Glutaredoxin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

monothiol glutaredoxin, putative

Species:

Leishmania major

UniProt:

E9AC00_LEIMA

TriTrypDb:

LmjF.01.0110 , LMJLV39_010006000 , LMJSD75_010006100

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005759	mitochondrial matrix	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AC00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AC00

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0019725	cellular homeostasis	2	2
GO:0042592	homeostatic process	3	2
GO:0045454	cell redox homeostasis	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004362	glutathione-disulfide reductase (NADPH) activity	2	2
GO:0005488	binding	1	11
GO:0015035	protein-disulfide reductase activity	3	12
GO:0015036	disulfide oxidoreductase activity	4	12
GO:0015038	glutathione disulfide oxidoreductase activity	5	2
GO:0016209	antioxidant activity	1	2
GO:0016491	oxidoreductase activity	2	12
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	12
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	2
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0047134	protein-disulfide reductase (NAD(P)) activity	4	2
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051540	metal cluster binding	2	11
GO:0097573	obsolete glutathione oxidoreductase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	117	119	PF00082	0.246
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.246
CLV_PCSK_SKI1_1	186	190	PF00082	0.467
DOC_MAPK_MEF2A_6	96	104	PF00069	0.290
LIG_14-3-3_CanoR_1	11	20	PF00244	0.488
LIG_14-3-3_CanoR_1	34	44	PF00244	0.584
LIG_deltaCOP1_diTrp_1	150	158	PF00928	0.246
LIG_FHA_2	129	135	PF00498	0.260
LIG_FHA_2	59	65	PF00498	0.577
LIG_FHA_2	92	98	PF00498	0.480
LIG_LIR_Gen_1	129	137	PF02991	0.231
LIG_LIR_Nem_3	129	133	PF02991	0.231
LIG_LIR_Nem_3	149	154	PF02991	0.231
LIG_LIR_Nem_3	5	9	PF02991	0.591
LIG_NRBOX	178	184	PF00104	0.440
LIG_SH2_CRK	6	10	PF00017	0.648
LIG_SH2_STAT5	130	133	PF00017	0.241
LIG_SH2_STAT5	144	147	PF00017	0.231
LIG_SH3_1	105	111	PF00018	0.231
LIG_SH3_2	46	51	PF14604	0.481
LIG_SH3_3	105	111	PF00018	0.277
LIG_SH3_3	149	155	PF00018	0.231
LIG_SH3_3	43	49	PF00018	0.656
LIG_SUMO_SIM_par_1	118	124	PF11976	0.246
LIG_WRC_WIRS_1	130	135	PF05994	0.231
MOD_CK1_1	14	20	PF00069	0.497
MOD_CK1_1	35	41	PF00069	0.556
MOD_CK2_1	58	64	PF00069	0.702
MOD_GlcNHglycan	13	16	PF01048	0.595
MOD_GlcNHglycan	175	178	PF01048	0.378
MOD_GSK3_1	14	21	PF00069	0.502
MOD_GSK3_1	146	153	PF00069	0.269
MOD_GSK3_1	30	37	PF00069	0.537
MOD_NEK2_1	29	34	PF00069	0.605
MOD_NEK2_1	36	41	PF00069	0.525
MOD_Plk_1	128	134	PF00069	0.237
MOD_Plk_1	91	97	PF00069	0.398
MOD_Plk_2-3	129	135	PF00069	0.231
MOD_SUMO_for_1	159	162	PF00179	0.231
MOD_SUMO_rev_2	178	188	PF00179	0.454
TRG_ENDOCYTIC_2	130	133	PF00928	0.231
TRG_ENDOCYTIC_2	6	9	PF00928	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEY6	Leptomonas seymouri	75%	93%
A0A0S4JPM6	Bodo saltans	57%	100%
A0A1X0P310	Trypanosomatidae	75%	100%
A0A3S5H4T1	Leishmania donovani	95%	100%
A0A3S5ISA3	Trypanosoma rangeli	77%	100%
A0A3S7WP17	Leishmania donovani	31%	97%
A4H326	Leishmania braziliensis	80%	100%
A4HRD2	Leishmania infantum	95%	100%
A4HSF1	Leishmania infantum	31%	97%
C9ZXG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	92%
E9AJ97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q0JM76	Oryza sativa subsp. japonica	35%	100%
Q4QJH1	Leishmania major	33%	95%
V5AMF2	Trypanosoma cruzi	62%	100%