Uncharacterized protein LmxM_21_0630_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHQ4_LEIMU

TriTrypDb:

LmxM.21.0630

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005657	replication fork	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0035861	site of double-strand break	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0090734	site of DNA damage	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E8NHQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHQ4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	16
GO:0006259	DNA metabolic process	4	16
GO:0006281	DNA repair	5	16
GO:0006725	cellular aromatic compound metabolic process	3	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0006950	response to stress	2	16
GO:0006974	DNA damage response	4	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0033554	cellular response to stress	3	16
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0043170	macromolecule metabolic process	3	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044260	obsolete cellular macromolecule metabolic process	3	16
GO:0046483	heterocycle metabolic process	3	16
GO:0050896	response to stimulus	1	16
GO:0051716	cellular response to stimulus	2	16
GO:0071704	organic substance metabolic process	2	16
GO:0090304	nucleic acid metabolic process	4	16
GO:1901360	organic cyclic compound metabolic process	3	16
GO:0000731	DNA synthesis involved in DNA repair	6	2
GO:0006301	postreplication repair	6	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009314	response to radiation	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019985	translesion synthesis	7	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0042276	error-prone translesion synthesis	8	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0071897	DNA biosynthetic process	5	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	16
GO:0003677	DNA binding	4	16
GO:0003684	damaged DNA binding	5	16
GO:0005488	binding	1	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901363	heterocyclic compound binding	2	16
GO:0003824	catalytic activity	1	3
GO:0003887	DNA-directed DNA polymerase activity	5	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016779	nucleotidyltransferase activity	4	3
GO:0034061	DNA polymerase activity	4	3
GO:0140097	catalytic activity, acting on DNA	3	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.691
CLV_C14_Caspase3-7	551	555	PF00656	0.491
CLV_NRD_NRD_1	136	138	PF00675	0.319
CLV_NRD_NRD_1	168	170	PF00675	0.328
CLV_NRD_NRD_1	350	352	PF00675	0.754
CLV_NRD_NRD_1	61	63	PF00675	0.348
CLV_PCSK_KEX2_1	136	138	PF00082	0.319
CLV_PCSK_KEX2_1	168	170	PF00082	0.328
CLV_PCSK_KEX2_1	352	354	PF00082	0.700
CLV_PCSK_KEX2_1	51	53	PF00082	0.353
CLV_PCSK_KEX2_1	61	63	PF00082	0.353
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.691
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.319
CLV_PCSK_SKI1_1	105	109	PF00082	0.277
CLV_PCSK_SKI1_1	221	225	PF00082	0.330
CLV_PCSK_SKI1_1	48	52	PF00082	0.319
CLV_Separin_Metazoa	189	193	PF03568	0.553
DEG_APCC_DBOX_1	135	143	PF00400	0.577
DEG_APCC_DBOX_1	60	68	PF00400	0.452
DEG_COP1_1	509	518	PF00400	0.367
