Nocturnin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nocturnin

Gene product:

Endonuclease/Exonuclease/phosphatase family, putative

Species:

Leishmania major

UniProt:

E9ABZ1_LEIMA

TriTrypDb:

LmjF.01.0020 , LMJLV39_010005100 , LMJSD75_010005200

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ABZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ABZ1

Function

Biological processes
Term	Name	Level	Count
GO:0007623	circadian rhythm	2	11
GO:0010468	regulation of gene expression	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0032501	multicellular organismal process	1	11
GO:0032922	circadian regulation of gene expression	2	11
GO:0048511	rhythmic process	1	11
GO:0050789	regulation of biological process	2	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	11
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004527	exonuclease activity	5	11
GO:0004532	RNA exonuclease activity	5	11
GO:0004535	poly(A)-specific ribonuclease activity	8	11
GO:0004540	RNA nuclease activity	4	11
GO:0008408	3'-5' exonuclease activity	6	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0004519	endonuclease activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.426
CLV_C14_Caspase3-7	36	40	PF00656	0.595
CLV_C14_Caspase3-7	534	538	PF00656	0.359
CLV_NRD_NRD_1	156	158	PF00675	0.289
CLV_NRD_NRD_1	210	212	PF00675	0.272
CLV_NRD_NRD_1	3	5	PF00675	0.574
CLV_NRD_NRD_1	395	397	PF00675	0.331
CLV_NRD_NRD_1	476	478	PF00675	0.311
CLV_NRD_NRD_1	73	75	PF00675	0.552
CLV_NRD_NRD_1	90	92	PF00675	0.314
CLV_PCSK_FUR_1	393	397	PF00082	0.270
CLV_PCSK_KEX2_1	156	158	PF00082	0.290
CLV_PCSK_KEX2_1	178	180	PF00082	0.370
CLV_PCSK_KEX2_1	3	5	PF00082	0.574
CLV_PCSK_KEX2_1	395	397	PF00082	0.303
CLV_PCSK_KEX2_1	73	75	PF00082	0.505
CLV_PCSK_KEX2_1	90	92	PF00082	0.326
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.370
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.496
CLV_PCSK_SKI1_1	179	183	PF00082	0.289
CLV_PCSK_SKI1_1	297	301	PF00082	0.349
CLV_PCSK_SKI1_1	477	481	PF00082	0.396
CLV_PCSK_SKI1_1	545	549	PF00082	0.588
CLV_PCSK_SKI1_1	75	79	PF00082	0.423
CLV_Separin_Metazoa	162	166	PF03568	0.335
CLV_Separin_Metazoa	335	339	PF03568	0.404
DEG_APCC_DBOX_1	156	164	PF00400	0.270
DEG_APCC_DBOX_1	296	304	PF00400	0.349
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DOC_CKS1_1	150	155	PF01111	0.270
DOC_CKS1_1	428	433	PF01111	0.459
DOC_CKS1_1	437	442	PF01111	0.376
DOC_MAPK_gen_1	156	163	PF00069	0.404
DOC_MAPK_gen_1	265	273	PF00069	0.271
