WGS CADB00000000 data, contig 97

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHS4_LEIMU

TriTrypDb:

LmxM.15.0440b

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHS4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.464
CLV_C14_Caspase3-7	513	517	PF00656	0.367
CLV_C14_Caspase3-7	52	56	PF00656	0.308
CLV_NRD_NRD_1	148	150	PF00675	0.380
CLV_NRD_NRD_1	218	220	PF00675	0.498
CLV_NRD_NRD_1	549	551	PF00675	0.554
CLV_NRD_NRD_1	555	557	PF00675	0.618
CLV_NRD_NRD_1	610	612	PF00675	0.414
CLV_PCSK_KEX2_1	148	150	PF00082	0.442
CLV_PCSK_KEX2_1	218	220	PF00082	0.498
CLV_PCSK_KEX2_1	262	264	PF00082	0.354
CLV_PCSK_KEX2_1	514	516	PF00082	0.447
CLV_PCSK_KEX2_1	548	550	PF00082	0.581
CLV_PCSK_KEX2_1	555	557	PF00082	0.604
CLV_PCSK_KEX2_1	610	612	PF00082	0.414
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.360
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.345
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.464
CLV_PCSK_SKI1_1	23	27	PF00082	0.378
CLV_PCSK_SKI1_1	515	519	PF00082	0.341
CLV_PCSK_SKI1_1	645	649	PF00082	0.415
CLV_Separin_Metazoa	447	451	PF03568	0.378
CLV_Separin_Metazoa	453	457	PF03568	0.337
CLV_Separin_Metazoa	66	70	PF03568	0.349
DEG_APCC_DBOX_1	488	496	PF00400	0.349
DEG_APCC_DBOX_1	99	107	PF00400	0.371
DEG_Nend_UBRbox_1	1	4	PF02207	0.395
DOC_CDC14_PxL_1	27	35	PF14671	0.294
DOC_CDC14_PxL_1	649	657	PF14671	0.435
DOC_CYCLIN_RxL_1	346	358	PF00134	0.416
DOC_MAPK_DCC_7	100	108	PF00069	0.342
DOC_MAPK_gen_1	100	108	PF00069	0.342
DOC_MAPK_gen_1	148	157	PF00069	0.314
DOC_MAPK_gen_1	262	269	PF00069	0.425
DOC_MAPK_MEF2A_6	100	108	PF00069	0.342
DOC_PP2B_LxvP_1	426	429	PF13499	0.321
DOC_USP7_MATH_1	112	116	PF00917	0.338
DOC_USP7_MATH_1	327	331	PF00917	0.354
DOC_WW_Pin1_4	221	226	PF00397	0.367
LIG_14-3-3_CanoR_1	555	561	PF00244	0.623
LIG_14-3-3_CanoR_1	601	605	PF00244	0.360
LIG_Actin_WH2_1	515	532	PF00022	0.362
LIG_APCC_ABBA_1	339	344	PF00400	0.391
LIG_APCC_ABBA_1	6	11	PF00400	0.331
LIG_APCC_ABBA_1	628	633	PF00400	0.419
LIG_APCC_ABBAyCdc20_2	504	510	PF00400	0.347
LIG_deltaCOP1_diTrp_1	119	124	PF00928	0.296
LIG_EH_1	336	340	PF12763	0.379
LIG_FHA_1	578	584	PF00498	0.580
LIG_FHA_2	167	173	PF00498	0.304
LIG_FHA_2	549	555	PF00498	0.631
LIG_FHA_2	561	567	PF00498	0.549
LIG_LIR_Gen_1	123	131	PF02991	0.311
LIG_LIR_Gen_1	277	288	PF02991	0.361
LIG_LIR_Gen_1	505	512	PF02991	0.411
LIG_LIR_Gen_1	591	602	PF02991	0.400
LIG_LIR_Nem_3	119	124	PF02991	0.310
LIG_LIR_Nem_3	181	186	PF02991	0.345
LIG_LIR_Nem_3	204	210	PF02991	0.381
LIG_LIR_Nem_3	277	283	PF02991	0.342
LIG_LIR_Nem_3	28	33	PF02991	0.332
LIG_LIR_Nem_3	505	511	PF02991	0.395
LIG_LIR_Nem_3	591	597	PF02991	0.401
LIG_LIR_Nem_3	650	655	PF02991	0.429
LIG_LYPXL_yS_3	257	260	PF13949	0.375
LIG_LYPXL_yS_3	30	33	PF13949	0.401
LIG_LYPXL_yS_3	652	655	PF13949	0.449
LIG_RPA_C_Fungi	14	26	PF08784	0.299
LIG_RPA_C_Fungi	460	472	PF08784	0.333
LIG_RPA_C_Fungi	636	648	PF08784	0.426