DEG_Nend_UBRbox_1	1	4	PF02207	0.270
DEG_SPOP_SBC_1	370	374	PF00917	0.431
DOC_CYCLIN_RxL_1	218	229	PF00134	0.553
DOC_MAPK_DCC_7	61	69	PF00069	0.452
DOC_MAPK_gen_1	439	447	PF00069	0.551
DOC_MAPK_MEF2A_6	112	119	PF00069	0.469
DOC_MAPK_MEF2A_6	61	69	PF00069	0.448
DOC_MAPK_RevD_3	155	169	PF00069	0.487
DOC_PP2B_LxvP_1	272	275	PF13499	0.411
DOC_PP4_FxxP_1	187	190	PF00568	0.553
DOC_PP4_FxxP_1	283	286	PF00568	0.503
DOC_USP7_MATH_1	147	151	PF00917	0.517
DOC_USP7_MATH_1	275	279	PF00917	0.447
DOC_USP7_MATH_1	299	303	PF00917	0.539
DOC_USP7_MATH_1	357	361	PF00917	0.735
DOC_USP7_MATH_1	493	497	PF00917	0.460
DOC_WW_Pin1_4	25	30	PF00397	0.553
DOC_WW_Pin1_4	355	360	PF00397	0.657
DOC_WW_Pin1_4	53	58	PF00397	0.527
LIG_14-3-3_CanoR_1	179	184	PF00244	0.540
LIG_14-3-3_CanoR_1	277	286	PF00244	0.413
LIG_14-3-3_CanoR_1	406	412	PF00244	0.522
LIG_14-3-3_CanoR_1	439	444	PF00244	0.546
LIG_14-3-3_CanoR_1	539	544	PF00244	0.568
LIG_14-3-3_CanoR_1	89	97	PF00244	0.410
LIG_APCC_ABBAyCdc20_2	236	242	PF00400	0.482
LIG_BRCT_BRCA1_1	205	209	PF00533	0.553
LIG_BRCT_BRCA1_1	279	283	PF00533	0.472
LIG_BRCT_BRCA1_1	400	404	PF00533	0.479
LIG_eIF4E_1	218	224	PF01652	0.553
LIG_FHA_1	160	166	PF00498	0.480
LIG_FHA_1	269	275	PF00498	0.414
LIG_FHA_1	406	412	PF00498	0.520
LIG_FHA_1	420	426	PF00498	0.335
LIG_FHA_1	453	459	PF00498	0.522
LIG_FHA_1	496	502	PF00498	0.466
LIG_FHA_1	510	516	PF00498	0.484
LIG_FHA_1	90	96	PF00498	0.423
LIG_FHA_2	407	413	PF00498	0.452
LIG_LIR_Apic_2	280	286	PF02991	0.406
LIG_LIR_Apic_2	313	318	PF02991	0.400
LIG_LIR_Apic_2	79	85	PF02991	0.527
LIG_LIR_Gen_1	10	21	PF02991	0.468
LIG_LIR_Gen_1	125	135	PF02991	0.468
LIG_LIR_Gen_1	28	38	PF02991	0.468
LIG_LIR_Gen_1	427	436	PF02991	0.525
LIG_LIR_Nem_3	10	16	PF02991	0.468
LIG_LIR_Nem_3	125	131	PF02991	0.468
LIG_LIR_Nem_3	28	33	PF02991	0.468
LIG_LIR_Nem_3	362	368	PF02991	0.430
LIG_LIR_Nem_3	37	41	PF02991	0.448
LIG_LIR_Nem_3	373	379	PF02991	0.385
LIG_LIR_Nem_3	401	407	PF02991	0.561
LIG_LIR_Nem_3	427	432	PF02991	0.486
LIG_PCNA_PIPBox_1	541	550	PF02747	0.471
LIG_PCNA_yPIPBox_3	535	548	PF02747	0.546
LIG_PTB_Apo_2	388	395	PF02174	0.373
LIG_PTB_Apo_2	446	453	PF02174	0.531
LIG_SH2_NCK_1	13	17	PF00017	0.468
LIG_SH2_PTP2	128	131	PF00017	0.553
LIG_SH2_SRC	128	131	PF00017	0.492
LIG_SH2_STAP1	245	249	PF00017	0.468
LIG_SH2_STAT5	128	131	PF00017	0.479
LIG_SH2_STAT5	376	379	PF00017	0.396
LIG_SH2_STAT5	82	85	PF00017	0.452
LIG_SH3_1	82	88	PF00018	0.527
LIG_SH3_3	154	160	PF00018	0.492
LIG_SH3_3	38	44	PF00018	0.468
LIG_SH3_3	387	393	PF00018	0.479
LIG_SH3_3	460	466	PF00018	0.516
LIG_SH3_3	82	88	PF00018	0.527
LIG_SH3_4	266	273	PF00018	0.388
LIG_SUMO_SIM_anti_2	408	415	PF11976	0.481
LIG_SUMO_SIM_anti_2	613	619	PF11976	0.563
LIG_SUMO_SIM_par_1	270	276	PF11976	0.437
LIG_SUMO_SIM_par_1	417	424	PF11976	0.419
LIG_SUMO_SIM_par_1	594	599	PF11976	0.610
LIG_SUMO_SIM_par_1	613	619	PF11976	0.453
LIG_TRFH_1	53	57	PF08558	0.298
LIG_WRC_WIRS_1	544	549	PF05994	0.627
MOD_CK1_1	459	465	PF00069	0.362
MOD_CK1_1	506	512	PF00069	0.579
MOD_CK1_1	575	581	PF00069	0.774
MOD_CK1_1	585	591	PF00069	0.540
MOD_CK1_1	599	605	PF00069	0.461
MOD_CK1_1	606	612	PF00069	0.498
MOD_CK2_1	406	412	PF00069	0.339
