Thymidylate_kin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UMP-CMP kinase, mitochondrial, putative

Species:

Leishmania major

UniProt:

E9ABZ8_LEIMA

TriTrypDb:

LmjF.01.0090 , LMJLV39_010005800 , LMJSD75_010005900

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ABZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ABZ8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006220	pyrimidine nucleotide metabolic process	5	2
GO:0006221	pyrimidine nucleotide biosynthetic process	6	2
GO:0006227	dUDP biosynthetic process	8	2
GO:0006233	dTDP biosynthetic process	8	2
GO:0006235	dTTP biosynthetic process	8	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	5
GO:0009058	biosynthetic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009132	nucleoside diphosphate metabolic process	5	2
GO:0009133	nucleoside diphosphate biosynthetic process	6	2
GO:0009138	pyrimidine nucleoside diphosphate metabolic process	6	2
GO:0009139	pyrimidine nucleoside diphosphate biosynthetic process	7	2
GO:0009141	nucleoside triphosphate metabolic process	5	2
GO:0009142	nucleoside triphosphate biosynthetic process	6	2
GO:0009147	pyrimidine nucleoside triphosphate metabolic process	6	2
GO:0009148	pyrimidine nucleoside triphosphate biosynthetic process	7	2
GO:0009165	nucleotide biosynthetic process	6	2
GO:0009186	deoxyribonucleoside diphosphate metabolic process	6	2
GO:0009189	deoxyribonucleoside diphosphate biosynthetic process	7	2
GO:0009196	pyrimidine deoxyribonucleoside diphosphate metabolic process	7	2
GO:0009197	pyrimidine deoxyribonucleoside diphosphate biosynthetic process	8	2
GO:0009211	pyrimidine deoxyribonucleoside triphosphate metabolic process	7	2
GO:0009212	pyrimidine deoxyribonucleoside triphosphate biosynthetic process	8	2
GO:0009219	pyrimidine deoxyribonucleotide metabolic process	6	2
GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process	7	2
GO:0009262	deoxyribonucleotide metabolic process	4	2
GO:0009263	deoxyribonucleotide biosynthetic process	5	2
GO:0009265	2'-deoxyribonucleotide biosynthetic process	6	2
GO:0009394	2'-deoxyribonucleotide metabolic process	5	2
GO:0009987	cellular process	1	5
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019692	deoxyribose phosphate metabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046072	dTDP metabolic process	7	2
GO:0046075	dTTP metabolic process	7	2
GO:0046077	dUDP metabolic process	7	2
GO:0046385	deoxyribose phosphate biosynthetic process	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072527	pyrimidine-containing compound metabolic process	4	2
GO:0072528	pyrimidine-containing compound biosynthetic process	5	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901293	nucleoside phosphate biosynthetic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:0016310	phosphorylation	5	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004127	cytidylate kinase activity	6	3
GO:0004550	nucleoside diphosphate kinase activity	5	2
GO:0004798	thymidylate kinase activity	6	2
GO:0009041	uridylate kinase activity	6	2
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	10
GO:0019205	nucleobase-containing compound kinase activity	5	10
GO:0050145	nucleoside monophosphate kinase activity	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.271
CLV_NRD_NRD_1	201	203	PF00675	0.299
CLV_NRD_NRD_1	210	212	PF00675	0.302
CLV_NRD_NRD_1	227	229	PF00675	0.245
CLV_NRD_NRD_1	64	66	PF00675	0.592
CLV_PCSK_FUR_1	198	202	PF00082	0.326
