WGS CADB00000000 data, contig 96

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHS3_LEIMU

TriTrypDb:

LmxM.08.1070partial

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 35, no: 6
NetGPI	no	yes: 0, no: 41

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	9
GO:0000323	lytic vacuole	6	8
GO:0005615	extracellular space	2	8
GO:0005764	lysosome	7	8
GO:0005773	vacuole	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

E8NHS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHS3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	42
GO:0006807	nitrogen compound metabolic process	2	42
GO:0008152	metabolic process	1	42
GO:0019538	protein metabolic process	3	42
GO:0043170	macromolecule metabolic process	3	42
GO:0044238	primary metabolic process	2	42
GO:0071704	organic substance metabolic process	2	42
GO:1901564	organonitrogen compound metabolic process	3	42
GO:0051603	proteolysis involved in protein catabolic process	5	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	42
GO:0004175	endopeptidase activity	4	28
GO:0004197	cysteine-type endopeptidase activity	5	28
GO:0008233	peptidase activity	3	42
GO:0008234	cysteine-type peptidase activity	4	42
GO:0016787	hydrolase activity	2	42
GO:0140096	catalytic activity, acting on a protein	2	42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.467
CLV_NRD_NRD_1	308	310	PF00675	0.280
CLV_NRD_NRD_1	48	50	PF00675	0.582
CLV_PCSK_KEX2_1	41	43	PF00082	0.428
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.426
DEG_APCC_DBOX_1	51	59	PF00400	0.547
DEG_Nend_UBRbox_1	1	4	PF02207	0.371
DEG_SPOP_SBC_1	278	282	PF00917	0.458
DOC_MAPK_MEF2A_6	189	197	PF00069	0.433
DOC_USP7_MATH_1	147	151	PF00917	0.364
DOC_USP7_MATH_1	156	160	PF00917	0.364
DOC_USP7_MATH_1	278	282	PF00917	0.293
DOC_USP7_MATH_1	78	82	PF00917	0.546
DOC_USP7_UBL2_3	310	314	PF12436	0.309
DOC_WW_Pin1_4	283	288	PF00397	0.348
DOC_WW_Pin1_4	329	334	PF00397	0.226
DOC_WW_Pin1_4	68	73	PF00397	0.421
LIG_14-3-3_CanoR_1	309	313	PF00244	0.442
LIG_BRCT_BRCA1_1	341	345	PF00533	0.225
LIG_FHA_1	209	215	PF00498	0.371
LIG_FHA_1	228	234	PF00498	0.463
LIG_FHA_2	280	286	PF00498	0.330
LIG_LIR_Gen_1	248	258	PF02991	0.401
LIG_LIR_LC3C_4	161	166	PF02991	0.251
LIG_LIR_Nem_3	143	149	PF02991	0.444
LIG_LIR_Nem_3	16	21	PF02991	0.551
LIG_LIR_Nem_3	200	205	PF02991	0.356
LIG_LIR_Nem_3	232	238	PF02991	0.379
LIG_LIR_Nem_3	248	254	PF02991	0.336
LIG_LYPXL_yS_3	146	149	PF13949	0.327
LIG_PCNA_PIPBox_1	12	21	PF02747	0.325
LIG_PCNA_yPIPBox_3	7	19	PF02747	0.333
LIG_SH2_GRB2like	30	33	PF00017	0.520
LIG_SH2_GRB2like	341	344	PF00017	0.284
LIG_SH2_PTP2	251	254	PF00017	0.356
LIG_SH2_SRC	30	33	PF00017	0.538
LIG_SH2_STAP1	341	345	PF00017	0.225
LIG_SH2_STAT5	148	151	PF00017	0.368
LIG_SH2_STAT5	154	157	PF00017	0.368
LIG_SH2_STAT5	251	254	PF00017	0.356
LIG_SH2_STAT5	30	33	PF00017	0.499
LIG_SH2_STAT5	36	39	PF00017	0.498
LIG_SH2_STAT5	363	366	PF00017	0.529
LIG_SH2_STAT5	96	99	PF00017	0.278
LIG_SUMO_SIM_par_1	101	107	PF11976	0.397
LIG_SUMO_SIM_par_1	290	295	PF11976	0.248
LIG_TYR_ITIM	233	238	PF00017	0.492
MOD_CDC14_SPxK_1	332	335	PF00782	0.225
