Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AC01_LEIMA

TriTrypDb:

LmjF.01.0120 , LMJLV39_010006100 , LMJSD75_010006200

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AC01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.627
CLV_C14_Caspase3-7	571	575	PF00656	0.721
CLV_C14_Caspase3-7	623	627	PF00656	0.743
CLV_NRD_NRD_1	236	238	PF00675	0.631
CLV_NRD_NRD_1	357	359	PF00675	0.770
CLV_NRD_NRD_1	42	44	PF00675	0.580
CLV_NRD_NRD_1	92	94	PF00675	0.751
CLV_PCSK_KEX2_1	319	321	PF00082	0.654
CLV_PCSK_KEX2_1	357	359	PF00082	0.770
CLV_PCSK_KEX2_1	42	44	PF00082	0.580
CLV_PCSK_KEX2_1	645	647	PF00082	0.798
CLV_PCSK_KEX2_1	92	94	PF00082	0.782
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.654
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.798
CLV_PCSK_SKI1_1	201	205	PF00082	0.615
CLV_PCSK_SKI1_1	564	568	PF00082	0.604
CLV_PCSK_SKI1_1	645	649	PF00082	0.704
DEG_SCF_FBW7_1	607	612	PF00400	0.617
DEG_SPOP_SBC_1	30	34	PF00917	0.699
DEG_SPOP_SBC_1	348	352	PF00917	0.717
DEG_SPOP_SBC_1	474	478	PF00917	0.819
DOC_CKS1_1	408	413	PF01111	0.694
DOC_MAPK_gen_1	272	280	PF00069	0.741
DOC_PP1_RVXF_1	70	76	PF00149	0.574
DOC_PP2B_LxvP_1	404	407	PF13499	0.839
DOC_PP2B_LxvP_1	468	471	PF13499	0.618
DOC_PP2B_LxvP_1	54	57	PF13499	0.784
DOC_PP2B_LxvP_1	550	553	PF13499	0.627
DOC_PP2B_LxvP_1	566	569	PF13499	0.504
DOC_PP4_FxxP_1	150	153	PF00568	0.606
DOC_PP4_FxxP_1	369	372	PF00568	0.601
DOC_SPAK_OSR1_1	646	650	PF12202	0.657
DOC_USP7_MATH_1	127	131	PF00917	0.724
DOC_USP7_MATH_1	172	176	PF00917	0.655
DOC_USP7_MATH_1	291	295	PF00917	0.674
DOC_USP7_MATH_1	30	34	PF00917	0.705
DOC_USP7_MATH_1	348	352	PF00917	0.717
DOC_USP7_MATH_1	370	374	PF00917	0.817
DOC_USP7_MATH_1	437	441	PF00917	0.790
DOC_USP7_MATH_1	442	446	PF00917	0.756
DOC_USP7_MATH_1	451	455	PF00917	0.597
DOC_USP7_MATH_1	458	462	PF00917	0.547
DOC_USP7_MATH_1	474	478	PF00917	0.556
DOC_USP7_MATH_1	481	485	PF00917	0.700
DOC_USP7_MATH_1	553	557	PF00917	0.776
DOC_USP7_MATH_1	601	605	PF00917	0.775
DOC_USP7_MATH_1	630	634	PF00917	0.780
DOC_WW_Pin1_4	106	111	PF00397	0.751
DOC_WW_Pin1_4	149	154	PF00397	0.695
DOC_WW_Pin1_4	155	160	PF00397	0.701
DOC_WW_Pin1_4	194	199	PF00397	0.832
DOC_WW_Pin1_4	221	226	PF00397	0.495
DOC_WW_Pin1_4	395	400	PF00397	0.768
DOC_WW_Pin1_4	407	412	PF00397	0.711
