Tubulin alpha chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Tubulin alpha chain

Gene product:

alpha tubulin, putative, (fragment)

Species:

Leishmania mexicana

UniProt:

E8NHR0_LEIMU

TriTrypDb:

LmxM.13.0300

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	3
GO:0099080	supramolecular complex	2	3
GO:0099081	supramolecular polymer	3	3
GO:0099512	supramolecular fiber	4	3
GO:0099513	polymeric cytoskeletal fiber	5	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E8NHR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHR0

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	3
GO:0009987	cellular process	1	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0005198	structural molecule activity	1	3
GO:0005200	structural constituent of cytoskeleton	2	3
GO:0005488	binding	1	3
GO:0005525	GTP binding	5	3
GO:0017076	purine nucleotide binding	4	3
GO:0019001	guanyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032561	guanyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.625
CLV_NRD_NRD_1	122	124	PF00675	0.341
CLV_NRD_NRD_1	214	216	PF00675	0.527
CLV_PCSK_KEX2_1	214	216	PF00082	0.527
CLV_PCSK_SKI1_1	64	68	PF00082	0.317
CLV_PCSK_SKI1_1	84	88	PF00082	0.322
DEG_Nend_UBRbox_1	1	4	PF02207	0.482
DOC_CYCLIN_RxL_1	79	90	PF00134	0.541
DOC_MAPK_MEF2A_6	112	119	PF00069	0.541
DOC_MAPK_MEF2A_6	2	9	PF00069	0.408
DOC_MAPK_MEF2A_6	243	252	PF00069	0.518
DOC_PP1_RVXF_1	262	268	PF00149	0.525
DOC_USP7_MATH_1	175	179	PF00917	0.500
DOC_USP7_MATH_1	274	278	PF00917	0.625
DOC_USP7_MATH_1	32	36	PF00917	0.550
DOC_WW_Pin1_4	171	176	PF00397	0.500
LIG_14-3-3_CanoR_1	156	160	PF00244	0.541
LIG_14-3-3_CanoR_1	214	218	PF00244	0.640
LIG_BRCT_BRCA1_1	240	244	PF00533	0.470
LIG_Clathr_ClatBox_1	23	27	PF01394	0.541
LIG_FHA_1	177	183	PF00498	0.541
LIG_FHA_1	189	195	PF00498	0.541
LIG_FHA_1	237	243	PF00498	0.452
LIG_FHA_1	255	261	PF00498	0.318
LIG_FHA_2	200	206	PF00498	0.625
LIG_FHA_2	71	77	PF00498	0.541
LIG_GBD_Chelix_1	234	242	PF00786	0.457
LIG_LIR_Apic_2	170	175	PF02991	0.541
LIG_LIR_Gen_1	183	189	PF02991	0.541
LIG_LIR_Gen_1	223	231	PF02991	0.487
LIG_LIR_Gen_1	46	53	PF02991	0.541
LIG_LIR_Nem_3	183	188	PF02991	0.541
LIG_LIR_Nem_3	223	227	PF02991	0.500
LIG_LIR_Nem_3	270	275	PF02991	0.625
LIG_LIR_Nem_3	46	52	PF02991	0.541
LIG_LIR_Nem_3	80	86	PF02991	0.541
LIG_LYPXL_yS_3	262	265	PF13949	0.408
LIG_NRBOX	148	154	PF00104	0.541
LIG_PCNA_yPIPBox_3	221	235	PF02747	0.483
LIG_Pex14_2	49	53	PF04695	0.541
LIG_Rb_LxCxE_1	22	39	PF01857	0.541
LIG_SH2_CRK	185	189	PF00017	0.541
LIG_SH2_CRK	224	228	PF00017	0.490
LIG_SH2_CRK	272	276	PF00017	0.625
LIG_SH2_CRK	83	87	PF00017	0.536
LIG_SH2_GRB2like	224	227	PF00017	0.498
LIG_SH2_NCK_1	224	228	PF00017	0.607