MOD_CDK_SPxK_1	329	335	PF00069	0.225
MOD_CDK_SPxK_1	68	74	PF00069	0.421
MOD_CDK_SPxxK_3	283	290	PF00069	0.225
MOD_CK1_1	159	165	PF00069	0.420
MOD_CK1_1	201	207	PF00069	0.360
MOD_CK1_1	281	287	PF00069	0.442
MOD_CK2_1	101	107	PF00069	0.338
MOD_CK2_1	19	25	PF00069	0.440
MOD_CK2_1	279	285	PF00069	0.314
MOD_GlcNHglycan	149	152	PF01048	0.379
MOD_GlcNHglycan	206	209	PF01048	0.523
MOD_GlcNHglycan	268	271	PF01048	0.380
MOD_GlcNHglycan	274	277	PF01048	0.339
MOD_GlcNHglycan	54	58	PF01048	0.582
MOD_GlcNHglycan	85	88	PF01048	0.509
MOD_GSK3_1	197	204	PF00069	0.377
MOD_GSK3_1	277	284	PF00069	0.428
MOD_GSK3_1	364	371	PF00069	0.490
MOD_N-GLC_1	159	164	PF02516	0.523
MOD_N-GLC_1	302	307	PF02516	0.311
MOD_N-GLC_2	259	261	PF02516	0.373
MOD_N-GLC_2	316	318	PF02516	0.456
MOD_N-GLC_2	370	372	PF02516	0.420
MOD_NEK2_1	13	18	PF00069	0.524
MOD_NEK2_1	133	138	PF00069	0.318
MOD_NEK2_1	197	202	PF00069	0.401
MOD_NEK2_1	364	369	PF00069	0.498
MOD_PIKK_1	302	308	PF00454	0.301
MOD_PKA_2	272	278	PF00069	0.245
MOD_PKA_2	308	314	PF00069	0.239
MOD_Plk_1	142	148	PF00069	0.348
MOD_Plk_1	197	203	PF00069	0.322
MOD_Plk_1	53	59	PF00069	0.570
MOD_Plk_2-3	101	107	PF00069	0.251
MOD_Plk_4	198	204	PF00069	0.338
MOD_Plk_4	308	314	PF00069	0.444
MOD_Plk_4	324	330	PF00069	0.264
MOD_Plk_4	364	370	PF00069	0.447
MOD_ProDKin_1	283	289	PF00069	0.348
MOD_ProDKin_1	329	335	PF00069	0.226
MOD_ProDKin_1	68	74	PF00069	0.421
MOD_SUMO_rev_2	354	361	PF00179	0.365
TRG_ENDOCYTIC_2	146	149	PF00928	0.340
TRG_ENDOCYTIC_2	235	238	PF00928	0.361
TRG_ENDOCYTIC_2	251	254	PF00928	0.330
TRG_NLS_MonoExtC_3	48	54	PF00514	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	40%	100%
A0A0N0P293	Leptomonas seymouri	33%	100%
A0A0N0P8D1	Leptomonas seymouri	28%	100%
A0A0N1PA65	Leptomonas seymouri	45%	80%
A0A0S4III3	Bodo saltans	47%	100%
A0A0S4IMD3	Bodo saltans	48%	100%
A0A0S4ISD8	Bodo saltans	43%	70%
A0A0S4IWQ5	Bodo saltans	35%	100%
A0A0S4IY45	Bodo saltans	36%	100%
A0A0S4J328	Bodo saltans	52%	100%
A0A0S4J3Q7	Bodo saltans	31%	100%
A0A0S4J628	Bodo saltans	47%	68%
A0A0S4J918	Bodo saltans	39%	100%
A0A0S4J9K9	Bodo saltans	51%	100%
A0A0S4JIQ4	Bodo saltans	27%	100%
A0A0S4JPQ2	Bodo saltans	34%	100%
A0A0S4JSZ3	Bodo saltans	34%	100%
A0A0S4JV57	Bodo saltans	35%	100%
A0A0S4JXJ3	Bodo saltans	32%	98%
A0A0S4KGP4	Bodo saltans	46%	100%
A0A0S4KJA5	Bodo saltans	43%	80%
A0A1X0NIG8	Trypanosomatidae	33%	86%
A0A1X0NTV4	Trypanosomatidae	27%	100%
A0A1X0NXC8	Trypanosomatidae	33%	99%
A0A3R7L7E7	Trypanosoma rangeli	48%	71%
A0A3S5H682	Leishmania donovani	80%	95%
A0A3S5H683	Leishmania donovani	77%	85%
A0A3S5H684	Leishmania donovani	77%	85%
A0A3S5H685	Leishmania donovani	77%	85%
A0A3S7WQD0	Leishmania donovani	77%	85%
A0A6L0WJ22	Leishmania infantum	78%	85%
A0E358	Paramecium tetraurelia	35%	100%
A1E295	Sus scrofa	30%	100%
A2XQE8	Oryza sativa subsp. indica	39%	100%
A4H5E4	Leishmania braziliensis	67%	100%
A4H5E5	Leishmania braziliensis	64%	100%
A4H5E6	Leishmania braziliensis	64%	100%
A4HA92	Leishmania braziliensis	45%	100%
A4HH90	Leishmania braziliensis	30%	100%
A4HTP0	Leishmania infantum	77%	98%