DOC_WW_Pin1_4	519	524	PF00397	0.835
DOC_WW_Pin1_4	569	574	PF00397	0.771
DOC_WW_Pin1_4	579	584	PF00397	0.690
DOC_WW_Pin1_4	605	610	PF00397	0.622
LIG_14-3-3_CanoR_1	133	139	PF00244	0.635
LIG_14-3-3_CanoR_1	140	146	PF00244	0.698
LIG_14-3-3_CanoR_1	147	153	PF00244	0.565
LIG_14-3-3_CanoR_1	19	23	PF00244	0.757
LIG_14-3-3_CanoR_1	191	199	PF00244	0.835
LIG_14-3-3_CanoR_1	207	215	PF00244	0.486
LIG_14-3-3_CanoR_1	219	225	PF00244	0.624
LIG_14-3-3_CanoR_1	230	236	PF00244	0.515
LIG_14-3-3_CanoR_1	257	266	PF00244	0.527
LIG_14-3-3_CanoR_1	29	39	PF00244	0.653
LIG_14-3-3_CanoR_1	360	370	PF00244	0.826
LIG_14-3-3_CanoR_1	589	594	PF00244	0.629
LIG_APCC_ABBA_1	240	245	PF00400	0.624
LIG_BRCT_BRCA1_1	439	443	PF00533	0.819
LIG_FHA_1	234	240	PF00498	0.515
LIG_FHA_1	33	39	PF00498	0.796
LIG_FHA_1	401	407	PF00498	0.701
LIG_FHA_1	53	59	PF00498	0.452
LIG_FHA_1	533	539	PF00498	0.730
LIG_FHA_1	547	553	PF00498	0.590
LIG_FHA_1	560	566	PF00498	0.668
LIG_FHA_1	637	643	PF00498	0.590
LIG_FHA_1	65	71	PF00498	0.575
LIG_FHA_2	222	228	PF00498	0.701
LIG_FHA_2	313	319	PF00498	0.633
LIG_FHA_2	329	335	PF00498	0.391
LIG_FHA_2	499	505	PF00498	0.768
LIG_FHA_2	86	92	PF00498	0.751
LIG_LIR_Apic_2	338	344	PF02991	0.768
LIG_LIR_Apic_2	368	372	PF02991	0.606
LIG_LIR_Apic_2	60	64	PF02991	0.766
LIG_LIR_Gen_1	241	250	PF02991	0.506
LIG_LIR_Nem_3	241	246	PF02991	0.505
LIG_PDZ_Class_1	652	657	PF00595	0.559
LIG_Rb_pABgroove_1	237	245	PF01858	0.628
LIG_SH2_CRK	341	345	PF00017	0.773
LIG_SH2_CRK	61	65	PF00017	0.763
LIG_SH2_NCK_1	243	247	PF00017	0.612
LIG_SH2_NCK_1	341	345	PF00017	0.773
LIG_SH2_SRC	243	246	PF00017	0.615
LIG_SH2_SRC	339	342	PF00017	0.776
LIG_SH2_STAP1	20	24	PF00017	0.735
LIG_SH2_STAP1	243	247	PF00017	0.612
LIG_SH2_STAT3	313	316	PF00017	0.419
LIG_SH2_STAT5	20	23	PF00017	0.735
LIG_SH2_STAT5	270	273	PF00017	0.645
LIG_SH2_STAT5	313	316	PF00017	0.638
LIG_SH3_1	581	587	PF00018	0.735
LIG_SH3_2	584	589	PF14604	0.606
LIG_SH3_3	340	346	PF00018	0.759
LIG_SH3_3	396	402	PF00018	0.805
LIG_SH3_3	405	411	PF00018	0.602
LIG_SH3_3	468	474	PF00018	0.615
LIG_SH3_3	486	492	PF00018	0.517
LIG_SH3_3	535	541	PF00018	0.657
LIG_SH3_3	567	573	PF00018	0.583
LIG_SH3_3	581	587	PF00018	0.549
LIG_SH3_3	604	610	PF00018	0.761
LIG_SH3_3	77	83	PF00018	0.576
LIG_SH3_4	283	290	PF00018	0.554
