WGS CADB00000000 data, contig 84

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHQ5_LEIMU

TriTrypDb:

LmxM.10.0380

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E8NHQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHQ5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.450
CLV_C14_Caspase3-7	669	673	PF00656	0.821
CLV_MEL_PAP_1	442	448	PF00089	0.297
CLV_NRD_NRD_1	275	277	PF00675	0.385
CLV_NRD_NRD_1	52	54	PF00675	0.524
CLV_PCSK_KEX2_1	137	139	PF00082	0.344
CLV_PCSK_KEX2_1	52	54	PF00082	0.525
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.344
CLV_PCSK_SKI1_1	120	124	PF00082	0.405
CLV_PCSK_SKI1_1	320	324	PF00082	0.422
DEG_SPOP_SBC_1	667	671	PF00917	0.655
DOC_CDC14_PxL_1	613	621	PF14671	0.379
DOC_CKS1_1	625	630	PF01111	0.479
DOC_CYCLIN_yCln2_LP_2	630	636	PF00134	0.424
DOC_MAPK_gen_1	137	143	PF00069	0.554
DOC_MAPK_gen_1	261	271	PF00069	0.597
DOC_MAPK_gen_1	641	650	PF00069	0.642
DOC_MAPK_MEF2A_6	231	238	PF00069	0.377
DOC_MAPK_MEF2A_6	524	531	PF00069	0.405
DOC_PP1_RVXF_1	499	505	PF00149	0.567
DOC_PP2B_LxvP_1	630	633	PF13499	0.415
DOC_PP2B_PxIxI_1	231	237	PF00149	0.333
DOC_USP7_MATH_1	203	207	PF00917	0.369
DOC_USP7_MATH_1	306	310	PF00917	0.637
DOC_USP7_MATH_1	565	569	PF00917	0.534
DOC_USP7_MATH_1	667	671	PF00917	0.692
DOC_WW_Pin1_4	302	307	PF00397	0.627
DOC_WW_Pin1_4	445	450	PF00397	0.416
DOC_WW_Pin1_4	624	629	PF00397	0.461
LIG_14-3-3_CanoR_1	108	115	PF00244	0.540
LIG_14-3-3_CanoR_1	261	271	PF00244	0.635
LIG_14-3-3_CanoR_1	308	315	PF00244	0.624
LIG_14-3-3_CanoR_1	445	449	PF00244	0.459
LIG_14-3-3_CanoR_1	501	505	PF00244	0.539
LIG_Actin_WH2_2	54	69	PF00022	0.675
LIG_APCC_ABBA_1	54	59	PF00400	0.690
LIG_APCC_ABBAyCdc20_2	53	59	PF00400	0.570
LIG_BIR_II_1	1	5	PF00653	0.803
LIG_BIR_III_4	17	21	PF00653	0.785
LIG_BIR_III_4	342	346	PF00653	0.570
LIG_Clathr_ClatBox_1	269	273	PF01394	0.495
LIG_EH1_1	503	511	PF00400	0.387
LIG_eIF4E_1	613	619	PF01652	0.279
LIG_FHA_1	121	127	PF00498	0.620
LIG_FHA_1	369	375	PF00498	0.640
LIG_FHA_1	386	392	PF00498	0.415
LIG_FHA_1	401	407	PF00498	0.354
LIG_FHA_1	485	491	PF00498	0.457
LIG_FHA_1	501	507	PF00498	0.528
LIG_FHA_1	625	631	PF00498	0.463
LIG_FHA_2	26	32	PF00498	0.740
LIG_FHA_2	273	279	PF00498	0.643
LIG_GBD_Chelix_1	482	490	PF00786	0.280
LIG_GBD_Chelix_1	505	513	PF00786	0.523
LIG_GBD_Chelix_1	543	551	PF00786	0.555
LIG_LIR_Apic_2	352	358	PF02991	0.578
LIG_LIR_Apic_2	420	426	PF02991	0.471
