WGS CADB00000000 data, contig 90

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHR4_LEIMU

TriTrypDb:

LmxM.08_29.1500a

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E8NHR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.420
CLV_NRD_NRD_1	56	58	PF00675	0.436
CLV_PCSK_FUR_1	193	197	PF00082	0.463
CLV_PCSK_KEX2_1	195	197	PF00082	0.438
CLV_PCSK_KEX2_1	56	58	PF00082	0.439
CLV_PCSK_SKI1_1	143	147	PF00082	0.403
CLV_PCSK_SKI1_1	57	61	PF00082	0.441
DEG_Nend_Nbox_1	1	3	PF02207	0.418
DOC_CYCLIN_yCln2_LP_2	93	99	PF00134	0.385
DOC_MAPK_MEF2A_6	170	177	PF00069	0.324
DOC_MAPK_MEF2A_6	28	35	PF00069	0.350
DOC_PP2B_LxvP_1	93	96	PF13499	0.382
LIG_14-3-3_CanoR_1	28	32	PF00244	0.344
LIG_14-3-3_CanoR_1	56	66	PF00244	0.643
LIG_BRCT_BRCA1_1	131	135	PF00533	0.511
LIG_FHA_1	136	142	PF00498	0.447
LIG_FHA_1	2	8	PF00498	0.366
LIG_FHA_1	60	66	PF00498	0.646
LIG_LIR_Gen_1	30	38	PF02991	0.379
LIG_LIR_Gen_1	81	89	PF02991	0.462
LIG_LIR_Nem_3	30	35	PF02991	0.387
LIG_LIR_Nem_3	67	73	PF02991	0.449
LIG_LIR_Nem_3	81	85	PF02991	0.341
LIG_Pex14_2	131	135	PF04695	0.511
LIG_Pex14_2	146	150	PF04695	0.451
LIG_SH2_GRB2like	119	122	PF00017	0.688
LIG_SH2_PTP2	32	35	PF00017	0.403
LIG_SH2_STAP1	119	123	PF00017	0.583
LIG_SH2_STAT5	32	35	PF00017	0.385
LIG_SH2_STAT5	82	85	PF00017	0.409
LIG_SUMO_SIM_par_1	75	81	PF11976	0.474
LIG_TRAF2_1	211	214	PF00917	0.706
LIG_UBA3_1	145	152	PF00899	0.580
MOD_CK1_1	101	107	PF00069	0.465
MOD_CK1_1	27	33	PF00069	0.373
MOD_CK2_1	58	64	PF00069	0.706
MOD_GlcNHglycan	132	135	PF01048	0.423
MOD_GlcNHglycan	39	42	PF01048	0.401
MOD_GlcNHglycan	46	49	PF01048	0.476
MOD_GSK3_1	130	137	PF00069	0.449
MOD_GSK3_1	152	159	PF00069	0.496
MOD_NEK2_1	1	6	PF00069	0.379
MOD_NEK2_1	129	134	PF00069	0.408
MOD_NEK2_1	135	140	PF00069	0.395
MOD_NEK2_1	66	71	PF00069	0.425
MOD_NEK2_1	78	83	PF00069	0.301
MOD_NEK2_1	98	103	PF00069	0.438
MOD_NEK2_2	111	116	PF00069	0.569
MOD_OFUCOSY	163	168	PF10250	0.634
MOD_PKA_1	57	63	PF00069	0.717
MOD_PKA_2	27	33	PF00069	0.388
MOD_Plk_1	152	158	PF00069	0.471
MOD_Plk_1	24	30	PF00069	0.475
MOD_Plk_4	27	33	PF00069	0.319
MOD_Plk_4	3	9	PF00069	0.402
MOD_Plk_4	66	72	PF00069	0.414
MOD_Plk_4	78	84	PF00069	0.313
MOD_SUMO_rev_2	207	216	PF00179	0.632
TRG_ENDOCYTIC_2	127	130	PF00928	0.576
TRG_ENDOCYTIC_2	32	35	PF00928	0.385
TRG_ENDOCYTIC_2	82	85	PF00928	0.416
TRG_ER_diArg_1	194	196	PF00400	0.601
TRG_ER_diArg_1	55	57	PF00400	0.650
TRG_ER_diLys_1	215	219	PF00400	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ99	Leptomonas seymouri	23%	92%
A0A3R7JSG1	Trypanosoma rangeli	37%	100%
A0A3R7LYU0	Trypanosoma rangeli	55%	81%
A0A3R7MH63	Trypanosoma rangeli	29%	85%
A0A3R7R895	Trypanosoma rangeli	41%	92%
A0A422MSR5	Trypanosoma rangeli	40%	89%
A0A422NV80	Trypanosoma rangeli	53%	87%
V5BIB8	Trypanosoma cruzi	61%	94%