Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHR1_LEIMU

TriTrypDb:

LmxM.14.0730a

Length:

249

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 48
NetGPI	no	yes: 0, no: 48

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	44
GO:0110165	cellular anatomical entity	1	46
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

E8NHR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHR1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	49
GO:0006629	lipid metabolic process	3	49
GO:0006631	fatty acid metabolic process	4	49
GO:0006633	fatty acid biosynthetic process	5	49
GO:0008152	metabolic process	1	49
GO:0008610	lipid biosynthetic process	4	49
GO:0009058	biosynthetic process	2	49
GO:0009987	cellular process	1	49
GO:0016053	organic acid biosynthetic process	4	49
GO:0019752	carboxylic acid metabolic process	5	49
GO:0032787	monocarboxylic acid metabolic process	6	49
GO:0043436	oxoacid metabolic process	4	49
GO:0044237	cellular metabolic process	2	49
GO:0044238	primary metabolic process	2	49
GO:0044249	cellular biosynthetic process	3	49
GO:0044255	cellular lipid metabolic process	3	49
GO:0044281	small molecule metabolic process	2	49
GO:0044283	small molecule biosynthetic process	3	49
GO:0046394	carboxylic acid biosynthetic process	5	49
GO:0071704	organic substance metabolic process	2	49
GO:0072330	monocarboxylic acid biosynthetic process	6	49
GO:1901576	organic substance biosynthetic process	3	49
GO:0000038	very long-chain fatty acid metabolic process	5	5
GO:0006643	membrane lipid metabolic process	4	5
GO:0006665	sphingolipid metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0019367	fatty acid elongation, saturated fatty acid	7	5
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	5
GO:0030148	sphingolipid biosynthetic process	5	5
GO:0030497	fatty acid elongation	6	5
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	5
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	5
GO:0042761	very long-chain fatty acid biosynthetic process	6	5
GO:0046467	membrane lipid biosynthetic process	4	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901566	organonitrogen compound biosynthetic process	4	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	49
GO:0004312	fatty acid synthase activity	5	49
GO:0009922	fatty acid elongase activity	6	49
GO:0016740	transferase activity	2	49
GO:0016746	acyltransferase activity	3	49
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	49
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.270
CLV_NRD_NRD_1	238	240	PF00675	0.469
CLV_NRD_NRD_1	54	56	PF00675	0.336
CLV_PCSK_KEX2_1	228	230	PF00082	0.274
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.278
CLV_PCSK_SKI1_1	20	24	PF00082	0.582
DEG_Nend_Nbox_1	1	2	PF02207	0.301
DOC_CKS1_1	40	45	PF01111	0.438
DOC_CYCLIN_RxL_1	219	227	PF00134	0.339
DOC_MAPK_MEF2A_6	114	122	PF00069	0.458
DOC_PP1_RVXF_1	54	61	PF00149	0.476
DOC_USP7_MATH_1	179	183	PF00917	0.184
DOC_USP7_MATH_1	80	84	PF00917	0.335
DOC_WW_Pin1_4	11	16	PF00397	0.477
DOC_WW_Pin1_4	39	44	PF00397	0.396
LIG_14-3-3_CanoR_1	55	61	PF00244	0.384
LIG_Actin_WH2_2	97	112	PF00022	0.386
LIG_BRCT_BRCA1_1	189	193	PF00533	0.182
LIG_BRCT_BRCA1_1	28	32	PF00533	0.273
LIG_eIF4E_1	99	105	PF01652	0.389
LIG_FHA_1	40	46	PF00498	0.300
LIG_GBD_Chelix_1	67	75	PF00786	0.207
LIG_KLC1_Yacidic_2	223	227	PF13176	0.382
LIG_LIR_Gen_1	135	144	PF02991	0.387
LIG_LIR_Gen_1	212	221	PF02991	0.300
LIG_LIR_Gen_1	47	58	PF02991	0.319
LIG_LIR_Gen_1	69	80	PF02991	0.409
LIG_LIR_Gen_1	96	105	PF02991	0.347
LIG_LIR_Nem_3	135	140	PF02991	0.303
LIG_LIR_Nem_3	151	156	PF02991	0.341
LIG_LIR_Nem_3	162	168	PF02991	0.351
LIG_LIR_Nem_3	212	216	PF02991	0.296
LIG_LIR_Nem_3	47	53	PF02991	0.318
LIG_LIR_Nem_3	69	75	PF02991	0.324
LIG_LIR_Nem_3	96	102	PF02991	0.317
LIG_Pex14_1	74	78	PF04695	0.439
LIG_Pex14_2	217	221	PF04695	0.305
LIG_Pex14_2	93	97	PF04695	0.349
LIG_PTB_Apo_2	160	167	PF02174	0.155
LIG_PTB_Phospho_1	160	166	PF10480	0.162
