Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 1, putative

Species:

Leishmania major

UniProt:

E9ABZ2_LEIMA

TriTrypDb:

LmjF.01.0030 , LMJLV39_010005200 , LMJSD75_010005300

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	2
GO:0005634	nucleus	5	2
GO:0005819	spindle	5	2
GO:0005874	microtubule	6	18
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	18
GO:0099081	supramolecular polymer	3	18
GO:0099512	supramolecular fiber	4	18
GO:0099513	polymeric cytoskeletal fiber	5	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

E9ABZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ABZ2

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	3
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	3
GO:0007017	microtubule-based process	2	18
GO:0007018	microtubule-based movement	3	18
GO:0007019	microtubule depolymerization	5	3
GO:0007051	spindle organization	3	2
GO:0007052	mitotic spindle organization	4	2
GO:0009987	cellular process	1	18
GO:0016043	cellular component organization	3	3
GO:0022402	cell cycle process	2	2
GO:0022411	cellular component disassembly	4	3
GO:0031109	microtubule polymerization or depolymerization	4	3
GO:0032984	protein-containing complex disassembly	5	3
GO:0043933	protein-containing complex organization	4	3
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051261	protein depolymerization	6	3
GO:0051983	regulation of chromosome segregation	4	2
GO:0065007	biological regulation	1	2
GO:0071840	cellular component organization or biogenesis	2	3
GO:0097435	supramolecular fiber organization	4	3
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	2
GO:1903047	mitotic cell cycle process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003774	cytoskeletal motor activity	1	18
GO:0003777	microtubule motor activity	2	18
GO:0005488	binding	1	18
GO:0005515	protein binding	2	18
GO:0005524	ATP binding	5	18
GO:0008017	microtubule binding	5	18
GO:0008092	cytoskeletal protein binding	3	18
GO:0015631	tubulin binding	4	18
GO:0017076	purine nucleotide binding	4	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:0140657	ATP-dependent activity	1	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.435
CLV_C14_Caspase3-7	80	84	PF00656	0.768
CLV_NRD_NRD_1	108	110	PF00675	0.703
CLV_NRD_NRD_1	130	132	PF00675	0.478
CLV_NRD_NRD_1	139	141	PF00675	0.337
CLV_NRD_NRD_1	176	178	PF00675	0.391
CLV_NRD_NRD_1	18	20	PF00675	0.538
CLV_NRD_NRD_1	280	282	PF00675	0.403
CLV_NRD_NRD_1	399	401	PF00675	0.271
CLV_NRD_NRD_1	460	462	PF00675	0.543
CLV_NRD_NRD_1	484	486	PF00675	0.686
CLV_NRD_NRD_1	635	637	PF00675	0.540
CLV_PCSK_KEX2_1	107	109	PF00082	0.711
CLV_PCSK_KEX2_1	130	132	PF00082	0.478
CLV_PCSK_KEX2_1	141	143	PF00082	0.348
CLV_PCSK_KEX2_1	18	20	PF00082	0.538
CLV_PCSK_KEX2_1	280	282	PF00082	0.408
CLV_PCSK_KEX2_1	345	347	PF00082	0.417
CLV_PCSK_KEX2_1	454	456	PF00082	0.480
CLV_PCSK_KEX2_1	460	462	PF00082	0.518
CLV_PCSK_KEX2_1	484	486	PF00082	0.684
CLV_PCSK_KEX2_1	548	550	PF00082	0.632
CLV_PCSK_KEX2_1	572	574	PF00082	0.720
CLV_PCSK_KEX2_1	634	636	PF00082	0.543
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.472