LIG_SH2_SRC	272	275	PF00017	0.625
LIG_SH2_STAT3	282	285	PF00017	0.625
LIG_SH2_STAT5	108	111	PF00017	0.541
LIG_SH2_STAT5	169	172	PF00017	0.547
LIG_SH2_STAT5	224	227	PF00017	0.498
LIG_SH3_3	178	184	PF00018	0.541
LIG_SH3_3	257	263	PF00018	0.507
LIG_TYR_ITIM	260	265	PF00017	0.506
LIG_TYR_ITSM	268	275	PF00017	0.625
LIG_WRC_WIRS_1	49	54	PF05994	0.541
MOD_CK1_1	190	196	PF00069	0.550
MOD_CK1_1	236	242	PF00069	0.450
MOD_CK1_1	35	41	PF00069	0.511
MOD_CK2_1	190	196	PF00069	0.541
MOD_CK2_1	91	97	PF00069	0.541
MOD_Cter_Amidation	161	164	PF01082	0.341
MOD_GlcNHglycan	146	149	PF01048	0.308
MOD_GlcNHglycan	276	279	PF01048	0.425
MOD_GlcNHglycan	93	96	PF01048	0.300
MOD_GSK3_1	167	174	PF00069	0.508
MOD_GSK3_1	195	202	PF00069	0.579
MOD_GSK3_1	234	241	PF00069	0.401
MOD_GSK3_1	250	257	PF00069	0.450
MOD_N-GLC_1	127	132	PF02516	0.341
MOD_N-GLC_2	18	20	PF02516	0.341
MOD_NEK2_1	167	172	PF00069	0.625
MOD_NEK2_1	238	243	PF00069	0.458
MOD_NEK2_1	267	272	PF00069	0.625
MOD_NEK2_1	53	58	PF00069	0.519
MOD_NEK2_2	48	53	PF00069	0.541
MOD_PKA_2	155	161	PF00069	0.541
MOD_PKA_2	213	219	PF00069	0.541
MOD_PKA_2	220	226	PF00069	0.485
MOD_Plk_2-3	155	161	PF00069	0.541
MOD_Plk_2-3	199	205	PF00069	0.625
MOD_Plk_2-3	284	290	PF00069	0.625
MOD_Plk_4	167	173	PF00069	0.541
MOD_Plk_4	190	196	PF00069	0.560
MOD_Plk_4	199	205	PF00069	0.578
MOD_Plk_4	48	54	PF00069	0.541
MOD_Plk_4	70	76	PF00069	0.541
MOD_ProDKin_1	171	177	PF00069	0.500
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.588
TRG_ENDOCYTIC_2	185	188	PF00928	0.541
TRG_ENDOCYTIC_2	224	227	PF00928	0.498
TRG_ENDOCYTIC_2	262	265	PF00928	0.408
TRG_ENDOCYTIC_2	272	275	PF00928	0.541
TRG_ENDOCYTIC_2	83	86	PF00928	0.536
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J1M4	Bodo saltans	45%	100%
A0A0S4KIB4	Bodo saltans	92%	100%
A0A1X0NXK9	Trypanosomatidae	43%	67%
A0A381MS01	Leishmania infantum	44%	67%
A0A3Q8IFB7	Leishmania donovani	43%	67%
A0A3Q8IM37	Leishmania donovani	44%	67%
A0A3S5H697	Leishmania donovani	43%	67%
A0A3S5H6A0	Leishmania donovani	43%	67%
A0A3S5H7U1	Leishmania donovani	44%	67%
A0AAL4	Dictyostelium purpureum	72%	89%
A4HC48	Leishmania braziliensis	43%	67%
A4HLC8	Leishmania braziliensis	44%	67%
A4HLC9	Leishmania braziliensis	44%	67%
A4HTR0	Leishmania infantum	43%	67%
A4HTR1	Leishmania infantum	44%	67%
A4HZJ3	Leishmania infantum	43%	67%
A6NHL2	Homo sapiens	63%	66%
A6NNZ2	Homo sapiens	40%	66%
C9ZIG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	67%
C9ZIG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	85%
E9AMJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	71%
E9AMJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	67%
E9AVI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	67%
