BSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BSD domain containing protein, putative

Species:

Leishmania major

UniProt:

E9ABZ6_LEIMA

TriTrypDb:

LmjF.01.0070 , LMJLV39_010005600 , LMJSD75_010005700

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ABZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ABZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.565
CLV_NRD_NRD_1	131	133	PF00675	0.617
CLV_NRD_NRD_1	140	142	PF00675	0.529
CLV_NRD_NRD_1	478	480	PF00675	0.582
CLV_PCSK_KEX2_1	130	132	PF00082	0.572
CLV_PCSK_KEX2_1	442	444	PF00082	0.449
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.449
CLV_PCSK_SKI1_1	142	146	PF00082	0.470
CLV_PCSK_SKI1_1	181	185	PF00082	0.486
CLV_PCSK_SKI1_1	375	379	PF00082	0.229
CLV_PCSK_SKI1_1	462	466	PF00082	0.551
CLV_PCSK_SKI1_1	491	495	PF00082	0.478
CLV_PCSK_SKI1_1	51	55	PF00082	0.352
DEG_SIAH_1	555	563	PF03145	0.574
DEG_SPOP_SBC_1	143	147	PF00917	0.481
DEG_SPOP_SBC_1	41	45	PF00917	0.428
DEG_SPOP_SBC_1	95	99	PF00917	0.751
DOC_CKS1_1	417	422	PF01111	0.432
DOC_CYCLIN_yCln2_LP_2	417	423	PF00134	0.423
DOC_MAPK_gen_1	29	38	PF00069	0.395
DOC_MAPK_HePTP_8	394	406	PF00069	0.393
DOC_MAPK_MEF2A_6	181	189	PF00069	0.486
DOC_MAPK_MEF2A_6	397	406	PF00069	0.458
DOC_PP1_RVXF_1	373	380	PF00149	0.332
DOC_PP1_RVXF_1	489	496	PF00149	0.388
DOC_PP2B_LxvP_1	406	409	PF13499	0.345
DOC_PP2B_LxvP_1	75	78	PF13499	0.411
DOC_PP4_FxxP_1	38	41	PF00568	0.412
DOC_USP7_MATH_1	116	120	PF00917	0.623
DOC_USP7_MATH_1	143	147	PF00917	0.463
DOC_USP7_MATH_1	157	161	PF00917	0.309
DOC_USP7_MATH_1	240	244	PF00917	0.604
DOC_USP7_MATH_1	341	345	PF00917	0.472
DOC_USP7_MATH_1	409	413	PF00917	0.497
DOC_USP7_MATH_1	521	525	PF00917	0.615
DOC_USP7_MATH_1	89	93	PF00917	0.707
DOC_USP7_MATH_1	94	98	PF00917	0.674
DOC_WW_Pin1_4	118	123	PF00397	0.568
DOC_WW_Pin1_4	255	260	PF00397	0.618
DOC_WW_Pin1_4	319	324	PF00397	0.431
DOC_WW_Pin1_4	416	421	PF00397	0.592
DOC_WW_Pin1_4	532	537	PF00397	0.675
DOC_WW_Pin1_4	548	553	PF00397	0.741
DOC_WW_Pin1_4	565	570	PF00397	0.638
DOC_WW_Pin1_4	60	65	PF00397	0.620
LIG_14-3-3_CanoR_1	141	151	PF00244	0.614
LIG_14-3-3_CanoR_1	580	588	PF00244	0.673
LIG_AP2alpha_2	67	69	PF02296	0.422
LIG_BIR_II_1	1	5	PF00653	0.517
LIG_BIR_III_2	93	97	PF00653	0.495
LIG_BRCT_BRCA1_1	2	6	PF00533	0.538
LIG_BRCT_BRCA1_1	34	38	PF00533	0.392
LIG_BRCT_BRCA1_1	65	69	PF00533	0.394
LIG_Clathr_ClatBox_1	345	349	PF01394	0.452
LIG_CSL_BTD_1	38	41	PF09270	0.427
LIG_deltaCOP1_diTrp_1	289	298	PF00928	0.426
LIG_deltaCOP1_diTrp_1	338	346	PF00928	0.489
LIG_FHA_1	109	115	PF00498	0.355
LIG_FHA_1	171	177	PF00498	0.497
LIG_FHA_1	182	188	PF00498	0.377
LIG_FHA_1	220	226	PF00498	0.541
LIG_FHA_1	83	89	PF00498	0.589
LIG_FHA_2	121	127	PF00498	0.671
LIG_FHA_2	417	423	PF00498	0.470
LIG_FXI_DFP_1	345	349	PF00024	0.452
LIG_LIR_Apic_2	35	41	PF02991	0.408
LIG_LIR_Gen_1	202	212	PF02991	0.483
LIG_LIR_Gen_1	297	306	PF02991	0.501
LIG_LIR_Gen_1	448	458	PF02991	0.491
LIG_LIR_Nem_3	160	164	PF02991	0.465
LIG_LIR_Nem_3	202	208	PF02991	0.471
LIG_LIR_Nem_3	297	301	PF02991	0.437
LIG_LIR_Nem_3	378	383	PF02991	0.291
LIG_LIR_Nem_3	448	453	PF02991	0.460
LIG_LIR_Nem_3	66	72	PF02991	0.416
LIG_PDZ_Class_3	593	598	PF00595	0.592
LIG_Pex14_1	380	384	PF04695	0.289
LIG_PTB_Apo_2	169	176	PF02174	0.402
