Uncharacterized protein LmxM_13_0290_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHQ9_LEIMU

TriTrypDb:

LmxM.13.0290partial

Length:

151

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	5
GO:0099080	supramolecular complex	2	5
GO:0099081	supramolecular polymer	3	5
GO:0099512	supramolecular fiber	4	5
GO:0099513	polymeric cytoskeletal fiber	5	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E8NHQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHQ9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	5
GO:0009987	cellular process	1	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0005198	structural molecule activity	1	5
GO:0005200	structural constituent of cytoskeleton	2	5
GO:0005488	binding	1	5
GO:0005525	GTP binding	5	5
GO:0017076	purine nucleotide binding	4	5
GO:0019001	guanyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032561	guanyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	101	103	PF00082	0.384
CLV_PCSK_KEX2_1	38	40	PF00082	0.159
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.384
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.159
CLV_PCSK_SKI1_1	101	105	PF00082	0.240
DEG_APCC_DBOX_1	121	129	PF00400	0.276
DEG_Nend_Nbox_1	1	3	PF02207	0.353
DOC_MAPK_gen_1	36	43	PF00069	0.359
DOC_PP1_RVXF_1	37	44	PF00149	0.359
LIG_CAP-Gly_1	145	151	PF01302	0.468
LIG_deltaCOP1_diTrp_1	45	51	PF00928	0.359
LIG_eIF4E_1	12	18	PF01652	0.352
LIG_FHA_2	1	7	PF00498	0.352
LIG_Integrin_RGD_1	20	22	PF01839	0.159
LIG_LIR_Gen_1	129	140	PF02991	0.310
LIG_LIR_Gen_1	86	95	PF02991	0.367
LIG_LIR_Nem_3	129	135	PF02991	0.288
LIG_LIR_Nem_3	86	91	PF02991	0.367
LIG_SH2_CRK	57	61	PF00017	0.359
LIG_SH2_NCK_1	132	136	PF00017	0.284
LIG_SH2_SRC	132	135	PF00017	0.284
LIG_SH2_SRC	57	60	PF00017	0.359
LIG_SH2_STAP1	99	103	PF00017	0.242
LIG_SH2_STAT5	108	111	PF00017	0.270
MOD_GlcNHglycan	138	141	PF01048	0.434
MOD_LATS_1	9	15	PF00433	0.353
MOD_N-GLC_1	79	84	PF02516	0.159
MOD_NEK2_1	97	102	PF00069	0.245
MOD_NEK2_2	31	36	PF00069	0.359
MOD_Plk_1	79	85	PF00069	0.400
MOD_Plk_4	58	64	PF00069	0.359
MOD_SUMO_rev_2	86	95	PF00179	0.359
TRG_ENDOCYTIC_2	132	135	PF00928	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IVQ1	Bodo saltans	84%	82%
A0A0S4J902	Bodo saltans	34%	100%
A0A0S4KMQ2	Bodo saltans	96%	79%
A0A1X0NW87	Trypanosomatidae	96%	100%
A0A3S7X6K6	Leishmania donovani	33%	100%
A4HLD1	Leishmania braziliensis	33%	100%
A4HLD6	Leishmania braziliensis	33%	100%
C9ZIG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	96%	79%
P02553	Lytechinus pictus	89%	94%
P02556	Lytechinus pictus	36%	85%
Q07972	Pneumocystis carinii	77%	71%
V5AN49	Trypanosoma cruzi	34%	100%