Uncharacterized protein LmxM_33_1810_1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tuzin-like protein

Species:

Leishmania mexicana

UniProt:

E8NHR9_LEIMU

TriTrypDb:

LmxM.33.1810

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E8NHR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.579
CLV_NRD_NRD_1	2	4	PF00675	0.548
CLV_NRD_NRD_1	284	286	PF00675	0.481
CLV_NRD_NRD_1	325	327	PF00675	0.674
CLV_NRD_NRD_1	380	382	PF00675	0.619
CLV_NRD_NRD_1	396	398	PF00675	0.692
CLV_NRD_NRD_1	407	409	PF00675	0.666
CLV_NRD_NRD_1	68	70	PF00675	0.469
CLV_PCSK_KEX2_1	127	129	PF00082	0.524
CLV_PCSK_KEX2_1	2	4	PF00082	0.548
CLV_PCSK_KEX2_1	284	286	PF00082	0.481
CLV_PCSK_KEX2_1	325	327	PF00082	0.675
CLV_PCSK_KEX2_1	380	382	PF00082	0.622
CLV_PCSK_KEX2_1	396	398	PF00082	0.577
CLV_PCSK_KEX2_1	407	409	PF00082	0.690
CLV_PCSK_KEX2_1	70	72	PF00082	0.466
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.450
CLV_PCSK_SKI1_1	202	206	PF00082	0.520
CLV_PCSK_SKI1_1	294	298	PF00082	0.452
CLV_PCSK_SKI1_1	371	375	PF00082	0.660
DEG_Nend_UBRbox_1	1	4	PF02207	0.612
DOC_CYCLIN_RxL_1	199	207	PF00134	0.699
DOC_CYCLIN_yClb5_NLxxxL_5	288	297	PF00134	0.523
DOC_MAPK_MEF2A_6	225	234	PF00069	0.636
DOC_PP1_RVXF_1	267	273	PF00149	0.477
DOC_PP2B_LxvP_1	198	201	PF13499	0.571
DOC_USP7_MATH_1	344	348	PF00917	0.404
DOC_USP7_MATH_1	35	39	PF00917	0.687
DOC_WW_Pin1_4	379	384	PF00397	0.387
DOC_WW_Pin1_4	58	63	PF00397	0.760
DOC_WW_Pin1_4	64	69	PF00397	0.786
LIG_14-3-3_CanoR_1	142	146	PF00244	0.684
LIG_14-3-3_CanoR_1	26	30	PF00244	0.746
LIG_14-3-3_CanoR_1	345	353	PF00244	0.380
LIG_14-3-3_CanoR_1	371	376	PF00244	0.475
LIG_14-3-3_CanoR_1	397	406	PF00244	0.358
LIG_14-3-3_CanoR_1	71	76	PF00244	0.706
LIG_Clathr_ClatBox_1	134	138	PF01394	0.710
LIG_DLG_GKlike_1	71	78	PF00625	0.640
LIG_EH1_1	162	170	PF00400	0.529
LIG_FHA_1	152	158	PF00498	0.625
LIG_FHA_1	174	180	PF00498	0.585
LIG_FHA_1	316	322	PF00498	0.546
LIG_FHA_2	333	339	PF00498	0.415
LIG_LIR_Gen_1	174	181	PF02991	0.635
LIG_LIR_Nem_3	174	180	PF02991	0.649
LIG_NRBOX	74	80	PF00104	0.645
LIG_Pex14_2	235	239	PF04695	0.659
LIG_Pex14_2	373	377	PF04695	0.377
LIG_SH2_PTP2	177	180	PF00017	0.630
LIG_SH2_STAP1	110	114	PF00017	0.615
LIG_SH2_STAT3	324	327	PF00017	0.380
LIG_SH2_STAT5	110	113	PF00017	0.605
LIG_SH2_STAT5	177	180	PF00017	0.630
LIG_SH2_STAT5	315	318	PF00017	0.465
LIG_SH3_3	218	224	PF00018	0.652
LIG_SH3_3	81	87	PF00018	0.650