A4HYH2	Leishmania infantum	50%	100%
A4I4D6	Leishmania infantum	32%	100%
A5HII1	Actinidia deliciosa	32%	99%
A8DS38	Tabernaemontana divaricata	39%	100%
B2LSD2	Mucuna pruriens	37%	87%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	83%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	83%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	93%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E8NHL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9ADT5	Leishmania major	30%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	85%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
F4JNL3	Arabidopsis thaliana	34%	100%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	39%	100%
O17473	Brugia pahangi	36%	95%
O23791	Ananas comosus	36%	100%
O45734	Caenorhabditis elegans	42%	100%
O46427	Sus scrofa	34%	100%
O60911	Homo sapiens	43%	100%
O65039	Ricinus communis	37%	100%
O97397	Phaedon cochleariae	33%	100%
P00784	Carica papaya	34%	100%
P00785	Actinidia chinensis var. chinensis	33%	99%
P00786	Rattus norvegicus	37%	100%
P00787	Rattus norvegicus	30%	100%
P04988	Dictyostelium discoideum	41%	100%
P04989	Dictyostelium discoideum	37%	100%
P05167	Hordeum vulgare	40%	100%
P06797	Mus musculus	43%	100%
P07154	Rattus norvegicus	43%	100%
P07711	Homo sapiens	41%	100%
P08176	Dermatophagoides pteronyssinus	28%	100%
P09668	Homo sapiens	37%	100%
P10056	Carica papaya	35%	100%
P10605	Mus musculus	30%	100%
P12412	Vigna mungo	38%	100%
P13277	Homarus americanus	42%	100%
P14080	Carica papaya	36%	100%
P14658	Trypanosoma brucei brucei	48%	83%
P15242	Rattus norvegicus	40%	100%
P16311	Dermatophagoides farinae	31%	100%
P22497	Theileria parva	35%	85%
P22895	Glycine max	37%	99%
P25249	Hordeum vulgare	43%	100%
P25250	Hordeum vulgare	39%	100%
P25251	Brassica napus	37%	100%
P25773	Felis catus	40%	100%
P25775	Leishmania mexicana	51%	100%
P25776	Oryza sativa subsp. japonica	39%	82%
P25777	Oryza sativa subsp. japonica	39%	80%
P25778	Oryza sativa subsp. japonica	40%	100%
P25779	Trypanosoma cruzi	47%	80%
P25780	Euroglyphus maynei	30%	100%
P25781	Theileria annulata	32%	85%
P25782	Homarus americanus	40%	100%
P25783	Autographa californica nuclear polyhedrosis virus	37%	100%
P25792	Schistosoma mansoni	27%	100%
P25803	Phaseolus vulgaris	39%	100%
P25804	Pisum sativum	44%	100%
P25807	Caenorhabditis elegans	29%	100%
P25975	Bos taurus	42%	100%
P35591	Leishmania pifanoi	51%	100%
P36184	Entamoeba histolytica	35%	100%
P36185	Entamoeba histolytica	29%	100%
P36400	Leishmania mexicana	99%	85%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	39%	100%
P41721	Bombyx mori nuclear polyhedrosis virus	37%	100%
P43156	Hemerocallis sp.	37%	100%
P43157	Schistosoma japonicum	28%	100%
P43234	Homo sapiens	36%	100%
P43295	Arabidopsis thaliana	42%	100%
P43296	Arabidopsis thaliana	42%	100%
P43297	Arabidopsis thaliana	39%	81%
P43507	Caenorhabditis elegans	26%	100%
P43508	Caenorhabditis elegans	24%	100%
P43510	Caenorhabditis elegans	29%	99%
P46102	Plasmodium vinckei	31%	74%
P49935	Mus musculus	35%	100%
P54640	Dictyostelium discoideum	36%	100%