MOD_CK2_1	424	430	PF00069	0.401
MOD_CK2_1	53	59	PF00069	0.320
MOD_Cter_Amidation	349	352	PF01082	0.541
MOD_DYRK1A_RPxSP_1	355	359	PF00069	0.469
MOD_GlcNHglycan	246	250	PF01048	0.321
MOD_GlcNHglycan	261	264	PF01048	0.395
MOD_GlcNHglycan	276	280	PF01048	0.311
MOD_GlcNHglycan	287	290	PF01048	0.417
MOD_GlcNHglycan	301	304	PF01048	0.481
MOD_GlcNHglycan	507	511	PF01048	0.592
MOD_GlcNHglycan	550	553	PF01048	0.603
MOD_GlcNHglycan	565	568	PF01048	0.665
MOD_GlcNHglycan	576	580	PF01048	0.634
MOD_GlcNHglycan	608	611	PF01048	0.655
MOD_GSK3_1	394	401	PF00069	0.283
MOD_GSK3_1	420	427	PF00069	0.329
MOD_GSK3_1	452	459	PF00069	0.287
MOD_GSK3_1	493	500	PF00069	0.353
MOD_GSK3_1	539	546	PF00069	0.634
MOD_GSK3_1	571	578	PF00069	0.701
MOD_GSK3_1	599	606	PF00069	0.685
MOD_GSK3_1	67	74	PF00069	0.269
MOD_GSK3_1	89	96	PF00069	0.372
MOD_LATS_1	437	443	PF00433	0.240
MOD_LATS_1	537	543	PF00433	0.531
MOD_N-GLC_1	459	464	PF02516	0.214
MOD_N-GLC_1	585	590	PF02516	0.715
MOD_NEK2_1	203	208	PF00069	0.468
MOD_NEK2_1	394	399	PF00069	0.322
MOD_NEK2_1	452	457	PF00069	0.388
MOD_NEK2_1	543	548	PF00069	0.602
MOD_NEK2_1	598	603	PF00069	0.585
MOD_PIKK_1	371	377	PF00454	0.290
MOD_PKA_2	178	184	PF00069	0.440
MOD_PKA_2	405	411	PF00069	0.330
MOD_PKA_2	452	458	PF00069	0.414
MOD_Plk_1	385	391	PF00069	0.420
MOD_Plk_1	430	436	PF00069	0.298
MOD_Plk_1	459	465	PF00069	0.208
MOD_Plk_1	610	616	PF00069	0.535
MOD_Plk_4	268	274	PF00069	0.382
MOD_Plk_4	34	40	PF00069	0.434
MOD_Plk_4	385	391	PF00069	0.376
MOD_Plk_4	394	400	PF00069	0.243
MOD_Plk_4	431	437	PF00069	0.279
MOD_Plk_4	539	545	PF00069	0.584
MOD_Plk_4	611	617	PF00069	0.582
MOD_ProDKin_1	25	31	PF00069	0.440
MOD_ProDKin_1	355	361	PF00069	0.658
MOD_ProDKin_1	53	59	PF00069	0.403
TRG_AP2beta_CARGO_1	430	439	PF09066	0.252
TRG_DiLeu_BaEn_1	220	225	PF01217	0.337
TRG_DiLeu_BaEn_4	430	436	PF01217	0.252
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.440
TRG_ENDOCYTIC_2	128	131	PF00928	0.355
TRG_ENDOCYTIC_2	13	16	PF00928	0.321
TRG_ENDOCYTIC_2	240	243	PF00928	0.369
TRG_ENDOCYTIC_2	429	432	PF00928	0.292
TRG_ER_diArg_1	235	238	PF00400	0.380
TRG_ER_diArg_1	379	382	PF00400	0.369
TRG_ER_diArg_1	438	441	PF00400	0.303
TRG_ER_diArg_1	60	62	PF00400	0.304
TRG_NES_CRM1_1	467	483	PF08389	0.298
TRG_NLS_MonoExtC_3	350	355	PF00514	0.569
TRG_NLS_MonoExtN_4	351	356	PF00514	0.697
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU7	Leptomonas seymouri	60%	78%
A0A0S4J2C8	Bodo saltans	37%	100%
A0A1X0NXK7	Trypanosomatidae	42%	100%
A0A3R7NDG4	Trypanosoma rangeli	45%	100%
A0A3S5H795	Leishmania donovani	72%	81%
A4HBQ9	Leishmania braziliensis	79%	82%
A4HBR0	Leishmania braziliensis	76%	100%
A4HZ61	Leishmania infantum	81%	79%
A4HZ62	Leishmania infantum	83%	81%
D0A1I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AV29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	80%
O42917	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	71%
Q04049	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	98%
Q4QCF2	Leishmania major	83%	100%
Q4QCF3	Leishmania major	81%	79%
Q9JJN0	Mus musculus	27%	89%
Q9VNX1	Drosophila melanogaster	26%	70%
Q9Y253	Homo sapiens	27%	87%
V5BMZ1	Trypanosoma cruzi	45%	100%