LIG_SH3_CIN85_PxpxPR_1	64	69	PF14604	0.650
LIG_SUMO_SIM_anti_2	176	183	PF11976	0.673
LIG_SUMO_SIM_anti_2	228	234	PF11976	0.633
LIG_SUMO_SIM_par_1	133	138	PF11976	0.653
LIG_UBA3_1	164	170	PF00899	0.552
LIG_UBA3_1	252	260	PF00899	0.491
MOD_CDC14_SPxK_1	67	70	PF00782	0.790
MOD_CDK_SPK_2	64	69	PF00069	0.792
MOD_CDK_SPxK_1	64	70	PF00069	0.792
MOD_CDK_SPxxK_3	64	71	PF00069	0.651
MOD_CK1_1	103	109	PF00069	0.757
MOD_CK1_1	25	31	PF00069	0.720
MOD_CK2_1	256	262	PF00069	0.662
MOD_CK2_1	332	338	PF00069	0.472
MOD_CK2_1	344	350	PF00069	0.442
MOD_CMANNOS	372	375	PF00535	0.575
MOD_CMANNOS	403	406	PF00535	0.564
MOD_GlcNHglycan	159	162	PF01048	0.425
MOD_GlcNHglycan	182	185	PF01048	0.345
MOD_GlcNHglycan	206	209	PF01048	0.488
MOD_GlcNHglycan	235	238	PF01048	0.310
MOD_GlcNHglycan	37	40	PF01048	0.487
MOD_GSK3_1	316	323	PF00069	0.540
MOD_GSK3_1	332	339	PF00069	0.400
MOD_GSK3_1	82	89	PF00069	0.778
MOD_NEK2_1	164	169	PF00069	0.675
MOD_NEK2_1	204	209	PF00069	0.686
MOD_NEK2_1	373	378	PF00069	0.508
MOD_PKA_2	141	147	PF00069	0.686
MOD_PKA_2	25	31	PF00069	0.746
MOD_PKA_2	344	350	PF00069	0.395
MOD_PKB_1	69	77	PF00069	0.643
MOD_Plk_1	106	112	PF00069	0.612
MOD_Plk_1	173	179	PF00069	0.626
MOD_Plk_1	186	192	PF00069	0.552
MOD_Plk_2-3	262	268	PF00069	0.633
MOD_Plk_4	164	170	PF00069	0.591
MOD_Plk_4	173	179	PF00069	0.651
MOD_Plk_4	25	31	PF00069	0.615
MOD_Plk_4	262	268	PF00069	0.498
MOD_Plk_4	86	92	PF00069	0.778
MOD_ProDKin_1	379	385	PF00069	0.387
MOD_ProDKin_1	58	64	PF00069	0.760
TRG_DiLeu_BaEn_1	228	233	PF01217	0.641
TRG_DiLeu_BaEn_1	242	247	PF01217	0.528
TRG_ENDOCYTIC_2	177	180	PF00928	0.630
TRG_ENDOCYTIC_2	277	280	PF00928	0.505
TRG_ER_diArg_1	1	3	PF00400	0.744
TRG_ER_diArg_1	127	129	PF00400	0.634
TRG_ER_diArg_1	283	285	PF00400	0.681
TRG_ER_diArg_1	324	326	PF00400	0.462
TRG_ER_diArg_1	395	397	PF00400	0.362
TRG_ER_diArg_1	406	408	PF00400	0.365
TRG_ER_diArg_1	68	71	PF00400	0.760
TRG_NES_CRM1_1	251	264	PF08389	0.567
TRG_NLS_MonoExtN_4	66	73	PF00514	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H5D0	Leishmania braziliensis	31%	69%
A4HB03	Leishmania braziliensis	61%	100%
C6K3V8	Leptomonas seymouri	26%	68%
E8NHF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	68%
E8NHI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E8NHS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AMF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q1U8	Leishmania major	75%	70%