Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC02_LEIMA

TriTrypDb:

LmjF.01.0130 , LMJLV39_010006200 , LMJSD75_010006300

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.628
CLV_NRD_NRD_1	113	115	PF00675	0.551
CLV_NRD_NRD_1	290	292	PF00675	0.468
CLV_NRD_NRD_1	311	313	PF00675	0.639
CLV_NRD_NRD_1	327	329	PF00675	0.569
CLV_PCSK_KEX2_1	112	114	PF00082	0.560
CLV_PCSK_KEX2_1	311	313	PF00082	0.640
CLV_PCSK_KEX2_1	327	329	PF00082	0.565
CLV_PCSK_SKI1_1	299	303	PF00082	0.515
CLV_Separin_Metazoa	9	13	PF03568	0.535
DEG_SPOP_SBC_1	261	265	PF00917	0.660
DEG_SPOP_SBC_1	353	357	PF00917	0.634
DOC_CKS1_1	231	236	PF01111	0.676
DOC_CYCLIN_RxL_1	333	344	PF00134	0.559
DOC_MAPK_gen_1	291	298	PF00069	0.527
DOC_PIKK_1	283	290	PF02985	0.593
DOC_PP2B_LxvP_1	175	178	PF13499	0.477
DOC_PP2B_LxvP_1	340	343	PF13499	0.518
DOC_USP7_MATH_1	10	14	PF00917	0.606
DOC_USP7_MATH_1	213	217	PF00917	0.637
DOC_USP7_MATH_1	221	225	PF00917	0.673
DOC_USP7_MATH_1	307	311	PF00917	0.654
DOC_USP7_MATH_1	317	321	PF00917	0.699
DOC_USP7_MATH_1	336	340	PF00917	0.564
DOC_USP7_MATH_1	349	353	PF00917	0.615
DOC_USP7_MATH_1	47	51	PF00917	0.559
DOC_USP7_MATH_1	65	69	PF00917	0.406
DOC_USP7_MATH_2	234	240	PF00917	0.588
DOC_WW_Pin1_4	192	197	PF00397	0.652
DOC_WW_Pin1_4	230	235	PF00397	0.696
DOC_WW_Pin1_4	37	42	PF00397	0.743
LIG_14-3-3_CanoR_1	149	154	PF00244	0.399
LIG_14-3-3_CanoR_1	188	196	PF00244	0.650
LIG_14-3-3_CanoR_1	338	343	PF00244	0.647
LIG_14-3-3_CanoR_1	36	43	PF00244	0.583
LIG_Actin_WH2_2	134	151	PF00022	0.409
LIG_Actin_WH2_2	72	90	PF00022	0.506
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BRCT_BRCA1_1	151	155	PF00533	0.401
LIG_FAT_LD_1	141	149	PF03623	0.315
LIG_FHA_1	226	232	PF00498	0.670
LIG_FHA_1	38	44	PF00498	0.678
LIG_FHA_2	231	237	PF00498	0.710
LIG_FHA_2	52	58	PF00498	0.458
LIG_LIR_Gen_1	68	76	PF02991	0.448
LIG_LIR_Nem_3	68	72	PF02991	0.445
LIG_NRP_CendR_1	363	364	PF00754	0.616
LIG_Pex14_2	155	159	PF04695	0.413
LIG_PTB_Apo_2	168	175	PF02174	0.457
LIG_PTB_Phospho_1	168	174	PF10480	0.459
LIG_SH2_SRC	23	26	PF00017	0.645
LIG_SH2_STAT5	174	177	PF00017	0.485
LIG_SH2_STAT5	246	249	PF00017	0.568
LIG_SH3_3	215	221	PF00018	0.528
LIG_SH3_3	228	234	PF00018	0.669
LIG_TRAF2_1	132	135	PF00917	0.398
LIG_TRAF2_1	161	164	PF00917	0.451
LIG_UBA3_1	286	292	PF00899	0.492
LIG_WRC_WIRS_1	52	57	PF05994	0.444
LIG_WW_3	324	328	PF00397	0.703
MOD_CDC14_SPxK_1	195	198	PF00782	0.672
MOD_CDK_SPK_2	230	235	PF00069	0.585
MOD_CDK_SPxK_1	192	198	PF00069	0.670
MOD_CK1_1	189	195	PF00069	0.784
MOD_CK1_1	203	209	PF00069	0.577
