GYF domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9ABZ3_LEIMA

TriTrypDb:

LmjF.01.0040 , LMJLV39_010005300 , LMJSD75_010005400

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ABZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ABZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.458
CLV_NRD_NRD_1	75	77	PF00675	0.440
CLV_PCSK_KEX2_1	120	122	PF00082	0.458
CLV_PCSK_KEX2_1	2	4	PF00082	0.602
CLV_PCSK_KEX2_1	75	77	PF00082	0.402
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.582
CLV_PCSK_SKI1_1	177	181	PF00082	0.465
CLV_PCSK_SKI1_1	51	55	PF00082	0.437
DEG_APCC_DBOX_1	50	58	PF00400	0.483
DEG_APCC_KENBOX_2	78	82	PF00400	0.350
DEG_Nend_UBRbox_1	1	4	PF02207	0.593
DEG_SPOP_SBC_1	33	37	PF00917	0.559
DOC_CYCLIN_RxL_1	48	58	PF00134	0.435
DOC_MAPK_DCC_7	121	131	PF00069	0.440
DOC_MAPK_gen_1	105	113	PF00069	0.439
DOC_MAPK_gen_1	174	182	PF00069	0.466
DOC_MAPK_MEF2A_6	174	182	PF00069	0.466
DOC_USP7_MATH_1	33	37	PF00917	0.559
DOC_WW_Pin1_4	29	34	PF00397	0.543
DOC_WW_Pin1_4	3	8	PF00397	0.646
LIG_14-3-3_CanoR_1	120	130	PF00244	0.519
LIG_14-3-3_CanoR_1	177	183	PF00244	0.458
LIG_14-3-3_CanoR_1	31	39	PF00244	0.578
LIG_Actin_WH2_2	49	67	PF00022	0.403
LIG_LIR_Gen_1	100	106	PF02991	0.413
LIG_SH2_STAT5	158	161	PF00017	0.474
LIG_SH3_4	137	144	PF00018	0.433
LIG_SUMO_SIM_par_1	52	58	PF11976	0.398
LIG_TRAF2_1	115	118	PF00917	0.445
LIG_TRAF2_1	41	44	PF00917	0.637
MOD_CK1_1	16	22	PF00069	0.593
MOD_CK1_1	32	38	PF00069	0.539
MOD_CK1_1	8	14	PF00069	0.604
MOD_CK2_1	37	43	PF00069	0.593
MOD_CK2_1	52	58	PF00069	0.283
MOD_Cter_Amidation	159	162	PF01082	0.473
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.591
MOD_GlcNHglycan	13	16	PF01048	0.567
MOD_GlcNHglycan	18	21	PF01048	0.508
MOD_GlcNHglycan	39	42	PF01048	0.560
MOD_GlcNHglycan	7	10	PF01048	0.632
MOD_GSK3_1	19	26	PF00069	0.577
MOD_GSK3_1	29	36	PF00069	0.459
MOD_GSK3_1	5	12	PF00069	0.587
MOD_NEK2_1	23	28	PF00069	0.625
MOD_PKA_1	120	126	PF00069	0.412
MOD_PKA_1	75	81	PF00069	0.459
MOD_PKA_2	104	110	PF00069	0.442
MOD_PKA_2	119	125	PF00069	0.540
MOD_PKA_2	75	81	PF00069	0.459
MOD_PKB_1	3	11	PF00069	0.580
MOD_Plk_1	9	15	PF00069	0.601
MOD_Plk_4	52	58	PF00069	0.361
MOD_ProDKin_1	29	35	PF00069	0.545
MOD_ProDKin_1	3	9	PF00069	0.648
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.428
TRG_ER_diArg_1	74	76	PF00400	0.441
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8D7	Leptomonas seymouri	58%	100%
A0A451EJ62	Leishmania donovani	95%	100%
A4H338	Leishmania braziliensis	82%	100%
E9AJ90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%