LIG_SH3_CIN85_PxpxPR_1	344	349	PF14604	0.561
LIG_SUMO_SIM_par_1	238	245	PF11976	0.465
LIG_SUMO_SIM_par_1	461	466	PF11976	0.729
LIG_SUMO_SIM_par_1	534	539	PF11976	0.600
LIG_TRAF2_1	315	318	PF00917	0.650
LIG_WW_3	198	202	PF00397	0.740
LIG_WW_3	586	590	PF00397	0.606
MOD_CDK_SPxK_1	519	525	PF00069	0.837
MOD_CDK_SPxxK_3	194	201	PF00069	0.744
MOD_CDK_SPxxK_3	221	228	PF00069	0.488
MOD_CDK_SPxxK_3	574	581	PF00069	0.605
MOD_CK1_1	158	164	PF00069	0.827
MOD_CK1_1	193	199	PF00069	0.832
MOD_CK1_1	202	208	PF00069	0.683
MOD_CK1_1	209	215	PF00069	0.482
MOD_CK1_1	233	239	PF00069	0.412
MOD_CK1_1	32	38	PF00069	0.704
MOD_CK1_1	350	356	PF00069	0.810
MOD_CK1_1	529	535	PF00069	0.772
MOD_CK1_1	94	100	PF00069	0.775
MOD_CK2_1	221	227	PF00069	0.665
MOD_CK2_1	287	293	PF00069	0.582
MOD_CK2_1	312	318	PF00069	0.644
MOD_CK2_1	328	334	PF00069	0.392
MOD_CK2_1	458	464	PF00069	0.810
MOD_CK2_1	498	504	PF00069	0.762
MOD_CK2_1	85	91	PF00069	0.748
MOD_GlcNHglycan	129	132	PF01048	0.692
MOD_GlcNHglycan	160	163	PF01048	0.832
MOD_GlcNHglycan	193	196	PF01048	0.752
MOD_GlcNHglycan	201	204	PF01048	0.649
MOD_GlcNHglycan	289	292	PF01048	0.605
MOD_GlcNHglycan	363	366	PF01048	0.683
MOD_GlcNHglycan	4	7	PF01048	0.592
MOD_GlcNHglycan	433	437	PF01048	0.784
MOD_GlcNHglycan	439	442	PF01048	0.744
MOD_GlcNHglycan	444	447	PF01048	0.659
MOD_GlcNHglycan	49	53	PF01048	0.748
MOD_GlcNHglycan	496	501	PF01048	0.620
MOD_GlcNHglycan	528	531	PF01048	0.733
MOD_GlcNHglycan	603	606	PF01048	0.643
MOD_GlcNHglycan	626	630	PF01048	0.798
MOD_GlcNHglycan	632	635	PF01048	0.743
MOD_GlcNHglycan	93	96	PF01048	0.837
MOD_GlcNHglycan	98	101	PF01048	0.749
MOD_GSK3_1	113	120	PF00069	0.636
MOD_GSK3_1	134	141	PF00069	0.745
MOD_GSK3_1	154	161	PF00069	0.497
MOD_GSK3_1	190	197	PF00069	0.841
MOD_GSK3_1	2	9	PF00069	0.595
MOD_GSK3_1	202	209	PF00069	0.631
MOD_GSK3_1	287	294	PF00069	0.600
MOD_GSK3_1	30	37	PF00069	0.718
MOD_GSK3_1	361	368	PF00069	0.662
MOD_GSK3_1	416	423	PF00069	0.639
MOD_GSK3_1	427	434	PF00069	0.636
MOD_GSK3_1	437	444	PF00069	0.737
MOD_GSK3_1	446	453	PF00069	0.627
MOD_GSK3_1	48	55	PF00069	0.554
MOD_GSK3_1	532	539	PF00069	0.778
MOD_GSK3_1	541	548	PF00069	0.721
MOD_GSK3_1	601	608	PF00069	0.820
MOD_GSK3_1	609	616	PF00069	0.739
MOD_GSK3_1	632	639	PF00069	0.636
MOD_GSK3_1	648	655	PF00069	0.686
MOD_GSK3_1	81	88	PF00069	0.812