MOD_CK1_1	222	228	PF00069	0.628
MOD_CK1_1	262	268	PF00069	0.673
MOD_CK1_1	271	277	PF00069	0.569
MOD_CK1_1	310	316	PF00069	0.681
MOD_CK1_1	341	347	PF00069	0.645
MOD_CK1_1	352	358	PF00069	0.657
MOD_CK1_1	51	57	PF00069	0.598
MOD_CK2_1	136	142	PF00069	0.530
MOD_CK2_1	158	164	PF00069	0.463
MOD_CK2_1	230	236	PF00069	0.712
MOD_CK2_1	251	257	PF00069	0.553
MOD_CK2_1	277	283	PF00069	0.536
MOD_CK2_1	3	9	PF00069	0.575
MOD_CK2_1	47	53	PF00069	0.469
MOD_CK2_1	65	71	PF00069	0.421
MOD_GlcNHglycan	209	212	PF01048	0.622
MOD_GlcNHglycan	215	218	PF01048	0.613
MOD_GlcNHglycan	221	224	PF01048	0.612
MOD_GlcNHglycan	270	273	PF01048	0.646
MOD_GlcNHglycan	279	282	PF01048	0.575
MOD_GlcNHglycan	319	322	PF01048	0.716
MOD_GlcNHglycan	347	350	PF01048	0.619
MOD_GlcNHglycan	37	40	PF01048	0.646
MOD_GlcNHglycan	6	9	PF01048	0.794
MOD_GSK3_1	184	191	PF00069	0.713
MOD_GSK3_1	203	210	PF00069	0.699
MOD_GSK3_1	221	228	PF00069	0.502
MOD_GSK3_1	268	275	PF00069	0.731
MOD_GSK3_1	334	341	PF00069	0.618
MOD_GSK3_1	345	352	PF00069	0.748
MOD_GSK3_1	353	360	PF00069	0.563
MOD_GSK3_1	37	44	PF00069	0.622
MOD_GSK3_1	47	54	PF00069	0.419
MOD_GSK3_1	75	82	PF00069	0.500
MOD_N-GLC_1	149	154	PF02516	0.399
MOD_NEK2_1	1	6	PF00069	0.595
MOD_NEK2_1	133	138	PF00069	0.520
MOD_NEK2_1	148	153	PF00069	0.326
MOD_NEK2_1	205	210	PF00069	0.644
MOD_NEK2_1	260	265	PF00069	0.725
MOD_NEK2_1	354	359	PF00069	0.703
MOD_NEK2_1	79	84	PF00069	0.497
MOD_OFUCOSY	270	276	PF10250	0.560
MOD_PIKK_1	1	7	PF00454	0.585
MOD_PIKK_1	186	192	PF00454	0.680
MOD_PIKK_1	315	321	PF00454	0.585
MOD_PIKK_1	82	88	PF00454	0.457
MOD_PK_1	149	155	PF00069	0.403
MOD_PKA_2	148	154	PF00069	0.401
MOD_PKA_2	310	316	PF00069	0.627
MOD_PKA_2	35	41	PF00069	0.603
MOD_Plk_1	149	155	PF00069	0.423
MOD_Plk_4	133	139	PF00069	0.489
MOD_Plk_4	200	206	PF00069	0.676
MOD_Plk_4	242	248	PF00069	0.591
MOD_Plk_4	349	355	PF00069	0.616
MOD_ProDKin_1	192	198	PF00069	0.655
MOD_ProDKin_1	230	236	PF00069	0.698
MOD_ProDKin_1	37	43	PF00069	0.735
MOD_SUMO_rev_2	161	167	PF00179	0.407
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.538
TRG_ENDOCYTIC_2	69	72	PF00928	0.433
TRG_ER_diArg_1	111	114	PF00400	0.535
TRG_ER_diArg_1	296	299	PF00400	0.502
TRG_ER_diArg_1	326	328	PF00400	0.676
TRG_ER_diArg_1	331	334	PF00400	0.623
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P3	Leptomonas seymouri	48%	92%
A0A3S5H4T3	Leishmania donovani	90%	100%
A4H328	Leishmania braziliensis	66%	100%
A4HRD4	Leishmania infantum	91%	100%
E9AJ99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%