P56202	Homo sapiens	33%	100%
P56203	Mus musculus	33%	100%
P80884	Ananas comosus	36%	100%
P92131	Giardia intestinalis	32%	100%
P92132	Giardia intestinalis	35%	100%
P92133	Giardia intestinalis	34%	100%
Q01958	Entamoeba histolytica	31%	100%
Q05094	Leishmania pifanoi	99%	84%
Q06964	Entamoeba histolytica	32%	100%
Q10716	Zea mays	42%	100%
Q10717	Zea mays	39%	100%
Q1EIQ3	Psoroptes ovis	29%	100%
Q23894	Dictyostelium discoideum	38%	100%
Q24940	Fasciola hepatica	41%	100%
Q26534	Schistosoma mansoni	39%	100%
Q26636	Sarcophaga peregrina	40%	100%
Q28944	Sus scrofa	43%	100%
Q3SZI1	Bos taurus	28%	79%
Q3T0I2	Bos taurus	36%	100%
Q40143	Solanum lycopersicum	38%	100%
Q4QD68	Leishmania major	52%	100%
Q4QI61	Leishmania major	71%	100%
Q4QI62	Leishmania major	82%	100%
Q4QI64	Leishmania major	83%	100%
Q4QI65	Leishmania major	83%	100%
Q4QI66	Leishmania major	71%	100%
Q4QI67	Leishmania major	82%	100%
Q4QI68	Leishmania major	82%	100%
Q54TR1	Dictyostelium discoideum	38%	71%
Q5E998	Bos taurus	42%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	39%	100%
Q6YD92	Petrosia ficiformis	40%	100%
Q7F3A8	Oryza sativa subsp. japonica	40%	100%
Q7GDU7	Oryza sativa subsp. japonica	39%	99%
Q7XR52	Oryza sativa subsp. japonica	41%	77%
Q7XWK5	Oryza sativa subsp. japonica	39%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	39%	100%
Q80UB0	Mus musculus	39%	100%
Q86GF7	Pandalus borealis	38%	100%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	37%	100%
Q8BM88	Mus musculus	37%	100%
Q8H166	Arabidopsis thaliana	41%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	38%	100%
Q8RWQ9	Arabidopsis thaliana	40%	100%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	40%	100%
Q8VYS0	Arabidopsis thaliana	40%	100%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	40%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	39%	100%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	38%	100%
Q94714	Paramecium tetraurelia	36%	100%
Q94715	Paramecium tetraurelia	32%	100%
Q94B08	Arabidopsis thaliana	39%	100%
Q95029	Drosophila melanogaster	41%	100%
Q9BIE1	Leishmania donovani	50%	100%
Q9FGR9	Arabidopsis thaliana	40%	100%
Q9FMH8	Arabidopsis thaliana	38%	81%
Q9GKL8	Chlorocebus aethiops	42%	100%
Q9GL24	Canis lupus familiaris	41%	100%
Q9GQM5	Leishmania donovani	32%	100%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	36%	100%
Q9JIA9	Mus musculus	36%	100%
Q9LT77	Arabidopsis thaliana	39%	100%
Q9LT78	Arabidopsis thaliana	40%	83%
Q9LXW3	Arabidopsis thaliana	38%	100%
Q9R013	Mus musculus	43%	81%
Q9R014	Mus musculus	38%	100%
Q9STL4	Arabidopsis thaliana	37%	100%
Q9STL5	Arabidopsis thaliana	39%	100%
Q9SUL1	Arabidopsis thaliana	40%	100%
Q9SUS9	Arabidopsis thaliana	37%	100%
Q9SUT0	Arabidopsis thaliana	36%	100%
Q9TST1	Felis catus	33%	100%
Q9UBX1	Homo sapiens	44%	77%
Q9UJW2	Homo sapiens	28%	79%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	37%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	39%	100%
Q9YWK4	Buzura suppressaria nuclear polyhedrosis virus	36%	100%
V5B261	Trypanosoma cruzi	33%	96%
V5LU01	Ambrosia artemisiifolia	39%	97%