LeishMANIAdb
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WGS CADB00000000 data, contig 85

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
WGS CADB00000000 data, contig 85
Gene product:
hypothetical protein
Species:
Leishmania mexicana
UniProt:
E8NHQ6_LEIMU
TriTrypDb:
LmxM.30.1440b
Length:
653

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 5, no: 0
NetGPI no yes: 0, no: 5
Cellular components
TermNameLevelCount
GO:0005929 cilium 4 6
GO:0016020 membrane 2 3
GO:0042995 cell projection 2 6
GO:0043226 organelle 2 6
GO:0043227 membrane-bounded organelle 3 6
GO:0110165 cellular anatomical entity 1 6
GO:0120025 plasma membrane bounded cell projection 3 6
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Expansion

Sequence features

E8NHQ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHQ6

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 226 228 PF00675 0.443
CLV_PCSK_KEX2_1 226 228 PF00082 0.443
CLV_PCSK_SKI1_1 178 182 PF00082 0.406
CLV_PCSK_SKI1_1 54 58 PF00082 0.406
DEG_SPOP_SBC_1 293 297 PF00917 0.627
DEG_SPOP_SBC_1 301 305 PF00917 0.615
DEG_SPOP_SBC_1 325 329 PF00917 0.585
DEG_SPOP_SBC_1 350 354 PF00917 0.583
DEG_SPOP_SBC_1 364 368 PF00917 0.538
DEG_SPOP_SBC_1 375 379 PF00917 0.551
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Homologs

ProteinTaxonomySequence identityCoverage
A0A3Q8IK15 Leishmania donovani 84% 100%
A4I6S2 Leishmania infantum 84% 100%
E8NHE9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q6B8 Leishmania major 80% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS