Uncharacterized protein LmxM_33_1840_1

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHS5_LEIMU

TriTrypDb:

LmxM.33.1840

Length:

310

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 52
NetGPI	no	yes: 0, no: 52

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	48
GO:0110165	cellular anatomical entity	1	48

Expansion

Sequence features

E8NHS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.359
CLV_NRD_NRD_1	27	29	PF00675	0.373
CLV_NRD_NRD_1	61	63	PF00675	0.401
CLV_PCSK_KEX2_1	103	105	PF00082	0.360
CLV_PCSK_KEX2_1	27	29	PF00082	0.373
CLV_PCSK_KEX2_1	45	47	PF00082	0.426
CLV_PCSK_KEX2_1	60	62	PF00082	0.405
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.423
CLV_PCSK_PC7_1	57	63	PF00082	0.402
CLV_PCSK_SKI1_1	260	264	PF00082	0.421
DEG_APCC_DBOX_1	27	35	PF00400	0.582
DEG_SPOP_SBC_1	305	309	PF00917	0.571
DOC_CKS1_1	140	145	PF01111	0.396
DOC_CYCLIN_yCln2_LP_2	88	91	PF00134	0.555
DOC_MAPK_DCC_7	68	78	PF00069	0.572
DOC_MAPK_MEF2A_6	226	234	PF00069	0.616
DOC_PP2B_LxvP_1	88	91	PF13499	0.555
DOC_USP7_MATH_1	305	309	PF00917	0.574
DOC_USP7_MATH_1	77	81	PF00917	0.562
DOC_USP7_MATH_1	8	12	PF00917	0.558
DOC_WW_Pin1_4	139	144	PF00397	0.442
DOC_WW_Pin1_4	301	306	PF00397	0.540
DOC_WW_Pin1_4	37	42	PF00397	0.602
DOC_WW_Pin1_4	6	11	PF00397	0.565
DOC_WW_Pin1_4	66	71	PF00397	0.590
LIG_14-3-3_CanoR_1	33	41	PF00244	0.603
LIG_14-3-3_CanoR_1	50	58	PF00244	0.627
LIG_14-3-3_CanoR_1	60	70	PF00244	0.598
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BRCT_BRCA1_1	221	225	PF00533	0.404
LIG_DLG_GKlike_1	27	34	PF00625	0.580
LIG_eIF4E_1	127	133	PF01652	0.306
LIG_FHA_1	172	178	PF00498	0.266
LIG_FHA_1	237	243	PF00498	0.439
LIG_FHA_1	265	271	PF00498	0.230
LIG_FHA_1	61	67	PF00498	0.593
LIG_FHA_2	140	146	PF00498	0.477
LIG_FHA_2	38	44	PF00498	0.603
LIG_GBD_Chelix_1	122	130	PF00786	0.238
LIG_IRF3_LxIS_1	10	17	PF10401	0.547
LIG_LIR_Apic_2	2	8	PF02991	0.577
LIG_LIR_Gen_1	224	235	PF02991	0.434
LIG_LIR_Nem_3	222	228	PF02991	0.523
LIG_Pex14_2	268	272	PF04695	0.387
LIG_SH2_CRK	5	9	PF00017	0.571
LIG_SH2_PTP2	127	130	PF00017	0.376
LIG_SH2_STAT5	127	130	PF00017	0.394
LIG_SH2_STAT5	176	179	PF00017	0.268
LIG_SH2_STAT5	208	211	PF00017	0.264
LIG_SH2_STAT5	5	8	PF00017	0.576
LIG_SH3_1	103	109	PF00018	0.549
LIG_SH3_3	103	109	PF00018	0.558
LIG_SH3_3	137	143	PF00018	0.374
LIG_SH3_3	23	29	PF00018	0.568
LIG_SH3_3	73	79	PF00018	0.574
LIG_SUMO_SIM_anti_2	121	127	PF11976	0.223
LIG_SUMO_SIM_anti_2	15	20	PF11976	0.543
LIG_SUMO_SIM_par_1	136	142	PF11976	0.311
LIG_TRFH_1	71	75	PF08558	0.574
LIG_TYR_ITIM	125	130	PF00017	0.477
MOD_CK1_1	293	299	PF00069	0.508
MOD_CK1_1	64	70	PF00069	0.584
MOD_GlcNHglycan	10	13	PF01048	0.350
MOD_GlcNHglycan	209	212	PF01048	0.234
MOD_GlcNHglycan	63	66	PF01048	0.390
MOD_GlcNHglycan	81	84	PF01048	0.371
MOD_GSK3_1	172	179	PF00069	0.296
MOD_GSK3_1	290	297	PF00069	0.347
MOD_GSK3_1	301	308	PF00069	0.631
MOD_GSK3_1	56	63	PF00069	0.609
MOD_GSK3_1	8	15	PF00069	0.552
MOD_N-GLC_1	172	177	PF02516	0.442
MOD_N-GLC_1	301	306	PF02516	0.343
MOD_NEK2_1	118	123	PF00069	0.530
MOD_NEK2_1	14	19	PF00069	0.544
MOD_NEK2_1	219	224	PF00069	0.291
MOD_NEK2_1	247	252	PF00069	0.400
MOD_NEK2_1	274	279	PF00069	0.238
MOD_NEK2_1	290	295	PF00069	0.294
MOD_NEK2_1	32	37	PF00069	0.606
MOD_NEK2_2	221	226	PF00069	0.406
MOD_PIKK_1	104	110	PF00454	0.540
MOD_PIKK_1	32	38	PF00454	0.597
MOD_PKA_1	27	33	PF00069	0.578
MOD_PKA_1	60	66	PF00069	0.593
MOD_PKA_2	27	33	PF00069	0.578
MOD_PKA_2	56	62	PF00069	0.609
MOD_PKB_1	48	56	PF00069	0.622
MOD_Plk_1	172	178	PF00069	0.273
MOD_Plk_1	264	270	PF00069	0.224
MOD_Plk_4	118	124	PF00069	0.441
MOD_Plk_4	160	166	PF00069	0.334
MOD_Plk_4	172	178	PF00069	0.265
MOD_Plk_4	247	253	PF00069	0.267
MOD_Plk_4	27	33	PF00069	0.578
MOD_ProDKin_1	139	145	PF00069	0.442
MOD_ProDKin_1	301	307	PF00069	0.545
MOD_ProDKin_1	37	43	PF00069	0.604
MOD_ProDKin_1	6	12	PF00069	0.562
MOD_ProDKin_1	66	72	PF00069	0.589
MOD_SUMO_for_1	262	265	PF00179	0.214
MOD_SUMO_rev_2	254	262	PF00179	0.208
TRG_ENDOCYTIC_2	127	130	PF00928	0.462
TRG_ER_diArg_1	102	104	PF00400	0.567
TRG_ER_diArg_1	26	28	PF00400	0.572
TRG_ER_diArg_1	46	49	PF00400	0.624
TRG_ER_diArg_1	60	62	PF00400	0.599
TRG_NLS_Bipartite_1	27	49	PF00514	0.598
TRG_NLS_MonoExtN_4	42	49	PF00514	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A381MTC7	Leishmania infantum	45%	100%
A0A3Q8IFH7	Leishmania donovani	45%	100%
A0A3Q8IHZ6	Leishmania donovani	53%	100%
A0A3S5H7L2	Leishmania donovani	43%	100%
A0A3S7X357	Leishmania donovani	28%	100%
A0A3S7X7E5	Leishmania donovani	49%	100%
A0A3S7X7M4	Leishmania donovani	53%	100%
A0A3S7X7U1	Leishmania donovani	45%	100%
A0A3S7X7W2	Leishmania donovani	40%	100%
A4H595	Leishmania braziliensis	42%	100%
A4H596	Leishmania braziliensis	43%	100%
A4H597	Leishmania braziliensis	43%	100%
A4H5G4	Leishmania braziliensis	42%	100%
A4H5G6	Leishmania braziliensis	37%	100%
A4H5G7	Leishmania braziliensis	40%	100%
A4H5H3	Leishmania braziliensis	44%	100%
A4H9E8	Leishmania braziliensis	46%	100%
A4HAJ4	Leishmania braziliensis	43%	100%
A4HAJ5	Leishmania braziliensis	41%	100%
A4HAJ6	Leishmania braziliensis	43%	100%
A4HBJ2	Leishmania braziliensis	44%	100%
A4HDI3	Leishmania braziliensis	27%	100%
A4I4J2	Leishmania infantum	42%	100%
A4I4J3	Leishmania infantum	41%	100%
A4I5B9	Leishmania infantum	28%	100%
A4I9X0	Leishmania infantum	41%	100%
A4IA59	Leishmania infantum	40%	100%
E8NHD3	Leishmania infantum	44%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AHT2	Leishmania infantum	53%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q397	Leishmania major	46%	100%
Q4Q3F7	Leishmania major	51%	100%
Q4Q7L6	Leishmania major	28%	100%