LIG_LIR_Apic_2	457	461	PF02991	0.407
LIG_LIR_Apic_2	596	600	PF02991	0.350
LIG_LIR_Gen_1	128	135	PF02991	0.568
LIG_LIR_Gen_1	206	214	PF02991	0.511
LIG_LIR_Gen_1	570	579	PF02991	0.564
LIG_LIR_Gen_1	91	99	PF02991	0.587
LIG_LIR_Nem_3	128	133	PF02991	0.542
LIG_LIR_Nem_3	136	142	PF02991	0.542
LIG_LIR_Nem_3	206	212	PF02991	0.399
LIG_LIR_Nem_3	246	252	PF02991	0.391
LIG_LIR_Nem_3	375	381	PF02991	0.546
LIG_LIR_Nem_3	420	425	PF02991	0.427
LIG_LIR_Nem_3	468	472	PF02991	0.353
LIG_Pex14_2	173	177	PF04695	0.412
LIG_Pex14_2	467	471	PF04695	0.359
LIG_Pex14_2	491	495	PF04695	0.418
LIG_PTB_Apo_2	463	470	PF02174	0.435
LIG_PTB_Apo_2	489	496	PF02174	0.487
LIG_PTB_Phospho_1	463	469	PF10480	0.308
LIG_SH2_CRK	106	110	PF00017	0.560
LIG_SH2_CRK	140	144	PF00017	0.422
LIG_SH2_CRK	155	159	PF00017	0.373
LIG_SH2_CRK	190	194	PF00017	0.563
LIG_SH2_CRK	355	359	PF00017	0.669
LIG_SH2_CRK	383	387	PF00017	0.392
LIG_SH2_CRK	458	462	PF00017	0.415
LIG_SH2_CRK	472	476	PF00017	0.359
LIG_SH2_CRK	597	601	PF00017	0.371
LIG_SH2_GRB2like	454	457	PF00017	0.429
LIG_SH2_GRB2like	613	616	PF00017	0.399
LIG_SH2_NCK_1	338	342	PF00017	0.485
LIG_SH2_NCK_1	458	462	PF00017	0.242
LIG_SH2_PTP2	36	39	PF00017	0.675
LIG_SH2_SRC	338	341	PF00017	0.488
LIG_SH2_SRC	36	39	PF00017	0.684
LIG_SH2_STAP1	135	139	PF00017	0.549
LIG_SH2_STAP1	190	194	PF00017	0.538
LIG_SH2_STAP1	383	387	PF00017	0.446
LIG_SH2_STAP1	573	577	PF00017	0.386
LIG_SH2_STAP1	92	96	PF00017	0.585
LIG_SH2_STAT5	135	138	PF00017	0.550
LIG_SH2_STAT5	250	253	PF00017	0.487
LIG_SH2_STAT5	36	39	PF00017	0.674
LIG_SH2_STAT5	437	440	PF00017	0.401
LIG_SH2_STAT5	454	457	PF00017	0.392
LIG_SH2_STAT5	469	472	PF00017	0.351
LIG_SH2_STAT5	537	540	PF00017	0.342
LIG_SH3_1	355	361	PF00018	0.635
LIG_SH3_3	355	361	PF00018	0.646
LIG_SH3_3	443	449	PF00018	0.423
LIG_SUMO_SIM_anti_2	518	523	PF11976	0.367
LIG_SUMO_SIM_par_1	555	561	PF11976	0.375
LIG_TRFH_1	155	159	PF08558	0.408
LIG_TYR_ITIM	153	158	PF00017	0.428
LIG_TYR_ITSM	468	475	PF00017	0.451
LIG_UBA3_1	153	161	PF00899	0.401
LIG_UBA3_1	269	277	PF00899	0.573
LIG_UBA3_1	490	497	PF00899	0.463
LIG_UBA3_1	636	641	PF00899	0.284
LIG_Vh1_VBS_1	381	399	PF01044	0.437
LIG_Vh1_VBS_1	471	489	PF01044	0.433
MOD_CDC14_SPxK_1	305	308	PF00782	0.282
MOD_CDK_SPxK_1	302	308	PF00069	0.282
MOD_CK1_1	110	116	PF00069	0.409
MOD_CK1_1	43	49	PF00069	0.442
MOD_CK1_1	624	630	PF00069	0.294
MOD_CK1_1	670	676	PF00069	0.677