O04386	Chlamydomonas incerta	44%	67%
O44388	Trichuris trichiura	43%	66%
O59837	Phytophthora cinnamomi	44%	66%
P02552	Gallus gallus	80%	72%
P02554	Sus scrofa	43%	66%
P04107	Trypanosoma brucei rhodesiense	43%	67%
P04350	Homo sapiens	42%	66%
P04690	Chlamydomonas reinhardtii	44%	67%
P05304	Giardia intestinalis	43%	66%
P07304	Stylonychia lemnae	84%	66%
P07437	Homo sapiens	43%	66%
P08070	Gallus gallus	72%	66%
P08562	Trypanosoma cruzi	43%	67%
P09203	Gallus gallus	43%	66%
P09206	Gallus gallus	43%	66%
P09207	Gallus gallus	41%	66%
P09244	Gallus gallus	43%	66%
P09653	Gallus gallus	42%	66%
P09734	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	67%	66%
P10876	Tetrahymena pyriformis	43%	67%
P11482	Volvox carteri	44%	67%
P11857	Stylonychia lemnae	43%	67%
P12456	Caenorhabditis elegans	43%	67%
P12457	Euglena gracilis	41%	67%
P12459	Glycine max	41%	66%
P13602	Xenopus laevis	43%	67%
P14140	Plasmodium falciparum	43%	66%
P14643	Plasmodium falciparum (isolate K1 / Thailand)	43%	66%
P16040	Blumeria hordei	41%	66%
P18025	Zea mays	43%	66%
P18026	Zea mays	44%	66%
P20365	Euplotes crassus	42%	66%
P20802	Achlya klebsiana	44%	66%
P21148	Leishmania mexicana	44%	66%
P22013	Colletotrichum graminicola	42%	66%
P22852	Polytomella agilis	44%	67%
P24636	Arabidopsis thaliana	43%	66%
P24637	Pneumocystis carinii	41%	67%
P25295	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	66%
P25862	Avena sativa	46%	76%
P28551	Glycine max	44%	72%
P29502	Pisum sativum	45%	67%
P29517	Arabidopsis thaliana	44%	66%
P30668	Schizophyllum commune	42%	66%
P30883	Xenopus laevis	43%	66%
P31863	Hypocrea rufa	41%	66%
P31864	Hypocrea rufa	42%	66%
P32882	Gallus gallus	43%	66%
P33188	Paramecium tetraurelia	43%	67%
P33624	Anemia phyllitidis	84%	81%
P33630	Anemia phyllitidis	42%	67%
P33631	Anemia phyllitidis	44%	72%
P34475	Caenorhabditis elegans	34%	66%
P36221	Notothenia neglecta	43%	66%
P37832	Oryza sativa subsp. japonica	43%	66%
P41352	Tetrahymena thermophila	43%	67%
P41386	Haliotis discus	44%	87%
P41387	Onchocerca gibsoni	43%	66%
P41742	Ajellomyces capsulatus	40%	66%
P41937	Caenorhabditis elegans	43%	66%
P49742	Schizophyllum commune	64%	66%
P50260	Oomycete-like sp. (strain MacKay2000)	44%	70%
P50261	Oomycete-like sp. (strain MacKay2000)	43%	66%
P53371	Ajellomyces capsulatus	67%	71%
P53374	Gibberella fujikuroi	41%	66%
P61857	Drosophila melanogaster	42%	66%
P61858	Drosophila hydei	42%	66%
P68371	Homo sapiens	43%	66%
P68372	Mus musculus	43%	66%
P69893	Cricetulus griseus	43%	66%
P69895	Macaca mulatta	43%	66%
P69897	Rattus norvegicus	43%	66%
P79008	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	42%	66%
P83130	Drosophila erecta	42%	66%