LIG_SH2_NCK_1	163	167	PF00017	0.306
LIG_SH2_PTP2	497	500	PF00017	0.352
LIG_SH2_SRC	163	166	PF00017	0.305
LIG_SH2_SRC	497	500	PF00017	0.352
LIG_SH2_STAP1	163	167	PF00017	0.306
LIG_SH2_STAP1	612	616	PF00017	0.387
LIG_SH2_STAT5	361	364	PF00017	0.316
LIG_SH2_STAT5	497	500	PF00017	0.352
LIG_SH3_1	497	503	PF00018	0.340
LIG_SH3_3	181	187	PF00018	0.350
LIG_SH3_3	189	195	PF00018	0.336
LIG_SH3_3	199	205	PF00018	0.337
LIG_SH3_3	28	34	PF00018	0.290
LIG_SH3_3	335	341	PF00018	0.422
LIG_SH3_3	411	417	PF00018	0.332
LIG_SH3_3	497	503	PF00018	0.397
LIG_SH3_3	586	592	PF00018	0.452
LIG_SH3_3	650	656	PF00018	0.433
LIG_TRAF2_1	249	252	PF00917	0.417
LIG_TRAF2_1	531	534	PF00917	0.355
LIG_TRAF2_1	56	59	PF00917	0.362
LIG_TRAF2_1	618	621	PF00917	0.392
LIG_TRAF2_1	94	97	PF00917	0.410
LIG_UBA3_1	127	136	PF00899	0.372
LIG_UBA3_1	507	514	PF00899	0.339
MOD_CK2_1	117	123	PF00069	0.336
MOD_CK2_1	517	523	PF00069	0.385
MOD_CK2_1	548	554	PF00069	0.481
MOD_CK2_1	560	566	PF00069	0.502
MOD_CK2_1	582	588	PF00069	0.532
MOD_CK2_1	600	606	PF00069	0.358
MOD_GlcNHglycan	584	587	PF01048	0.523
MOD_GSK3_1	556	563	PF00069	0.545
MOD_NEK2_1	422	427	PF00069	0.463
MOD_NEK2_1	600	605	PF00069	0.385
MOD_NEK2_2	474	479	PF00069	0.353
MOD_NEK2_2	612	617	PF00069	0.390
MOD_PIKK_1	166	172	PF00454	0.312
MOD_PIKK_1	353	359	PF00454	0.329
MOD_PKA_1	548	554	PF00069	0.497
MOD_PKA_1	555	561	PF00069	0.517
MOD_PKA_2	247	253	PF00069	0.394
MOD_PKA_2	548	554	PF00069	0.712
MOD_PKA_2	555	561	PF00069	0.508
MOD_PKA_2	600	606	PF00069	0.370
MOD_Plk_1	474	480	PF00069	0.360
MOD_Plk_4	600	606	PF00069	0.392
MOD_ProDKin_1	221	227	PF00069	0.364
TRG_AP2beta_CARGO_1	277	287	PF09066	0.347
TRG_AP2beta_CARGO_1	505	515	PF09066	0.336
TRG_DiLeu_BaEn_1	123	128	PF01217	0.324
TRG_DiLeu_BaEn_2	100	106	PF01217	0.370
TRG_DiLeu_BaEn_2	180	186	PF01217	0.369
TRG_DiLeu_BaEn_2	27	33	PF01217	0.288
TRG_DiLeu_BaEn_2	649	655	PF01217	0.425
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.378
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.334
TRG_DiLeu_BaLyEn_6	579	584	PF01217	0.547
TRG_ENDOCYTIC_2	257	260	PF00928	0.375
TRG_ENDOCYTIC_2	30	33	PF00928	0.401
TRG_ENDOCYTIC_2	594	597	PF00928	0.393
TRG_ENDOCYTIC_2	652	655	PF00928	0.511
TRG_ER_diArg_1	148	150	PF00400	0.375
TRG_ER_diArg_1	217	219	PF00400	0.480
TRG_ER_diArg_1	308	311	PF00400	0.386
TRG_ER_diArg_1	368	371	PF00400	0.427
TRG_ER_diArg_1	549	552	PF00400	0.575
TRG_ER_diArg_1	555	557	PF00400	0.627
TRG_ER_diArg_1	60	63	PF00400	0.383
TRG_ER_diArg_1	609	611	PF00400	0.431
TRG_ER_diArg_1	81	84	PF00400	0.365
TRG_NLS_MonoExtC_3	547	552	PF00514	0.458
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYQ1	Trypanosomatidae	34%	70%
A0A3R7KIM7	Trypanosoma rangeli	36%	100%
A4H817	Leishmania braziliensis	52%	100%
A4I2N7	Leishmania infantum	27%	100%
E8NHH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	93%
E8NHP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
V5BG02	Trypanosoma cruzi	29%	100%