MOD_N-GLC_1	419	424	PF02516	0.728
MOD_NEK2_1	139	144	PF00069	0.746
MOD_NEK2_1	328	333	PF00069	0.652
MOD_NEK2_1	418	423	PF00069	0.775
MOD_NEK2_1	482	487	PF00069	0.820
MOD_NEK2_1	536	541	PF00069	0.594
MOD_NEK2_1	73	78	PF00069	0.658
MOD_NEK2_2	451	456	PF00069	0.589
MOD_NEK2_2	546	551	PF00069	0.630
MOD_PIKK_1	258	264	PF00454	0.588
MOD_PIKK_1	312	318	PF00454	0.425
MOD_PIKK_1	463	469	PF00454	0.740
MOD_PIKK_1	476	482	PF00454	0.567
MOD_PIKK_1	510	516	PF00454	0.627
MOD_PIKK_1	553	559	PF00454	0.734
MOD_PIKK_1	613	619	PF00454	0.778
MOD_PIKK_1	632	638	PF00454	0.496
MOD_PK_1	589	595	PF00069	0.629
MOD_PKA_1	42	48	PF00069	0.574
MOD_PKA_1	425	431	PF00069	0.617
MOD_PKA_2	132	138	PF00069	0.740
MOD_PKA_2	139	145	PF00069	0.659
MOD_PKA_2	18	24	PF00069	0.735
MOD_PKA_2	190	196	PF00069	0.842
MOD_PKA_2	206	212	PF00069	0.491
MOD_PKA_2	231	237	PF00069	0.512
MOD_PKA_2	348	354	PF00069	0.728
MOD_PKA_2	42	48	PF00069	0.657
MOD_PKA_2	588	594	PF00069	0.625
MOD_PKA_2	91	97	PF00069	0.835
MOD_PKB_1	228	236	PF00069	0.438
MOD_PKB_1	358	366	PF00069	0.733
MOD_PKB_1	46	54	PF00069	0.686
MOD_Plk_1	135	141	PF00069	0.747
MOD_Plk_1	463	469	PF00069	0.828
MOD_Plk_4	34	40	PF00069	0.797
MOD_Plk_4	427	433	PF00069	0.610
MOD_Plk_4	458	464	PF00069	0.789
MOD_Plk_4	482	488	PF00069	0.739
MOD_ProDKin_1	106	112	PF00069	0.745
MOD_ProDKin_1	149	155	PF00069	0.697
MOD_ProDKin_1	194	200	PF00069	0.830
MOD_ProDKin_1	221	227	PF00069	0.490
MOD_ProDKin_1	395	401	PF00069	0.768
MOD_ProDKin_1	407	413	PF00069	0.711
MOD_ProDKin_1	519	525	PF00069	0.837
MOD_ProDKin_1	569	575	PF00069	0.773
MOD_ProDKin_1	579	585	PF00069	0.693
MOD_ProDKin_1	605	611	PF00069	0.631
MOD_SUMO_rev_2	499	508	PF00179	0.846
TRG_DiLeu_BaEn_4	317	323	PF01217	0.655
TRG_DiLeu_BaLyEn_6	561	566	PF01217	0.608
TRG_ENDOCYTIC_2	243	246	PF00928	0.494
TRG_ER_diArg_1	228	231	PF00400	0.686
TRG_ER_diArg_1	357	360	PF00400	0.788
TRG_ER_diArg_1	41	43	PF00400	0.658
TRG_NES_CRM1_1	254	267	PF08389	0.459
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.804
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	320	325	PF00026	0.669
TRG_Pf-PMV_PEXEL_1	646	650	PF00026	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4T2	Leishmania donovani	84%	100%
A4H327	Leishmania braziliensis	50%	100%
A4HRD3	Leishmania infantum	84%	100%