Plus3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9ABZ5_LEIMA

TriTrypDb:

LmjF.01.0060 , LMJLV39_010005500 , LMJSD75_010005600

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ABZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ABZ5

PDB structure(s): 7aih_As , 7am2_As , 7ane_As

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.499
CLV_NRD_NRD_1	184	186	PF00675	0.582
CLV_NRD_NRD_1	197	199	PF00675	0.560
CLV_NRD_NRD_1	2	4	PF00675	0.579
CLV_NRD_NRD_1	57	59	PF00675	0.432
CLV_NRD_NRD_1	9	11	PF00675	0.580
CLV_PCSK_FUR_1	156	160	PF00082	0.483
CLV_PCSK_KEX2_1	158	160	PF00082	0.471
CLV_PCSK_KEX2_1	178	180	PF00082	0.293
CLV_PCSK_KEX2_1	184	186	PF00082	0.585
CLV_PCSK_KEX2_1	2	4	PF00082	0.560
CLV_PCSK_KEX2_1	57	59	PF00082	0.432
CLV_PCSK_KEX2_1	9	11	PF00082	0.560
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.471
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.293
CLV_PCSK_SKI1_1	165	169	PF00082	0.538
CLV_PCSK_SKI1_1	194	198	PF00082	0.570
DEG_APCC_DBOX_1	57	65	PF00400	0.431
DEG_Nend_UBRbox_1	1	4	PF02207	0.584
DOC_CKS1_1	131	136	PF01111	0.456
DOC_CYCLIN_RxL_1	159	171	PF00134	0.385
DOC_MAPK_gen_1	57	64	PF00069	0.425
DOC_USP7_MATH_1	17	21	PF00917	0.700
DOC_USP7_MATH_1	173	177	PF00917	0.555
DOC_USP7_MATH_1	210	214	PF00917	0.753
DOC_USP7_MATH_1	34	38	PF00917	0.649
DOC_WW_Pin1_4	130	135	PF00397	0.447
DOC_WW_Pin1_4	206	211	PF00397	0.575
DOC_WW_Pin1_4	68	73	PF00397	0.409
LIG_14-3-3_CanoR_1	172	176	PF00244	0.617
LIG_14-3-3_CanoR_1	44	52	PF00244	0.526
LIG_Clathr_ClatBox_1	61	65	PF01394	0.440
LIG_FHA_1	85	91	PF00498	0.427
LIG_FHA_2	172	178	PF00498	0.579
LIG_FHA_2	51	57	PF00498	0.449
LIG_LIR_Nem_3	56	62	PF02991	0.424
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.433
LIG_UBA3_1	131	136	PF00899	0.531
LIG_UBA3_1	152	158	PF00899	0.526
LIG_WW_3	245	249	PF00397	0.795
MOD_CDK_SPxK_1	130	136	PF00069	0.484
MOD_CK1_1	215	221	PF00069	0.820
MOD_CK1_1	22	28	PF00069	0.732
MOD_GlcNHglycan	139	143	PF01048	0.572
MOD_GlcNHglycan	19	22	PF01048	0.706
MOD_GlcNHglycan	214	217	PF01048	0.705
MOD_GlcNHglycan	241	244	PF01048	0.731
MOD_GlcNHglycan	25	28	PF01048	0.742
MOD_GlcNHglycan	32	35	PF01048	0.577
MOD_GlcNHglycan	48	51	PF01048	0.574
MOD_GSK3_1	143	150	PF00069	0.599
MOD_GSK3_1	15	22	PF00069	0.673
MOD_GSK3_1	206	213	PF00069	0.774
MOD_GSK3_1	30	37	PF00069	0.594
MOD_GSK3_1	46	53	PF00069	0.555
MOD_NEK2_1	186	191	PF00069	0.576
MOD_NEK2_1	30	35	PF00069	0.645
MOD_PIKK_1	143	149	PF00454	0.688
MOD_PKA_1	9	15	PF00069	0.685
MOD_PKA_2	171	177	PF00069	0.586
MOD_PKA_2	186	192	PF00069	0.476
MOD_PKA_2	221	227	PF00069	0.717
MOD_PKA_2	239	245	PF00069	0.555
MOD_PKA_2	50	56	PF00069	0.451
MOD_PKA_2	9	15	PF00069	0.635
MOD_Plk_1	179	185	PF00069	0.482
MOD_Plk_2-3	171	177	PF00069	0.618
MOD_Plk_4	34	40	PF00069	0.586
MOD_Plk_4	71	77	PF00069	0.414
MOD_ProDKin_1	130	136	PF00069	0.452
MOD_ProDKin_1	206	212	PF00069	0.581
MOD_ProDKin_1	68	74	PF00069	0.405
TRG_ER_diArg_1	1	3	PF00400	0.587
TRG_ER_diArg_1	183	185	PF00400	0.415
TRG_ER_diArg_1	57	59	PF00400	0.432
TRG_ER_diArg_1	9	11	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N8	Leptomonas seymouri	77%	100%
A0A0S4JMA4	Bodo saltans	62%	100%
A0A3R7NZX6	Trypanosoma rangeli	80%	100%
A0A451EJ64	Leishmania donovani	94%	100%
A4H340	Leishmania braziliensis	75%	100%
A4HRC7	Leishmania infantum	93%	100%
C9ZXG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AJ92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%