOD_Plk_2-3	190	196	PF00069	0.684
MOD_Plk_4	139	145	PF00069	0.725
MOD_Plk_4	165	171	PF00069	0.814
MOD_Plk_4	384	390	PF00069	0.686
MOD_Plk_4	413	419	PF00069	0.713
MOD_Plk_4	420	426	PF00069	0.650
MOD_Plk_4	57	63	PF00069	0.709
MOD_Plk_4	79	85	PF00069	0.646
MOD_ProDKin_1	121	127	PF00069	0.709
MOD_ProDKin_1	20	26	PF00069	0.833
MOD_ProDKin_1	305	311	PF00069	0.744
MOD_ProDKin_1	348	354	PF00069	0.589
MOD_ProDKin_1	376	382	PF00069	0.771
MOD_ProDKin_1	417	423	PF00069	0.759
MOD_ProDKin_1	424	430	PF00069	0.725
MOD_ProDKin_1	88	94	PF00069	0.627
MOD_SUMO_for_1	332	335	PF00179	0.699
MOD_SUMO_rev_2	148	153	PF00179	0.578
TRG_DiLeu_BaEn_1	295	300	PF01217	0.640
TRG_ENDOCYTIC_2	186	189	PF00928	0.707
TRG_ER_diArg_1	209	212	PF00400	0.669
TRG_ER_diArg_1	217	220	PF00400	0.549
TRG_ER_diArg_1	259	262	PF00400	0.527
TRG_ER_diArg_1	300	302	PF00400	0.687
TRG_ER_diArg_1	407	410	PF00400	0.586
TRG_ER_diArg_1	446	449	PF00400	0.707
TRG_Pf-PMV_PEXEL_1	330	335	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4T6	Leishmania donovani	85%	100%
A4H341	Leishmania braziliensis	52%	98%
A4HRD8	Leishmania infantum	86%	100%
E9AJA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%