CLV_PCSK_KEX2_1	200	202	PF00082	0.314
CLV_PCSK_KEX2_1	210	212	PF00082	0.299
CLV_PCSK_KEX2_1	227	229	PF00082	0.236
DEG_APCC_DBOX_1	18	26	PF00400	0.400
DEG_SCF_FBW7_1	39	46	PF00400	0.456
DEG_SPOP_SBC_1	54	58	PF00917	0.536
DOC_CKS1_1	40	45	PF01111	0.394
DOC_CKS1_1	96	101	PF01111	0.271
DOC_MAPK_gen_1	19	27	PF00069	0.414
DOC_MAPK_gen_1	227	235	PF00069	0.204
DOC_MAPK_gen_1	65	72	PF00069	0.411
DOC_MAPK_MEF2A_6	227	235	PF00069	0.204
DOC_MAPK_MEF2A_6	65	72	PF00069	0.477
DOC_PP1_SILK_1	245	250	PF00149	0.358
DOC_PP2B_LxvP_1	179	182	PF13499	0.413
DOC_PP2B_PxIxI_1	67	73	PF00149	0.326
DOC_USP7_MATH_1	136	140	PF00917	0.398
DOC_USP7_MATH_1	236	240	PF00917	0.394
DOC_USP7_MATH_1	243	247	PF00917	0.418
DOC_USP7_MATH_1	43	47	PF00917	0.424
DOC_WW_Pin1_4	32	37	PF00397	0.446
DOC_WW_Pin1_4	39	44	PF00397	0.392
DOC_WW_Pin1_4	95	100	PF00397	0.276
LIG_14-3-3_CanoR_1	107	111	PF00244	0.270
LIG_14-3-3_CanoR_1	119	128	PF00244	0.216
LIG_14-3-3_CanoR_1	146	156	PF00244	0.271
LIG_14-3-3_CanoR_1	210	218	PF00244	0.345
LIG_CAP-Gly_1	267	274	PF01302	0.458
LIG_Clathr_ClatBox_1	187	191	PF01394	0.289
LIG_CSL_BTD_1	40	43	PF09270	0.400
LIG_EVH1_2	99	103	PF00568	0.404
LIG_FHA_1	227	233	PF00498	0.321
LIG_FHA_1	82	88	PF00498	0.330
LIG_FHA_2	262	268	PF00498	0.373
LIG_FHA_2	84	90	PF00498	0.406
LIG_PDZ_Class_3	269	274	PF00595	0.452
LIG_SH2_CRK	162	166	PF00017	0.335
LIG_SH2_NCK_1	122	126	PF00017	0.289
LIG_SH2_STAT5	127	130	PF00017	0.275
LIG_SH3_3	232	238	PF00018	0.394
LIG_SH3_3	33	39	PF00018	0.414
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.394
LIG_SUMO_SIM_par_1	139	145	PF11976	0.338
LIG_SUMO_SIM_par_1	67	73	PF11976	0.329
MOD_CK1_1	137	143	PF00069	0.292
MOD_CK1_1	254	260	PF00069	0.320
MOD_CK2_1	211	217	PF00069	0.439
MOD_CK2_1	261	267	PF00069	0.385
MOD_CK2_1	83	89	PF00069	0.314
MOD_GlcNHglycan	122	125	PF01048	0.309
MOD_GlcNHglycan	167	170	PF01048	0.313
MOD_GlcNHglycan	253	256	PF01048	0.462
MOD_GlcNHglycan	57	60	PF01048	0.545
MOD_GlcNHglycan	91	94	PF01048	0.392
MOD_GSK3_1	161	168	PF00069	0.466
MOD_GSK3_1	39	46	PF00069	0.391
MOD_GSK3_1	53	60	PF00069	0.385
MOD_N-GLC_2	158	160	PF02516	0.291
MOD_NEK2_1	134	139	PF00069	0.335
MOD_NEK2_1	161	166	PF00069	0.250
MOD_NEK2_1	55	60	PF00069	0.484
MOD_NEK2_1	7	12	PF00069	0.450
MOD_NEK2_1	75	80	PF00069	0.400
MOD_PIKK_1	134	140	PF00454	0.357
MOD_PIKK_1	211	217	PF00454	0.313
MOD_PIKK_1	261	267	PF00454	0.374
MOD_PKA_1	210	216	PF00069	0.326
MOD_PKA_2	106	112	PF00069	0.404
MOD_PKA_2	210	216	PF00069	0.335
MOD_PKA_2	226	232	PF00069	0.459
MOD_Plk_2-3	267	273	PF00069	0.456
MOD_Plk_4	137	143	PF00069	0.350
MOD_Plk_4	243	249	PF00069	0.475
MOD_Plk_4	78	84	PF00069	0.311
MOD_ProDKin_1	32	38	PF00069	0.441
MOD_ProDKin_1	39	45	PF00069	0.382
MOD_ProDKin_1	95	101	PF00069	0.276
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.377
TRG_ENDOCYTIC_2	162	165	PF00928	0.335
TRG_ER_diArg_1	18	21	PF00400	0.466
TRG_ER_diArg_1	198	201	PF00400	0.276
TRG_ER_diArg_1	210	212	PF00400	0.275
TRG_ER_diArg_1	226	228	PF00400	0.236
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.255
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL87	Leptomonas seymouri	64%	97%
A0A0S4JME8	Bodo saltans	44%	93%
A0A1X0P3H2	Trypanosomatidae	54%	100%
A0A3S5H4S9	Leishmania donovani	92%	100%
A0A422NYA0	Trypanosoma rangeli	53%	100%
A4H324	Leishmania braziliensis	85%	100%
A4HRD0	Leishmania infantum	92%	100%
E9AJ95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5D316	Trypanosoma cruzi	53%	100%