LIG_Rb_pABgroove_1	20	28	PF01858	0.149
LIG_REV1ctd_RIR_1	151	159	PF16727	0.169
LIG_SH2_CRK	213	217	PF00017	0.204
LIG_SH2_PTP2	133	136	PF00017	0.438
LIG_SH2_PTP2	72	75	PF00017	0.444
LIG_SH2_STAT5	133	136	PF00017	0.343
LIG_SH2_STAT5	137	140	PF00017	0.334
LIG_SH2_STAT5	168	171	PF00017	0.355
LIG_SH2_STAT5	213	216	PF00017	0.299
LIG_SH2_STAT5	225	228	PF00017	0.456
LIG_SH2_STAT5	39	42	PF00017	0.306
LIG_SH2_STAT5	72	75	PF00017	0.346
LIG_SH2_STAT5	92	95	PF00017	0.321
LIG_SH2_STAT5	99	102	PF00017	0.309
LIG_SH3_3	112	118	PF00018	0.457
LIG_SH3_3	9	15	PF00018	0.459
LIG_TRFH_1	142	146	PF08558	0.184
LIG_UBA3_1	106	111	PF00899	0.377
LIG_UBA3_1	216	222	PF00899	0.300
LIG_UBA3_1	36	41	PF00899	0.334
LIG_UBA3_1	49	56	PF00899	0.300
LIG_WRC_WIRS_1	94	99	PF05994	0.421
MOD_CK1_1	173	179	PF00069	0.182
MOD_CK1_1	198	204	PF00069	0.191
MOD_GlcNHglycan	27	31	PF01048	0.462
MOD_GlcNHglycan	82	85	PF01048	0.469
MOD_GSK3_1	170	177	PF00069	0.182
MOD_GSK3_1	26	33	PF00069	0.230
MOD_NEK2_1	109	114	PF00069	0.507
MOD_NEK2_1	132	137	PF00069	0.319
MOD_NEK2_1	209	214	PF00069	0.300
MOD_NEK2_1	45	50	PF00069	0.325
MOD_NEK2_1	93	98	PF00069	0.290
MOD_OFUCOSY	196	202	PF10250	0.374
MOD_PKA_2	109	115	PF00069	0.400
MOD_PKA_2	179	185	PF00069	0.139
MOD_Plk_1	20	26	PF00069	0.273
MOD_Plk_1	231	237	PF00069	0.707
MOD_Plk_2-3	21	27	PF00069	0.149
MOD_Plk_4	132	138	PF00069	0.291
MOD_Plk_4	148	154	PF00069	0.325
MOD_Plk_4	170	176	PF00069	0.374
MOD_Plk_4	21	27	PF00069	0.261
MOD_Plk_4	231	237	PF00069	0.673
MOD_Plk_4	45	51	PF00069	0.227
MOD_Plk_4	56	62	PF00069	0.454
MOD_Plk_4	74	80	PF00069	0.291
MOD_Plk_4	93	99	PF00069	0.312
MOD_ProDKin_1	11	17	PF00069	0.478
MOD_ProDKin_1	39	45	PF00069	0.396
TRG_ENDOCYTIC_2	101	104	PF00928	0.308
TRG_ENDOCYTIC_2	133	136	PF00928	0.353
TRG_ENDOCYTIC_2	137	140	PF00928	0.338
TRG_ENDOCYTIC_2	213	216	PF00928	0.296
TRG_ENDOCYTIC_2	64	67	PF00928	0.320
TRG_ENDOCYTIC_2	72	75	PF00928	0.320
TRG_ENDOCYTIC_2	78	81	PF00928	0.265
TRG_ER_diLys_1	245	249	PF00400	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E5	Leptomonas seymouri	40%	83%
A0A0N0P7D1	Leptomonas seymouri	40%	75%
A0A0N0P7R2	Leptomonas seymouri	39%	82%
A0A0N1ILQ4	Leptomonas seymouri	36%	85%
A0A0N1PDR8	Leptomonas seymouri	36%	92%
A0A0S4IS29	Bodo saltans	38%	97%
A0A0S4IVS6	Bodo saltans	38%	88%
A0A0S4IW98	Bodo saltans	41%	79%
A0A1X0NNK7	Trypanosomatidae	40%	87%
A0A1X0NNM4	Trypanosomatidae	33%	87%
A0A1X0NNM5	Trypanosomatidae	38%	81%
A0A3Q8I9T2	Leishmania donovani	87%	66%
A0A3Q8I9X8	Leishmania donovani	38%	74%
A0A3Q8IC05	Leishmania donovani	40%	82%
A0A3R7KG78	Trypanosoma rangeli	40%	88%
A0A3R7MJR2	Trypanosoma rangeli	33%	89%
A0A3S7WSZ1	Leishmania donovani	39%	83%
A0A3S7WT03	Leishmania donovani	41%	83%
A0A3S7WT16	Leishmania donovani	34%	77%
A0A422NNP1	Trypanosoma rangeli	35%	83%
A4H7M6	Leishmania braziliensis	40%	100%
A4H7M7	Leishmania braziliensis	35%	77%
A4H7N0	Leishmania braziliensis	42%	100%
A4HW12	Leishmania infantum	39%	74%
A4HW14	Leishmania infantum	34%	77%
A4HW15	Leishmania infantum	88%	66%
A4HW16	Leishmania infantum	93%	67%
A4HW18	Leishmania infantum	39%	82%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	92%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	81%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	66%
E9AGL0	Leishmania infantum	41%	83%
E9AGL2	Leishmania infantum	39%	83%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	83%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	83%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	74%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	77%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	83%
Q4QFQ9	Leishmania major	39%	100%
Q4QFR2	Leishmania major	87%	66%
Q4QFR3	Leishmania major	35%	77%
Q4QFR5	Leishmania major	37%	69%
Q4QFR6	Leishmania major	40%	100%
Q9VV87	Drosophila melanogaster	31%	79%
Q9XVQ9	Caenorhabditis elegans	31%	91%
V5BE99	Trypanosoma cruzi	39%	87%
V5BIX9	Trypanosoma cruzi	34%	89%
V5BND3	Trypanosoma cruzi	35%	83%
V5DF68	Trypanosoma cruzi	33%	86%