LIG_PTB_Phospho_1	169	175	PF10480	0.498
LIG_Rb_pABgroove_1	340	348	PF01858	0.432
LIG_SH2_CRK	367	371	PF00017	0.274
LIG_SH2_STAT5	175	178	PF00017	0.529
LIG_SH2_STAT5	265	268	PF00017	0.504
LIG_SH2_STAT5	383	386	PF00017	0.304
LIG_SH3_3	156	162	PF00018	0.445
LIG_SH3_3	500	506	PF00018	0.583
LIG_SH3_3	75	81	PF00018	0.538
LIG_SUMO_SIM_anti_2	418	425	PF11976	0.386
LIG_TRAF2_1	124	127	PF00917	0.573
LIG_TRAF2_1	287	290	PF00917	0.558
LIG_TRAF2_1	591	594	PF00917	0.520
LIG_TRFH_1	367	371	PF08558	0.274
LIG_WW_3	535	539	PF00397	0.736
MOD_CDK_SPK_2	567	572	PF00069	0.571
MOD_CDK_SPxK_1	532	538	PF00069	0.755
MOD_CDK_SPxxK_3	565	572	PF00069	0.598
MOD_CK1_1	206	212	PF00069	0.560
MOD_CK1_1	232	238	PF00069	0.542
MOD_CK1_1	243	249	PF00069	0.560
MOD_CK1_1	257	263	PF00069	0.662
MOD_CK1_1	300	306	PF00069	0.354
MOD_CK1_1	469	475	PF00069	0.428
MOD_CK1_1	484	490	PF00069	0.379
MOD_CK1_1	97	103	PF00069	0.644
MOD_CK2_1	120	126	PF00069	0.655
MOD_CK2_1	319	325	PF00069	0.392
MOD_CK2_1	416	422	PF00069	0.526
MOD_CK2_1	484	490	PF00069	0.508
MOD_GlcNHglycan	100	103	PF01048	0.683
MOD_GlcNHglycan	2	5	PF01048	0.540
MOD_GlcNHglycan	234	237	PF01048	0.649
MOD_GlcNHglycan	242	245	PF01048	0.595
MOD_GlcNHglycan	248	251	PF01048	0.584
MOD_GlcNHglycan	259	262	PF01048	0.549
MOD_GlcNHglycan	358	361	PF01048	0.350
MOD_GlcNHglycan	523	526	PF01048	0.740
MOD_GlcNHglycan	573	578	PF01048	0.664
MOD_GSK3_1	116	123	PF00069	0.511
MOD_GSK3_1	181	188	PF00069	0.484
MOD_GSK3_1	199	206	PF00069	0.383
MOD_GSK3_1	207	214	PF00069	0.540
MOD_GSK3_1	251	258	PF00069	0.710
MOD_GSK3_1	270	277	PF00069	0.663
MOD_GSK3_1	481	488	PF00069	0.482
MOD_GSK3_1	548	555	PF00069	0.730
MOD_GSK3_1	563	570	PF00069	0.616
MOD_GSK3_1	94	101	PF00069	0.659
MOD_N-GLC_1	252	257	PF02516	0.588
MOD_N-GLC_1	41	46	PF02516	0.543
MOD_N-GLC_1	415	420	PF02516	0.427
MOD_NEK2_1	170	175	PF00069	0.461
MOD_NEK2_1	207	212	PF00069	0.552
MOD_NEK2_1	219	224	PF00069	0.549
MOD_NEK2_1	251	256	PF00069	0.613
MOD_NEK2_1	309	314	PF00069	0.486
MOD_NEK2_1	58	63	PF00069	0.461
MOD_NEK2_2	12	17	PF00069	0.511
MOD_NEK2_2	341	346	PF00069	0.480
MOD_NEK2_2	409	414	PF00069	0.425
MOD_PIKK_1	466	472	PF00454	0.533
MOD_PIKK_1	580	586	PF00454	0.687
MOD_PKA_2	12	18	PF00069	0.462
MOD_PKA_2	229	235	PF00069	0.584
MOD_Plk_1	375	381	PF00069	0.417
MOD_Plk_1	482	488	PF00069	0.376
MOD_Plk_4	12	18	PF00069	0.442
MOD_Plk_4	297	303	PF00069	0.478
MOD_Plk_4	341	347	PF00069	0.429
MOD_Plk_4	375	381	PF00069	0.400
MOD_ProDKin_1	118	124	PF00069	0.577
MOD_ProDKin_1	255	261	PF00069	0.618
MOD_ProDKin_1	319	325	PF00069	0.424
MOD_ProDKin_1	416	422	PF00069	0.587
MOD_ProDKin_1	532	538	PF00069	0.677
MOD_ProDKin_1	548	554	PF00069	0.742
MOD_ProDKin_1	565	571	PF00069	0.633
MOD_ProDKin_1	60	66	PF00069	0.617
TRG_DiLeu_BaEn_1	297	302	PF01217	0.386
TRG_ENDOCYTIC_2	367	370	PF00928	0.274
TRG_ER_diArg_1	130	132	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ7	Leptomonas seymouri	45%	96%
A0A0S4JIQ1	Bodo saltans	31%	79%
A0A1X0P2Y2	Trypanosomatidae	31%	100%
A0A3R7LAJ1	Trypanosoma rangeli	31%	100%
A0A451EJ65	Leishmania donovani	85%	100%
A4H322	Leishmania braziliensis	70%	97%
A4HRC8	Leishmania infantum	86%	100%
C9ZXG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AJ93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5AME8	Trypanosoma cruzi	29%	100%