P85108	Rattus norvegicus	43%	66%
P86221	Mesocricetus auratus	35%	100%
P92120	Encephalitozoon hellem	59%	78%
P99024	Mus musculus	43%	66%
Q04709	Babesia bovis	43%	67%
Q08115	Euplotoides octocarinatus	42%	66%
Q13885	Homo sapiens	43%	66%
Q17299	Caenorhabditis briggsae	43%	67%
Q24829	Encephalitozoon hellem	41%	67%
Q2HJ81	Bos taurus	42%	66%
Q2KJD0	Bos taurus	43%	66%
Q39697	Daucus carota	44%	66%
Q3KRE8	Rattus norvegicus	43%	66%
Q3MHM5	Bos taurus	43%	66%
Q3UX10	Mus musculus	63%	66%
Q3ZBU7	Bos taurus	42%	66%
Q3ZCM7	Homo sapiens	40%	66%
Q40665	Oryza sativa subsp. japonica	44%	66%
Q41783	Zea mays	44%	66%
Q41784	Zea mays	43%	66%
Q41785	Zea mays	44%	66%
Q41874	Zea mays	35%	70%
Q43695	Zea mays	42%	66%
Q43697	Zea mays	44%	66%
Q4HZS8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	41%	66%
Q4Q4C4	Leishmania major	44%	67%
Q4QBZ6	Leishmania major	43%	67%
Q4QI42	Leishmania major	43%	67%
Q4R4X8	Macaca fascicularis	42%	66%
Q4R5B3	Macaca fascicularis	43%	66%
Q5R943	Pongo abelii	43%	66%
Q6B856	Bos taurus	43%	66%
Q6EVK8	Suillus bovinus	41%	66%
Q6GLE7	Xenopus tropicalis	43%	66%
Q6P9T8	Rattus norvegicus	43%	66%
Q6VAF4	Gossypium hirsutum	44%	66%
Q6VAF5	Gossypium hirsutum	43%	66%
Q6VAF7	Gossypium hirsutum	43%	66%
Q6VAF8	Gossypium hirsutum	44%	69%
Q767L7	Sus scrofa	43%	66%
Q76FS2	Oryza sativa subsp. japonica	43%	66%
Q76FS3	Oryza sativa subsp. japonica	44%	66%
Q7JJU6	Pan troglodytes	43%	66%
Q7KQL5	Plasmodium falciparum (isolate 3D7)	43%	66%
Q7TMM9	Mus musculus	43%	66%
Q875L2	Hypocrea virens	41%	66%
Q875L3	Hypocrea virens	42%	66%
Q8J1R4	Suillus bovinus	40%	66%
Q8SRD2	Encephalitozoon cuniculi (strain GB-M1)	34%	68%
Q8SRI6	Encephalitozoon cuniculi (strain GB-M1)	61%	67%
Q8SS99	Encephalitozoon cuniculi (strain GB-M1)	41%	67%
Q8WP13	Papio hamadryas	40%	66%
Q8WP14	Pan troglodytes	40%	66%
Q8WZE0	Microbotryum violaceum	41%	66%
Q91240	Pseudopleuronectes americanus	43%	66%
Q91575	Xenopus laevis	43%	66%
Q92268	Pleurotus sajor-caju	41%	66%
Q9BUF5	Homo sapiens	42%	66%
Q9BVA1	Homo sapiens	43%	66%
Q9CWF2	Mus musculus	43%	66%
Q9D6F9	Mus musculus	42%	66%
Q9GSR5	Encephalitozoon intestinalis	40%	67%
Q9LKI8	Thalassiosira weissflogii	44%	67%
Q9N2N6	Euplotes focardii	42%	66%
Q9NFZ5	Echinococcus multilocularis	41%	67%
Q9NFZ6	Echinococcus multilocularis	44%	66%
Q9SEA4	Guillardia theta	25%	70%
Q9SEV2	Guillardia theta	42%	67%
Q9UV72	Pestalotiopsis microspora	41%	66%
Q9Y882	Schizosaccharomyces japonicus	39%	66%
Q9YHC3	Gadus morhua	43%	66%
Q9ZPN7	Eleusine indica	44%	66%
Q9ZPN8	Eleusine indica	44%	66%
Q9ZPP0	Eleusine indica	43%	66%
Q9ZRA9	Triticum aestivum	44%	66%
Q9ZRB0	Triticum aestivum	43%	66%
Q9ZRB2	Triticum aestivum	44%	66%
R9TL42	Trypanosoma rangeli	43%	67%