Glycosyl transferase family 11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fucosyltransferase 1

Species:

Leishmania major

UniProt:

E9ABZ9_LEIMA

TriTrypDb:

LmjF.01.0100 , LMJLV39_010005900 , LMJSD75_010006000

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	12
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ABZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ABZ9

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006486	protein glycosylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	2
GO:0036065	fucosylation	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043413	macromolecule glycosylation	3	2
GO:0044238	primary metabolic process	2	12
GO:0070085	glycosylation	2	2
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	7	12
GO:0008417	fucosyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0031127	alpha-(1,2)-fucosyltransferase activity	6	12
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.323
CLV_NRD_NRD_1	290	292	PF00675	0.236
CLV_NRD_NRD_1	73	75	PF00675	0.506
CLV_PCSK_KEX2_1	137	139	PF00082	0.323
CLV_PCSK_KEX2_1	290	292	PF00082	0.236
CLV_PCSK_PC7_1	286	292	PF00082	0.370
CLV_PCSK_SKI1_1	162	166	PF00082	0.474
CLV_PCSK_SKI1_1	256	260	PF00082	0.302
DEG_APCC_DBOX_1	161	169	PF00400	0.424
DEG_APCC_DBOX_1	255	263	PF00400	0.297
DEG_APCC_DBOX_1	285	293	PF00400	0.388
DEG_SPOP_SBC_1	28	32	PF00917	0.430
DOC_MAPK_gen_1	219	228	PF00069	0.353
DOC_MAPK_MEF2A_6	221	230	PF00069	0.343
DOC_MAPK_MEF2A_6	256	263	PF00069	0.292
DOC_MAPK_NFAT4_5	256	264	PF00069	0.309
DOC_USP7_MATH_1	102	106	PF00917	0.355
DOC_USP7_MATH_1	182	186	PF00917	0.638
DOC_USP7_MATH_1	244	248	PF00917	0.653
DOC_USP7_MATH_1	28	32	PF00917	0.406
DOC_WW_Pin1_4	169	174	PF00397	0.482
DOC_WW_Pin1_4	178	183	PF00397	0.539
DOC_WW_Pin1_4	245	250	PF00397	0.630
DOC_WW_Pin1_4	56	61	PF00397	0.457
LIG_14-3-3_CanoR_1	143	151	PF00244	0.347
LIG_14-3-3_CanoR_1	209	215	PF00244	0.324
LIG_14-3-3_CanoR_1	243	249	PF00244	0.545
LIG_14-3-3_CanoR_1	286	290	PF00244	0.430
LIG_AP2alpha_1	144	148	PF02296	0.476
LIG_APCC_ABBA_1	201	206	PF00400	0.285
LIG_BRCT_BRCA1_1	295	299	PF00533	0.277
LIG_BRCT_BRCA1_1	93	97	PF00533	0.307
LIG_BRCT_BRCA1_2	295	301	PF00533	0.388
LIG_EH1_1	5	13	PF00400	0.281
LIG_FHA_1	129	135	PF00498	0.339
LIG_FHA_1	68	74	PF00498	0.548
LIG_FHA_2	37	43	PF00498	0.328
LIG_FHA_2	64	70	PF00498	0.376
LIG_Integrin_RGD_1	138	140	PF01839	0.325
LIG_LIR_Gen_1	140	148	PF02991	0.329
LIG_LIR_Gen_1	39	48	PF02991	0.293
LIG_LIR_Nem_3	140	144	PF02991	0.334
LIG_LIR_Nem_3	145	151	PF02991	0.315
LIG_LIR_Nem_3	278	283	PF02991	0.243
LIG_LIR_Nem_3	39	44	PF02991	0.326
LIG_MYND_1	194	198	PF01753	0.392
LIG_NRBOX	164	170	PF00104	0.454
LIG_PCNA_PIPBox_1	150	159	PF02747	0.364
LIG_PCNA_yPIPBox_3	143	157	PF02747	0.382
LIG_PDZ_Class_2	313	318	PF00595	0.277
LIG_Pex14_1	279	283	PF04695	0.243
