Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania major

UniProt:

E9ABZ0_LEIMA

TriTrypDb:

LmjF.01.0010 , LMJLV39_010005000 , LMJSD75_010005000

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 15, no: 2
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

E9ABZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ABZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.701
CLV_NRD_NRD_1	274	276	PF00675	0.408
CLV_NRD_NRD_1	282	284	PF00675	0.451
CLV_PCSK_KEX2_1	160	162	PF00082	0.564
CLV_PCSK_KEX2_1	273	275	PF00082	0.433
CLV_PCSK_KEX2_1	280	282	PF00082	0.469
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.599
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.482
CLV_PCSK_SKI1_1	105	109	PF00082	0.626
CLV_PCSK_SKI1_1	112	116	PF00082	0.531
CLV_PCSK_SKI1_1	2	6	PF00082	0.577
CLV_PCSK_SKI1_1	233	237	PF00082	0.690
DEG_APCC_DBOX_1	1	9	PF00400	0.318
DEG_Nend_UBRbox_1	1	4	PF02207	0.442
DEG_SPOP_SBC_1	24	28	PF00917	0.468
DEG_SPOP_SBC_1	59	63	PF00917	0.310
DOC_MAPK_MEF2A_6	2	10	PF00069	0.394
DOC_USP7_MATH_1	204	208	PF00917	0.493
DOC_USP7_MATH_1	210	214	PF00917	0.487
DOC_USP7_MATH_1	297	301	PF00917	0.661
DOC_USP7_MATH_1	327	331	PF00917	0.781
DOC_USP7_MATH_1	69	73	PF00917	0.432
DOC_USP7_UBL2_3	220	224	PF12436	0.337
DOC_WW_Pin1_4	126	131	PF00397	0.440
LIG_14-3-3_CanoR_1	133	141	PF00244	0.522
LIG_14-3-3_CanoR_1	306	311	PF00244	0.704
LIG_BIR_III_2	127	131	PF00653	0.370
LIG_BRCT_BRCA1_1	176	180	PF00533	0.438
LIG_BRCT_BRCA1_1	35	39	PF00533	0.330
LIG_deltaCOP1_diTrp_1	100	108	PF00928	0.412
LIG_eIF4E_1	157	163	PF01652	0.458
LIG_FHA_1	109	115	PF00498	0.486
LIG_FHA_1	132	138	PF00498	0.432
LIG_FHA_1	179	185	PF00498	0.375
LIG_FHA_2	127	133	PF00498	0.539
LIG_FHA_2	140	146	PF00498	0.403
LIG_FHA_2	296	302	PF00498	0.742
LIG_FHA_2	319	325	PF00498	0.730
LIG_FHA_2	95	101	PF00498	0.443
LIG_GBD_Chelix_1	251	259	PF00786	0.473
LIG_IRF3_LxIS_1	258	265	PF10401	0.318
LIG_LIR_Apic_2	232	237	PF02991	0.505
LIG_LIR_Gen_1	138	149	PF02991	0.465
LIG_LIR_Gen_1	177	188	PF02991	0.439
LIG_LIR_Gen_1	45	54	PF02991	0.399
LIG_LIR_Nem_3	100	104	PF02991	0.372
LIG_LIR_Nem_3	138	144	PF02991	0.461
LIG_LIR_Nem_3	151	155	PF02991	0.418
LIG_LIR_Nem_3	177	183	PF02991	0.386
LIG_LIR_Nem_3	186	190	PF02991	0.370
LIG_LIR_Nem_3	45	51	PF02991	0.344
LIG_SH2_CRK	104	108	PF00017	0.373
LIG_SH2_GRB2like	141	144	PF00017	0.374
LIG_SH2_GRB2like	290	293	PF00017	0.797
LIG_SH2_PTP2	256	259	PF00017	0.357
LIG_SH2_SRC	188	191	PF00017	0.488
LIG_SH2_STAP1	25	29	PF00017	0.342
LIG_SH2_STAT3	290	293	PF00017	0.681
LIG_SH2_STAT5	141	144	PF00017	0.408
LIG_SH2_STAT5	188	191	PF00017	0.406
LIG_SH2_STAT5	221	224	PF00017	0.511
LIG_SH2_STAT5	256	259	PF00017	0.431
LIG_SH2_STAT5	29	32	PF00017	0.276
LIG_SH3_1	198	204	PF00018	0.441
LIG_SH3_3	161	167	PF00018	0.415
LIG_SH3_3	198	204	PF00018	0.507
LIG_SUMO_SIM_par_1	42	47	PF11976	0.282
LIG_TRAF2_1	65	68	PF00917	0.384
LIG_TYR_ITIM	119	124	PF00017	0.468
LIG_TYR_ITIM	254	259	PF00017	0.451
MOD_CDK_SPxxK_3	126	133	PF00069	0.407
MOD_CK1_1	215	221	PF00069	0.501
MOD_CK1_1	318	324	PF00069	0.727
MOD_CK1_1	33	39	PF00069	0.385
MOD_CK2_1	139	145	PF00069	0.456
MOD_CK2_1	295	301	PF00069	0.699
MOD_CK2_1	326	332	PF00069	0.793
MOD_CK2_1	62	68	PF00069	0.365
MOD_CK2_1	94	100	PF00069	0.450
MOD_Cter_Amidation	158	161	PF01082	0.663
MOD_Cter_Amidation	222	225	PF01082	0.592
MOD_GlcNHglycan	137	140	PF01048	0.683
MOD_GlcNHglycan	167	170	PF01048	0.661
MOD_GlcNHglycan	206	209	PF01048	0.611
MOD_GlcNHglycan	214	217	PF01048	0.763
MOD_GlcNHglycan	32	35	PF01048	0.569
MOD_GlcNHglycan	62	65	PF01048	0.559
MOD_GlcNHglycan	71	74	PF01048	0.526
MOD_GSK3_1	131	138	PF00069	0.532
MOD_GSK3_1	139	146	PF00069	0.502
MOD_GSK3_1	171	178	PF00069	0.461
MOD_GSK3_1	19	26	PF00069	0.355
MOD_GSK3_1	211	218	PF00069	0.521
MOD_GSK3_1	302	309	PF00069	0.675
MOD_GSK3_1	311	318	PF00069	0.689
MOD_GSK3_1	55	62	PF00069	0.350
MOD_N-GLC_1	153	158	PF02516	0.710
MOD_N-GLC_1	239	244	PF02516	0.689
MOD_NEK2_1	107	112	PF00069	0.449
MOD_NEK2_1	211	216	PF00069	0.420
MOD_NEK2_1	262	267	PF00069	0.473
MOD_NEK2_1	302	307	PF00069	0.662
MOD_NEK2_1	310	315	PF00069	0.659
MOD_NEK2_1	60	65	PF00069	0.298
MOD_PIKK_1	227	233	PF00454	0.532
MOD_PIKK_1	285	291	PF00454	0.702
MOD_PIKK_1	295	301	PF00454	0.680
MOD_PIKK_1	94	100	PF00454	0.422
MOD_PKA_2	108	114	PF00069	0.527
MOD_PKA_2	132	138	PF00069	0.377
MOD_PKA_2	310	316	PF00069	0.708
MOD_Plk_1	153	159	PF00069	0.501
MOD_Plk_1	239	245	PF00069	0.454
MOD_Plk_2-3	320	326	PF00069	0.767
MOD_Plk_4	153	159	PF00069	0.474
MOD_Plk_4	311	317	PF00069	0.712
MOD_ProDKin_1	126	132	PF00069	0.436
TRG_ENDOCYTIC_2	104	107	PF00928	0.448
TRG_ENDOCYTIC_2	121	124	PF00928	0.447
TRG_ENDOCYTIC_2	141	144	PF00928	0.392
TRG_ENDOCYTIC_2	256	259	PF00928	0.440
TRG_ER_diArg_1	272	275	PF00400	0.688
TRG_ER_diArg_1	281	283	PF00400	0.739

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P471	Leptomonas seymouri	38%	100%
A0A0N1I022	Leptomonas seymouri	51%	97%
A0A1X0NWG7	Trypanosomatidae	25%	90%
A0A1X0NWG9	Trypanosomatidae	26%	91%
A0A1X0NXT1	Trypanosomatidae	24%	91%
A0A1X0NY10	Trypanosomatidae	27%	100%
A0A3Q8IBH3	Leishmania donovani	37%	100%
A0A3S5H4S6	Leishmania donovani	95%	100%
A4H335	Leishmania braziliensis	84%	100%
A4HRC3	Leishmania infantum	96%	100%
A4HYN5	Leishmania infantum	36%	100%
E9AI94	Leishmania braziliensis	35%	100%
E9AJ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
E9AUH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q4QD05	Leishmania major	35%	100%
V5DS51	Trypanosoma cruzi	30%	94%