MOD_CK2_1	25	31	PF00069	0.584
MOD_CK2_1	272	278	PF00069	0.487
MOD_Cter_Amidation	301	304	PF01082	0.519
MOD_DYRK1A_RPxSP_1	445	449	PF00069	0.463
MOD_GlcNHglycan	162	166	PF01048	0.406
MOD_GlcNHglycan	238	241	PF01048	0.418
MOD_GlcNHglycan	383	386	PF01048	0.269
MOD_GSK3_1	107	114	PF00069	0.458
MOD_GSK3_1	213	220	PF00069	0.374
MOD_GSK3_1	232	239	PF00069	0.490
MOD_GSK3_1	302	309	PF00069	0.416
MOD_GSK3_1	368	375	PF00069	0.529
MOD_GSK3_1	381	388	PF00069	0.462
MOD_GSK3_1	440	447	PF00069	0.297
MOD_GSK3_1	467	474	PF00069	0.425
MOD_GSK3_1	500	507	PF00069	0.411
MOD_GSK3_1	582	589	PF00069	0.421
MOD_GSK3_1	666	673	PF00069	0.694
MOD_N-GLC_1	323	328	PF02516	0.236
MOD_N-GLC_1	465	470	PF02516	0.401
MOD_NEK2_1	115	120	PF00069	0.423
MOD_NEK2_1	133	138	PF00069	0.330
MOD_NEK2_1	141	146	PF00069	0.385
MOD_NEK2_1	173	178	PF00069	0.391
MOD_NEK2_1	213	218	PF00069	0.373
MOD_NEK2_1	272	277	PF00069	0.482
MOD_NEK2_1	323	328	PF00069	0.425
MOD_NEK2_1	381	386	PF00069	0.420
MOD_NEK2_1	400	405	PF00069	0.406
MOD_NEK2_1	440	445	PF00069	0.501
MOD_NEK2_1	467	472	PF00069	0.403
MOD_NEK2_1	504	509	PF00069	0.414
MOD_NEK2_1	582	587	PF00069	0.402
MOD_NEK2_1	621	626	PF00069	0.517
MOD_NEK2_1	72	77	PF00069	0.506
MOD_NEK2_2	232	237	PF00069	0.517
MOD_PIKK_1	183	189	PF00454	0.373
MOD_PIKK_1	323	329	PF00454	0.236
MOD_PK_1	108	114	PF00069	0.500
MOD_PKA_2	107	113	PF00069	0.423
MOD_PKA_2	444	450	PF00069	0.508
MOD_PKA_2	500	506	PF00069	0.396
MOD_PKA_2	565	571	PF00069	0.381
MOD_PKB_1	279	287	PF00069	0.264
MOD_Plk_1	465	471	PF00069	0.401
MOD_Plk_4	203	209	PF00069	0.392
MOD_Plk_4	213	219	PF00069	0.383
MOD_Plk_4	40	46	PF00069	0.571
MOD_Plk_4	418	424	PF00069	0.441
MOD_Plk_4	467	473	PF00069	0.447
MOD_Plk_4	478	484	PF00069	0.384
MOD_Plk_4	500	506	PF00069	0.373
MOD_Plk_4	567	573	PF00069	0.457
MOD_Plk_4	632	638	PF00069	0.435
MOD_Plk_4	672	678	PF00069	0.674
MOD_ProDKin_1	302	308	PF00069	0.507
MOD_ProDKin_1	445	451	PF00069	0.416
MOD_ProDKin_1	624	630	PF00069	0.461
MOD_SUMO_rev_2	646	655	PF00179	0.452
TRG_DiLeu_BaEn_2	265	271	PF01217	0.359
TRG_DiLeu_BaLyEn_6	625	630	PF01217	0.359
TRG_DiLeu_LyEn_5	614	619	PF01217	0.236
TRG_ENDOCYTIC_2	106	109	PF00928	0.372
TRG_ENDOCYTIC_2	140	143	PF00928	0.400
TRG_ENDOCYTIC_2	155	158	PF00928	0.390
TRG_ENDOCYTIC_2	190	193	PF00928	0.391
TRG_ENDOCYTIC_2	383	386	PF00928	0.397
TRG_ENDOCYTIC_2	437	440	PF00928	0.405
TRG_ENDOCYTIC_2	472	475	PF00928	0.403