DOC_MAPK_gen_1	3	9	PF00069	0.630
DOC_MAPK_MEF2A_6	267	275	PF00069	0.271
DOC_PP1_RVXF_1	186	193	PF00149	0.414
DOC_PP2B_LxvP_1	245	248	PF13499	0.404
DOC_PP2B_LxvP_1	503	506	PF13499	0.271
DOC_PP4_FxxP_1	150	153	PF00568	0.279
DOC_PP4_FxxP_1	491	494	PF00568	0.289
DOC_USP7_MATH_1	13	17	PF00917	0.605
DOC_USP7_MATH_1	217	221	PF00917	0.270
DOC_USP7_MATH_1	311	315	PF00917	0.323
DOC_USP7_MATH_1	378	382	PF00917	0.396
DOC_USP7_MATH_1	458	462	PF00917	0.457
DOC_USP7_UBL2_3	474	478	PF12436	0.314
DOC_WW_Pin1_4	109	114	PF00397	0.512
DOC_WW_Pin1_4	149	154	PF00397	0.371
DOC_WW_Pin1_4	427	432	PF00397	0.368
DOC_WW_Pin1_4	436	441	PF00397	0.386
DOC_WW_Pin1_4	450	455	PF00397	0.384
LIG_14-3-3_CanoR_1	3	8	PF00244	0.543
LIG_14-3-3_CanoR_1	340	348	PF00244	0.331
LIG_14-3-3_CanoR_1	352	358	PF00244	0.345
LIG_14-3-3_CanoR_1	95	100	PF00244	0.365
LIG_APCC_ABBA_1	527	532	PF00400	0.347
LIG_BIR_III_4	104	108	PF00653	0.569
LIG_BIR_III_4	304	308	PF00653	0.335
LIG_BIR_III_4	398	402	PF00653	0.292
LIG_deltaCOP1_diTrp_1	185	192	PF00928	0.270
LIG_deltaCOP1_diTrp_1	532	539	PF00928	0.476
LIG_deltaCOP1_diTrp_1	92	99	PF00928	0.357
LIG_FHA_1	109	115	PF00498	0.519
LIG_FHA_1	270	276	PF00498	0.273
LIG_FHA_1	342	348	PF00498	0.349
LIG_FHA_1	370	376	PF00498	0.254
LIG_FHA_1	494	500	PF00498	0.289
LIG_FHA_2	110	116	PF00498	0.450
LIG_FHA_2	299	305	PF00498	0.363
LIG_FHA_2	431	437	PF00498	0.204
LIG_LIR_Apic_2	488	494	PF02991	0.289
LIG_LIR_Gen_1	98	105	PF02991	0.419
LIG_LIR_Nem_3	144	150	PF02991	0.458
LIG_LIR_Nem_3	184	190	PF02991	0.319
LIG_LIR_Nem_3	486	492	PF02991	0.271
LIG_LIR_Nem_3	537	542	PF02991	0.432
LIG_LIR_Nem_3	92	96	PF02991	0.368
LIG_MYND_1	149	153	PF01753	0.279
LIG_NRBOX	159	165	PF00104	0.270
LIG_PCNA_yPIPBox_3	178	190	PF02747	0.317
LIG_Pex14_1	535	539	PF04695	0.501
LIG_SH2_CRK	195	199	PF00017	0.271
LIG_SH2_CRK	402	406	PF00017	0.335
LIG_SH2_SRC	139	142	PF00017	0.406
LIG_SH2_SRC	492	495	PF00017	0.335
LIG_SH2_STAP1	367	371	PF00017	0.407
LIG_SH2_STAT3	484	487	PF00017	0.326
LIG_SH2_STAT5	189	192	PF00017	0.305
LIG_SH2_STAT5	274	277	PF00017	0.406
LIG_SH2_STAT5	371	374	PF00017	0.351
LIG_SH3_3	116	122	PF00018	0.391
LIG_SH3_3	345	351	PF00018	0.289
LIG_SH3_3	434	440	PF00018	0.300
LIG_SH3_3	74	80	PF00018	0.432
LIG_SUMO_SIM_anti_2	468	476	PF11976	0.335
LIG_SUMO_SIM_par_1	298	304	PF11976	0.404
LIG_SUMO_SIM_par_1	501	510	PF11976	0.271
LIG_TRAF2_1	226	229	PF00917	0.404
LIG_TRAF2_1	387	390	PF00917	0.334
LIG_TYR_ITIM	193	198	PF00017	0.349
LIG_WRC_WIRS_1	96	101	PF05994	0.379
MOD_CDK_SPK_2	427	432	PF00069	0.270
MOD_CDK_SPxxK_3	149	156	PF00069	0.371
MOD_CK1_1	314	320	PF00069	0.314
MOD_CK1_1	453	459	PF00069	0.363
MOD_CK1_1	82	88	PF00069	0.438
MOD_CK2_1	109	115	PF00069	0.432
MOD_CK2_1	42	48	PF00069	0.700
MOD_CK2_1	430	436	PF00069	0.307
MOD_CK2_1	543	549	PF00069	0.474
MOD_CMANNOS	353	356	PF00535	0.271
MOD_GlcNHglycan	15	18	PF01048	0.635
MOD_GlcNHglycan	44	47	PF01048	0.677
MOD_GlcNHglycan	455	458	PF01048	0.414
MOD_GSK3_1	177	184	PF00069	0.412
MOD_GSK3_1	194	201	PF00069	0.234
MOD_GSK3_1	24	31	PF00069	0.725
MOD_GSK3_1	278	285	PF00069	0.271
MOD_GSK3_1	426	433	PF00069	0.347
MOD_GSK3_1	531	538	PF00069	0.392
MOD_GSK3_1	79	86	PF00069	0.472
MOD_N-GLC_1	269	274	PF02516	0.311
MOD_N-GLC_2	134	136	PF02516	0.318
MOD_NEK2_1	198	203	PF00069	0.303
MOD_NEK2_1	24	29	PF00069	0.748
MOD_NEK2_1	473	478	PF00069	0.373
MOD_NEK2_1	84	89	PF00069	0.448
MOD_NEK2_2	194	199	PF00069	0.289
MOD_NEK2_2	543	548	PF00069	0.531
MOD_PIKK_1	483	489	PF00454	0.271
MOD_PIKK_1	79	85	PF00454	0.584
MOD_PK_1	3	9	PF00069	0.700
MOD_PKA_1	3	9	PF00069	0.609
MOD_PKA_2	24	30	PF00069	0.673
MOD_PKA_2	3	9	PF00069	0.566
MOD_PKA_2	33	39	PF00069	0.468
MOD_PKA_2	351	357	PF00069	0.294
MOD_PKB_1	338	346	PF00069	0.243
MOD_Plk_1	269	275	PF00069	0.311
MOD_Plk_1	531	537	PF00069	0.317
MOD_Plk_4	194	200	PF00069	0.281
MOD_Plk_4	269	275	PF00069	0.408
MOD_Plk_4	298	304	PF00069	0.390
MOD_Plk_4	3	9	PF00069	0.630
MOD_Plk_4	33	39	PF00069	0.706
MOD_Plk_4	366	372	PF00069	0.397
MOD_Plk_4	50	56	PF00069	0.550
MOD_ProDKin_1	109	115	PF00069	0.510
MOD_ProDKin_1	149	155	PF00069	0.371
MOD_ProDKin_1	427	433	PF00069	0.368
MOD_ProDKin_1	436	442	PF00069	0.386
MOD_ProDKin_1	450	456	PF00069	0.384
MOD_SUMO_rev_2	170	180	PF00179	0.292
MOD_SUMO_rev_2	45	52	PF00179	0.599
TRG_DiLeu_BaEn_2	145	151	PF01217	0.314
TRG_ENDOCYTIC_2	189	192	PF00928	0.291
TRG_ENDOCYTIC_2	195	198	PF00928	0.254
TRG_ENDOCYTIC_2	402	405	PF00928	0.335
TRG_ER_diArg_1	117	120	PF00400	0.487
TRG_ER_diArg_1	2	4	PF00400	0.575
TRG_ER_diArg_1	394	396	PF00400	0.318
TRG_NLS_MonoExtN_4	474	481	PF00514	0.292
TRG_NLS_MonoExtN_4	70	77	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Q6	Leptomonas seymouri	64%	99%
A0A0S4JIK0	Bodo saltans	39%	86%
A0A1X0P355	Trypanosomatidae	47%	99%
A0A3S5H4S7	Leishmania donovani	94%	99%
A4H336	Leishmania braziliensis	87%	99%
A4HRC4	Leishmania infantum	94%	100%
C9ZXH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AJ88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B795	Trypanosoma cruzi	51%	98%