Uncharacterized protein LmxM_21_0620a_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHQ3_LEIMU

TriTrypDb:

LmxM.21.0620a

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHQ3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.449
CLV_NRD_NRD_1	201	203	PF00675	0.449
CLV_NRD_NRD_1	94	96	PF00675	0.449
CLV_PCSK_KEX2_1	169	171	PF00082	0.449
CLV_PCSK_KEX2_1	201	203	PF00082	0.449
CLV_PCSK_KEX2_1	84	86	PF00082	0.449
CLV_PCSK_KEX2_1	94	96	PF00082	0.324
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.449
CLV_PCSK_SKI1_1	138	142	PF00082	0.449
CLV_PCSK_SKI1_1	254	258	PF00082	0.449
CLV_PCSK_SKI1_1	81	85	PF00082	0.449
CLV_Separin_Metazoa	222	226	PF03568	0.650
DEG_APCC_DBOX_1	168	176	PF00400	0.650
DEG_APCC_DBOX_1	93	101	PF00400	0.650
DEG_Nend_Nbox_1	1	3	PF02207	0.812
DOC_CYCLIN_RxL_1	251	262	PF00134	0.650
DOC_MAPK_DCC_7	94	102	PF00069	0.650
DOC_MAPK_MEF2A_6	145	152	PF00069	0.650
DOC_MAPK_MEF2A_6	94	102	PF00069	0.650
DOC_MAPK_RevD_3	188	202	PF00069	0.650
DOC_PP4_FxxP_1	220	223	PF00568	0.650
DOC_USP7_MATH_1	16	20	PF00917	0.665
DOC_USP7_MATH_1	180	184	PF00917	0.650
DOC_USP7_MATH_1	22	26	PF00917	0.532
DOC_USP7_MATH_1	7	11	PF00917	0.805
DOC_WW_Pin1_4	18	23	PF00397	0.810
DOC_WW_Pin1_4	58	63	PF00397	0.650
DOC_WW_Pin1_4	86	91	PF00397	0.650
LIG_14-3-3_CanoR_1	122	130	PF00244	0.650
LIG_14-3-3_CanoR_1	17	22	PF00244	0.815
LIG_14-3-3_CanoR_1	212	217	PF00244	0.650
LIG_APCC_ABBAyCdc20_2	269	275	PF00400	0.650
LIG_BRCT_BRCA1_1	238	242	PF00533	0.650
LIG_eIF4E_1	251	257	PF01652	0.650
LIG_FHA_1	123	129	PF00498	0.650
LIG_FHA_1	193	199	PF00498	0.650
LIG_FHA_2	10	16	PF00498	0.819
LIG_LIR_Apic_2	112	118	PF02991	0.650
LIG_LIR_Gen_1	158	168	PF02991	0.650
LIG_LIR_Gen_1	43	54	PF02991	0.650
LIG_LIR_Gen_1	61	71	PF02991	0.424
LIG_LIR_Nem_3	158	164	PF02991	0.650
LIG_LIR_Nem_3	43	49	PF02991	0.650
LIG_LIR_Nem_3	61	66	PF02991	0.424
LIG_LIR_Nem_3	70	74	PF02991	0.537
LIG_PDZ_Class_2	275	280	PF00595	0.650
LIG_SH2_NCK_1	46	50	PF00017	0.650
LIG_SH2_PTP2	161	164	PF00017	0.650
LIG_SH2_SRC	161	164	PF00017	0.650
LIG_SH2_STAT5	115	118	PF00017	0.650
LIG_SH2_STAT5	161	164	PF00017	0.650
LIG_SH3_1	115	121	PF00018	0.650
LIG_SH3_3	115	121	PF00018	0.650
LIG_SH3_3	187	193	PF00018	0.650
LIG_SH3_3	71	77	PF00018	0.650
LIG_TRFH_1	86	90	PF08558	0.549
MOD_CK1_1	26	32	PF00069	0.770
MOD_CK2_1	86	92	PF00069	0.549
MOD_GlcNHglycan	28	31	PF01048	0.772
MOD_GSK3_1	100	107	PF00069	0.549
MOD_GSK3_1	122	129	PF00069	0.549
MOD_GSK3_1	18	25	PF00069	0.807
MOD_NEK2_1	236	241	PF00069	0.549
MOD_PKA_2	16	22	PF00069	0.817
MOD_PKA_2	211	217	PF00069	0.549
MOD_Plk_4	67	73	PF00069	0.549
MOD_ProDKin_1	18	24	PF00069	0.809
MOD_ProDKin_1	58	64	PF00069	0.549
MOD_ProDKin_1	86	92	PF00069	0.549
TRG_DiLeu_BaEn_1	253	258	PF01217	0.549
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.549
TRG_ENDOCYTIC_2	161	164	PF00928	0.549
TRG_ENDOCYTIC_2	273	276	PF00928	0.549
TRG_ENDOCYTIC_2	46	49	PF00928	0.549
TRG_ER_diArg_1	268	271	PF00400	0.549
TRG_ER_diArg_1	93	95	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
O42917	SCHPO	45%	32%
Q04049	YEAST	37%	44%
Q8H2D5	ARATH	39%	42%
Q9JJN0	MOUSE	34%	40%
Q9UNA4	HUMAN	28%	38%
Q9VHV1	DROME	34%	38%
Q9VNX1	DROME	30%	32%
Q9Y253	HUMAN	33%	39%