TRG_ENDOCYTIC_2	573	576	PF00928	0.389
TRG_ENDOCYTIC_2	613	616	PF00928	0.472
TRG_ENDOCYTIC_2	92	95	PF00928	0.399
TRG_ER_diArg_1	52	54	PF00400	0.644
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	45%	99%
A0A0N1HY49	Leptomonas seymouri	44%	100%
A0A0N1HZ06	Leptomonas seymouri	35%	100%
A0A0N1IHL1	Leptomonas seymouri	38%	98%
A0A0N1PAY4	Leptomonas seymouri	46%	79%
A0A0N1PB77	Leptomonas seymouri	35%	100%
A0A0N1PBZ2	Leptomonas seymouri	64%	100%
A0A0N1PCC1	Leptomonas seymouri	42%	100%
A0A381MBI0	Leishmania infantum	43%	100%
A0A3Q8I8X7	Leishmania donovani	43%	100%
A0A3Q8IAZ0	Leishmania donovani	88%	100%
A0A3Q8IH50	Leishmania donovani	60%	97%
A0A3Q8IVN0	Leishmania donovani	37%	100%
A0A3R7M4J1	Trypanosoma rangeli	42%	100%
A0A3S5H5P4	Leishmania donovani	43%	100%
A0A3S5H5V2	Leishmania donovani	42%	100%
A0A3S5H6F6	Leishmania donovani	88%	100%
A0A3S5H763	Leishmania donovani	51%	100%
A0A3S7WR10	Leishmania donovani	43%	94%
A0A3S7WR14	Leishmania donovani	78%	100%
A0A3S7WR15	Leishmania donovani	72%	82%
A0A3S7WR24	Leishmania donovani	88%	99%
A4H4T8	Leishmania braziliensis	43%	100%
A4H5Y4	Leishmania braziliensis	44%	100%
A4H617	Leishmania braziliensis	78%	100%
A4H618	Leishmania braziliensis	80%	100%
A4H619	Leishmania braziliensis	80%	100%
A4H620	Leishmania braziliensis	58%	100%
A4H6C3	Leishmania braziliensis	44%	100%
A4HNH7	Leishmania braziliensis	36%	100%
A4HSS2	Leishmania infantum	43%	100%
A4HUE4	Leishmania infantum	43%	94%
A4HUE5	Leishmania infantum	72%	100%
A4HUE6	Leishmania infantum	78%	100%
A4HUE7	Leishmania infantum	89%	100%
A4HUE8	Leishmania infantum	88%	99%
A4HUF4	Leishmania infantum	88%	100%
A4HUF5	Leishmania infantum	59%	100%
A4HYA9	Leishmania infantum	51%	100%
A4IC33	Leishmania infantum	35%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AG72	Leishmania infantum	42%	100%
E9AI40	Leishmania braziliensis	74%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	94%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	98%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4QDC4	Leishmania major	51%	100%
Q4QH81	Leishmania major	44%	100%
Q4QHH7	Leishmania major	60%	100%
Q4QHH8	Leishmania major	88%	100%
Q4QHH9	Leishmania major	87%	100%
Q4QHI0	Leishmania major	88%	99%
Q4QHI1	Leishmania major	81%	100%
Q4QHI2	Leishmania major	76%	100%
Q4QIU9	Leishmania major	42%	100%
Q4QJ48	Leishmania major	42%	100%
Q7KIP2	Leishmania major	35%	97%