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.374
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.254
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.602
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.632
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.649
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.515
CLV_PCSK_PC7_1	480	486	PF00082	0.578
CLV_PCSK_PC7_1	568	574	PF00082	0.660
CLV_PCSK_SKI1_1	184	188	PF00082	0.248
CLV_PCSK_SKI1_1	249	253	PF00082	0.372
CLV_PCSK_SKI1_1	296	300	PF00082	0.354
CLV_PCSK_SKI1_1	36	40	PF00082	0.555
CLV_PCSK_SKI1_1	384	388	PF00082	0.318
CLV_PCSK_SKI1_1	451	455	PF00082	0.461
CLV_Separin_Metazoa	412	416	PF03568	0.294
DEG_APCC_DBOX_1	279	287	PF00400	0.248
DOC_CKS1_1	530	535	PF01111	0.553
DOC_CYCLIN_RxL_1	381	391	PF00134	0.318
DOC_MAPK_gen_1	130	139	PF00069	0.409
DOC_MAPK_gen_1	168	176	PF00069	0.361
DOC_MAPK_MEF2A_6	130	139	PF00069	0.414
DOC_MAPK_MEF2A_6	168	176	PF00069	0.381
DOC_MAPK_MEF2A_6	333	342	PF00069	0.352
DOC_USP7_MATH_1	159	163	PF00917	0.412
DOC_USP7_MATH_1	28	32	PF00917	0.377
DOC_USP7_MATH_1	506	510	PF00917	0.671
DOC_USP7_MATH_1	550	554	PF00917	0.702
DOC_USP7_MATH_1	563	567	PF00917	0.620
DOC_USP7_MATH_1	583	587	PF00917	0.547
DOC_USP7_MATH_1	637	641	PF00917	0.468
DOC_USP7_MATH_1	74	78	PF00917	0.609
DOC_USP7_UBL2_3	341	345	PF12436	0.389
DOC_USP7_UBL2_3	349	353	PF12436	0.202
DOC_WW_Pin1_4	428	433	PF00397	0.318
DOC_WW_Pin1_4	518	523	PF00397	0.686
DOC_WW_Pin1_4	529	534	PF00397	0.717
DOC_WW_Pin1_4	538	543	PF00397	0.728
DOC_WW_Pin1_4	93	98	PF00397	0.669
LIG_14-3-3_CanoR_1	108	118	PF00244	0.571
LIG_14-3-3_CanoR_1	121	129	PF00244	0.608
LIG_14-3-3_CanoR_1	177	186	PF00244	0.361
LIG_14-3-3_CanoR_1	254	263	PF00244	0.375
LIG_14-3-3_CanoR_1	455	463	PF00244	0.703
LIG_14-3-3_CanoR_1	484	490	PF00244	0.592
LIG_14-3-3_CanoR_1	508	512	PF00244	0.674
LIG_14-3-3_CanoR_1	515	521	PF00244	0.707
LIG_14-3-3_CanoR_1	628	638	PF00244	0.515
LIG_Actin_WH2_1	48	63	PF00022	0.337
LIG_BRCT_BRCA1_1	350	354	PF00533	0.240
LIG_FHA_1	114	120	PF00498	0.515
LIG_FHA_1	257	263	PF00498	0.226
LIG_FHA_1	409	415	PF00498	0.318
LIG_FHA_1	422	428	PF00498	0.318
LIG_FHA_1	485	491	PF00498	0.641
LIG_FHA_2	123	129	PF00498	0.599
LIG_FHA_2	209	215	PF00498	0.309
LIG_FHA_2	302	308	PF00498	0.226
LIG_FHA_2	309	315	PF00498	0.194
LIG_FHA_2	32	38	PF00498	0.501
LIG_FHA_2	353	359	PF00498	0.282
LIG_FHA_2	373	379	PF00498	0.313
LIG_FHA_2	641	647	PF00498	0.528
LIG_Integrin_isoDGR_2	278	280	PF01839	0.248
LIG_LIR_Gen_1	150	159	PF02991	0.399
LIG_LIR_Gen_1	250	258	PF02991	0.308
LIG_LIR_Gen_1	351	360	PF02991	0.325
LIG_LIR_Nem_3	150	156	PF02991	0.399
LIG_LIR_Nem_3	250	255	PF02991	0.312
LIG_LIR_Nem_3	264	269	PF02991	0.341
LIG_LIR_Nem_3	351	357	PF02991	0.323
LIG_LIR_Nem_3	44	49	PF02991	0.425
LIG_LIR_Nem_3	570	574	PF02991	0.601
LIG_LIR_Nem_3	590	595	PF02991	0.475
LIG_NRBOX	272	278	PF00104	0.290
LIG_PCNA_TLS_4	635	642	PF02747	0.518
LIG_Pex14_2	187	191	PF04695	0.294
LIG_Pex14_2	25	29	PF04695	0.491
LIG_RPA_C_Fungi	623	635	PF08784	0.517
LIG_SH2_NCK_1	201	205	PF00017	0.226
LIG_SH2_NCK_1	244	248	PF00017	0.294