LIG_Pex14_1	41	45	PF04695	0.309
LIG_Pex14_2	144	148	PF04695	0.425
LIG_PTB_Apo_2	271	278	PF02174	0.336
LIG_SH2_GRB2like	283	286	PF00017	0.243
LIG_SH2_SRC	23	26	PF00017	0.414
LIG_SH2_STAP1	157	161	PF00017	0.253
LIG_SH2_STAT3	51	54	PF00017	0.248
LIG_SH2_STAT5	141	144	PF00017	0.353
LIG_SH2_STAT5	217	220	PF00017	0.316
LIG_SH2_STAT5	23	26	PF00017	0.414
LIG_SH2_STAT5	283	286	PF00017	0.258
LIG_SH2_STAT5	311	314	PF00017	0.277
LIG_SH3_3	192	198	PF00018	0.432
LIG_SH3_3	246	252	PF00018	0.553
LIG_SH3_3	289	295	PF00018	0.243
LIG_SH3_3	297	303	PF00018	0.243
LIG_SH3_3	57	63	PF00018	0.423
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.382
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.312
LIG_SUMO_SIM_par_1	63	70	PF11976	0.465
LIG_SxIP_EBH_1	101	110	PF03271	0.325
LIG_WW_2	60	63	PF00397	0.438
MOD_CK1_1	128	134	PF00069	0.448
MOD_CK1_1	238	244	PF00069	0.497
MOD_CK1_1	247	253	PF00069	0.592
MOD_CK1_1	275	281	PF00069	0.267
MOD_CK2_1	28	34	PF00069	0.389
MOD_CK2_1	63	69	PF00069	0.375
MOD_GlcNHglycan	114	117	PF01048	0.371
MOD_GlcNHglycan	184	187	PF01048	0.679
MOD_GlcNHglycan	236	240	PF01048	0.476
MOD_GlcNHglycan	31	34	PF01048	0.515
MOD_GSK3_1	11	18	PF00069	0.362
MOD_GSK3_1	178	185	PF00069	0.623
MOD_GSK3_1	238	245	PF00069	0.547
MOD_GSK3_1	36	43	PF00069	0.491
MOD_GSK3_1	63	70	PF00069	0.501
MOD_N-GLC_1	273	278	PF02516	0.243
MOD_NEK2_1	11	16	PF00069	0.339
MOD_NEK2_1	112	117	PF00069	0.427
MOD_NEK2_1	210	215	PF00069	0.383
MOD_NEK2_1	262	267	PF00069	0.298
MOD_NEK2_1	272	277	PF00069	0.277
MOD_NEK2_1	55	60	PF00069	0.549
MOD_NEK2_2	125	130	PF00069	0.396
MOD_NEK2_2	40	45	PF00069	0.306
MOD_PIKK_1	262	268	PF00454	0.419
MOD_PKA_2	142	148	PF00069	0.358
MOD_PKA_2	242	248	PF00069	0.516
MOD_PKA_2	285	291	PF00069	0.420
MOD_PKA_2	36	42	PF00069	0.437
MOD_Plk_1	139	145	PF00069	0.395
MOD_Plk_1	235	241	PF00069	0.463
MOD_Plk_1	273	279	PF00069	0.243
MOD_Plk_4	103	109	PF00069	0.386
MOD_Plk_4	119	125	PF00069	0.405
MOD_Plk_4	171	177	PF00069	0.450
MOD_Plk_4	226	232	PF00069	0.377
MOD_Plk_4	36	42	PF00069	0.362
MOD_ProDKin_1	169	175	PF00069	0.483
MOD_ProDKin_1	178	184	PF00069	0.541
MOD_ProDKin_1	245	251	PF00069	0.627
MOD_ProDKin_1	56	62	PF00069	0.455
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.476
TRG_ENDOCYTIC_2	141	144	PF00928	0.336
TRG_ER_diArg_1	136	138	PF00400	0.304
TRG_ER_diArg_1	289	291	PF00400	0.240
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE7	Leptomonas seymouri	58%	98%
A0A0S4JMG1	Bodo saltans	37%	76%
A0A1X0P2U6	Trypanosomatidae	50%	99%
A0A3S5H4T0	Leishmania donovani	96%	100%
A0A422NY61	Trypanosoma rangeli	51%	100%
A4H325	Leishmania braziliensis	83%	99%
A4HRD1	Leishmania infantum	96%	100%
C9ZXG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AJ96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q58YV9	Escherichia coli	23%	100%
V5BBV1	Trypanosoma cruzi	53%	100%