LIG_SH2_STAP1	244	248	PF00017	0.294
LIG_SH2_STAP1	446	450	PF00017	0.318
LIG_SH2_STAT5	111	114	PF00017	0.513
LIG_SH2_STAT5	12	15	PF00017	0.511
LIG_SH2_STAT5	179	182	PF00017	0.318
LIG_SH2_STAT5	595	598	PF00017	0.381
LIG_SH2_STAT5	66	69	PF00017	0.382
LIG_SH3_2	533	538	PF14604	0.706
LIG_SH3_3	460	466	PF00018	0.663
LIG_SH3_3	530	536	PF00018	0.653
LIG_SH3_3	559	565	PF00018	0.544
LIG_SUMO_SIM_par_1	385	391	PF11976	0.279
LIG_TRAF2_1	125	128	PF00917	0.420
LIG_UBA3_1	135	141	PF00899	0.422
LIG_UBA3_1	337	345	PF00899	0.265
LIG_UBA3_1	386	390	PF00899	0.318
LIG_WRC_WIRS_1	262	267	PF05994	0.279
LIG_WRC_WIRS_1	638	643	PF05994	0.523
MOD_CDK_SPK_2	529	534	PF00069	0.701
MOD_CDK_SPxxK_3	93	100	PF00069	0.670
MOD_CK1_1	122	128	PF00069	0.518
MOD_CK1_1	228	234	PF00069	0.313
MOD_CK1_1	31	37	PF00069	0.457
MOD_CK1_1	321	327	PF00069	0.250
MOD_CK1_1	331	337	PF00069	0.372
MOD_CK1_1	348	354	PF00069	0.240
MOD_CK1_1	408	414	PF00069	0.318
MOD_CK1_1	483	489	PF00069	0.749
MOD_CK1_1	498	504	PF00069	0.753
MOD_CK1_1	513	519	PF00069	0.583
MOD_CK1_1	521	527	PF00069	0.626
MOD_CK1_1	553	559	PF00069	0.696
MOD_CK1_1	640	646	PF00069	0.573
MOD_CK2_1	122	128	PF00069	0.443
MOD_CK2_1	142	148	PF00069	0.201
MOD_CK2_1	261	267	PF00069	0.311
MOD_CK2_1	301	307	PF00069	0.254
MOD_CK2_1	372	378	PF00069	0.318
MOD_CK2_1	573	579	PF00069	0.478
MOD_CK2_1	619	625	PF00069	0.535
MOD_CK2_1	640	646	PF00069	0.314
MOD_CK2_1	92	98	PF00069	0.803
MOD_Cter_Amidation	278	281	PF01082	0.405
MOD_GlcNHglycan	144	147	PF01048	0.254
MOD_GlcNHglycan	160	164	PF01048	0.159
MOD_GlcNHglycan	2	5	PF01048	0.711
MOD_GlcNHglycan	227	230	PF01048	0.311
MOD_GlcNHglycan	269	272	PF01048	0.259
MOD_GlcNHglycan	316	319	PF01048	0.327
MOD_GlcNHglycan	350	353	PF01048	0.271
MOD_GlcNHglycan	497	500	PF01048	0.620
MOD_GlcNHglycan	554	558	PF01048	0.716
MOD_GlcNHglycan	565	568	PF01048	0.704
MOD_GlcNHglycan	575	578	PF01048	0.535
MOD_GlcNHglycan	76	79	PF01048	0.696
MOD_GSK3_1	109	116	PF00069	0.521
MOD_GSK3_1	147	154	PF00069	0.293
MOD_GSK3_1	296	303	PF00069	0.321
MOD_GSK3_1	314	321	PF00069	0.279
MOD_GSK3_1	327	334	PF00069	0.234
MOD_GSK3_1	344	351	PF00069	0.397
MOD_GSK3_1	455	462	PF00069	0.671
MOD_GSK3_1	476	483	PF00069	0.648
MOD_GSK3_1	484	491	PF00069	0.668
MOD_GSK3_1	495	502	PF00069	0.616
MOD_GSK3_1	506	513	PF00069	0.627
MOD_GSK3_1	516	523	PF00069	0.673
MOD_GSK3_1	525	532	PF00069	0.693
MOD_GSK3_1	534	541	PF00069	0.644
MOD_GSK3_1	563	570	PF00069	0.713
MOD_GSK3_1	72	79	PF00069	0.569
MOD_N-GLC_1	327	332	PF02516	0.248
MOD_N-GLC_1	382	387	PF02516	0.318
MOD_N-GLC_1	455	460	PF02516	0.467
MOD_NEK2_1	208	213	PF00069	0.382
MOD_NEK2_1	29	34	PF00069	0.496
MOD_NEK2_1	405	410	PF00069	0.306
MOD_NEK2_1	414	419	PF00069	0.301
MOD_NEK2_1	497	502	PF00069	0.679
MOD_NEK2_1	507	512	PF00069	0.638
MOD_NEK2_1	544	549	PF00069	0.522
MOD_NEK2_2	216	221	PF00069	0.318
MOD_PIKK_1	521	527	PF00454	0.566
MOD_PIKK_1	6	12	PF00454	0.482
MOD_PIKK_1	640	646	PF00454	0.552
MOD_PKA_1	130	136	PF00069	0.403
MOD_PKA_1	177	183	PF00069	0.361
MOD_PKA_1	345	351	PF00069	0.381
MOD_PKA_1	484	490	PF00069	0.659
MOD_PKA_2	113	119	PF00069	0.528
MOD_PKA_2	120	126	PF00069	0.577
MOD_PKA_2	130	136	PF00069	0.394
MOD_PKA_2	253	259	PF00069	0.424
MOD_PKA_2	345	351	PF00069	0.412
MOD_PKA_2	372	378	PF00069	0.318
MOD_PKA_2	405	411	PF00069	0.314
MOD_PKA_2	414	420	PF00069	0.301
MOD_PKA_2	459	465	PF00069	0.701
MOD_PKA_2	483	489	PF00069	0.643
MOD_PKA_2	507	513	PF00069	0.579
MOD_PKA_2	550	556	PF00069	0.686
MOD_PKA_2	563	569	PF00069	0.560
MOD_PKB_1	107	115	PF00069	0.549
MOD_PKB_1	140	148	PF00069	0.325
MOD_Plk_1	382	388	PF00069	0.318
MOD_Plk_1	437	443	PF00069	0.290
MOD_Plk_1	656	662	PF00069	0.359
MOD_Plk_2-3	308	314	PF00069	0.226
MOD_Plk_4	114	120	PF00069	0.515
MOD_Plk_4	208	214	PF00069	0.320
MOD_Plk_4	230	236	PF00069	0.318
MOD_Plk_4	261	267	PF00069	0.318
MOD_Plk_4	308	314	PF00069	0.392
MOD_Plk_4	382	388	PF00069	0.313
MOD_Plk_4	414	420	PF00069	0.276
MOD_Plk_4	507	513	PF00069	0.680
MOD_Plk_4	526	532	PF00069	0.542
MOD_Plk_4	637	643	PF00069	0.492
MOD_ProDKin_1	428	434	PF00069	0.318
MOD_ProDKin_1	518	524	PF00069	0.688
MOD_ProDKin_1	529	535	PF00069	0.712
MOD_ProDKin_1	538	544	PF00069	0.728
MOD_ProDKin_1	93	99	PF00069	0.669
MOD_SUMO_for_1	603	606	PF00179	0.467
MOD_SUMO_rev_2	164	172	PF00179	0.385
MOD_SUMO_rev_2	334	342	PF00179	0.248
TRG_DiLeu_BaEn_1	625	630	PF01217	0.394
TRG_DiLeu_BaEn_2	390	396	PF01217	0.381
TRG_DiLeu_LyEn_5	625	630	PF01217	0.394
TRG_ENDOCYTIC_2	179	182	PF00928	0.343
TRG_ENDOCYTIC_2	49	52	PF00928	0.439
TRG_ER_diArg_1	107	109	PF00400	0.695
TRG_ER_diArg_1	139	142	PF00400	0.300
TRG_ER_diArg_1	17	19	PF00400	0.536
TRG_ER_diArg_1	280	282	PF00400	0.417
TRG_ER_diArg_1	58	61	PF00400	0.397
TRG_ER_diArg_1	585	588	PF00400	0.543
TRG_ER_diArg_1	626	629	PF00400	0.571
TRG_NLS_Bipartite_1	130	144	PF00514	0.395
TRG_NLS_MonoExtC_3	129	134	PF00514	0.552
TRG_NLS_MonoExtN_4	130	135	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.248
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	587	591	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	628	633	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	74%	100%
A0A0S4IP49	Bodo saltans	27%	83%
A0A1X0NL76	Trypanosomatidae	48%	93%
A0A1X0NQ03	Trypanosomatidae	27%	81%
A0A1X0P2U1	Trypanosomatidae	59%	95%
A0A3S5H4S8	Leishmania donovani	97%	99%
A0A3S7WST0	Leishmania donovani	46%	92%
A0A3S7X9Y1	Leishmania donovani	34%	100%
A0A422NY45	Trypanosoma rangeli	55%	96%
A4H337	Leishmania braziliensis	88%	100%
A4H7F1	Leishmania braziliensis	46%	92%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HDC2	Leishmania braziliensis	40%	99%
A4HND6	Leishmania braziliensis	33%	100%
A4HRC5	Leishmania infantum	97%	99%
A4HSA6	Leishmania infantum	34%	100%
A4HVT9	Leishmania infantum	46%	92%
A4IC09	Leishmania infantum	34%	100%
C9ZXH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
E9AFU7	Leishmania major	34%	100%
E9AJ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	99%
E9API5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	92%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
P48467	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	72%
Q4QFZ3	Leishmania major	46%	92%
Q5R9Y9	Pongo abelii	39%	90%
Q940Y8	Arabidopsis thaliana	39%	98%
V5D311	Trypanosoma cruzi	47%	99%